Nuclear localization show clear subcellular localization localization of specific rnas. Medical search. Frequent questions

It has been previously shown that rbf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy. (sdbonline.org)
Blocking the interaction between PIF7 and 14-3-3 proteins or reducing the expression of 14-3-3 proteins accelerates shade-induced nuclear localization and de-phosphorylation of PIF7, and enhances the shade phenotype. (elifesciences.org)
These studies have revealed that 14-3-3 proteins can interact with the phosphorylated forms of their client proteins in response to certain signals, and that this binding finalizes the signaling event by enabling a change in the subcellular localization, protein stability or intrinsic enzymatic activity of the client, or by promoting an association between the client and other proteins. (elifesciences.org)
We examined each of the individual SARS-CoV-2 proteins for their cytotoxicity in HEK 293 T cells and their subcellular localization in COS-7 cells. (biomedcentral.com)
We also used Mass-Spec Affinity purification to identify the host proteins interacting with SARS-CoV-2 Orf6 protein and tested a drug that could inhibit a specific Orf6 and host protein interaction. (biomedcentral.com)
All three proteins showed membrane localization in COS-7 cells. (biomedcentral.com)
First, we co-expressed fluorescently tagged VAPYRIN with a range of subcellular marker proteins, and secondly, we employed biochemical tools to identify interacting partner proteins of VAPYRIN. (frontiersin.org)
As an important tool for the quantitative analysis of confocal microscopic data sets from co-expression of fluorescent proteins, we developed a semi-automated image analysis pipeline that allows for precise spatio-temporal quantification of protein co-localization and of the dynamics of organelle association from movies. (frontiersin.org)
In contrast, both proteins were jointly detectable in most CCA cell lines and showed nuclear/cytoplasmic shuttling in a cell density-dependent manner. (biomedcentral.com)
Transcriptional regulators or transcription factors (TFs) are proteins that bind to specific sequences of the DNA, i.e. promoters, and hereby facilitate or inhibit the binding of RNA polymerase (RNAP). (hormonessignaling.com)
compared to the other strains L. sakei MF1053 showed a higher expression of seven proteins related to stress whatever the carbon source used for growth (Figure 1c). (hormonessignaling.com)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (nih.gov)
Of the 5379 expected proteins in prototype UPEC strain CFT073, only six proteins met all of our founded criteria: (1) surface exposure (expected and shown), (2) induction during growth in human being urine, (3) high manifestation in experimentally infected mice Minocycline hydrochloride and (4) high manifestation in ladies with UTI, (5) immunogenicity, and (6) pathogen-specificity. (morainetownshipdems.org)
The kinetic parameters of recombinant proteins showed that ZmHXK4-7 have high catalytic efficiency for Glc, fructose (Fru) and mannose (Man), ZmHXK7 has a lower Km for ATP, and together with ZmHXK8 they have lower sensitivity to inhibition by ADP, G6P and N-acetylglucosamine than ZmHXK4-6 and ZmHXK9. (biomedcentral.com)
Our observations suggest that the HXKs may be redundant proteins with specific roles depending on carbon and ATP availability, metabolic needs, or sensor requirements. (biomedcentral.com)
We found that the FERM domain in the tail region, which is known to bind to lipids as well as other proteins, is essential for both nuclear and chloroplast positioning, whereas the proximal MyTH4 domain plays a supporting role in chloroplast transport. (go.jp)

Two classes of ER exist: nuclear estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors (mERs) (GPER (GPR30), ER-X, and Gq-mER), which are mostly G protein-coupled receptors. (wikipedia.org)
Capsid protein p24 forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. (proteopedia.org)
Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. (proteopedia.org)
Here, we discover a previously unknown type of SBD in four independent families caused by bi-allelic loss-of-function pathogenic variants in TMEM53 , which encodes a nuclear envelope transmembrane protein. (nature.com)
In this study, we discover a previously unknown type of SBD and identify its causal gene, TMEM53 , which encodes nuclear envelope transmembrane (NET) protein 53 (TMEM53, also known as NET4). (nature.com)
In addition, nuclear Dicer fosters termination of RNAPII transcription [ 11 ] and alternative polyadenylation at a subset of protein-coding genes [ 12 ]. (prolekarniky.cz)
The authors showed that transfection of exogenous small interfering (exo-si)RNA triggers silencing of a subset of protein-coding gene promoters. (prolekarniky.cz)
More recently, two studies point toward Dicer-dependent nuclear RNAi in mammals by demonstrating that nuclear, chromatin-associated Dicer impairs expression of the microtubule-binding protein Doublecortin in mouse adult neural stem cells [ 14 ] and transactivation of the human secreted frizzled-related protein 1 promoter in cholangiocarcinoma cells [ 15 ]. (prolekarniky.cz)
First identified in Drosophila, the conserved Polycomb group (Pc-G) protein complexes were shown to be both writers (Polycomb Repressive Complex 2, PRC2) and readers (Polycomb Repressive Complex 1, PRC1) of H3K27me3 [ 19 , 20 , 21 ]. (biomedcentral.com)
An analysis of MAFB protein subcellular localization revealed a strong nuclear and perinuclear localization in the CdtB-distended nuclei in intestinal and hepatic cells. (bvsalud.org)
One of the most significant differences was the overexpression, in nonresponders, of CHEK1, a gene encoding Chk1, a protein kinase that can be blocked by specific inhibitors. (bvsalud.org)
The human BRCA2 gene encodes a nuclear protein of 3,418 amino acids [ 5 ], and is believed to play a pivotal role in DNA damage repair [ 6 ]. (ijbs.com)
The BRCA2 protein has been shown to bind to RAD51, the mammalian homolog of the RecA recombinase [ 6 - 9 ], and thus is believed to be involved in the repair of DNA double-strand breaks [ 6 ]. (ijbs.com)
The goal of this study was to examine the nature and expression pattern of the protein product(s) of the Thap1 transcription factor ( DYT6 gene) in mouse neurons, and to study the regional and developmental distribution, and subcellular localization of Thap1 protein. (biomedcentral.com)
Deep RNA-DNA, RNA-protein interaction studies, and phenotype rescue analyses reveal that LETR1 is a nuclear trans-acting lncRNA modulating, via key epigenetic factors, the expression of essential target genes, including KLF4 and SEMA3C , governing the growth and migratory ability of LECs. (nature.com)
Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. (cancerindex.org)
The antiadipogenic mechanism of endostatin lies in its interaction with Sam68 RNA-binding protein in the nuclei of preadipocytes. (diabetesjournals.org)
In line with a more complex picture, multiple isoforms of the protein likely exist and non-centrosomal sites of localisation have been reported. (springer.com)
These data highlight that ESE-1 contains NLS and NES signals that play a critical role in regulating its subcellular localization and function, and that an intact SAR domain mediates MEC transformation exclusively in the cytoplasm, via a novel nontranscriptional mechanism, whereby the SAR motif is accessible for ligand and/or protein interactions. (biomedcentral.com)
The human ETS (E26 Transformation-Specific) protein family is a diverse group of 27 known transcription factors that regulate such varied cellular processes as differentiation and apoptosis, but also appear to induce oncogenesis when mutated or aberrantly expressed [ 1 - 4 ]. (biomedcentral.com)
Overexpression of one ETS protein in particular, the epithelium-specific ETS factor ESE-1, is implicated in human mammary transformation. (biomedcentral.com)
The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. (nih.gov)
Furthermore, the deleterious aftereffect of missense mutations can occur not merely from immediate disruption of CAPN3 function(s), but additionally from disruption from the protein's structural integrity, that could affect its intra or intermolecular protein lead and interactions to decreased stability or altered localization. (exposed-skin-care.net)

Some miRNAs are hosted in pri-miRNAs annotated as long non-coding RNAs (lncRNAs) and defined as MIRHGs (for miRNA Host Genes). (mdpi.com)
Recent studies have revealed the importance of long noncoding RNAs (lncRNAs) as tissue-specific regulators of gene expression. (nature.com)
We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
Subsequent antisense oligonucleotide-knockdown transcriptomic profiling of two LEC- and two BEC-specific lncRNAs identifies LETR1 as a critical gatekeeper of the global LEC transcriptome. (nature.com)
In the latest genome annotation, lncRNAs, which are arbitrarily defined as noncoding RNAs longer than 200 nucleotides, constitute ~72% of the transcribed genome 13 , whereas mRNAs comprise only 19%, indicating the need for functional annotation of lncRNAs. (nature.com)
Long non-coding RNAs (lncRNAs) may act as potential markers for prognosis and progression of liver diseases and furthermore as direct targets for therapeutic purposes. (biomedcentral.com)

Transcriptome comparisons of SOX9+ cells with GLT1+ cells showed that the two populations of cells exhibit largely overlapping gene expression. (jneurosci.org)
Notably, circRNAs display cell-type, tissue-type and developmental-stage specific expression patterns in eukaryotic transcriptome, which reveals their significant regulatory functions in gene expression. (ijbs.com)
However, it has been proven that more than 62% of genomic DNA serves as a template for transcription, which indicates that there are abundant non-coding RNAs (ncRNAs) in human transcriptome [ 2 , 3 ]. (ijbs.com)

This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3' to 5' endonucleasic mode. (proteopedia.org)
It is not clear if both polymerase and RNase H activities are simultaneous. (proteopedia.org)
RNase H probably can proceed both in a polymerase-dependent (RNA cut into small fragments by the same RT performing DNA synthesis) and a polymerase-independent mode (cleavage of remaining RNA fragments by free RTs). (proteopedia.org)

Therefore, a clearer understanding capsid expression was analyzed by immunofluorescent assay of WNV is necessary in order to identify new strategies to treat in HeLa, 293-T, RD, or SH-SY5Y cells by using anti-His tag or prevent this viral infection (3). (cdc.gov)
This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)
Murine skin melanoma cells (B16F0 and B16F1) also show the expression regulation of Tβ4 by Smad and TCF/LEF. (aacrjournals.org)
Tβ4-knockout B16F1 (Tβ4 KO) clones show significantly diminished expression level of tumor-associated genes, which is regulated by the TGFβ/MRTFs pathway. (aacrjournals.org)
Phosphorylation-resistant site mutations in PIF7 result in increased nuclear localization and shade-induced gene expression, and consequently augment hypocotyl elongation. (elifesciences.org)
In contrast, the 'facultative' heterochromatin corresponds to the deposition of H3K27me3 on gene-rich regions, whose silencing is transient and dynamic across developmental processes, allowing cell type-specific differentiation and rapid adaptation of gene expression [ 5 ]. (biomedcentral.com)
Taken together, these data show that the CDT of enterohepatic Helicobacters modulates the expression of the MAFB oncoprotein, which is translocated in the nucleus and is associated with the remodeling of the nuclei and actin cytoskeleton. (bvsalud.org)
To identify a nuclear marker pathognomonic of astrocytic phenotype, we assessed differential RNA expression by FACS-purified adult astrocytes and, on that basis, evaluated the expression of the transcription factor SOX9 in both mouse and human brain. (jneurosci.org)
In particular, the FANTOM (Functional Annotation of the Mammalian Genome) consortium pioneered the discovery of the noncoding RNA world by providing, through Cap Analysis of Gene Expression (CAGE-Seq), the first evidence that large portions of our genome are transcribed, producing a multitude of sense and antisense transcripts 12 . (nature.com)
Although a direct link between Snail expression and tumor metastasis has not yet been reported, a number of studies have shown that the overexpression of Snail is correlated with tumor invasion ( 7 ). (spandidos-publications.com)
Studies have shown a correlation between Snail expression and the degree of infiltration in breast carcinomas ( 8 ). (spandidos-publications.com)
A number of reports have shown that RhoA expression is upregulated in a group of malignancies ( 13 ) and that the activity of RhoA is correlated with lymph node metastasis in colorectal cancer ( 14 ). (spandidos-publications.com)
Statistical analysis of gene expression data [10] showed that ArcA regulates the expression of a wide variety of genes learn more involved in the biosynthesis of small and macromolecules, transport, carbon and energy metabolism, cell structure, etc. (hormonessignaling.com)
Cell cycle analysis showed an accumulation of tumor cells predominantly in 511296-88-1 manufacture G0/G1 phase with an increase in concentration of TD-MSCs, which was confirmed by increased mRNA expression of cell cycle negative regulator p21. (immune-source.com)
Subcellular location of ZAR2 and its expression from the reverse promoter of the BRCA2 gene are stringently regulated in a cell cycle dependent manner. (biomedcentral.com)
Expression and subcellular localization of USH1C/harmonin in human retina provides insights into pathomechanisms and therapy. (nih.gov)

The latter two studies conclude that Dicer association with chromatin may be mediated by the localised production of dsRNA, which is processed into endogenous small interfering (endo-si)RNA to mediate heterochromatin formation by recruitment of G9a methyltransferase in a Dicer-dependent manner. (prolekarniky.cz)
SncRNAs are less than 200 nt in length, consisting of microRNAs (miRNAs), Piwi-interacting RNAs (piRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and transcription initiation RNAs (tiRNAs) [ 6 ]. (ijbs.com)

Employing the same cells as used by Much and colleagues, we combined super-resolution microscopy followed by 3D reconstitution and biochemical assays to show that endogenously tagged HA-Dicer prominently localises in the nucleus under physiological conditions. (prolekarniky.cz)

A clear genotype/phenotype relationship has not been established, nor is it definitively known that alterations in transcription of Thap1 downstream targets are responsible for DYT6, as Thap1 may have other, yet to be identified functions. (biomedcentral.com)
ESE-1 initiates transformation of MCF-12A cells via a non-transcriptional, cytoplasmic process that is mediated by a unique 40-amino acid serine and aspartic acid rich (SAR) subdomain, whereas, ESE-1's nuclear transcriptional property is required to maintain the transformed phenotype of MCF7, ZR-75-1 and T47D breast cancer cells. (biomedcentral.com)

Notably, Debcl modulates Drp1 mitochondrial localization during apoptosis. (sdbonline.org)

This paper challenges several studies reporting various RNA metabolic functions of Dicer in human nuclei. (prolekarniky.cz)
Catalytically active Dicer was purified from human nuclei and shown to promote processing of dsRNA hairpin structures [ 9 ] and stimulate initiation of RNAPII transcription at hormone-responsive genes [ 10 ]. (prolekarniky.cz)

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. (cancerindex.org)

In addition to the catalytic domain, eukaryotic sirtuins contain variable amino- and carboxy-terminal extensions that regulate their subcellular localizations and catalytic activity. (biomedcentral.com)

However, we lack a clear under- mas Jefferson University, Philadelphia, PA) has been reported standing of WNV pathogenesis, and little specific treatment to inhibit the caspase cascade (5). (cdc.gov)

On the basis of cell line experiments, abiraterone acetate and Chk1 inhibitor combination showed at least additive effect on cell viability, cell cycle, apoptosis, and accumulation of DNA damages. (bvsalud.org)

The ERs are regarded to be cytoplasmic receptors in their unliganded state, but visualization research has shown that only a small fraction of the ERs reside in the cytoplasm, with most ER constitutively in the nucleus. (wikipedia.org)
Cytoplasmic Dicer is a key component of the canonical micro (mi)RNA biogenesis pathway. (prolekarniky.cz)
employed an endogenously HA-tagged Dicer knock-in mouse cell line to show that Dicer is exclusively cytoplasmic. (prolekarniky.cz)
This surprisingly wide range of YAP positivity in independent CCA cohorts might be due to different scoring algorithms (e.g., if only nuclear and/or cytoplasmic YAP positivity was considered) or variable cohort composition with regard to CCA subtypes. (biomedcentral.com)
Furthermore, we show that exclusive cytoplasmic targeting of the SAR domain is sufficient to initiate transformation, and we report that an intact SAR domain is required, since block mutagenesis reveals that an intact SAR domain is necessary to maintain its full transforming potency. (biomedcentral.com)

Examination of the dJmj localization in various Polycomb group (PcG) mutant lines at the late growth stage allowed identification of some PcG genes, including Polycomb (Pc) , to be responsible for dJmj recruitment to nucleolus. (sdbonline.org)
The genome of P. falciparum contains hundreds of genes that show CVGE, such that individual parasites within an isogenic population express these genes at very different levels, often fully active or completely silenced [15] . (plos.org)

MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed into mature miRNAs. (mdpi.com)

However, the mechanism by which nuclear translocation is regulated remains unclear. (nature.com)
LncARSR was observed to bind to YAP1, which inhibited phosphorylation nuclear translocation. (biomedcentral.com)

POL_HV1B5 Gag-Pol polyprotein and Gag polyprotein may regulate their own translation, by the binding genomic RNA in the 5'-UTR. (proteopedia.org)
At low concentration, Gag-Pol and Gag would promote translation, whereas at high concentration, the polyproteins encapsidate genomic RNA and then shutt off translation (By similarity). (proteopedia.org)
Facilitates rearangement of nucleic acid secondary structure during retrotranscription of genomic RNA. (proteopedia.org)
Conversion of viral genomic RNA into dsDNA requires many steps. (proteopedia.org)

Here, we show that shade light induces the de-phosphorylation and nuclear accumulation of PIF7. (elifesciences.org)

Importantly, missense mutations have also been identified outside the DBD, and these mutations may alter Thap1 conformation and/or localization in such a way as to indirectly affect the structure and/or function of the DBD. (biomedcentral.com)
It really is plausible which the subcellular localization of CAPN3 determines its particular mobile function, which mutations make a difference some of those features straight or indirectly (1). (exposed-skin-care.net)

Analysis revealed that Buffy acted to rescue the associated loss of locomotor ability observed in the alpha-synuclein-induced model of PD, while Buffy RNA interference resulted in an enhanced alpha-synuclein-induced loss of climbing ability. (sdbonline.org)
Here, BRCA2 heterozygosity was mimicked in HT-29 colon cells by reducing levels of BRCA2 through stable RNA interference. (ijbs.com)
In this report, we have utilized HT-29 colon cancer cells and have mimicked the heterozygous state of BRCA2 in these cells through RNA interference. (ijbs.com)

Together, our study provides several lines of evidence supporting the intriguing concept that every cell type expresses precise lncRNA signatures to control lineage-specific regulatory programs. (nature.com)
In some processes, chromatin modifications carry heritable regulatory information that is transmitted from mother to daughter cells, whereas in other cases, they are implicated in the execution of the information contained in the DNA sequence, or occur as a consequence of dynamic nuclear processes such as transcription. (plos.org)
Hexokinase (HXK) is the only plant enzyme that phosphorylates glucose (Glc), so it is key to fueling several metabolic pathways depending on their substrate specificity, metabolite regulatory responses and subcellular localization. (biomedcentral.com)

Interestingly, Dicer depletion in human cells caused defects in precursor messenger (pre-m)RNA processing [ 8 ]. (prolekarniky.cz)
These findings are in line with previous studies, reporting the existence of nuclear RNAi in human cells [ 13 ]. (prolekarniky.cz)
In support of this notion, cells lacking a functional BRCA2 gene show hypersensitivity to DNA damaging agents such as mitomycin C (MMC) and sensitivity to chemicals such as methyl methane sulfonate [ 10 ]. (ijbs.com)
As shown for HCC, inactivation of the Hippo kinase cassette or activation of YAP is leading to liver overgrowth via expansion of liver progenitor cells and eventually cancer development with combined hepatocellular/cholangiocellular differentiation [ 5 ]. (biomedcentral.com)
This study was intended to identify the function of long non-coding RNA (lncRNA) lncARSR in NAFLD and its role in human HCC cells (HepG2) proliferation and invasion. (biomedcentral.com)
We show that Lrp6 opposes Wnt11 activity and localizes to the posterior edge of migrating DMZ cells and that Lrp6 downregulation enhances cortical and nuclear localization of Dsh and phospho-JNK, respectively. (silverchair.com)
The transcription factor Nuclear Factor-kappa B (NF-κB) is pivotal in mediating inflammatory processes in general and is considered as the central regulator activating cells in response to silica [ 6 ]. (biomedcentral.com)
Here we showed that in migrating MDA-MB-231 cells Rab40c regulates focal adhesion's number, size, and distribution. (life-science-alliance.org)
In contrast, the KCBP knockout (KO) line in the moss Physcomitrella patens showed a defect in nuclear and organelle positioning in apical stem cells. (go.jp)

The endoribonuclease Dicer recognises and processes double-stranded (ds)RNA substrates of various origins into small non-coding (nc)RNA [ 1 ]. (prolekarniky.cz)

From transcription to transport: emerging roles for nuclear myosin I. Hofmann WA, et al . (nih.gov)
Further investigation is necessary to understand their specific or redundant physiological roles. (biomedcentral.com)

We show that TMEM53 acts as an inhibitor of BMP-SMAD signaling by preventing SMAD accumulation in the cell nucleus and that its deficiency enhances osteogenic differentiation by overactivating the BMP signaling pathway. (nature.com)
In particular, we show that ITCH enhances epithelial-to-mesenchymal transition (EMT) through boosting YAP oncogenic function. (oncotarget.com)

Overexpression of Snail has been associated with breast cancer metastasis, although the specific role of Snail in the process remains unclear. (spandidos-publications.com)

Binds these RNAs through its zinc fingers. (proteopedia.org)

We show that Lrp6 downregulation (by morpholino injection) or overexpression in Xenopus embryos disrupts convergent extension, a hallmark feature of Wnt/PCP components. (silverchair.com)

To assess the role of NES2 in regulating ESE-1 subcellular localization and subsequent transformation potency, we site-specifically mutagenized NES2, within full-length GFP-ESE-1 and GFP-NES2-SAR reporter constructs. (biomedcentral.com)

Our data indicate evolutionary conservation of nuclear Dicer localisation and function in mammals in response to DNA damage. (prolekarniky.cz)

SIGNIFICANCE STATEMENT Astrocytes are traditionally identified immunohistochemically by antibodies that target cell-specific antigens in the cytosol or plasma membrane. (jneurosci.org)

A closely related debate around chromatin modifications is about causality: several histone PTMs correlate with specific transcriptional states, but in many cases they are not responsible for a transcriptional outcome but rather are a consequence of it [7] . (plos.org)

ROC analysis showed high diagnostic performance of miR-34a (AUC = 0.854), MET (AUC = 0.765), and E2F3 (AUC = 0.761). (hindawi.com)
The analysis showed that SOX9+ astrocytes constitute ∼10-20% of the total cell number in most CNS regions, a smaller fraction of total cell number than previously estimated in the normal adult brain. (jneurosci.org)

Activation of the classical NF-κB pathway in macrophages and type II pneumocytes was indicated by enhanced immunostaining of phospho-IκBα in these specific lung cell types. (biomedcentral.com)

In support of this hypothesis, heterozygosity for a BRCA2 mutation has been shown to cause sensitivity to DNA damage agents and reduced RAD51 focus formation after irradiation in the chicken B cell line DT40 [ 16 ]. (ijbs.com)
For short hairpin RNA (shRNA) targeting of BRCA2, the pRETRO-SUPER plasmid [ 19 ] was utilized as previously described [ 20 ]. (ijbs.com)
Loss of BRCA2 function has been shown to lead to centrosome amplification, chromosomal rearrangement, aneuploidy, and reduced efficiency of homologous recombination-mediated double-strand break repair. (biomedcentral.com)

citation needed] Due to alternative RNA splicing, several ER isoforms are known to exist. (wikipedia.org)

Studies have shown that several transcription factors, including the Snail/Slug family ( 3 ), δEF1/ZEB1 ( 4 ) and SIP1 ( 5 ) have been implicated in E-cadherin repression. (spandidos-publications.com)

To map the minimal functional nuclear localization (NLS) and nuclear export (NES) signals, we fused in-frame putative NLS and NES motifs between GFP and the SAR domain. (biomedcentral.com)

Although a report has shown that RhoB, a small GTPase involved in cytoskeletal actin rearrangement, lies downstream of Slug ( 11 ), another member of the Snail super-family, there is no evidence to support a link between Snail and Rho GTPases. (spandidos-publications.com)

The C-terminal F domain function is not entirely clear and is variable in length. (wikipedia.org)
The second function is to play a role in nuclear localization of the viral genome at the very start of cell infection. (proteopedia.org)
Elucidating the function of the mutated gene, ALMS1 , is critical for the development of specific treatments and may uncover pathways relevant to a range of other disorders including common forms of obesity and type 2 diabetes. (springer.com)

Human Dicer may also interact with the nuclear pore complex component NUP153 [ 7 ]. (prolekarniky.cz)
Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a. (nih.gov)
Initial, CAPN3 is AZ-33 normally mostly muscle-specific (9), but is normally detectable in zoom lens, liver, human brain and cardiac muscles during advancement (10C13). (exposed-skin-care.net)

We show here that SOX9 is an astrocyte-specific nuclear marker in all major areas of the CNS outside of the neurogenic regions. (jneurosci.org)

These studies show that site-specific mutation of NES2 completely abrogates ESE-1 transforming activity. (biomedcentral.com)

A series of studies imply nuclear localisation of mammalian Dicer and association with chromatin. (prolekarniky.cz)
In a mutant of testis-specific TAF homolog (tTAF) that is responsible for nucleolus localization of Pc, dJmj signals were detected not only at nucleolus but also on the condensed chromatin in the late growth stage. (sdbonline.org)

Moreover, we are yet unable to predict response to a specific therapy in an individual patient and the optimal sequence of these therapies needs to be clarified. (oaepublish.com)

We report that the WNV capsid (Cp) by itself induces rapid nuclear condensation and cell death in tissue culture. (cdc.gov)

Immunocytochemical analyses was performed with specific antibodies to dJmj and tri-methylation at lysine 27 on histone H3 (H3K27me3). (sdbonline.org)

Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that converts the viral RNA genome into dsDNA in the cytoplasm, shortly after virus entry into the cell. (proteopedia.org)
No difference in RAD51 subcellular localization and focus formation was observed between control and mimicked heterozygous cell lines. (ijbs.com)
Jarid2 methylation is shown to be important to promote PRC2 activity at a locus devoid of H3K27me3 and for the correct deposition of this mark during cell differentiation. (sdbonline.org)
It was shown in Arabidopsis that KCBP controls trichome cell shape by orchestrating MT and actin cytoskeletons using its tail and motor domains. (go.jp)

We have shown that antibodies bind to the surface of UPEC expressing the antigens. (morainetownshipdems.org)

We shown for all four vaccine antigens that antigen-specific serum IgG represents a strong correlate of safety in vaccinated mice. (morainetownshipdems.org)

The Filipowicz lab reported enrichment of mammalian Dicer at ribosomal RNA loci, suggesting a possible role for Dicer in maintaining integrity of ribosomal DNA arrays. (prolekarniky.cz)
However, the role of lncARSR in NAFLD is less clear. (biomedcentral.com)

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