Loading...
  • intrinsic
  • Apoptosis is an organized mechanism of cellular death triggered through either an extrinsic pathway (death receptor signaling) or a cellular intrinsic pathway (mitochondrial breakdown). (frontiersin.org)
  • About 50% of animals reconstituted with BM cells expressing "gain-of-function" Notch alleles developed CD4 + -CD8 + T-ALLs closely resembling their human counterparts by 10 to 40 weeks posttransplantation, whereas animals reconstituted with cells expressing full-length Notch1, which lacks intrinsic signaling activity, remained healthy ( 38 ). (asm.org)
  • roles
  • FGFR (fibroblast growth factor receptor) signalling plays critical roles in embryogensis, adult physiology, tissue repair and many pathologies. (clinsci.org)
  • In the present review, we focus on two distinct but emerging hot topics in FGF biology: its role in stromal cross-talk during cancer progression and the potential roles of FGFR signalling in the nucleus. (clinsci.org)
  • 2 , 3 In the eye, studies have shown that sphingolipid signaling plays important roles in the homeostasis of photoreceptors and retinal pigment epithelium and the modulation of conventional outflow resistance. (arvojournals.org)
  • interfere
  • Thus, nEGFR has an old origin resembling the cancer evolution, but TM may interfere NLS driven signaling for natural selection of survival to evade NLS induced aggressive cancers. (jcancer.org)
  • However, these deletions also inhibit some of the early microglial activation - within 24 h and long before the appearance of cell death, suggesting that these transcription factors may also interfere with the synthesis of injury signals from lesioned but not dying neurons. (frontiersin.org)
  • Distinct
  • Distinct functions of β-catenin in Wnt signaling and cell adhesion have been implicated by studies with Drosophila and Xenopus ( 11 , 48 , 60 ). (asm.org)
  • genes
  • It contains a characteristic Forkhead box DNA binding domain, and is able to up- and downregulate expression of a variety of genes via binding of its consensus Forkhead Recognition Element, or similar sequences (including Insulin Response Elements). (cisreg.ca)
  • apoptosis
  • Extending these observations, colon biopsies from E. faecalis -colonized IL-10 −/− mice exhibited crypt hyperplasia and increased staining for macrophages, TNF-α, netrin-1, NF-κB, Tnfrsf1b, and the proliferation marker proliferating cell nuclear antigen while also displaying a reduction in epithelial cell apoptosis. (aacrjournals.org)
  • molecular
  • Our previous study has developed an effective algorithm to predict nuclear import activity, in which molecular interaction energy components (MIECs) were used to characterize NLS-import receptor interaction, and a support vector regression machine(SVR) was used to learn the relationship between the characterized NLS-import receptor interaction and the corresponding nuclear import activity . (ommegaonline.org)
  • receptors
  • Nuclear receptors are less acknowledged as targets, largely due to historical scepticism as to their existence or importance. (clinsci.org)
  • However, increasing evidence from across the receptor tyrosine kinase field is now strong enough to make the study of nuclear growth factor receptors a major area of interest. (clinsci.org)
  • complexes
  • In addition to its function in the Wnt signaling pathway, β-catenin is also an essential component of adhesion complexes ( 18 , 24 ). (asm.org)
  • Wnt signaling has been shown to increase the pool of β-catenin-APC complexes and the pool of free, or uncomplexed, β-catenin ( 49 , 58 ). (asm.org)
  • novel
  • See commentary " Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family " in J Cell Biol , volume 169 on page 623. (pubmedcentralcanada.ca)
  • cancers
  • For example, dysregulated nuclear transport of NF- κB is associated with cancers ( 2 , 7 , 8 ). (jcancer.org)
  • Of particular interest over recent years, it has been implicated in a wide range of cancers, and concerted efforts are underway to target different aspects of FGFR signalling networks. (clinsci.org)
  • Biol
  • See commentary " Spatial Localization of m-Calpain to the Plasma Membrane by Phosphoinositide Biphosphate Binding during Epidermal Growth Factor Receptor-Mediated Activation " in Mol Cell Biol , volume 26 on page 5481. (pubmedcentralcanada.ca)
  • function
  • Finally, we show that a Wnt-1 signal and β-catenin association are not required for the architectural function of LEF-1 in the regulation of the T-cell receptor α enhancer, which involves association of LEF-1 with a different cofactor, ALY. (asm.org)
  • cell
  • Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. (uniprot.org)
  • Both the ankyrin repeat and C-terminal transactivation domains were required for T-cell leukemogenesis, whereas the N-terminal RAM domain and a C-terminal domain that includes a PEST sequence were nonessential. (asm.org)
  • found
  • Nuclear localized EGFR has been found in regenerated hepatocytes, benign and cancerous tumors ( 9 , 11 , 13 , 14 , 15 ). (jcancer.org)
  • genetic
  • One of the prominent features of eukaryotic cells is the spatial separation of genetic materials from the translational machinery by the nuclear envelope ( 1 , 2 ). (jcancer.org)
  • thought
  • Message Body (Your Name) thought you would like to see this page from the Science Signaling web site. (sciencemag.org)
  • Wnt signaling is thought to be mediated via interactions between β-catenin and members of the LEF-1/TCF family of transcription factors. (asm.org)