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  • interactions
  • The nuclear lamina is assembled by interactions of two lamin polypeptides in which the α-helical regions are wound around each other to form a two stranded α-helical coiled-coil structure, followed by a head-to-tail association of the multiple dimers. (wikipedia.org)
  • muscular
  • The chromatin-lamina network is increasingly studied due to the growing number of phenotypes found in mutations of Lamin A, B1 or B2 such as Hutchison Gilford Progeria, subtypes of cardiomyopathy, muscular dystrophy, CMT, lipodystrophy, or leukodystrophy. (uni-halle.de)
  • Functions
  • The nuclear lamina is involved in numerous nuclear functions including maintaining nuclear shape, determining nuclear positioning, organizing chromatin and regulating the cell cycle, DNA replication, transcription, cell differentiation, apoptosis, and aging. (nih.gov)
  • These alterations can have a downstream effect on cellular functions such as cell cycle facilitation, DNA replication, nuclear transport, and alteration of nuclear structure. (wikipedia.org)
  • autophagy
  • Although extensive studies have focused on autophagic turnover of cytoplasmic materials, little is known about the role of autophagy in degrading nuclear components. (qmul.ac.uk)
  • cyclin
  • Nuclear-dominant expression of cyclin B1 leads to poorer prognosis due to its weak activity compared to cytoplasmic cyclin B1. (wikipedia.org)
  • diseases
  • Understanding the molecular mechanisms responsible for disease manifestations has also led to the development of novel therapeutic strategies to address lamina‐related diseases. (els.net)
  • nucleocytoplasmic
  • Stoffler D, Feja B, Fahrenkrog B, Walz J, Typke D, and Aebi U (2003) Cryo-electron tomography provides novel insights into nuclear pore architecture: implications for nucleocytoplasmic transport. (springer.com)
  • refers
  • The specific epithet stenophylla is formed from the Greek words steno (narrow) and phylla (leaves), and refers to the shape of the lamina. (wikipedia.org)
  • In contrast to true epithelium, however, the cell layers of the Placozoa possess no basal lamina, which refers to a thin layer of extracellular material underlying epithelium that stiffens it and separates it from the body's interior. (wikipedia.org)
  • cell
  • Targeting of p21 promoter is responsible for inducing cell differentiation, which is promoted by modifying the DNA nuclear microenvironment. (wikipedia.org)
  • Nuclear DNA damage can contribute to aging either indirectly (by increasing apoptosis or cellular senescence) or directly (by increasing cell dysfunction). (wikipedia.org)