Nuclear hela cells. Medical search. Frequent questions

EB06619 (1µg/ml) staining of HeLa (A) and Jurkat (B) cell lysate (35µg protein in RIPA buffer). (everestbiotech.com)
EB06277 (1µg/ml) staining of Human Ovary (A) lysate and HEK293 (B) cell lysate (35µg protein in RIPA buffer). (everestbiotech.com)
Western Blot: cIAP-2/HIAP-1 Antibody [NBP1-27972] - HeLa whole cell lysate. (novusbio.com)

Approx 50kDa band observed in lysates of cell line HeLa and approx 55kDa in lysates of cell line Jurkat (calculated MW of 51.5kDa according to NP_057207.1). (everestbiotech.com)
Approx 60kDa band observed in lysates of cell line HEK293 and in Human Ovary lysates (calculated MW of 60.3kDa according to NP_110379.2). (everestbiotech.com)
Description Western blot analysis of Human Cell line lysates showing detection of HSP90 protein using Rabbit Anti-HSP90 Polyclonal Antibody (11107). (qedbio.com)

We initially used maps statically to generate a database with localization and absolute copy number information for over 8700 proteins from HeLa cells, approaching comprehensive coverage. (elifesciences.org)
Proteins are the tools and machines of the cell, and each organelle has its own set of proteins that it requires to work correctly. (elifesciences.org)
Each cell contains ten or more organelles, and several thousand different types of proteins. (elifesciences.org)
The location of many proteins in a cell is unclear or simply not known. (elifesciences.org)
set out to develop a method that reveals the locations of all the proteins in a cell at any given time. (elifesciences.org)
The resulting technique maps the location of most of the proteins in a human cancer cell line and, in addition, determines how many copies of each protein there are. (elifesciences.org)
To travel between the cytoplasm and the nucleus, proteins must pass through a gateway called the nuclear pore complex (NPC). (mpg.de)
However, it is unknown whether the cell can monitor the proteins that go through the NPC. (mpg.de)
Using in situ cryo-electron tomography to look into cells that are frozen in a life-like state, scientists at the Max Planck Institute of Biochemistry discovered that NPCs are decorated with highly organized clusters of proteasomes, molecular machines that destroy misfolded and mislocalized proteins to ensure healthy cell function. (mpg.de)
They are large protein complexes that defend the cell by destroying misfolded and mislocalized proteins. (mpg.de)
Without protection from the proteasomes, cells eventually die because they are unable to get rid of these dangerous proteins. (mpg.de)
Using high-resolution averaging and nanometer-precision localization, they observed that tethering proteins attach these proteasomes to two sites on the nuclear side of the NPC: the NPC's nuclear basket and the membrane encircling the NPC. (mpg.de)
In vivo studies further confirmed the inhibitory effect of celastrol on the expression of HIF-1α proteins, leading to a decreased growth of Hep3B cells in a xenograft tumor model. (spandidos-publications.com)
Biological Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. (qedbio.com)
It is also highly expressed in unstressed cells where it participates in controlling the activity, turnover, and trafficking of a variety of proteins. (qedbio.com)
Most of the Hsp90-regulated proteins are involved in cell signaling and include the kinases, v-Src, Wee1, c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of hepatitis B virus and telomerase. (qedbio.com)
Cell 75:495, 1993), and a series of unique E6-AP homologous proteins have been identified (Huibregtse et al. (justia.com)
Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. (uni-frankfurt.de)
1000 endogenous mRNAs required individual SR proteins for nuclear export in vivo. (uni-frankfurt.de)
SR proteins function in nuclear pre-mRNA processing, mRNA export, and translation. (uni-frankfurt.de)
Our findings indicate that posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells. (uni-frankfurt.de)
Cell-based and in vitro assays show that Retro-2 blocks delivery of newly-synthesized TA-proteins to the ER-targeting factor ASNA1 (TRC40). (elifesciences.org)
To study the interactions between these sequences and regulatory factors, HeLa cell nuclear proteins were analyzed by band-shift assay using a 95-base pair (bp) DNA probe containing a part of the human MT-IIA gene upstream sequences. (go.jp)
Analysis of HeLa cell nuclear proteins fractionated by glycerol gradient centrifugation showed that ZRF is distinct from another MRE-binding protein, MREBP. (go.jp)
These approaches promise to enable researchers to assess, on a large scale, both expression level and functional state of the proteins that carry out most functions in a cell. (lu.se)
The proteins evaluated were p53, P16/INK4A, MSH2, nuclear protein transcriptional regulator 1 (NUPR1), and HSPB1 (total: HSPB1/t and phosphorylated: HSPB1/p). (bvsalud.org)

As your recommendaion, the Jurkat cells treated with anti Fas antibody to induce cleavage is positive control. (abcam.com)
Immunofluorescence staining in HeLa cell line with Anti-TUFM monoclonal antibody, showing distinct mitochondrial staining in green. (atlasantibodies.com)
Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic and nuclear staining. (everestbiotech.com)
Immunocytochemistry/ Immunofluorescence: cIAP-2/HIAP-1 Antibody [NBP1-27972] - HIAD1 staining in Hela cells detected with a Dylight 488 labeled secondary antibody (Green) with Hoechst 33258 nuclear counterstain (Blue). (novusbio.com)
Immunohistochemistry-Paraffin: cIAP-2/HIAP-1 Antibody [NBP1-27972] - cIAP2 staining in Oral Squamous Cell Carcinoma (OSCC). (novusbio.com)
Immunohistochemistry: cIAP-2/HIAP-1 Antibody [NBP1-27972] - Analysis of human adenocarcinoma cells and adjacent glands using anti-cIAP2. (novusbio.com)
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)

By contrast, intercellular transfer of HeLa nuclei to fibroblasts from aged donors restored cytochrome c oxidase activity, suggesting that the age-related phenotype was nuclear recessive. (nih.gov)
However, as early as 2 h after dilution into fresh medium, a striking prereplicative increase of the two activities was seen in the nuclear matrix fraction but not in cytosol or isolated nuclei. (neb.com)
Overall, the nuclear matrix was the cell fraction where the highest induction (about 10-fold) of both enzymatic activities was seen at 30 h after dilution, whereas in cytosol and isolated nuclei the increase was about two- and fourfold, respectively. (neb.com)
Strong expression of the protein seen in the cytoplasm and nuclei of HeLa cells. (everestbiotech.com)

Inactivation of CIP2A-TOPBP1 caused acentric fragments to disperse throughout the mitotic cytoplasm, stochastically partition into the nucleus of both daughter cells and aberrantly misaccumulate as cytoplasmic DNA. (nature.com)
For HeLa cell nucleus volume of 690 um^3 see BNID 104716 . (harvard.edu)
Yet that is exactly what the pair achieved: engineering dots that are small enough (10-15 nm in diameter) to track the biological processes inside the nucleus of live HeLa cells. (the-scientist.com)
Chen and Gerion attached a nuclear localization signal from the SV40 virus large T antigen to the dots to target them to the nucleus. (the-scientist.com)
Dots conjugated to a random peptide, in contrast, distributed about the cell, but remained locked out of the nucleus. (the-scientist.com)
This may sound like a scene from a science fiction movie or a comic book, but it is actually taking place at the gateway between the cytoplasm and nucleus inside a single cell. (mpg.de)

The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. (wikipedia.org)
Although snRNP profiles are not perturbed in SMN-depleted cells, we found that SMN depletion gives rise to cytoplasmic accumulation of a GFP-SmB reporter protein. (cnrs.fr)
We also demonstrate that the SMN protein depletion induces defects in Cajal body formation with coilin being localized in multiple nuclear foci and in nucleolus instead of canonical Cajal bodies. (cnrs.fr)
Proliferating cell nuclear antigen (PCNA) was originally identified by immunofluorescence as a nuclear protein whose appearance correlated with the proliferative state of the cell. (ihcworld.com)
Synthesis of the nuclear protein cyclin and DNA in quiescent mouse fibroblasts is coordinately induced by serum and purified growth factors. (ihcworld.com)
Synthesis of the nuclear protein cyclin (PCNA) and its relationship with DNA replication. (ihcworld.com)
This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. (nih.gov)
When cells were transfected with GFP-HIF-1α, treatment with TSA increased the number of green fluorescence protein (GFP)-positive cells. (oncotarget.com)
TSA also enhanced the nuclear translocation of HIF-1α protein, as assessed by immunoblotting and as evidenced by increased nuclear localization of GFP-HIF-1α. (oncotarget.com)
Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. (jci.org)
Sequence analysis of five tryptic peptides revealed that their sequences matched corresponding sequences of the A2 protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. (jci.org)
Subcellular localization critically influences protein function, and cells control protein localization to regulate biological processes. (elifesciences.org)
Combining spatial and abundance information yielded an unprecedented quantitative view of HeLa cell anatomy and organellar composition, at the protein level. (elifesciences.org)
Dynamic Organellar Maps enable the proteome-wide analysis of physiological protein movements, without requiring any reagents specific to the investigated process, and will thus be widely applicable in cell biology. (elifesciences.org)
Projection of a HeLa cell expressing a YFP-SC35 fusion protein that localizes to nuclear speckles and in a diffuse nuclear localization. (cellimagelibrary.org)
Strong expression of the protein seen in the cytoplasm and microtubules of HeLa cells. (everestbiotech.com)
The resulting three-dimensional images, called tomograms, reveal the crowded environment of the cell in its native state and at a resolution that is high enough to see the fine details on protein structures. (mpg.de)
c-IAP2 (inhibitor of apoptosis protein-2) belongs to IAPs family and besides exerting antiapoptotic effects through its interaction with multiple cytokines, it participates in inflammation, immunity and mitogenic kinase signal transduction, cell proliferation, invasion and metastasis also. (novusbio.com)
Background Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. (qedbio.com)
Combining individual-resolution cross-linking and immunoprecipitation (iCLIP) and mass spectrometry, we show that elevated arginine methylation of SRSF5 and lower phosphorylation levels of cobound SRSF2 enhance shuttling of SRSF5 in P19 cells by modulating protein-protein and protein-RNA interactions. (uni-frankfurt.de)
In addition, by South-western blotting analysis of nuclear extracts using the 95-bp probe or MRE oligonucleotide probe, we detected a Zn-dependent DNA-binding protein with a molecular mass of 116 kDa, which is likely to be ZRF. (go.jp)
The success of proteomics experiments, such as studies of protein function and cell signaling pathways, ultimately de- pends on how well the protein content in samples is identified and annotated. (lu.se)

Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. (cdc.gov)
Semithin (1.0-µm) sections resulted in apoptosis and inflammation of muscle cells. (cdc.gov)
The ability of E2F-1 to prompt apoptosis in DNA damaged cells coincides with enhanced PRMT1 methylation. (embl.de)

To characterize RA33, the antigen was purified from HeLa cell nuclear extracts to more than 90% homogeneity by affinity chromatography on heparin-Sepharose and by chromatofocusing. (jci.org)

EB06619 Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. (everestbiotech.com)
EB06277 Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. (everestbiotech.com)

HeLa cells are human epithelial cells from a fatal cervical carcinoma. (abcam.com)
Presented in Figure 2(a) is the fluorescence emission intensity from a culture of rat kangaroo ( PtK2 ) epithelial cells that were immunofluorescently labeled with primary anti-bovine alpha -tubulin mouse monoclonal antibodies followed by goat anti-mouse Fab fragments conjugated to Alexa Fluor 488. (microscopyu.com)

Like other members of the Rel family of transcriptional activators, NF-κB is sequestered in an inactive form in the cytoplasm of most cell types. (justia.com)
NF-κB in the cytoplasm of nonstimulated cells. (justia.com)

The cell line was derived from cervical cancer cells taken from Henrietta Lacks, in 1951. (abcam.com)

Localization of the gene for human proliferating nuclear antigen/cyclin by in situ hybridization. (ihcworld.com)

The transcription of DNA and processing of RNA in mitochondria was investigated using isolated HeLa cell mitochondria. (caltech.edu)
Removal of the mitochondria from the cellular environment simplified the investigations of the nuclear-cytoplasmic influences upon the mitochondrial transcription. (caltech.edu)

Figure 2(c) illustrates a culture of Indian Muntjac cells that were labeled with phalloidin conjugated to Alexa Fluor 488 for the intracellular actin cytoskeletal network. (microscopyu.com)
Surprisingly, the RGD(-) CAV-2 capsid also induced the reorganization of actin filaments in HeLa cells. (cnrs.fr)

We report that the WNV capsid (Cp) by itself induces rapid nuclear condensation and cell death in tissue culture. (cdc.gov)

In astrocytes the OGD enhanced the nuclear translocation of hypoxia-inducible factor 1 (HIF-1), the major transcription factor regulating EPO expression. (jneurosci.org)

HeLa cells have a modal chromosome number of 82, with 4 copies of chromosome 12 and 3 copies of chromosomes 6, 8, and 17. (abcam.com)
As each chromosome contains a single centromere, it remains unclear how acentric fragments derived from shattered chromosomes are inherited between daughter cells during mitosis 6 . (nature.com)
The stochastic inheritance of chromosome fragments by both newly formed daughter cells could in part contribute to the alternating DNA copy-number states that are characteristic of chromothripsis 2 . (nature.com)

Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. (nih.gov)
The role of mtDNA and nuclear genome in human aging was examined by their intercellular transfer using skin fibroblasts and mtDNA-less HeLa cells (rho o-HeLa cells). (nih.gov)
These observations support the idea that accumulation of nuclear recessive somatic mutations, but not mtDNA mutations, is responsible for the in vivo age-related mitochondrial dysfunction observed in human skin fibroblasts. (nih.gov)
Horizontal gene transfer from human papillomavirus 18 (HPV18) to human cervical cells created the HeLa genome which is different from either parent genome in various ways including its number of chromosomes. (abcam.com)
Immunohistochemical staining of human fallopian tube shows strong granular cytoplasmic positivity in glandular cells. (atlasantibodies.com)
In paraffin embedded Human Testis shows only cytoplasmic staining in some germ cells, and both cytoplasmic and nuclear staining in other germ cells with unstained nucleoli. (everestbiotech.com)
Celastrol showed a potent inhibitory activity against HIF-1 activation induced by hypoxia in various human cancer cell lines. (spandidos-publications.com)
We showed that CAV-2 also attaches to and uses CAR to enter cells, but CAV-2 transduction could be notably different from that of the prototype human adenovirus serotype 5 (Ad5). (cnrs.fr)
Arsenic exposure of human HaCaT keratinocytes induced nuclear accumulation of PRMT1 and PRMT4, histone H4R3 and H3R17 methylation proximal to the ARE, but not to the non-ARE regions of ferritin genes. (embl.de)
It is the first continuous human cell line. (apicells.com)

In this article, we have used an RNA interference approach in order to analyse the effects of SMN depletion on snRNP assembly in HeLa cells. (cnrs.fr)
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. (nih.gov)

Activation and nuclear translocation of NF-κB occurs following signal-induced phosphorylation of IκB, which leads to proteolysis via the ubiquitin pathway. (justia.com)

Several major species of E2 enzymes have been characterized in mammalian cells, plants, and yeast. (justia.com)

The hallmark of eukaryotic cells is their compartmentalization into distinct membrane-bound organelles. (elifesciences.org)
In eukaryotic organisms, there is a multitude of specialized, differentiated cells that are formed by specific gene programs. (cytoskeleton.com)
Eukaryotic cells destroy many endocytosed pathogens by targeting them to the lysosome. (elifesciences.org)

Maul GG, Deaven L. Quantitative determination of nuclear pore complexes in cycling cells with differing DNA content. (harvard.edu)
As with FRET, nuclear transport is bounded by size constraints, in this case the diameter of the nuclear pore, which is between 20 and 50 nm. (the-scientist.com)

1996. Appearance of micronuclei in generation of hela cells irradiated at low doses. (cdc.gov)

Here we tracked micronucleated chromosomes with live-cell imaging and show that acentric fragments cluster in close spatial proximity throughout mitosis for asymmetric inheritance by a single daughter cell. (nature.com)

They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. (wikipedia.org)

Cytoplasmic HSPB1/t expression levels decreased significantly following cisplatin therapy while nuclear HSPB1/t and HSPB1/p tended to increase. (bvsalud.org)

This is due to acute alterations in the tissues surrounding the tumor and in the environment as a result of treatment with anticancer therapeutics, which facilitate the drug resistance of tumor cells. (oncotarget.com)

We found that Ad5 and CAV-2 vectors have comparable kinetics of binding (10 min), internalization (10 min), endosomal escape (17 min), attachment to the nuclear membrane (35 min), and formation (18 hr) and release (34 hr) of functional virions. (cnrs.fr)

Mol Cell Proteomics. (embl.de)

However, the quantity of MSCs is very low in bone marrow (about 0.001 to 0.01% of the mononuclear cells) and in vitro expansion is the prerequisite for their clinical application. (biomedcentral.com)
In situ identification of lymphocytes and other mononuclear cells in early lesions caused by Leishmania braziliensis panamensis / by Gloria Ines Palma Alvarez. (who.int)

J Cell Biol (1972) 52 (2): 292-307. (rupress.org)
J Cell Biol. (harvard.edu)

Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. (qedbio.com)

As expected, SRSF2 and SRSF5 shuttle poorly in HeLa cells but surprisingly display considerable shuttling in pluripotent murine P19 cells. (uni-frankfurt.de)

The nuclear stain is DAPI (blue). (everestbiotech.com)
A) DAPI (blue) nuclear stain. (qedbio.com)

Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)

DNA and Cell Biology. (umn.edu)
Molecular Cell Biology Research Communications. (umn.edu)

Mitotic clustering drives the unequal inheritance of acentric fragments by a single daughter cell, providing an explanation for the origins of distinct patterns of chromothripsis found across diverse cancer types and congenital disorders. (nature.com)

DVTP nick-end labeling (TUNEL) assay with the In Situ Cell determined according to the manufacturer's protocol. (cdc.gov)
To perform in situ cryo-ET, cells are rapidly frozen and then thinned with a focused ion beam to make transparent "windows" into the cells that can be imaged by a transmission electron microscope. (mpg.de)

Cell 86:453, 1996). (justia.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

These findings, which are at variance with our own previous results obtained with cell cultures synchronized by either a double thymidine block or aphidicolin exposure, strengthen the contention that DNA replication is associated with an underlying nuclear structure and demonstrate the artifacts that may be generated by procedures commonly used to synchronize cell cultures. (neb.com)

The nuclear envelope (grey), ribosomes (black/white) and a mitochondrion (red, with rows of yellow ATP Synthase) are also shown. (mpg.de)

Therefore, a clearer understanding capsid expression was analyzed by immunofluorescent assay of WNV is necessary in order to identify new strategies to treat in HeLa, 293-T, RD, or SH-SY5Y cells by using anti-His tag or prevent this viral infection (3). (cdc.gov)

EB06619 Flow cytometric analysis of paraformaldehyde fixed HeLa cells (blue line), permeabilized with 0.5% Triton. (everestbiotech.com)
EB06277 Flow cytometric analysis of paraformaldehyde fixed HeLa cells (blue line), permeabilized with 0.5% Triton. (everestbiotech.com)
Tissue: Heat Shocked Cervical cancer cell line (HeLa). (qedbio.com)
The HeLa cell line was established from an adenocarcinoma of the cervix in 1952. (apicells.com)

Flow cytometric analysis demonstrated that just before dilution about 85% of the cells were in the G1 phase of the cycle, whereas 8% were in the S phase. (neb.com)
As judged by [3H]-thymidine incorporation and flow cytometric analysis, an increase in the number of S-phase cells was evident at least 6 h after dilution. (neb.com)
Flow Cyt (intra): Permeabilized HepG2 cells. (abcam.com)
Flow cytometric analysis of HeLa cells. (everestbiotech.com)

In contrast, cyclin A binding to E2F-1 impedes PRMT1 methylation and augments PRMT5 methylation, thus ensuring that E2F-1 is locked into its cell-cycle progression mode. (embl.de)

HeLa cells are adherent cells (they stick to surfaces) and maintain contact inhibition in vitro. (abcam.com)
RD cells transfected with pcWNV-Cp-DJY or pcDNA3.1 sis in vitro through the mitochodrial/caspase-9 pathway. (cdc.gov)

It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. (nih.gov)

Failure to downregulate NF-kappaB transcriptional activity results in chronic inflammation and cell death, as observed in A20-deficient mice. (nih.gov)

Interest in ALMS1 is heightened by the recent discovery of its involvement in neonatal cardiomyocyte cell cycle arrest, a process with potential relevance to regenerative medicine. (springer.com)

NF-κB is a transcription factor that plays a pivotal role in the highly specific pattern of gene expression observed for immune, inflammatory and acute phase response genes, including interleukin 1, interleukin 8, tumor necrosis factor and certain cell adhesion molecules. (justia.com)
This subset of transcription factors, known as pioneer transcription factors (PTFs), possess the ability to engage closed chromatin that is not accessible by other types of transcription factors, establish gene expression, and elicit cell reprogramming. (cytoskeleton.com)

Most prominent in this image are the cell bodies and proximal dendrites (including the stalk o. (cellimagelibrary.org)

The ability to monitor changes in organellar composition would provide a powerful tool to investigate cell biological processes at the systems level. (elifesciences.org)

Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. (justia.com)
The present invention relates generally to compositions and methods for modulating the activation of nuclear factor κB (NF-κB). (justia.com)

Anatomy9

Organisms6

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes31

Information Science3

Health Care1

Lysate3

Lysates3

Proteins26

Antibody7

Nuclei4

Nucleus6

Protein22

Apoptosis3

Extracts1

Immunofluorescence2

Epithelial cells2

Cytoplasm2

Cervical cancer cells1

Localization1

Mitochondria2

Actin2

Induces1

Enhanced the nuclear translocation1

Chromosome3

Human10

SnRNP2

Translocation1

Species1

Eukaryotic3

Pore2

Micronuclei1

Chromosomes1

Mitochondrial1

Cytoplasmic1

Tumor cells1

Membrane1

Proteomics1

Mononuclear cells2

Biol2

Counterstain1

Murine1

DAPI2

Nrf21

Biology2

Mitotic1

Situ2

19961

Pathways1

Replication1

Envelope1

Capsid1

Line4

Flow4

Contrast1

Vitro2

Small Nuclear1

Transcriptional1

Involvement1

Gene2

Proximal1

Biological processes1

Activation2