Nuclear glial cell. Medical search. Frequent questions

These results suggest that the slow progression and lack of full-fledged Alzheimer's disease pathology in the hippocampal neurons of APP Sw mice result from the genetic reprogramming of neural cells to cope with increased levels of Aβ. (jneurosci.org)
These intracellular aggregations of misfolded proteins, such as the nuclear TAR DNA-binding protein of 43 kDa (TDP-43) that accumulates in the cytoplasm, are toxic to the affected neurons and are thought to contribute to neuronal cell death. (atlasantibodies.com)
Immunocytochemical studies in adult rat brain preparations with a polyclonal antibody that cross-reacts with MT-I and MT-II indicated that immunostaining was always nuclear in glial cells, whereas in neurons it was nuclear in the cerebral cortex, hippocampus and the granular layer of the cerebellum, and nuclear plus cytoplasmic in Purkinje cells in the cerebellum, hypothalamic nuclei and gigantocellular reticular nucleus in the brain stem. (nih.gov)
Chromosome 21 aneuploid cells constitute ∼4% of the estimated one trillion cells in the human brain and include non-neuronal cells and postmitotic neurons identified by the neuronspecific nuclear protein marker. (jneurosci.org)
Together, these data demonstrate that human brain cells (both neurons and non-neuronal cells) can be aneuploid and that the resulting genetic mosaicism is a normal feature of the human CNS. (jneurosci.org)
Toward determining the presence of constitutional aneuploidy in the human brain, we report here an analysis of the frequency of chromosome 21 gain and loss among neurons and non-neuronal cells isolated from the cerebral cortex and hippocampus of normal individuals ranging from 2 to 86 years of age. (jneurosci.org)
The UCHL1 antibody produces strong staining of the cell body and dendrites in neurons. (neuromics.com)
Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB signaling pathway. (genscript.com)
Consequently, the present research looked into whether SHH could be changed by purmorphamine within the transdifferentiation of Mller glial cells to retinal neurons, and therefore, attempted to give a far more convenient, stabilized and effective therapy. (exposed-skin-care.net)
[1] They are found in the vertebrate retina , which serve as support cells for the neurons, as all glial cells do. (iiab.me)
They are the only retinal glial cell that shares a common cell lineage with retinal neurons. (iiab.me)
[4] Müller glia have also been implicated to serve as guidepost cells for the developing axons of neurons in the chick retina. (iiab.me)
As glial cells, Müller glia serve a secondary but important role to neurons . (iiab.me)
Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission. (phoenixpeptide.com)
The in vitro generation of uniform populations of neurons from mouse embryonic stem cells (ESCs) provides a novel opportunity to study gene function in neurons. (phoenixpeptide.com)
Induced pluripotent stem cells made from human tissue samples and then differentiated into neurons and grown into organoids are still quite immature and function in an artificial environment. (technologynetworks.com)
Cerevance's proprietary NETSseq platform was invented by Nat Heintz and Xiao Xu at Rockefeller University and is being used to comprehensively profile-specific brain cell types, including both neurons and glial cells, in mature human brain tissue. (technologynetworks.com)
also known as NR4A2) is an orphan nuclear receptor initially characterized as a transcription factor which is important for development of midbrain dopamine (mDA) neurons, including the generation, maturation, and axonal pathfinding of mDA neurons. (justia.com)
These findings support that Nurr1 exerts a protective effect on adult mDA neurons in a cell-autonomous manner Indeed, several intrinsic mechanisms associated with Nurr1-mediated cell survival have been identified. (justia.com)
Cell 137: 47-59) has identified an unexpected effect of Nurr1 which is expressed in glial cells in response to stimuli which trigger inflammation, and this Nurr1 suppresses the production of pro-inflammatory cytokines that cause the death of mDA neurons, but does not suggest a therapeutic effect through induction of Nurr1 expression. (justia.com)
In particular, glial cells in nerve tissues include astrocytes and microglial cells and are accessory cells that aid in promoting the functions and survival of neurons. (justia.com)
However, under a pathologic condition, the glial cells are instead activated to set up an environment in which the glial cells cause damage to neurons (M1 activation). (justia.com)
Meanwhile, it is known that glial cells with an M1 phenotype which set up a diseased environment can be converted into glial cells with an M2 phenotype which promote a therapeutic environment in which the survival and regeneration of neurons is set up. (justia.com)
Meanwhile, both MH and Ac-DEVD-CHO had similar eﬀects in protecting cell morphology, reducing LDH release, and inhibiting OGD-induced apoptosis in neurons. (syksignal.com)
Exposed dogs had (a) nuclear neuronal NFkappaB p65, (b) endothelial, glial and neuronal iNOS, (c) endothelial and glial COX2, (d) ApoE in neuronal, glial and vascular cells, and (e) APP and beta amyloid(1-42) in neurons, diffuse plaques (the earliest at age 11 months), and in subarachnoid blood vessels. (rti.org)
Huntington disease (HD) is an incurable, adult-onset, autosomal dominant inherited disorder associated with cell loss within a specific subset of neurons in the basal ganglia and cortex. (medscape.com)

They also need a protein's assistance, like a channel protein or some other transmembrane protein, to cross the cell membrane. (atlasantibodies.com)
MT-I levels in glial cells were about ten times higher than those in neuronal cells (538 +/- 194 vs. 49 +/- 16 pg MT-I/micrograms protein, mean +/- S.D. from three separate cell preparations). (nih.gov)
Immunohistochemical examination revealed positive expression of cluster of differentiation 34(CD34), vimentin and CD99, and negative expression of epithelial membrane antigen, S100 and glial fibrillary acidic protein. (spandidos-publications.com)
The single band at 24 kDa mark corresponds to UCHL1 protein which is detectable in CNS extracts and lysates of cells with neuronal properties. (neuromics.com)
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. (nih.gov)
The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. (nih.gov)
A large 220-kDa protein is found in human main glioblastoma skin cells. (trasos.org)
The brain is composed of hundreds of different brain cell types intermingled in intricate circuits and pathways, making it hard to know which protein or pathway to target to treat a disease. (technologynetworks.com)
We evaluated apurinic/apyrimidinic (AP) sites in nasal and brain genomic DNA, and explored by immunohistochemistry the expression of nuclear factor NFkappaB p65, inducible nitric oxide synthase (iNOS), cyclo-oxygenase 2 (COX2), metallothionein I and II, apolipoprotein E, amyloid precursor protein (APP), and beta-amyloid(1-42) in healthy dogs naturally exposed to urban pollution in Mexico City. (rti.org)
Nestin is an intermediate filament protein known to play several roles, including as a marker of neural progenitor and proliferating endothelial cells. (molvis.org)
The localization of the protein was specified by co-immunoreactivity with glial fibrillary protein (GFAP), glutamine synthetase (GS), and von Willebrand factor (vWF). (molvis.org)
Nestin was also observed in some vascular cells, as demonstrated by the co-immunoreactivity of the protein with vWF in the choroid and retina. (molvis.org)
After any retinal injury in experimental conditions, glial cells are activated and undergo reactive gliosis with increased an expression level of glial fibrillary acid protein (GFAP), which leads to overgrowth of outer Müller glial cell processes. (molvis.org)
Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)
In animals receiving excitotoxic lesions of the striatum we detected an eightfold increase of green ¯uorescent protein (GFP)-expressing cells. (lu.se)
Synuclein is a neuronal and glial cell protein that can aggregate into insoluble fibrils and form Lewy bodies. (msdmanuals.com)

Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. (medsci.org)
Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
2000). We of glial cell line-derived neurotrophic factor (GDNF) in models of have recently reported that this vector directs transgene expression to Parkinson's disease (Georgievska et al. (lu.se)

2016). PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes . (neuromics.com)
Using machine learning techniques, the regional and state dependent heterogeneity in human astrocytes is better understood and leveraged to help to define the role of these cells in disease and identify cell type specific targets for drug discovery. (itbusinessnet.com)
The major observation considered to be involved in the pathogenesis of retinal lesions is abnormalities in the internal limiting membrane formed by Müller cells, which is corresponding to the glia limitans formed by astrocytes in the brain. (intechopen.com)
Our results confirmed the presence of nestin in glial (e.g., astrocytes), reactive Müller, and endothelial cells. (molvis.org)

Lymphoid tissues, glial cells and myocytes were weakly stained or negative. (wikipedia.org)
The antibody works cleanly on appropriate lysates of cell and tissues. (neuromics.com)
In this study, we investigated the role of autophagy and apoptosis in Newcastle disease virus (NDV)-infected chicken cells and tissues. (immune-source.com)
In bottom line, we confirmed that autophagy brought about by genotype VII NDV infections was important for virus-like replication, NDV-induced apoptosis, and cell survival in buy 480-11-5 chicken cells and tissues. (immune-source.com)
Lipofuscin consists of highly autofluorescent granules of oxidized proteins and lipids that build up in the lysosomes of aging cells in a variety of tissues. (biotium.com)

The glial cell line-derived neurotrophic factors (GDNFs), a family of neurotrophic factors, were initially thought to be able to regulate the growth, survival, and differentiation of neural-derived cell types. (medsci.org)
Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions. (mayo.edu)
Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. (genscript.com)
Subsequently, the cells were transferred to fresh culture medium, without purmorphamine or SHH-N, for a further 2 days to investigate Mller glia-derived cell differentiation. (exposed-skin-care.net)
ERK1: a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. (assaygenie.com)
Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. (assaygenie.com)

Using antibody staining, most normal cells showed moderate cytoplasmic and nuclear immunoreactivity. (wikipedia.org)
MSA-P is characterized by the presence of glial cytoplasmic inclusions (GCIs) in oligodendroglial cells. (medscape.com)
Neuronal cytoplasmic inclusions and neuronal nuclear inclusions can also be found but are far less prominent relative to GCIs. (medscape.com)
This nuclear-cytoplasmic trafficking might contribute to neurological disorders. (atlasantibodies.com)
Dysfunctional nuclear-cytoplasmic trafficking of RNA-binding proteins might contribute to neurological disorders. (atlasantibodies.com)
She employs human patient-derived induced pluripotent stem cells to elucidate the nuclear-cytoplasmic trafficking mechanisms in neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). (atlasantibodies.com)
A characteristic finding is cytoplasmic inclusion bodies containing alpha-synuclein within oligodendroglial cells. (msdmanuals.com)

The vimentin antibody stains intermediate filaments in fibroblastic and developing glial cells. (neuromics.com)
This antibody is therefore an excellent marker of cells of this lineage and can also be used to study the leading edges particularly of neutrophils. (biosensis.com)
Since the only hematopoetic cells found within the central nervous system are microglia, this antibody is also an excellent marker of this important cell type. (biosensis.com)
Immunocytochemistry of a mixed neuron/glial culture from newborn rat brain stained with Rabbit polyclonal antibody to Coronin 1a R-1335-50 (green) at a dilution of 1:10,000 and Chicken polyclonal antibody to Vimentin C-1409-50 at 1:5,000. (biosensis.com)

Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
An inflammatory response for YTX, OA, and AZA1 was suggested by the nuclear translocation of NF-κB. (hal.science)
[ 7 ] More recent data from striatal neuronal cultures transfected with mutant huntingtin and transgenic mice carrying the spinocerebellar ataxia-1 (SCA-1) gene (another CAG repeat disorder) suggest that NIIs may not be necessary or sufficient to cause neuronal cell death, but translocation into the nucleus is sufficient to cause neuronal cell death. (medscape.com)

During embryonic and fetal life, GFAP is also expressed by radial glial cells of the CNS. (neuromics.com)
Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells. (neuromics.com)
In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. (neuromics.com)
In the control retina, nestin was found principally in glial structures in the ganglion cell layer, as confirmed by nestin/GFAP immunolabeling. (molvis.org)
The nature of these processes was not clearly defined, but co-immunolabeling with GFAP suggested that they were principally in activated Müller cells from the third day after the laser impacts. (molvis.org)
The vast majority of these cells did not divide, suggesting that the transgene was indeed regulated in a similar fashion as the endogenous GFAP gene. (lu.se)
There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)

Staining of whole-mount retina showed that the number of activated microglia cells was significantly increased at 48 hours post-injection, which was suppressed after GTE treatment in a dose-dependent manner. (nature.com)
3D animation of Müller cell processes (red) interconnected with a retinal microglia cell (green). (iiab.me)
Glial cells and fibroblasts stain with Vimentin, while microglia alone stain strongly and specifically for Coronin 1a, which can therefore be used as a robust marker of this important cell type. (biosensis.com)

Oral administration of GTE reduces significantly infiltration of inflammatory cells and exudation of proteins in the aqueous humor, which are associated with reduced expression and secretion of proinflammatory factors in the ciliary body and iris 13 . (nature.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
During ischemic stroke (IS), adenosine 5′-triphosphate (ATP) is released from damaged nerve cells of the infract core region to the extracellular space, invoking peri-infarct glial cellular P2 purinoceptors singling, and causing pro-inflammatory cytokine secretion, which is likely to initiate or aggravate motor and cognitive impairment. (biomedcentral.com)
It is well-documented that extracellular ATP triggers surrounding glial purinergic receptors signaling pathway and pro-inflammatory cytokines release to aggravate neural injury in cerebral ischemia [ 8 , 9 ]. (biomedcentral.com)
Our previous studies have demonstrated that EA protects cerebral neural cells against inflammatory injury after cerebral ischemia, which appears at 24 h to 14 days after treatment. (biomedcentral.com)
Specifically, a method of converting glial cells from an M1 phenotype to an M2 phenotype, wherein Nurr1 and Foxa2 are introduced into the glial cells to be overexpressed in the glial cells and a method of preventing or treating an inflammatory neurologic disorder, which includes glial cells into which Nurr1 and Foxa2 are introduced, or a viral vector loaded with Nurr1 and Foxa2, are provided. (justia.com)
Moreover, lupeol treatment prevented neuroinflammation by suppressing activated glial cells and inflammatory mediators. (gnu.ac.kr)

[14] Studies in human models have demonstrated that Müller glia have the potential to serve as stem cells in the adult retina [15] and are efficient rod photoreceptor progenitors. (iiab.me)
The progenitor cell can then divide and differentiate into a number of retinal cell types, including photoreceptor cells , that may have been damaged during injury. (iiab.me)
CMP revealed an absence of red green opsin and a decrease in rhodopsin expression with mislocalization to the photoreceptor inner segments (IS) and cell bodies as early as 6 weeks of age. (marclab.org)
As early as 12 weeks of age, some glial reaction to photoreceptor death was observed followed by formation of a glial seal, rewiring and inner nuclear layer cells migration. (marclab.org)

Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes both survival and neuritogenesis in PC12 cells through activation of nuclear factor ?B (NF-?B) pathway: involvement of extracellular signal-regulated kinase (ERK), calcium, and c-REL. (genscript.com)

Apoptosis of tumor cells increased significantly as concentration of cocultured TD-MSCs increased. (immune-source.com)

Immunofluorescent analysis of cortical neuron-glial cell culture from E20 rat stained with chicken pAb to UCHL1, CH22140, dilution 1:500 in red, and costained with mouse mAb to vimentin in green. (neuromics.com)

Systemic sublethal administration of Shiga toxin 2 produced a deterioration of the cells that integrate the vascular unit displaying astrocytic and microglial reactive profiles, while edema and lipid peroxidation were also observed. (biomedcentral.com)

arrows indicate mineralization and viral inclusion bodies in a neuron and glial cell. (cdc.gov)
12. BK virus-transformed inbred hamster brain cells: status of viral DNA in subclones. (crsociety.org)

PACAP promotes both survival and neuritogenesis in PC12 cells by activating NF-kappaB pathway, most likely via classical and alternative signaling cascades involving ERK1/2 kinases, Ca(2+), and c-Rel/p52 dimers. (genscript.com)
These results suggested that the endogenous neurogenic capacity of retinal Mller glial cells could be improved by this little molecular agonist from the SHH signaling pathway. (exposed-skin-care.net)
R&D Systems, Inc.) was added to purmorphamine-stimulated Mller glial cells to determine whether the Wnt pathway was involved. (exposed-skin-care.net)

The aim of the study was to elucidate RUNX3 changes in different regulation levels of molecular biology starting from epigenetics to function in particular cases of astrocytic origin tumours of different grade evaluating significance of molecular changes of RUNX3 for patient clinical characteristics as well as evaluate RUNX3 reexpression effect to GBM cells. (hindawi.com)
For instance, grade I tumours, like pilocytic astrocytomas (according to the 4th edition of WHO classification), are curable glial tumours, while grade IV astrocytic tumours, glioblastomas, are rapidly progressive and lethal [ 2 ]. (hindawi.com)

The nuclear membrane contains nuclear pore complexes, the bilateral gateways connecting the nucleoplasm and cytoplasm that allow transporting material into and out of the cellular nucleus. (atlasantibodies.com)
A cellular transport disease is caused by defects at the nuclear pore complexes resulting in traffic jams at the cellular and nuclear membranes. (atlasantibodies.com)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)

Here, using double-label fluorescence in situ hybridization for the autosome chromosome 21 (chromosome 21 point probes combined with chromosome 21 "paint" probes), along with immunocytochemistry and cell sorting, we present evidence for chromosome gain and loss in the human brain. (jneurosci.org)
Cell sorting and immunocytochemistry. (jneurosci.org)
Following 2 days of culture, cells on the coverslips were fixed in 4% paraformaldehyde at 4C for 10 min and processed for immunocytochemistry to detect proliferation-associated markers. (exposed-skin-care.net)

Cell viability, morphology, oxidative stress, inflammation, cell cycle, and specific glial markers were evaluated using RT-qPCR and high content analysis (HCA) approaches. (hal.science)

Mller glial cell tradition Primary ethnicities of retinal Mller glial cells had been ready as previously referred to (14). (exposed-skin-care.net)
18. Transformation of primary human embryonic kidney cells to anchorage independence by a combination of BK virus DNA and the Harvey-ras oncogene. (crsociety.org)

The company utilizes its proprietary NETSseq platform and advanced machine learning techniques to uncover the gene expression profiles of select cell types to identify novel targets that are uniquely expressed in relevant circuits affected by diseases or are altered in disease states. (itbusinessnet.com)
The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. (nih.gov)

Meninges, choroidal plexus, ependymal and endothelial cells were also MT-immunoreactive. (nih.gov)

MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. (assaygenie.com)
Radiation can disrupt the structure of the DNA (and other macromolecules), thereby disrupting normal cell and organ functions. (cdc.gov)

Therefore, the present inventors have found that various neurologic disorders based on inflammation may be treated since transcription factors Nurr1 and Foxa2 interact with each other to convert glial cells from an M1 phenotype to an M2 phenotype which sets up a therapeutic environment, when the transcription factors are overexpressed in the glial cells. (justia.com)

It is rapid, simple, and has minimal effect on signal from fluorescent antibodies or nuclear dyes, thus preserving specific staining. (biotium.com)
The NETSseq approach involves using antibodies against nuclear proteins, endoplasmic reticulum proteins and membrane proteins, as well as RNA probes against any cell-type-specific transcripts in brain tissue to allow for sorting of each cell type's nuclei. (technologynetworks.com)

Glial brain tumours originating from glial cells are intracranial solid neoplasms. (hindawi.com)
SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)

AD is associated with β-amyloid (Aβ) plaques, neurofibrillary tangles, and large-scale neuronal cell loss. (jneurosci.org)
AD is characterized by the formation and accumulation of amyloid-beta (A beta) plaques, neurofibrillary tangles, and neuronal cell loss. (gnu.ac.kr)

However, the co-immunoreactivity of nestin and GS, a marker of mature functional Müller cells, could be observable only from the seventh day. (molvis.org)

In nuclear fusion reactions, two light atomic nuclei combine to form a heavy atomic nucleus, which releases an enormous amount of light and heat energy. (cafe25.cz)
Each cell (except for red blood cells) contains a nucleus that houses these chromosomes. (cdc.gov)
N-terminal fragments of mutant huntingtin accumulate and form inclusions in the cell nucleus in the brains of patients with HD, as well as in various animal and cell models of HD. (medscape.com)

[ 8 ] Caspase inhibition in clonal striatal cells showed no correlation between the reduction of aggregates in the cells and increased survival. (medscape.com)

She employs human patient-derived induced pluripotent stem cells ( iPSC s) to elucidate the mechanisms of neuronal cell death in numerous neurodegenerative disorders, including ALS / FTD. (atlasantibodies.com)
These findings suggest that PTX2, YTX, OA, AZA1, and PlTX may affect intestinal barrier integrity through alterations of the human enteric glial system. (hal.science)
A method for deeply profiling transcriptional and epigenetic differences between specific cell types in mature human tissue has been missing. (technologynetworks.com)
7. Transformation of rodent cells by RFV, the human papovavirus with dual genome. (crsociety.org)
17. Human papillomavirus types 16 and 18 sequences in carcinoma cell lines of the cervix. (crsociety.org)
22. Expression of the control elements of BK and SV40 viruses in human cells exhibiting different transformed phenotypes. (crsociety.org)
The human body has nearly 1013 cells. (cdc.gov)

Histological section of the eye showed that LPS induced substantial accumulation of infiltrating cells in the vitreous humor 48 hrs after injection (n = 7) (Fig. 1b ), which was not detected in the saline-injected rats (n = 7, Fig. 1a ). (nature.com)
up-regulates COX-2 in chronic progressive nephropathy through nuclear accumulation of RelB and NF-?B2. (genscript.com)
Cell cycle analysis showed an accumulation of tumor cells predominantly in 511296-88-1 manufacture G0/G1 phase with an increase in concentration of TD-MSCs, which was confirmed by increased mRNA expression of cell cycle negative regulator p21. (immune-source.com)

Furthermore, SHH-treated cells had been shifted to neural lineage by expressing neuron-specific course III -tubulin (Tuj1), directing cell destiny to pole Cbz-B3A cells (14). (exposed-skin-care.net)

BOSTON, June 28, 2023 (GLOBE NEWSWIRE) - Cerevance, a private, clinical-stage drug discovery and development company focused on developing novel therapeutics for central nervous system (CNS) diseases using the company's proprietary Nuclear Enriched Transcript Sort sequencing (NETSseq) platform, today announced plans to present a poster presentation at the upcoming XVI European Meeting on Glial Cells in Health and Disease, taking place in Berlin, Germany, July 8 - July 11, 2023. (itbusinessnet.com)
He also explains how Cerevance's Nuclear Enriched Transcript Sort sequencing (NETSseq) platform is helping to discover promising targets that could be exploited therapeutically. (technologynetworks.com)
LL: What is Nuclear Enriched Transcript Sort sequencing (NETSseq) and how can this technique be used to identify novel therapeutic targets for disease affecting the central nervous system? (technologynetworks.com)

Cell transport is the passage of molecules across the cell membrane, either into or out of the cell. (atlasantibodies.com)

Although VDR immunoreactivity has been discovered in a number of glial cell lines, no information has been shown that the occurrence of VDR in glia is a cause of increased likelihood of tumorigenesis. (trasos.org)

An intermediate filament is one of three major components of the cytoskeletons of eukaryotic cells. (daviddarling.info)
The mammalian coronin family members are abundant components of eukaryotic cells and each type has a restricted cell type specific expression pattern. (biosensis.com)

Unlike the highly conserved actins and tubulins , more than 40 distinct IF proteins are encoded by a number of genes in mammalian cells. (daviddarling.info)
Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)

The outer and middle retinal layers, including the outer plexiform and outer nuclear layers, the photoreceptors, and the retinal pigment epithelium, are nourished by branches of the posterior ciliary arteries, which enter the back of the eye outside the optic nerve. (medscape.com)

The knowledge of brain metallothionein (MT) regulation and especially of MT presence in specific cell types is scarce. (nih.gov)
In other cell types, IFs are modified by phosphorylation when they are required to be disassembled for example during cell division. (daviddarling.info)
VDRs happen to be expressed in the parathyroid glands, intestines, epithelial skin cells, and many the immune system cell types. (trasos.org)

Maletta, H and Holub-Krappe, E ( 2003 ) In Nuclear Instruments & Methods in Physics Research. (lu.se)

Rattus norvegicus nuclear factor kappa B subunit 2 (Nfkb2), mRNA. (genscript.com)

The major role of the Müller cells is to maintain the structural and functional stability of retinal cells. (iiab.me)
Damage to retinal cells results in Müller cells to undergo gliosis . (iiab.me)

In vitro and in vivo studies have shown that phycotoxins can impact intestinal epithelial cells and can cross the intestinal barrier to some extent. (hal.science)

Reexpression of RUNX3 in U87-MG cells significantly reduced glioma cell viability compared to control transfection. (hindawi.com)

Müller glia are derived developmentally from two distinct populations of cells. (iiab.me)

According to classification system of the World Health Organisation (WHO) based on histological evaluation, brain tumour grade is determined by necrotic cells in the centre of the tumour, increased mitotic activity, the presence of nuclear pleomorphism, and angiogenesis. (hindawi.com)
Once Stx2 reaches the circulation it may target endothelial, kidney and/or brain cells through the Stx2 globotriaosylceramide receptor (Gb3) causing cytotoxicity [ 1 ]. (biomedcentral.com)
The action of LPS has been described as an enhancer of the deleterious effects of Stx2 in different cells [ 4 ] and organs such as the brain [ 4 , 5 ]. (biomedcentral.com)
For example, there is still a lack of understanding of why specific cell populations are more vulnerable or resilient in many brain diseases. (technologynetworks.com)
9. BK virus-transformed inbred hamster brain cells. (crsociety.org)
Lupeol decreased the oxidative stress via the activation of nuclear factor erythroid 2-related factor-2 (Nrf-2) and heme oxygenase-1 (HO-1) in the brain of adult mice. (gnu.ac.kr)

injection of purmorphamine promoted the activation of Mller glial cells, and in turn, the production of rod-like photoreceptors in acute damaged retina. (exposed-skin-care.net)
They are the most common type of glial cell found in the retina. (iiab.me)
While their cell bodies are located in the inner nuclear layer of the retina, they span across the entire retina. (iiab.me)
Müller cells line up radially across the entire thickness of the retina. (molvis.org)

The nuclei from each cell type are then captured by florescence-activated sorting (FACS) to obtain the sequence of the nuclear messages, with the goal of quantifying the expression levels of genes in that cell type. (technologynetworks.com)

The process of autophagy in mammalian cells involves six principal actions: initiation, nucleation, elongation, closure, maturation, buy 480-11-5 and degradation [27]. (immune-source.com)

The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)

Therefore, phycotoxins can reach cells underlying the epithelium, such as enteric glial cells (EGCs), which are involved in gut homeostasis, motility, and barrier integrity. (hal.science)

Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)

[2] [17] It has been shown in zebrafish that Müller glia undergo dedifferentiation into multipotent progenitor cells . (iiab.me)

DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. (medscape.com)

Coronin 1A is found exclusively in hematopoetic lineage cells such as lymphocytes, macrophages and neutrophils. (biosensis.com)

Specifically, the phosphorylation of Ser51 by PKC reduced VDR nuclear localization. (trasos.org)

The results of a k-NN prediction attributed 60.9% to mitochondrial localization and 26.1% to nuclear localization. (wikipedia.org)

Anatomy68

Organisms18

Diseases26

Chemicals and Drugs74

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Psychiatry and Psychology1

Phenomena and Processes40

Disciplines and Occupations3

Information Science3

Health Care1

Neurons26

Protein16

Line-derived neurotrophic factor3

Astrocytes4

Tissues5

Differentiation7

Cytoplasmic7

Antibody4

Translocation3

GFAP7

Microglia3

Inflammatory7

Photoreceptor4

Extracellular1

Apoptosis1

Vimentin1

Reactive1

Viral2

Pathway3

Astrocytic2

Cellular3

Immunocytochemistry3

Markers were evaluated1

Primary2

Gene2

Endothelial cells1

Functions2

Inflammation1

Antibodies2

Neoplasms2

Neuronal cell loss2

Marker1

Nucleus3

Survival1

Human7

Accumulation3

Neuron-specific1

Transcript Sort3

Membrane1

Immunoreactivity1

Eukaryotic cells2

Proteins3

Outer1

Types3

Methods1

Factor kappa1

Retinal cells2

Epithelial cells1

Significantly1

Distinct1

Brain6

Retina4

Expression1

Mammalian1

Receptor1

Motility1

Oxidative stress1

Undergo1

Nuclei1

Lineage1

Phosphorylation1

Localization1