Nuclear factor erythroid 2 related factor erythroid. Medical search. Frequent questions

The intracellular reactive oxygen species (ROS) levels and the transcriptional activity of nuclear factor-erythroid 2-related factor 2 (Nrf2) were determined. (biomedcentral.com)
The mRNA and protein expression levels of Nrf2, the antioxidant gene heme oxygenase-1 (HO-1), osteogenic markers, including runt-related transcription factor 2 (Runx2) and bone morphogenetic protein 2 (BMP2), and Kelch-like ECH-associated protein 1 (Keap1) were also measured. (biomedcentral.com)
The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-kB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor (Nrf2)) related to antioxidant defence and survival and proliferation pathways in HepG2 cells. (udl.cat)
Time-dependent activation of the AP-1 pathway, in concert with enhanced c-Jun nuclear levels and induction of Nrf2 translocation and phosphorylation were also demonstrated. (udl.cat)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
It can also induce other antioxidants, such as nuclear factor erythroid 2-related factor 2 (Nrf2). (nature.com)
Our previous cell and animal experiments confirmed that zinc supplementation could activate Nrf2 and up-regulate its downstream antioxidant factors, thus reducing oxidative damage to renal tubular epithelial cells and kidney tissues [ 11 ]. (nature.com)
Studies have suggested that nuclear factor erythroid 2-related factor 2 (Nrf2) constitutes one of the chemical-sensing and transcription systems that play an essential role(s) in chemical toxicity, carcinogenesis, and pathological processes. (cdc.gov)
The levels of peroxisome proliferator‑activated receptor gamma coactivator (PGC)‑1α/nuclear factor erythroid‑2‑related factor 2 (Nrf2) signalling, oxidative stress and pyroptosis‑related proteins were detected by western blotting. (spandidos-publications.com)
Inhibition of miR‑132 activated PGC‑1α/Nrf2 signalling and inhibited oxidative stress and the expression of the pyroptosis‑related proteins NLRP3, caspase‑1 and IL‑1β, which were all reversed by inhibiting SIRT1 with EX527. (spandidos-publications.com)
It has been reported that SIRT1/peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α/nuclear factor erythroid-2-related factor 2 (Nrf2) signalling can mediate oxidative stress, which plays an important role in myocardial I/R injury ( 14 , 15 ). (spandidos-publications.com)
Nrf2 (nuclear factor erythroid 2-related factor 2) is an important molecule that regulate antioxidant and protective genes. (usda.gov)
SFN can activate Nrf2 and several studies have shown promising effects of SFN on CVD risk factors. (usda.gov)
Our results suggest that the age-associated decline in Nrf2 signaling activity and the associated mitochondrial dysfunction might be related to the development of age-related disease processes. (usda.gov)
Though the role of Nrf2, a transcription factor that regulates cytoprotective gene expression, in myopathy remains poorly defined, it has shown beneficial properties in both sarcopenia and CVD. (usda.gov)
Sulforaphane (SFN), a natural compound Nrf2-related activator of cytoprotective genes, provides protection in several disease states including CVD and is in various stages of clinical trials, from cancer prevention to reducing in-sulin resistance. (usda.gov)
Nuclear factor erythroid-derived 2-related factor 2 (Nrf2) regulates oxidative stress. (hindawi.com)
The beneficial effects of DMF treatment include an increase in renal Nrf2 gene expression, reduction of oxidative stress, decrease in plasma asymmetric dimethylarginine (ADMA) and renal soluble epoxide hydrolase protein levels, increase in the L -arginine-to-ADMA ratio, and activation of genes related to nutrient sensing and autophagy (e.g. (hindawi.com)
Nuclear factor erythroid-derived 2-related factor 2 (Nrf2) is a key transcription factor in the regulation of several genes involved in the oxidative stress response. (hindawi.com)
In a spontaneously hypertensive rat, the development of hypertension is related to impaired Nrf2 signaling, which can be attenuated by resveratrol, an Nrf2 activator [ 14 ]. (hindawi.com)
Because glucocorticoid can inhibit the Nrf2-dependent antioxidant response and the Nrf2 activator can prevent HF diet-induced obesity and related diseases [ 15 - 17 ], we hypothesize that the activation of Nrf2 could be a therapeutic approach in the prevention of prenatal DEX- and postnatal HF-induced programmed hypertension via the regulation of oxidative stress, SEH, and nutrient sensing. (hindawi.com)
They decided to develop a CRISPR-gene editing strategy to knock out a gene called nuclear factor erythroid-2-related factor 2 (NRF2). (genengnews.com)
One of these transcriptional regulators is nuclear factor erythroid 2-related factor 2, or NRF2, identified in 1994 by another research group. (asbmb.org)
Also known as Nuclear Factor Erythroid 2-related factor , your NRF2 is your system's bodyguard. (susansmithjones.com)
Nrf2, or nuclear factor (erythroid-derived 2)-like 2, is a protein that protects against oxidative damage triggered by inflammation and injury. (elanaspantry.com)
The expression of Nrf2 and its related genes in vehicle or DMF treated rats were determined via RT-PCR and Western blot analysis. (biomedcentral.com)
The pathophysiological features associated with an imbalance between harmful ROS and protective antioxidant defenses are primarily controlled by endogenous cytoprotective pleiotropic transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) [ 21 ]. (biomedcentral.com)
Therefore, the functionality of the Nrf2-kelch-like erythroid-cell-derived protein with the CNC homology (ECH)-associated protein1 (Nrf2-Keap1) axis is necessary for protection against diseases that involve oxidative stress and ROS as a pathophysiological mechanism. (biomedcentral.com)
The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. (nih.gov)
However, the link between Nrf2 promoter polymorphisms and susceptibility to oxidative stress-related diseases such as vitiligo is unknown. (nih.gov)
Using genetic and single-cell RNA transcriptomic analysis in mice, the researchers found that being female confers striking protection against ferroptosis through a particular pathway called nuclear factor erythroid 2-related factor 2, or NRF2. (eurasiareview.com)
There is also a dysregulated response to the ensuing redox assault, as the master regulator of oxidative stress, nuclear factor erythroid 2-related factor-2 (Nrf2), demonstrates marked down-regulation. (curefa.org)
and (3) inhibited nuclear translocation of Nrf2. (curefa.org)
Otherwise, carnosic acid is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) protein, a transcription factor found in an inactive form in the cytosol bound to Kelch-like ECH-associated protein 1 (Keap1). (databasefootball.com)
At low concentrations, carnosic acid is detected by the cells as a xenobiotic and the Nrf2 transcription factor is activated, leading to an increase in the expression of proteins involved in cytoprotection, as mentioned above. (databasefootball.com)
Utilizing genetics in conjunction with products that activate NRF1 (Nuclear respiratory factor 1) and Nrf2 (nuclear factor erythroid 2 (NFE2)-related factor 2) pathways to create internal cellular molecules can turn back the aging process and become part of a full preventive program. (oraldna.com)
The Nrf2 genetic pathway turns on over 400 transcription genes such as GSTP1, which is related to detoxification. (oraldna.com)
Cap'n'collar (CNC) transcription factors including nuclear factor erythroid-2-related factor 1 (NFE2L1/NRF1) and NFE2L2/NRF2 can both regulate oxidative stress pathways but are each regulated in a distinct manner, and whether these two transcription factors can regulate ferroptosis independent of one another is unclear. (stanford.edu)
We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs. (go.jp)
These results suggest that arsenite promotes TF synthesis by activating the Nrf2 pathway in HASMCs and that the induction of TF expression by arsenite may be related to the progression of atherosclerosis. (go.jp)
The nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant response promotes melanocyte viability and reduces toxicity of the vitiligo-inducing phenol monobenzone. (msdmanuals.com)

Meanwhile, macrophage inflammatory protein 2 (MIP-2) expression levels were upregulated in nontumoral liver tissue from the end of Week 13 of CDAA-HF-T(-) feeding to the end of Week 63. (bvsalud.org)

It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] ( 13 ), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma. (spandidos-publications.com)
This powerful genetic pathway turns on over 200 genes, many of which are related to detoxification and cellular repair. (elanaspantry.com)

Monomethyl fumarate alters the NFE2L2 (Nuclear factor erythroid 2-related factor 2) transcription factor. (wikipedia.org)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)

In addition, it is also important to exclude other, more specific AML categories (ie, AML with myelodysplasia-related changes, therapy-related myeloid neoplasm, AML with germline predisposition, myeloid proliferations related to Down syndrome) before classifying a condition as AML NOS. (medscape.com)
The maturing myeloid cells in MDS may show immunophenotypic abnormalities by flow cytometric immunophenotyping, as follows: a decrease in side light scatter properties (due to hypogranulosis), increased intensity of CD33 expression, persistence of CD33 to later myeloid stages, decreased CD10 expression, abnormal patterns of CD11b versus CD16 expression or CD13 versus CD16 expression, deviations in myeloid antigen intensity, dyssynchronous expression of 2 myeloid antigens, and aberrant nonmyeloid antigen expression. (medscape.com)

Subsequent work by Pickett's lab and others helped identify the transcription factors that recognize the ARE and activate the transcription of GST and other oxidative stress response genes. (asbmb.org)

For example, hydrogen peroxide (H 2 O 2 ) is a classic oxidant stressor that promotes vascular cell calcification by increasing the expression of the osteogenic transcription factor runt-related transcription factor 2 (Runx2) [ 11 ]. (biomedcentral.com)
When administrated to some mammalian cells at the concentration of 1 µM, carnosic acid protects the cellular components ( i.e. lipids, proteins, DNA, RNA) against chemical stressors such as hydrogen peroxide (H 2 O 2 ), paraquat (an agrochemical), 6-hydroxydopamine (which is used to induce Parkinson's like disease experimentally), among other toxicants. (databasefootball.com)

These data suggest that the epicatechin-induced survival effect occurs by the induction of redox-sensitive transcription factors through a tight regulation of survival and proliferation pathways. (udl.cat)

By definition, the diagnosis of AML with myelodysplasia-related features requires the presence of at least 20% blasts in the peripheral blood (PB) or bone marrow (BM), an absence of any of the recurrent cytogenetic abnormalities seen in AML, and the absence of a history of cytotoxicity or radiation therapy for an unrelated disease. (medscape.com)

Sirtuin 1 (SIRT1), a member of the sirtuin family, regulates the cellular ageing process, participates in metabolic diseases, such as diabetes, and is related to cancer development ( 13 ). (spandidos-publications.com)

The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. (cdc.gov)

It is a major chronic disease that is predicted to become the third leading cause of death world-wide by 2030 ( 1 ) and has a huge economic burden costing $50 billion annually in the USA alone ( 2 ). (frontiersin.org)
Chronic kidney disease is directly related to cardiovascular disorders. (bvsalud.org)
The increase in chronic and degenerative diseases, such as chronic kidney disease (CKD), constitutes one of the most significant challenges of public health, as it is considered a worldwide social and economic problem, and associated to many co-morbidities, as well as to high expenses in public health 1,2 . (bvsalud.org)
Since its discovery, B19 has been shown to be the causative agent of erythema infectiosum (EI) (also known as fifth disease) and is the primary etiologic agent of TAC in patients with chronic hemolytic anemias (2-4). (cdc.gov)
1976. Combination of genetic factors and chronic exposure to benzene in the aetiology of leukaemia. (cdc.gov)

2022),2 and Armenta, et al. (stanford.edu)

Incorporating the genetic analysis from the Celsus One™ report helps me establish personalized health recommendations utilizing genetic risk factors related to the oral and systemic inflammatory response. (oraldna.com)
Cause is unknown, but genetic and autoimmune factors are likely. (msdmanuals.com)

Their study is published in Molecular Cancer Research in an article titled, " Kinetics of Nuclear Uptake and Site-Specific DNA Cleavage during CRISPR-Directed Gene Editing in Solid Tumor Cells . (genengnews.com)

Here we used two-electrode voltage clamp electrophysiology to compare the actions of CBD with those of the major central endocannabinoid, 2-arachidonoyl glycerol (2-AG) on human recombinant GABAA receptors (synaptic α1-6βg2 and extrasynaptic α4β2δ) expressed on Xenopus oocytes. (researchgate.net)
CBD and 2-AG were positive allosteric modulators at α1-6βγ2 receptors, with low micromolar potencies. (researchgate.net)
the endocannabinoid 2-arachidonoyl glycerol (2-AG), THC and CBD potentiate GABA A receptors [21, 22] . (researchgate.net)

Patients with infection-related diseases, malignant tumors, severe hypertension, and severe liver dysfunction were excluded. (nature.com)
For example, even though glucocorticoids are recommended to women at risk of preterm birth to accelerate fetal lung maturation [ 2 ], a growing body of evidence indicates that prenatal glucocorticoid exposure induces a variety of adult diseases, including hypertension [ 3 - 5 ]. (hindawi.com)
By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. (stanford.edu)

Reverse transcription‑quantitative PCR was performed to determine the expression of miR‑132, SIRT1 and inflammatory factors. (spandidos-publications.com)
Since oxidative stress in airway cells increases platelet-activating factor receptor (PAFR) expression, and PAFR is co-opted by pneumococci to adhere to host cells, we hypothesised that E-cigarette vapour increases pneumococcal adhesion to airway cells. (ersjournals.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)

The pyroptosis‑related proteins NLRP3, caspase‑1 and interleukin (IL)‑1β were also significantly elevated by I/R induction. (spandidos-publications.com)

To establish firm adhesion, pneumococci co-opt host-expressed platelet-activating factor receptor (PAFR), and then use the receptor as a Trojan horse to enter airway cells as the receptor is internalised [ 7 ]. (ersjournals.com)
The maximal level of enhancement seen with either CBD or 2-AG were on α2-containing GABAA receptor subtypes, with approximately a 4-fold enhancement of the GABA EC5 evoked current, more than twice the potentiation seen with other α-subunit receptor combinations. (researchgate.net)
SAA is a functional agonist for formyl peptide receptor 2 (FPR2/ALX), where it promotes chemotaxis and survival of neutrophils. (frontiersin.org)
The three innate gene markers: Beta-defensin 1 (DEFB1), CD14 (CD14), and Toll-like receptor 4 (TLR4), and five acquired gene markers: Tumor necrosis factor-alpha (TNF-alpha) Interleukin 1 (IL1), Interleukin 6 (IL6) Interleukin 17A (IL17A) Matrix Metallopeptidase 3 (MMP3) have different variations in degree of severity in association with inflammatory disease processes. (oraldna.com)

Commercial kits were used to measure the levels of serum myocardial enzymes and inflammatory factors. (spandidos-publications.com)
Apparent histologic injury and elevated levels of serum myocardial enzymes and inflammatory factors were observed in the myocardial I/R model. (spandidos-publications.com)

vasogenic factors, thrombin formation, erythrocyte lysis and hemoglobin (Hb) toxicity [ 5 ] have been proved to be related to brain edema growth [ 6 ]. (karger.com)

Kroemer, G. Molecular definitions of autophagy and related processes. (benthamscience.com)

In the last 2 decades, the high mortality and morbidity of ICH does not decrease over time. (karger.com)

According to the latest statistical report from the American Cancer Center from 2021, lung cancer has the second-highest incidence and the highest mortality rate among all malignancies ( 2 ). (spandidos-publications.com)
Future studies are needed to understand the biology of LVC and its related better prognostic outcomes when compared to other laryngeal malignancies. (bvsalud.org)

The rates of successful treatment and survival remain low and the 5-year survival rate is 21% ( 2 ), which may be attributed to the fact that NSCLC is usually diagnosed at an advanced stage, with no surgical options ( 6 , 7 ). (spandidos-publications.com)

Tissue factor (TF) is the initiator of the coagulation cascade, constitutively expressed in subendothelial cells such as vascular smooth muscle cells and initiating rapid coagulation when the vascular vessel is damaged. (go.jp)

Prenatal dexamethasone (DEX) exposure, postnatal high-fat (HF) intake, and oxidative stress are closely related to the development of hypertension. (hindawi.com)

Cases with an erythroid predominance but less than 20% blasts among the total number of marrow cells are now classified as myelodysplastic syndrome (MDS). (medscape.com)

Arsenic, an environmental pollutant, is related to the progression of atherosclerosis, although the pathogenic mechanisms are not fully elucidated. (go.jp)

Vitiligo affects up to 2% of the population. (msdmanuals.com)

New research directions on disparities in obesity and type 2 diabetes. (cdc.gov)

The overall aim of this monograph is to demonstrate how nutrition has the potential to ameliorate adverse SHS-related outcomes in children. (degruyter.com)
Until infants and children are no longer exposed to SHS, however, we propose investigating nutrition-focused interventions as a method to reduce the risk of SHS-related health outcomes for infants and children. (degruyter.com)

Intracerebral hemorrhage (ICH) accounts for about 10-15% of all strokes with high mortality [ 1 ], 1-month mortality of ICH is approximate 40% and it increases with age [ 2 ]. (karger.com)

OPA1 is a dynamin-related GTPase that is critical for the maintenance of mitochondrial morphology and mtDNA. (thermofisher.com)

This may be related to multiple health problems including loss of muscle mass and cardiovascular disease. (usda.gov)

Immunocompromised people make up 1%-2% of patients seen in US travel clinics, and they largely pursue itineraries like those of immunocompetent travelers. (cdc.gov)

Lung cancer is the most common cause of cancer-related death worldwide ( 1 ). (spandidos-publications.com)

Anatomy15

Organisms3

Diseases2

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes17

Information Science2

Nrf245

Protein1

Pathway2

NFE2L22

Myeloid2

Genes1

Hydrogen peroxide2

Transcription factors1

Myelodysplasia-related1

Regulates1

Genome-Wide1

Chronic5

20221

Genetic2

Uptake1

Receptors3

Diseases3

Expression3

Vitro1

Proteins1

Receptor4

Inflammatory2

Thrombin1

Autophagy1

Morbidity1

Malignancies2

Survival1

Tissue1

Hypertension1

Blasts1

Progression1

Vitiligo1

Obesity1

Outcomes2

Increases with age1

Mitochondrial1

Cardiovascular1

Patients1

Lung1