• Under electron microscope, chromatin gathered along the inside of the nuclear membrane, vacuole bodies appeared. (researchgate.net)
  • In spindle-B melanoma cells, coarse, granular chromatin and plump, large nuclei are seen. (aao.org)
  • Their nuclei have a conspicuous nuclear membrane, very coarse chromatin, and large nucleoli. (aao.org)
  • However, instead of 10 separate nucleoli, the typical human nucleus contains a single large nucleolus representing the fusion of loops of chromatin from the 10 separate chromosomes with NORs ( Fig. 8.48 ). (nanomedicine.com)
  • In addition, analysis of cell-cycle parameters, chromatin condensation and cytochrome c release showed that SLTM induced apoptosis in a range of cultured cell lines. (bris.ac.uk)
  • c) Cells with abundant granular to glassy cytoplasm and nuclei with coarse irregularly distributed chromatin and macroprominent nucleoli (Pap, ×40). (cytojournal.com)
  • Chromosomes are made of a material called chromatin, which is dispersed throughout the cell nucleus during interphase. (visionlearning.com)
  • The nucleoplasm is the semi-solid fluid inside the nucleus where we find the chromatin and the nucleolus. (coursehero.com)
  • The nucleus stores chromatin (DNA plus proteins) in a gel-like substance called the nucleoplasm.The nucleolus is a condensed region of chromatin where ribosome synthesis occurs.The boundary of the nucleus is called the nuclear envelope.It consists of two phospholipid bilayers: an outer membrane and an inner membrane.The nuclear membrane is continuous with the endoplasmic reticulum.Nuclear pores allow substances to enter and exit the nucleus. (coursehero.com)
  • Trnp1 interacts with factors located in several nuclear membrane‐less organelles, the nucleolus, nuclear speckles, and condensed chromatin. (uni-muenchen.de)
  • d) smears showing cells forming acini with nuclei showing fine chromatin, small nucleoli, clear cytoplasm and occasional atypical mitotic figure (arrow) (May-Grunwald-Giemsa, ×40). (cytojournal.com)
  • The cells showed mild pleomorphism, abundant pale cytoplasm with vacuolation and nuclei having coarse chromatin, and a few with prominent nuclei. (cytojournal.com)
  • Chromatin appears differentiated into coarse, darkly stained heterochromatin that accumulates near the nuclear periphery and the nucleolus and less darkly staining euchromatin. (cellimagelibrary.org)
  • Maturation (decrease in nuclear size of melanocytes with chromatin becoming darker accompanied by reduction in the amount of cytoplasm) with depth is present in many cases (Requena et al. (atlasgeneticsoncology.org)
  • the chromatin and the nuclear-cellular ratio (N/C) of each plasma cell. (bvsalud.org)
  • In cell biology, mitosis (/maɪˈtoʊsɪs/) is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. (wikipedia.org)
  • Figure 12-16 Spindle-cell choroidal nevus (between arrows) is composed of slender spindle-shaped cells with thin, homogeneously staining nuclei. (aao.org)
  • Histologically, a melanocytoma is composed of large polyhedral cells with small round to oval nuclei and abundant cytoplasm. (aao.org)
  • Spindle-A melanoma cells have slender, elongated nuclei with small nucleoli. (aao.org)
  • Epithelioid melanoma cells resemble epithelium because of their abundant eosinophilic cytoplasm and enlarged round to oval nuclei. (aao.org)
  • The Weiss criteria define malignancy based on the presence of three or more of the following features: high-grade nuclei, high mitotic rate (more than 5 mitoses per 50 high-power fields (HPF)), atypical mitotic figures, clear cells comprising less than 25% of cells, diffuse architecture, tumor necrosis, venous invasion, sinusoidal invasion, and capsular invasion. (cap.org)
  • The tumor cells appeared spindled with normochromatic, small nuclei and indistinct nucleoli (Figure 7 ). (upmc.edu)
  • immature cells with clear and oval nuclei, with visible nucleoli. (iarc.fr)
  • Using histone-fluorescent parental isolates, we tracked male and female nuclei during fertilisation in the model ascomycetes Neurospora crassa using live-cell-imaging. (exeter.ac.uk)
  • These nuclei were exceptionally large and they frequently contained several small nucleoli of different sizes rather than the one, central nucleolus which is characteristic of a normal interphase nucleus. (rupress.org)
  • In nuclei having a centrally located nucleolus, the nuclear envelope is folded to form a nucleolar canal that is in direct contact with the nucleolus. (nanomedicine.com)
  • Most human nuclei contain only one nucleolus, except for liver cell nuclei which may contain more than one nucleolus 935 and cultured HeLa (cancer) cells which may have up to six. (nanomedicine.com)
  • however, the presence of large rhabdoid cells and tissue fragments of round to oval hyperchromatic nuclei with scant cytoplasm cells excluded adenocarcinoma. (cytojournal.com)
  • The term mitosis refers specifically to the process whereby the nucleus of a eukaryotic cell splits into two identical daughter nuclei prior to cell division. (visionlearning.com)
  • Having complex cells in which the genetic material is organized into membrane-bound nuclei. (coursehero.com)
  • Human cell nuclei are functionally organized into structurally stable yet dynamic bodies whose cell cycle inheritance is poorly understood. (nuigalway.ie)
  • Their nuclei are relatively large, round to oval in shape, and show mild pleomorphism with mostly small, round, regular nucleoli. (atlasgeneticsoncology.org)
  • Strong expression of the protein seen in the cytoplasm and nuclei of HeLa cells. (everestbiotech.com)
  • Prokaryotic cells, which lack a nucleus, divide by a different process called binary fission. (wikipedia.org)
  • For example, animal cells undergo an "open" mitosis, where the nuclear envelope breaks down before the chromosomes separate, whereas fungi undergo a "closed" mitosis, where chromosomes divide within an intact cell nucleus. (wikipedia.org)
  • The jellylike material outside the cell nucleus in which the organelles are located. (enchantedlearning.com)
  • The nucleus controls many of the functions of the cell (by controlling protein synthesis) and contains DNA (in chromosomes). (enchantedlearning.com)
  • The nucleus is surrounded by the nuclear membrane. (enchantedlearning.com)
  • plump polyhedral nevus cells: Abundant cytoplasm is filled with pigment and has a small round to oval nucleus with bland appearance. (aao.org)
  • slender spindle nevus cells (Fig 12-16): The cytoplasm contains scant pigment and a small, dark, elongated nucleus. (aao.org)
  • balloon cells: Abundant, foamy cytoplasm lacks pigment and has a bland nucleus. (aao.org)
  • Cell Nucleus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • A cell may contain more than one nucleus. (harvard.edu)
  • This graph shows the total number of publications written about "Cell Nucleus" by people in Harvard Catalyst Profiles by year, and whether "Cell Nucleus" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Cell Nucleus" by people in Profiles. (harvard.edu)
  • Contains nuclear envelope = separates nucleus from cytoplasm. (cheatography.com)
  • a colouring substance in the nucleus of the cell. (infovisual.info)
  • small spherical body with the cell nucleus. (infovisual.info)
  • 1141 The number of nucleoli in a eukaryotic cell nucleus normally is determined by the number of chromosomes with secondary constrictions, or nucleolus organizer regions (NORs). (nanomedicine.com)
  • these enlarge, eventually fusing into the single large nucleolus characteristic of the interphase human nucleus. (nanomedicine.com)
  • Immunofluorescence of intact cells and quantitative immunoblotting of cell extracts indicate that PKR occurs in both the cytoplasm and the cell nucleus, with staining specifically in the nucleolus. (pasteur.fr)
  • Here, we show that SLTM is localized to the cell nucleus, but excluded from nucleoli, and to a large extent it co-localizes with SAFB1. (bris.ac.uk)
  • A cell has three main parts: the plasma membrane, the cytoplasm, and the nucleus. (visiblebody.com)
  • The nucleus is a large membrane-bound organelle that contains the genetic information of eukaryotic cells. (visiblebody.com)
  • A double membrane known as the nuclear envelope, similar in composition to the plasma membrane, surrounds the nucleus, and openings in the nuclear membrane called nuclear pores control the flow of substances in and out. (visiblebody.com)
  • A viscous liquid inside called nucleoplasm contains the contents of the nucleus, which include one or more spherical bodies, known as nucleoli. (visiblebody.com)
  • The nucleus stores information in the form of DNA and controls the activities of the cell by selectively transcribing RNA, which exits via the nuclear pores. (visiblebody.com)
  • But what all these life forms have in common is that their genetic code is copied from cell to cell thanks to the process of mitosis, whereby the nucleus of a cell splits into two before the cell divides. (visionlearning.com)
  • A eukaryotic cell has a true membrane-bound nucleus and has other membranous organelles that allow for compartmentalization of functions. (coursehero.com)
  • Eukaryotic cells are larger than prokaryotic cells and have a "true" nucleus, membrane-bound organelles, and rod-shaped chromosomes. (coursehero.com)
  • Typically, the nucleus is the most prominent organelle in a cell. (coursehero.com)
  • Eukaryotic cells have a true nucleus, which means the cell's DNA is surrounded by a membrane. (coursehero.com)
  • The nuclear envelope is a double-membrane structure that constitutes the outermost portion of the nucleus. (coursehero.com)
  • TMF1‐regulated nuclear protein 1 (Trnp1) has been shown to exert potent roles in neural development affecting neural stem cell self‐renewal and brain folding, but its molecular function in the nucleus is still unknown. (uni-muenchen.de)
  • Figure 113 from Chapter 4 (Nucleus) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. A PDF copy of the corresponding chapter is available on the ASCB's BioEDUCATE website. (cellimagelibrary.org)
  • Cell division by mitosis gives rise to genetically identical cells in which the total number of chromosomes is maintained. (wikipedia.org)
  • During mitosis, the chromosomes, which have already duplicated, condense and attach to spindle fibers that pull one copy of each chromosome to opposite sides of the cell. (wikipedia.org)
  • The genome is composed of a number of chromosomes-complexes of tightly coiled DNA that contain genetic information vital for proper cell function. (wikipedia.org)
  • Microtubules project from opposite ends of the cell, attach to the centromeres, and align the chromosomes centrally within the cell. (wikipedia.org)
  • Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). (harvard.edu)
  • In SCNT they take the nucleolus out of an egg cell, replace it with the nucleolus of a somatic cell (body cell with two complete sets of chromosomes), and make the egg cell divide into a blastocyst ("What Is Cloning? (bartleby.com)
  • Typically, when a diploid cell divides, it first duplicates each of its chromosomes. (jove.com)
  • Then, the cell distributes a copy of each chromosome between the two daughter cells so that each daughter cell receives a complete set of chromosomes. (jove.com)
  • During mitosis, the chromosomes condense into a more compact form and the nucleolus shrinks, then disappears altogether. (nanomedicine.com)
  • Aneuploidy is an abnormality in the number of chromosomes in a cell due to loss or duplication. (genome.gov)
  • In Cell Division I: The Cell Cycle , we learned that Flemming observed how chromosomes became visible in patterns that repeated each time the cells of fire salamanders divided. (visionlearning.com)
  • which divides the cytoplasm, organelles and cell membrane of one cell into two new cells containing roughly equal shares of these cellular components. (wikipedia.org)
  • cell membrane - the thin layer of protein and fat that surrounds the cell, but is inside the cell wall. (enchantedlearning.com)
  • The cell membrane is semipermeable, allowing some substances to pass into the cell and blocking others. (enchantedlearning.com)
  • A thick, rigid membrane that surrounds a plant cell. (enchantedlearning.com)
  • The golgi body packages proteins and carbohydrates into membrane-bound vesicles for "export" from the cell. (enchantedlearning.com)
  • A vast system of interconnected, membranous, infolded and convoluted sacks that are located in the cell's cytoplasm (the ER is continuous with the outer nuclear membrane). (enchantedlearning.com)
  • Rough ER transport materials through the cell and produces proteins in sacks called cisternae (which are sent to the Golgi body, or inserted into the cell membrane). (enchantedlearning.com)
  • Part of the chloroplasts in plant cells, located within the inner membrane of chloroplasts, between the grana. (enchantedlearning.com)
  • membrane surrounding the nucleolus. (infovisual.info)
  • The largest and most prominent "nuclear organelle" is the nucleolus, a highly coiled structure associated with numerous particles but not surrounded by a membrane. (nanomedicine.com)
  • The Golgi body (Golgi apparatus, Golgi complex) is a membrane-bound organelle located in the cytoplasm of eukaryotic cells. (visiblebody.com)
  • Mitochondria are membrane-bound organelles located in the cytoplasm of eukaryotic cells. (visiblebody.com)
  • This arrangement creates a selectively permeable barrier, enabling the plasma membrane to surround and protect the cytoplasm while allowing the passage of certain materials in and out of the cell. (visiblebody.com)
  • Proteins synthesized by ribosomes are used by organelles in the cell, by the plasma membrane, or by structures outside the cell. (visiblebody.com)
  • The endoplasmic reticulum (ER) is a network of membrane-enclosed sacs and tubules in a cell. (visiblebody.com)
  • It extends from the outer nuclear membrane throughout the cytoplasm. (visiblebody.com)
  • Rough ER is continuous with the outer nuclear membrane, and it has numerous, protein-synthesizing ribosomes attached to it. (visiblebody.com)
  • Like a prokaryotic cell, a eukaryotic cell has a plasma membrane, cytoplasm, and ribosomes. (coursehero.com)
  • Other than the fact that vacuoles are somewhat larger than vesicles, there is a very subtle distinction between them: the membranes of vesicles can fuse with either the plasma membrane or other membrane systems within the cell. (coursehero.com)
  • Thus, we identified Trnp1 as a novel regulator of several nuclear membrane‐less compartments, a function important to maintain cells in a self‐renewing proliferative state. (uni-muenchen.de)
  • The nucleolus, which makes ribosomes in the cell, also disappears. (wikipedia.org)
  • In cells characterized by a high rate of protein synthesis and hence by the need for many ribosomes, the nucleolus can occupy 20-25% of nuclear volume (3-5 micron diameter in a 20-micron cell), mostly comprised of the granular component. (nanomedicine.com)
  • Cells contain a large number of small organelles called ribosomes. (visiblebody.com)
  • Ribosomes are made mostly of rRNA (ribosomal ribonucleic acid), and bacterial cells contain more than 50 associated proteins, whereas plant and animal cells contain 80 associated proteins. (visiblebody.com)
  • A specialized structure found inside cells that carries out a specific life process (e.g. ribosomes, vacuoles). (coursehero.com)
  • Nucleoli are prominent. (aao.org)
  • The cells have prominent nucleoli and areas of necrosis and mitoses are present. (cap.org)
  • Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
  • In some eukaryotes, for example animals, the nuclear envelope, which segregates the DNA from the cytoplasm, disintegrates into small vesicles. (wikipedia.org)
  • 1141 Nucleoli are frequently located at or near the nuclear envelope, adhering directly to the nuclear lamina or attaching to it by a pedicle. (nanomedicine.com)
  • Both the inner and outer membranes of the nuclear envelope are phospholipid bilayers. (coursehero.com)
  • The nuclear envelope is punctuated with pores that control the passage of ions, molecules, and RNA between the nucleoplasm and cytoplasm. (coursehero.com)
  • Because each resultant daughter cell should be genetically identical to the parent cell, the parent cell must make a copy of each chromosome before mitosis. (wikipedia.org)
  • Certain cells undergo multiple cycles of chromosome duplication without undergoing any cell division. (jove.com)
  • Such cells, called polyploid cells, contain multiple sets of each chromosome. (jove.com)
  • Here, hundreds to thousands of copies of each chromosome are generated without any cell division. (jove.com)
  • The identified DEGs included 20 downregulated genes and 51 upregulated genes, which were highly associated with the cell cycle, organelle fission, chromosome segregation, cell division and spindle stability. (cancerindex.org)
  • 1141 The nucleolus is a ribosome-manufacturing machine. (nanomedicine.com)
  • Predominantly localized in the CELL NUCLEOLUS, involved in diverse cellular processes such as ribosome biogenesis, cytoplasmic-nuclear trafficking, centrosome duplication, and regulation of p53. (bvsalud.org)
  • Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)
  • Histologically, the tumor is composed of sheets of cells with nuclear pleomorphism and areas of oncocytic appearance. (cap.org)
  • Historically, Carcinoma ex pleomorphic adenoma is considered a high-grade malignancy with malignant features like increased mitosis, marked nuclear pleomorphism, necrosis and infiltrative growth. (org.pk)
  • MTT colorimetric assays, colony formation assays and 5‑ethynyl‑20‑deoxyuridine incorporation assays were also conducted to evaluate ACC cell proliferation. (cancerindex.org)
  • Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)
  • The cytoplasmic melanin content in melanoma cells can vary considerably. (aao.org)
  • Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic and nuclear staining. (everestbiotech.com)
  • In paraffin embedded Human Testis shows only cytoplasmic staining in some germ cells, and both cytoplasmic and nuclear staining in other germ cells with unstained nucleoli. (everestbiotech.com)
  • The determination of autoantibody titers from 1:80 to 1:1280 was performed by serial dilution on samples that showed a 3+ or greater nuclear and/or cytoplasmic immunofluorescence pattern. (cdc.gov)
  • the expression levels of protein associated with apoptosis and endoplasmic reticulum stress (ERS) of SKO-007 cells in various groups were detected by Western blotting method. (researchgate.net)
  • The different stages of mitosis altogether define the mitotic (M) phase of a cell cycle-the division of the mother cell into two daughter cells genetically identical to each other. (wikipedia.org)
  • Producing three or more daughter cells instead of the normal two is a mitotic error called tripolar mitosis or multipolar mitosis (direct cell triplication / multiplication). (wikipedia.org)
  • Other errors during mitosis can induce mitotic catastrophe, apoptosis (programmed cell death) or cause mutations. (wikipedia.org)
  • Most animal cells undergo a shape change, known as mitotic cell rounding, to adopt a near spherical morphology at the start of mitosis. (wikipedia.org)
  • Most human cells are produced by mitotic cell division. (wikipedia.org)
  • low mitotic rate TYPES ▪ Embryonic origin of GI tract (e.g. foregut, midgut, hindgut) Foregut tumors (e.g. stomach) ▪ Type I ▫ Most common ▫ Originates from enterochromaffin-like (ECL) cells ▫ In association with high gastrin levels secondary to chronic atrophic gastritis ▫ Small, usually benign ▪ Type II ▫ Originates from ECL cells ▫ In association with high gastrin levels induced by gastrinomas (e.g. (osmosis.org)
  • The biopsy showed spindle cell component with mild atypia, invasion into surrounding tissue, and increased mitotic activity on the basis of which a diagnosis of Low-grade carcinoma ex pleomorphic adenoma developing in a background of pleomorphic adenoma was made. (org.pk)
  • The different phases of mitosis can be visualized in real time, using live cell imaging. (wikipedia.org)
  • Mitosis occurs only in eukaryotic cells. (wikipedia.org)
  • In animal cells, cell division with mitosis was discovered in frog, rabbit, and cat cornea cells in 1873 and described for the first time by the Polish histologist Wacław Mayzel in 1875. (wikipedia.org)
  • The primary result of mitosis and cytokinesis is the transfer of a parent cell's genome into two daughter cells. (wikipedia.org)
  • During cell division (mitosis), the centrosome divides and the two parts move to opposite sides of the dividing cell. (enchantedlearning.com)
  • In the myxomycete, Physarum polycephalum , the bulk of nuclear DNA replication occurs during a period of a few hours immediately following upon mitosis. (rupress.org)
  • A cell undergoing mitosis thus has no nucleolus and synthesizes no rRNA. (nanomedicine.com)
  • Once mitosis is complete, the nucleolus reappears. (nanomedicine.com)
  • The rate at which mitosis occurs depends on the cell type. (visionlearning.com)
  • However, sebaceous carcinoma was excluded due to the absence of cells with bubbly cytoplasm along with the absence of admixed basaloid cells (option C). Clear cell hidradenoma is a rare tumor usually seen in the females and mostly shows the presence of dual population of clear cells and cells with moderate eosinophilic cytoplasm with no atypical mitosis (option D). (cytojournal.com)
  • the cell is a highly complex system that is the site of intense energy exchange and which presents vast interphase surfaces. (infovisual.info)
  • Ones found freely in cytoplasm or as part of the Rough endopl-asmic reticulum in Eukaryotic cells. (cheatography.com)
  • 100s/1000s of times smaller than eukaryotic cells. (cheatography.com)
  • While all eukaryotic cells contain the aforementioned organelles and structures, there are some striking differences between animal and plant cells. (coursehero.com)
  • There was no significant nuclear atypia and mitoses were difficult to find. (upmc.edu)
  • The proper regulation and spatial organization of heterochromatin is crucial for a broad range of cellular processes, ranging from gene silencing to maintenance of genomic integrity and cell division. (cipsm.de)
  • We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
  • The nucleolus is composed of DNA, RNA, and proteins. (nanomedicine.com)
  • Enzymes in the cisternae modify these proteins and pack them into vesicles that bud off the Golgi body and transport the proteins to different areas in the cell. (visiblebody.com)
  • Organelles are specialized subunits in a cell that are contained within the cytoplasm. (visiblebody.com)
  • Those nevus cells lack gp100 expression (with HMB-45) and show very low Ki67 expression (features characteristic of benign melanocytes). (medscape.com)
  • Unfortunately, the dyes killed the cells, and since the structures under the microscope were difficult to see as it was, Flemming's forerunners weren't sure they were seeing anything characteristic of a live, functional cell. (visionlearning.com)
  • however, a tumor consisting entirely of spindle-A cells is considered a nevus. (aao.org)
  • By immunohistochemistry, the tumor cells are positive for inhibin and negative for chromogranin and S100. (cap.org)
  • Oftentimes, ACCs have thick capsules, broad fibrous bands, tumor cells arranged in disordered nests and trabeculae, and necrosis. (cap.org)
  • Originally described by Headington in the 1970s, trichoblastoma (TBL) is now appreciated as a rare benign tumor that originates from the follicular germ cell line [1, 2]. (karger.com)
  • The tumor cells were focally embedded in a myxochondroid and osteoid-like matrix (Figures 8 and 9 ) with scattered areas of dystrophic calcification (Figure 8 ). (upmc.edu)
  • The tumor was penetrated by capillary-sized vessels and intermixed with scattered osteoclast-like giant cells (Figure 11 ). (upmc.edu)
  • After the operation, the pathological examination results suggested the following: Renal clear cell carcinoma, pT1aN0M0, the tumor sized ~4.0×4×3.5 cm 3 , with no lymph node cancer metastases or distant metastasis. (spandidos-publications.com)
  • Histopathological examination of the tumor mass revealed an admixture of spindle cells and epithelioid cells. (cytojournal.com)
  • Pathologists and clinicians should be aware of this rare entity to prevent misdiagnosis of MACF as fibrosarcoma or adult granulosa cell tumor and resultant overtreatment. (iiarjournals.org)
  • The histopathological diagnosis of ovarian fibromatous tumor is usually unequivocal due to their distinct spindle-cell morphology and fascicular growth pattern. (iiarjournals.org)
  • It was identified that the nuclear division cycle 80, cyclin B2 and topoisomerase 2‑α may serve important roles in adrenocortical tumor development. (cancerindex.org)
  • plump fusiform dendritic nevus cells: Morphology is intermediate between that of plump polyhedral and slender spindle. (aao.org)
  • Histologically, posterior uveal melanomas are composed of spindle cells and/or epithelioid melanoma cells (Figs 12-17, 12-18, 12-19). (aao.org)
  • Spindle cell melanoma consists primarily of spindle-B melanoma cells (see Fig 12-18). (aao.org)
  • Tumors composed of a mix of spindle-A and spindle-B melanoma cells are designated spindle cell melanomas . (aao.org)
  • Squamous cell carcinoma (SCC) was excluded since the spindle cells that are present in this case look different from pleomorphic cells such as "tadpole" and "fiber" cells that are seen particularly in keratinizing type of SCC. (cytojournal.com)
  • 2004). Less common are histologic variants such as desmoplastic/sclerosing, angiomatoid, myxoid and plexiform Spitz nevi (Lyon, 2010), and pigmented spindle cell nevus (Ferrara et al. (atlasgeneticsoncology.org)
  • Pigmented spindle cell nevus from right thigh of 11 year old female, 7mm in diameter. (atlasgeneticsoncology.org)
  • However, the sequential fungal cell biology of fertilisation and the associated nuclear dynamics after plasmogamy are poorly understood. (exeter.ac.uk)
  • International Journal of Biochemistry and Cell Biology , 407 (3), 355 - 362. (bris.ac.uk)
  • In most cell types chromocenters are attached to the nuclear lamina or to nucleoli. (cipsm.de)
  • Conclusion: Prion protein 106-126 peptide can induce apoptosis in differentiated PC12 cells and present cellular toxicity definitely. (researchgate.net)
  • CMI) , cellular i. immune responses that are initiated by an antigen-presenting cell interacting with and mediated by T lymphocytes ( e.g., graft rejection, delayed-type hypersensitivity). (theodora.com)
  • These organelles are often called the "energy factories" of a cell because they are responsible for making adenosine triphosphate (ATP), the cell's main energy-carrying molecule, by conducting cellular respiration. (coursehero.com)
  • Cytological smears were cellular with cells arranged in sheets, acini, and few papillaroid structures in hemorrhagic background [ Figure 1a ]. (cytojournal.com)
  • Testing of IgG autoantibodies to human cellular antigens was performed by the HEp-2 cell immunofluorescence assay using slides from INOVA Diagnostics, San Diego, CA (Cat # 508100) following the manufacturer's instructions and evaluated primarily using their NOVA View system. (cdc.gov)
  • Metastasis of clear cell renal cell carcinoma (ccRCC) to the thyroid gland is rare, and simultaneous occurrence of ccRCC and papillary thyroid carcinoma (PTC) is even rarer. (spandidos-publications.com)
  • Renal cell carcinoma (RCC) is the most common solid lesion within the kidney and accounts for ~90% of all kidney malignancies. (spandidos-publications.com)
  • However, even these patients are at risk of dying from lung cancer (both small and non-small cell types). (cancer.gov)
  • In less active cells, the nucleolus is much smaller -- as small as 0.5 micron in a mature lymphocyte. (nanomedicine.com)
  • Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
  • Animal cells usually have one or several Golgi bodies, whereas plant cells can have hundreds. (visiblebody.com)
  • The World Health Organization recognizes some variations of osteosarcoma, which differ in location, clinical presentation and level of cell atypia. (bvsalud.org)
  • Animal cells have a centrosome and lysosomes while plant cells do not. (coursehero.com)
  • Note the balloon cells (arrowheads) with abundant foamy cytoplasm. (aao.org)
  • The most common variant, oncocytic ACC, is characterized by cells with abundant eosinophilic cytoplasm. (cap.org)
  • 3B-C) Lesion is composed of large epithelioid and oval cells admixed with abundant collagenous stroma. (atlasgeneticsoncology.org)
  • Methods: The human multiple myeloma SKO-007 cells in logarithm growth phase were selected and randomly divided into control group, LDM group, BZM group, and BZM combined with LDM group. (researchgate.net)
  • Objective: To identify the different types of plasma cells in multiple myeloma. (bvsalud.org)
  • Results: Morphological aspects of plasma cells of 55 cases of multiple myeloma from 2004 to 2010 were analyzed in two laboratories in Kinshasa. (bvsalud.org)
  • Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
  • In the oral mucosa, melanocytes are observed in a ratio of about 1 melanocyte to 10 basal cells. (medscape.com)
  • EB06277 Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. (everestbiotech.com)
  • EB06277 Flow cytometric analysis of paraformaldehyde fixed HeLa cells (blue line), permeabilized with 0.5% Triton. (everestbiotech.com)
  • Flow cytometric analysis of HeLa cells. (everestbiotech.com)
  • Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. (harvard.edu)
  • RCC comprises different subtypes with specific histopathological and genetic characteristics, of which clear cell RCC (ccRCC) is the predominant pathological type, accounting for nearly 80% of all RCC cases ( 2 ). (spandidos-publications.com)
  • Sickle cell anemia is an example of an autosomal recessive genetic disorder. (genome.gov)
  • Dermatofibroma Versus Dermatofibrosarcoma Protuberans: A Nuclear Morphology Study. (harvard.edu)
  • d) Large bizarre cells with strap-like, rhabdoid morphology (Pap, ×20). (cytojournal.com)
  • To evaluate the survival of patients according to plasma cell morphology. (bvsalud.org)
  • type II consists of serous carcinoma, clear cell carcinoma, and carcinosarcoma. (karger.com)
  • In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the synthesis of a protein. (genome.gov)
  • Acute tip re-orientation occurred only in cells where forward growth was countered by hyphal friction sufficient to generate a tip force of ∼ 8.7 μN (1.2 MPa), more than that required to penetrate host-cell membranes. (exeter.ac.uk)
  • I joined the MRC CMM in 2021 as Senior Experimental Officer to support the CMM teams with experimental, technological and analytical know-how to visualise and measure how fungal pathogens respond, regulate and impinge on host model organisms at the single-cell level. (exeter.ac.uk)
  • PU.1 and C/EBPα work together to regulate hematopoietic stem cell differentiation. (bvsalud.org)
  • Diagnosis of TBL is challenging given its resemblance to basal cell carcinoma (BCC) but is important given possible malignant transformation and potential metastasis. (karger.com)
  • 3 Low-grade carcinoma ex pleomorphic adenoma can be of the following types: myoepithelial Carcinoma, epithelial-myoepithelial Carcinoma, basal cell adenocarcinoma, etc. (org.pk)
  • Squamous cell carcinoma. (cytojournal.com)
  • The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
  • The absence of inflammatory cells clearly excluded the possibility of abscess (option A). The skin adnexal tumors with clear cells which constituted the differential diagnosis include sebaceous carcinoma and clear cell hidradenomas. (cytojournal.com)
  • Objective: To investigate the effects of prion protein 106-126 peptide on inducing apoptosis in differentiated PC12 cells. (researchgate.net)
  • To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
  • Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)
  • Objective: To investigate the induction of tanshinone [1 A (Tan fl A) on the differentiation of human placenta-derived mesenchymal stem cells (hPDMSCs) into cardiomyocytes, and to provide an experimental basis for Tan IT A as a cardiomyocytc differentiation inducer. (researchgate.net)
  • The commitment of mesenchymal stem cells (MSCs) to preadipocytes and the termination of differentiation to adipocytes are critical for maintaining systemic energy homeostasis. (bvsalud.org)
  • Attached to the vacuole of cells. (cheatography.com)
  • Plant cells have a cell wall, a large central vacuole, chloroplasts, and other specialized plastids, whereas animal cells do not. (coursehero.com)
  • Since analysis of the cytomorphologic features of such nevus cells in the lymph node is so important, it is always recommended to compare these cells with the melanoma cells in the primary lesion. (medscape.com)
  • The mitochondrion converts the energy stored in glucose into ATP (adenosine triphosphate) for the cell. (enchantedlearning.com)
  • Mitochondria generate adenosine triphosphate (ATP)-the cell's main source of energy-via aerobic respiration, and as a result, they are known as the "power plants" of the cell. (visiblebody.com)
  • However, the presence of nevus cells contiguous with a choroidal melanoma on histologic examination provides evidence that melanomas may arise from choroidal nevi. (aao.org)
  • Because the nevus cells are so heavily pigmented, it is usually necessary to apply melanin bleaching techniques to sections to accurately study the cytologic features (see Chapter 15, Fig 15-12D). (aao.org)
  • Histologic subtypes of medulloblastoma include: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, and (3) large-cell/anaplastic medulloblastoma. (medscape.com)
  • [ 1 ] Several subtypes of medulloblastoma have been recognized including: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, (3) large-cell variant, and (4) anaplastic medulloblastoma. (medscape.com)
  • Longitudinal nuclear grooves (arrows). (iarc.fr)
  • H-29 cells were used for in vitro experiments in this study. (wjgnet.com)
  • Importantly, Trnp1 co‐regulates the architecture and function of these nuclear compartments in vitro and in the developing brain in vivo. (uni-muenchen.de)
  • Therefore, we investigated the role of Sox6 in regulating the differentiation of adipocytes by monitoring the effects of its overexpression in C3H10T1/2 cells (in vitro) and C57BL/6J mouse (in vivo) models of adipogenesis. (bvsalud.org)