Nrf2 activating transcription factors. Medical search. Frequent questions

As signal transducer and activator of transcription (STAT) 3 phosphorylation directly regulates retinoic acid receptor-related orphan receptor (ROR) γ t, which is the master molecule of Th17, the Janus kinase (JAK)2-STAT3 pathway initiated by IL-6 is essential in the Th17 development. (hindawi.com)
In conclusion, the present study confirmed that GRh2 could reduce oxidative stress and inflammation in cardiomyocytes after reperfusion, and its mechanism of action may be related to its regulation of the Nrf2/HO‑1/NLRP3 signalling pathway. (spandidos-publications.com)
Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)
Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the Nrf2 pathway. (cdc.gov)
Res strongly activated the Nrf2 signaling pathway and induced antioxidant response element-dependent cytoprotective genes. (cdc.gov)
Curcumin interacts with specific proteins in adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells, where it suppresses several cellular proteins such as transcription factor NF-kB, STAT-3, Wnt/β-catenin and activates PPAR-γ, Nrf2 cell signaling pathway. (greenmedinfo.com)
Knockdown of the C. elegans IMPACT homolog impt-1 activated the ISR pathway and increased lifespan and stress resistance of worms in a gcn-2 -dependent manner. (biomedcentral.com)
IMPACT inhibits the ISR pathway, thus limiting the activation of stress response factors that are beneficial during aging and required under DR. (biomedcentral.com)
Blueberries are not a nutrient…but they are really high in anthocyanins, which activate the NRF2 pathway. (foundmyfitness.com)
Scientific research has shown that very low carbohydrate diets may activate the Nrf2 pathway. (eatcleantrainclean.com)
Turning on the Nrf2 pathway seems to lead to chronic cellular adaptation, induction of protective proteins, and improvement of the mitochondrial redox state. (eatcleantrainclean.com)
So what foods turn on the Nrf2 pathway? (eatcleantrainclean.com)
NRF2 signaling pathway is an antioxidant defense mechanism, which it is dysregulated in AD. (uc.pt)
Besides reactive oxygen species (ROS), electrophiles can activate NRF2 pathway and, consequently, increase detoxifying proteins and modulate inflammation. (uc.pt)
In this article we describe the hormesis hypothesis of phytochemical actions with a focus on the Nrf2/ARE signaling pathway as a prototypical example of a neuroprotective mechanism of action of specific dietary phytochemicals. (psychosocialsomatic.com)
Amongst the dysregulated pathophysiological pathways in AD, oxidative stress seems to play a critical role in the pathogenesis progression of AD, with a dominant role of nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap1)/antioxidant responsive elements (ARE) pathway. (encyclopedia.pub)

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
Because ATF4 can simultaneously participate in multiple distinct heterodimers, the overall set of genes that require ATF4 for maximal expression in a specific context (ATF4-dependent genes) can be a mixture of genes that are regulated by different ATF4 heterodimers, with some ATF4-dependent genes activated by one ATF4 heterodimer and other ATF4-dependent genes activated by other ATF4 heterodimers. (wikipedia.org)
Keap1 may be viewed as the regulator of Nrf2, and reactive species/free radicals and electrophiles react with the Nrf2-Keap1 complex causing the release of Nrf2, which migrates to the cell nucleus and triggers the expression of selected genes whose products, i.e. proteins with or without enzymatic activity, participate in the antioxidant defense and in the metabolism of xenobiotics in mammals. (databasefootball.com)
Subsequent work by Pickett's lab and others helped identify the transcription factors that recognize the ARE and activate the transcription of GST and other oxidative stress response genes. (asbmb.org)
The complicated explanation is Nrf2 (nuclear erythroid-related factor 2) is a critical transcription factor that activates hundreds of genes via molecules called sirtuins. (xendurance.com)
Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)
NRF2 is a transcription factor that increases antioxidant, anti-inflammatory, DNA repair genes and more. (foundmyfitness.com)
Nrf2 has been shown (repeatedly) to be critical for neuronal protection, through the induction of various cytoprotective genes. (eatcleantrainclean.com)
The transcription factor nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) controls the basal and inducible expression of a plethora of genes, predominantly those associated with oxidative stress response through its regulation of the glutathione and thioredoxin based antioxidant systems, and the maintenance of cellular redox homeostasis. (dundee.ac.uk)
When the Nrf2 gene is disrupted, many genes involved in lipogenesis, which are known to be regulated by Pparα, are upregulated, indicating a potential role for Nrf2 in the repression of Pparα, a master regulator of hepatic lipid metabolism. (dundee.ac.uk)
Upon genetic knockout of Pparα the target genes which were upregulated in the Nrf2-/- animals were not induced in response to fasting, indicating that their increased expression in response to fasting is solely regulated by Pparα. (dundee.ac.uk)
In order to further verify that the induction of these fasting-associated genes in the absence of Nrf2 was Pparα-dependent, animals null for both transcription factors were subjected to an extended fast and were shown not to support increased expression of the Pparα target genes despite the absence of Nrf2. (dundee.ac.uk)
Examination of gene induction at the more acute 24 hr time point revealed that Nrf2-/- animals showed similar expression levels of Pparα target genes as WT animals, in addition to exhibiting similar plasma free fatty acid concentrations as their WT counterparts, suggesting that the negative regulation of Pparα by Nrf2 reflects chronic biochemical changes. (dundee.ac.uk)
NRF2 is a transcription factor that activates the expression of cytoprotective genes encoding antioxidative, detoxifying and metabolic enzymes as well as transporters. (elsevierpure.com)
When cells are exposed to stresses, KEAP1 stops promoting NRF2 degradation, and NRF2 rapidly accumulates and activates the transcription of target genes. (elsevierpure.com)
Hormetic pathways activated by phytochemicals may involve kinases and transcription factors that induce the expression of genes that encode antioxidant enzymes, protein chaperones, phase-2 enzymes, neurotrophic factors and other cytoprotective proteins. (psychosocialsomatic.com)

Special cellular machinery should be activated to fight against increased reactive oxygen species (ROS) level to protect from oxidative injury. (springer.com)
In addition, GRh2 reduced the expression levels of NOD‑like receptor family pyrin domain‑containing 3 (NLRP3), apoptosis‑associated speck‑like protein, caspase‑1, malondialdehyde and reactive oxygen species and increased the expression levels of nuclear factor E2‑related factor 2 (Nrf2), heme oxygenase‑1 (HO‑1), glutathione peroxidase and superoxide dismutase. (spandidos-publications.com)
Importantly, this activation also occurred in the absence of Pparα, indicating that it is not via direct crosstalk between the transcription factors, nor is it a consequence of the generation of reactive oxygen species by the oxidation of fatty acids. (dundee.ac.uk)
Many external factors are implicated with carcinogenesis, one of which are reactive oxygen species. (5dok.net)

Oxidative stress pathways regulate redox balance by Nrf2 and other ways. (springer.com)
NF-κB pathways can be mainly activated by two pathways. (springer.com)
Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)
The Sirtuin spices are our most popular spices that activate stress coping pathways, making them work better. (anti-agingfirewalls.com)
The levels of proteins in mitogen-activated protein kinases (MAPKs), nuclear factor erythroid 2-related factor 2 (Nrf2), and nuclear factor-κB (NF-κB) signaling pathways were determined by western immunoblotting. (uky.edu)
Underlying pathogenic mechanisms in chronic kidney disease (CKD) include chronic inflammation, oxidant stress, and matrix remodeling associated with dysregulated nuclear factor- κ B, nuclear factor- κ B, and SMAD signaling pathways, respectively. (aspetjournals.org)
Three arms exist in the ER stress response: the protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1 (IRE1) pathways, where each of the sensor proteins is a membrane protein ( Figure 1 ). (encyclopedia.pub)
The mammalian ER stress response consists of three arms: the inositol-requiring enzyme 1 (IRE1), protein kinase R (PKR)-like ER kinase (PERK), and activating transcription factor 6 (ATF6) pathways. (encyclopedia.pub)
While Nrf2 has long been studied in this context, it has more recently become apparent that the role of Nrf2 goes far beyond this narrow spectrum, including a clear role in the regulation of pathways involved in NADPH generation, gluconeogenesis, and lipid metabolism, although the true extent of the contribution of Nrf2 in vivo to many of these processes has yet to be fully elucidated. (dundee.ac.uk)
One general mechanism of action of phytochemicals that is emerging from recent studies is that they activate adaptive cellular stress response pathways. (psychosocialsomatic.com)
Although some beneficial phytochemicals might function solely as antioxidants, it is becoming clear that many of the beneficial chemicals in vegetables, herbs, plants and fruits evolved as toxins (to dissuade insects and other predators) that, at subtoxic doses, activate adaptive cellular stress-response pathways in a variety of cells including neurons. (psychosocialsomatic.com)
Examples of such 'preconditioning' or 'neurohormesis' pathways include those involving cell-survival signaling kinases, the transcription factors NRF2 and CREB, and histone deacetylases of the sirtuin family. (psychosocialsomatic.com)
Nrf2/Keap1/ARE has shown to be the upstream orchestrate of oxidative pathways, which also ameliorates various inflammatory and apoptotic pathways. (encyclopedia.pub)
Oxidative stress seems to be an upstream orchestrate of neurodegeneration either by activating the inflammatory and apoptotic pathways in neurodegenerative diseases. (encyclopedia.pub)
On the other hand, Nrf2 is now identified as a key upstream defence mediator against oxidative pathways. (encyclopedia.pub)

Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
Under normal conditions, Keap1 promotes ubiquitination and eventual degradation of Nrf2. (springer.com)
Otherwise, carnosic acid is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) protein, a transcription factor found in an inactive form in the cytosol bound to Kelch-like ECH-associated protein 1 (Keap1). (databasefootball.com)
The KEAP1-NRF2 system regulates the cellular defence against oxidative and xenobiotic stresses. (elsevierpure.com)
Under normal conditions, KEAP1 represses NRF2 activity by degrading the NRF2 protein. (elsevierpure.com)
Constitutive accumulation of NRF2 via a variety of mechanisms that disrupt KEAP1-mediated NRF2 degradation has been observed in various cancer types. (elsevierpure.com)
Plant secondary metabolites through targeting Nrf2/Keap1/ARE could counteract AD. (encyclopedia.pub)
The plant kingdom is now a great source of natural secondary metabolites in targeting Nrf2/Keap1/ARE. (encyclopedia.pub)
Prevailing evidence has shown that activating Nrf2/ARE and downstream antioxidant enzymes, as well as inhibiting Keap1 could play hopeful roles in overcoming AD. (encyclopedia.pub)
The current review highlights the neuroprotective effects of plant secondary metabolites through targeting Nrf2/Keap1/ARE and downstream interconnected mediators in combating AD. (encyclopedia.pub)

and boosted Nrf2 activation, all of which were partially reversed by the MKP-1 inhibitor, BCI. (uky.edu)

The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. (wikipedia.org)
At low concentrations, carnosic acid is detected by the cells as a xenobiotic and the Nrf2 transcription factor is activated, leading to an increase in the expression of proteins involved in cytoprotection, as mentioned above. (databasefootball.com)
An Nrf2 activator is a compound found in many plants that activates the Nrf proteins. (xendurance.com)
Important cytoprotective mechanisms activated by oxidative inflammatory conditions are mediated by nitrated fatty acids that covalently modify proteins to limit inflammation and oxidant stress. (aspetjournals.org)
In these ways, neurohormetic phytochemicals such as resveratrol, sulforaphanes and curcumin might protect neurons against injury and disease by stimulating the production of antioxidant enzymes, neurotrophic factors, protein chaperones and other proteins that help cells to withstand stress. (psychosocialsomatic.com)

The induction of HO-1 by KMS99220 occurred within 1 h, and this appeared not to involve the transcription factor Nrf2, because Nrf2 knockdown did not affect the compound's HO-1 inducing- and anti-inflammatory effects in this time window. (en-journal.org)

Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene. (wikipedia.org)
ATF4 is not a functional transcription factor by itself but one-half of many possible heterodimeric transcription factors. (wikipedia.org)
ATF4 transcription factor is also known to play role in osteoblast differentiation along with RUNX2 and osterix. (wikipedia.org)
Here, we have shown that activating transcription factor 4 (ATF4), a master transcriptional effector of the ISR, protects transformed cells against anoikis - a specialized form of apoptosis - following matrix detachment and also contributes to tumor metastatic properties. (jci.org)
Upon loss of attachment, ATF4 activated a coordinated program of cytoprotective autophagy and antioxidant responses, including induced expression of the major antioxidant enzyme heme oxygenase 1 (HO-1). (jci.org)
HO-1 upregulation was the result of simultaneous activation of ATF4 and the transcription factor NRF2, which converged on the HO1 promoter. (jci.org)
Under these conditions only certain mRNAs such as those encoding activating transcription factor 4 (ATF4) are translated, in order to maintain functions important for cell survival. (encyclopedia.pub)

In this study, we investigated the effects of KMS99220 on the signaling involving AMP-activated protein kinase (AMPK) and heme oxygenase-1 (HO-1), the enzymes thought to regulate inflammation. (en-journal.org)
Jawed Alam focuses on Heme oxygenase, Biochemistry, Molecular biology, Regulation of gene expression and Transcription factor. (research.com)
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. (research.com)
How Many Transcription Factors Does It Take to Turn On the Heme Oxygenase-1 Gene? (research.com)

Sulforaphane, a phytochemical contained in broccoli sprouts at relatively high concentrations, has been known to exert effects of cancer prevention by activating a transcription factor, Nrf2 (nuclear factor (erythroid-derived 2)-like 2), which regulates the balance of oxidation/reduction in the cell, and by enhancing the anti-oxidation ability of the body and detoxication of chemical compounds. (medicalxpress.com)
To test our hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, H4R3 and H3R17 protein arginine (R) methyltransferases 1 and 4 (PRMT1 and PRMT4) were investigated. (embl.de)

Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
Nrf2 is an antioxidant-activated transcription factor that recently emerged as a critical regulator of cellular defense against oxidative and inflammatory lesions. (cdc.gov)
The study highlights that some NSAID (non-steroidal anti-inflammatory) painkillers activate a protein responsible for anti-inflammatory, anti-oxidative, and detoxification action in body cells. (zmescience.com)
Activated, inflammatory microglia are neurotoxic, as they release various neurotoxic molecules such as nitric oxide (NO), TNF-α and IL-1β, among others. (en-journal.org)

His work carried out in the field of Transcription factor brings together such families of science as Ubiquitin, Antioxidant, Cycloheximide and Protein kinase A, p38 mitogen-activated protein kinases. (research.com)

If activated, a protein called NRF2 (nuclear factor erythroid 2-related factor 2) protects the body cells against the damage from oxidative stress and according to the researchers at Yale, some NSAIDs like ibuprofen can also activate NRF2. (zmescience.com)
One of these transcriptional regulators is nuclear factor erythroid 2-related factor 2, or NRF2, identified in 1994 by another research group. (asbmb.org)
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a transcription factor involved in the regulation of cell redox homeostasis. (uc.pt)

Nrf2 is referred to as a master regulator of intracellular redox homeostasis. (eatcleantrainclean.com)

Because NRF2 binds ARE, suggesting it helps regulate oxidative stress responses, Pickett and his team focused on it next and helped uncover key aspects of how NRF2 itself is regulated. (asbmb.org)

AMP-activated protein kinase (AMPK) is an enzyme involved in the regulation of cellular homeostasis and metabolic function. (en-journal.org)

Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA-binding domain. (wikipedia.org)
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)

What is an Nrf2 Activator? (xendurance.com)
His study looks at the intersection of Signal transduction and topics like Gene expression with HMOX1, Activator, Transcription and Proinflammatory cytokine. (research.com)
The various areas that Jawed Alam examines in his Gene expression study include HMOX1, Transcription factor, Transcription and Activator. (research.com)

however, its role in antioxidant gene transcription remains elusive. (embl.de)
Dr. Das noted the activation of the Nrf2 gene transcription factor was the controlling mechanism. (resveratrolnews.com)

encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)

Our findings support the hypothesis that edaravone-dexborneol can alleviate cerebral ischemic injury via the upregulation of MKP-1, which inhibits MAPKs and activates Nrf2. (uky.edu)

The function of mitogen-activated protein kinase phosphatase 1 (MKP-1) was investigated using both western blot and immunofluorescence methods, and the effect of the MKP-1 inhibitor, (2E)-2-benzylidene-3-(cyclohexylamino)-3H-inden-1-one (BCI), was investigated. (uky.edu)

Impt-1 knockdown exacerbated DR-induced longevity and required several DR-activated transcription factors to extend lifespan, among them SKN-1 and DAF-16, which were induced during larval development and adulthood, respectively, in response to impt-1 RNAi. (biomedcentral.com)
By activating Nrf2's, you are turning on the path to overall well-being and longevity. (xendurance.com)

Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. (embl.de)

Physiological aging refers to the physiological degeneration occurring after maturity, while pathological aging involves age-related changes caused by various external factors such as various diseases. (frontiersin.org)
In conclusion, this thesis describes data that provide further insight into the physiological role of Nrf2 in fatty acid metabolism. (dundee.ac.uk)

Nrf2 activates endogenous enzymatic antioxidants (glutathione, catalase, superoxide dismutase-SOD) in cardiac stem cells. (resveratrolnews.com)
Allicin and DADS activate the transcription factor Nrf2, which promotes the production of glutathione S-transferase and other endogenous antioxidant enzymes involved in Phase II liver detoxification. (peachvitamins.com)

For example, during their study, the researchers found that certain NSAIDs including common painkillers like ibuprofen and aspirin are involved in the activation of NRF2. (zmescience.com)
However, the new method is still needed to be tested on humans and for now, the researchers are not 100% sure that many unexplained effects of NSAIDs like ibuprofen and aspirin are caused due to NRF2 activation. (zmescience.com)
On the flip side, we also demonstrated a cost to activating NRF2, and our studies might suggest that these NSAIDs might want to be avoided in diseases in which NRF2 activation leads to unintentional harm. (zmescience.com)
Pickett's team reported that ARE is one of the motifs required for xenobiotics-induced activation of transcription of the GST Ya gene and also defined the ARE consensus sequence . (asbmb.org)
Nrf2 activation can be accomplished through exercise, diet, calorie reduction and even fasting. (xendurance.com)
Additionally, it was demonstrated for the first time that robust activation of Nrf2 occurs in response to prolonged fasting, with highly significant induction of the prototypic Nrf2 target gene Nqo1. (dundee.ac.uk)
Future work is required to build upon this foundation and fully elucidate the signal(s) which leads to Nrf2 activation in response to prolonged periods of fasting. (dundee.ac.uk)
In this study, we proposed to explore the potential of hexamethylene diisocyanate (HDI), an electrophilic molecule, in reverting some of the oxidative stress and neuroinflammation events associated to AD, via NRF2 activation. (uc.pt)

On the other hand, knockout or knockdown of Nrf2 markedly increased PQ-induced cytotoxicity, cytokine production, and myofibroblast transformation, and abolished protection by Res. (cdc.gov)
On the other hand, since Nrf2-knockout mice fed with high-fat food supplemented with sulforaphane did not show reduced body weight increase or fat burning through adipose tissue browning, the importance of Nrf2 is now clearly shown as the target molecule of sulforaphane for ameliorating obesity. (medicalxpress.com)
Pparα-/- double knockout were utilised during the course of this study in an effort to tease apart the interactions of transcription factors Nrf2 and Pparα under acute and extended fasting conditions, when Pparα is strongly activated, to better understand their in vivo relationship. (dundee.ac.uk)

NRF2 is a transcription factor that orchestrates anti-oxidant and detoxification programs and can be activated in most cells of the body. (zmescience.com)

When you add in phytochemicals, bioactive nutrient plant chemicals such as Nrf2s, they have been shown to activate antioxidant responses to help fight inflammation. (xendurance.com)

Constitutive NRF2 accumulation confers cancer cells with a proliferative advantage as well as resistance to anti-cancer drugs and radiotherapies. (elsevierpure.com)
To suppress the chemo- and radio-resistance of cancer cells caused by NRF2 accumulation, we conducted high-throughput chemical library screening for NRF2 inhibitors and identified febrifugine derivatives. (elsevierpure.com)

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. (wikipedia.org)
Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)

For example, many NRF2 activating drugs are being developed for specific conditions, and one could imagine that these NRF2 activating NSAIDs could be considered in those diseases. (zmescience.com)
3 . Activates Response To Inflammation - Chronic Inflammation is a culprit in cardiovascular disease, cancer, arthritis, diabetes and many other diseases. (xendurance.com)
Autoimmune diseases are affected by complex pathophysiology involving multiple cell types, cytokines, antibodies and mimicking factors. (bvsalud.org)
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
In this chapter, revisiting known TFs, we would argue if transcription controlling strategies could contribute for the novel therapies on human diseases. (intechopen.com)

I will look at dietary and supplemental factors that control SCD1 expression, how you can test to see what your levels of SCD1 are and introduce a natural inhibitor of the enzyme. (fireinabottle.net)

Although the exact molecular mechanism of the RA pathogenesis remains elusive, proinflammatory cytokines including tumor necrosis factor- (TNF-) α and interleukin- (IL-) 1 β and autoreactive T cells are known to play central roles in the development and progression of RA [ 1 ]. (hindawi.com)
Transforming growth factor- (TGF-) β and IL-6 primes initial differentiation and IL-23 promotes functional maturation of Th17 cells [ 7 ]. (hindawi.com)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
This activates cascade of events which, in the end, affects oxidative status of the cells and provides robust protection against oxidative challenge. (springer.com)
Halofuginone treatment ameliorated the resistance of NRF2-addicted cancer cells to anti-cancer drugs both in vitro and in vivo. (elsevierpure.com)
Our results showed that HDI increased nuclear (nuc) and cytoplasmatic (cyt) NRF2 levels and Hmox-1 gene expression and HMOX-1 protein levels, in N2a-APPswe cells. (uc.pt)
Given that OKSM (Yamanaka) factors convert somatic cells into induced pluripotent stem (iPS) cells, alterations in transcriptional state could affect destiny of the cells. (intechopen.com)
the prodrug approach may be truly selective because it requires the aberrant high ROS levels in cancer cells to activate it. (5dok.net)

In most metazoans, GCN2 is one of the four known kinases that phosphorylate eukaryotic initiation factor 2, α subunit (eIF2α) to inhibit translation initiation [ 19 ]. (biomedcentral.com)

or by developing prodrugs that are activated by ROS molecules. (5dok.net)

The primary aim of this thesis was to further define the role of Nrf2 during metabolic stress and to determine the mechanism of action of such a function. (dundee.ac.uk)

He combines subjects such as Proteasome, Protein biosynthesis, Promoter, HMOX1 and Transcription with his study of Transcription factor. (research.com)

Brain-derived neurotrophic factor (BDNF) is another element that can be positively or negatively impacted by diet. (eatcleantrainclean.com)
Together, these data substantiate our hypothesis that under prolonged fasting conditions, the Pparα response is negatively regulated by Nrf2. (dundee.ac.uk)

PERK, (a component of the integrated stress response) then phosphorylates the eukaryotic translation initiation factor 2 subunit −α (eIF2α), which results in global translational arrest. (encyclopedia.pub)

The findings demonstrate that Res attenuates PQ-induced ROS production, inflammation, and fibrotic reactions by activating Nrf2 signaling. (cdc.gov)

Most of the anti-angiogenic agents approved for cancer treatment rely on targeting vascular endothelial growth factor (VEGF) actions, as VEGF signaling is considered the main angiogenesis promotor. (mdpi.com)
These results provide preclinical proof-of-concept evidence for halofuginone as an NRF2 inhibitor applicable to treatment of chemo- and radio-resistant forms of cancer. (elsevierpure.com)

Here we analyzed the molecular mechanism of the fibrogenic response to PQ and its inhibition by Res and Nrf2. (cdc.gov)

Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)

Anatomy16

Organisms8

Chemicals and Drugs135

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes70

Disciplines and Occupations1

Information Science3

Pathway16

Genes19

Reactive oxygen4

Pathways15

Keap110

Boosted Nrf2 activation1

Proteins5

Knockdown did not1

ATF47

Heme4

Regulates2

Inflammatory4

Mitogen-activat1

Nuclear factor3

Regulator1

Binds1

Homeostasis1

Leucine zipper3

Activator3

Gene transcription2

Redox balance1

Inhibits1

Protein kinase1

Longevity2

Regulation1

Physiological2

Glutathione2

Activation8

Knockout3

Anti-oxidant1

Phytochemicals1

Accumulation2

Mammalian2

Diseases5

Enzyme1

Cells8

Kinases1

Molecules1

Metabolic1

HMOX11

Negatively2

Eukaryotic1

Inflammation1

Cancer2

Inhibition1

Upregulation1