Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that in humans is encoded by the NFE2L1 gene. (wikipedia.org)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The prognostic significance of the major redox regulator nuclear factor erythroid-2-related factor (NRF2) is recognized in many cancers, but the role of NRF1 is not generally well understood in cancer. (hindawi.com)
Nuclear factor erythroid-2-related factor 2 (NRF2) is the most studied member of the Cap 'n' collar basic leucine zipper (CNC-bZIP) family of transcription factors. (hindawi.com)
Family of transcription factors2
Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
From the same family of transcription factors, NRF1 is generally far less studied and its role in carcinogenesis is insufficiently explored. (hindawi.com)
BZIP1
NFE2L1 is a cap 'n' collar, basic-leucine zipper (bZIP) transcription factor. (wikipedia.org)
Nrf28
This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
We characterized the immunohistochemical expression of NRF1 and NRF2 in 99 naevi, 88 primary skin melanomas, and 67 lymph node metastases. (hindawi.com)
In addition, NRF1 and NRF2 mRNA and miR-23B, miR-93, miR-144, miR-212, miR-340, miR-383, and miR-510 levels were analysed with real-time qPCR from 54 paraffin-embedded naevi and melanoma samples. (hindawi.com)
Furthermore, the miRNAs correlated negatively with the immunohistochemical expression of NRF1 and NRF2 but positively with their respective mRNA. (hindawi.com)
Both, NRF1 and NRF2 reside outside of the nucleus under unstressed conditions: NRF1 in the endoplasmic reticulum (ER) and NRF2 in the cytoplasm [ 5 ]. (hindawi.com)
Several events contribute to NRF1 and NRF2 activation, among them the proteolytic cleavage of NRF1 from the ER membrane and the phosphorylation of NRF2. (hindawi.com)
In particular, miR-23B, miR-93, miR-144, and miR-212 were found to play a role as NRF2 inhibitors, while miR-340 appears to have a role as an NRF1 and MAPK inhibitor with miR-383 and miR-510 having a less clear role in the regulation of NRF1 and NRF2 levels [ 7 ]. (hindawi.com)
Genes1
As a consequence, both factors are transported to the nucleus to induce the expression of their target genes. (hindawi.com)
Nuclear factor2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Nuclear Factor I/X (NFIX) in Tissue homogenates and other biological fluids. (operatiebrp.nl)
Description: A sandwich quantitative ELISA assay kit for detection of Human Nuclear Factor I/X (NFIX) in samples from tissue homogenates or other biological fluids. (operatiebrp.nl)
Redox2
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Our aim was to investigate these redox transcription factors in conjunction with redox-related microRNAs in naevi and melanoma. (hindawi.com)
Conditions1
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
Transcriptional3
Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells. (nih.gov)
The nuclear factor (erythroid 2)-like (NRF) transcription factors are a subset of cap'n'collar transcriptional regulators. (nih.gov)
However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. (nih.gov)
NRF26
In addition, the lack of NRF1 in HaCaT cells did not disturb iAs 3+ -induced NRF2 accumulation but noticeably decreased Kelch-like ECH-associated protein 1 (KEAP1) levels under basal and iAs 3+ -exposed conditions, suggesting a potential interaction between NRF1 and KEAP1. (nih.gov)
Analysis of the ARE motifs identified in ChIP peaks revealed that NRF2 prefers binding to AREs flanked by GC-rich regions and that NRF1 prefers AT-rich flanking regions. (nih.gov)
9. Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap 'n' collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction. (nih.gov)
10. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. (nih.gov)
11. Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. (nih.gov)
18. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. (nih.gov)
Erythroid1
Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that in humans is encoded by the NFE2L1 gene. (wikipedia.org)
PROTEINS2
It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. (nih.gov)
HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
In cultured human keratinocyte HaCaT cells, inorganic arsenite (iAs 3+ ) enhanced the protein accumulation of long isoforms (120-140 kDa) of NRF1 in a dose- and time-dependent fashion. (nih.gov)
Here, we demonstrate for the first time that long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes and protect the cells from acute arsenic cytotoxicity. (nih.gov)
Antioxidant response1
We investigated the role of NRF1 in arsenic-induced antioxidant response and cytotoxicity in human keratinocytes. (nih.gov)
Maff2
MafF expression was induced by interleukin-1ß (IL-1ß) or tumor necrosis factor alpha (TNF-α) treatment in both HepG2 and PXB cells, in an NF-κB-dependent manner. (bvsalud.org)
MafF was shown to suppress transcription from the HBV core promoter, leading to significant suppression of the HBV life cycle. (bvsalud.org)
Protein1
HBZ protein suppresses transcription of the tax gene through blocking the LTR recruitment of not only ATF/CREB factors but also CBP/p300. (biomedcentral.com)
Targets2
The lack of experimental information regarding the regulation of the whole set of transcription factors and their targets in different cell types is one of the main reasons to this incompleteness. (hindawi.com)
A basic-leucine zipper transcription factor that is involved in regulating inflammatory responses, MORPHOGENESIS , and HEME biosynthesis. (nih.gov)
Regulation2
We believe that an approach, such as the one shown here, could help to understand the one regulation of transcription in eukaryotic cells. (hindawi.com)
The said phenomena are indicative of a sophisticated machinery involved in the regulation of gene transcription: highly connected TFs are also regulated by others, which may (or may not) be highly connected. (hindawi.com)
Promotes1
HBZ promotes transcription of Foxp3, CCR4, and T-cell immunoreceptor with Ig and ITIM domains (TIGIT). (biomedcentral.com)
Expression3
Selective deficiency of NRF1 by lentiviral short-hairpin RNAs in HaCaT cells [ NRF1 -knockdown (KD)] led to decreased expression of γ-glutamate cysteine ligase catalytic subunit (GCLC) and regulatory subunit (GCLM) and a reduced level of intracellular glutathione. (nih.gov)
However, the iAs 3 -induced expression of heme oxygenase 1 ( HMOX-1 ) was unaltered by silencing NRF1 , suggesting that HMOX-1 is not regulated by NRF1. (nih.gov)
On the other hand, results were totally different when analyzing sense and antisense transcription from viral constructs containing both LTRs: Tax did not activate antisense transcription from the 3′ LTR in this case [ 14 ]. (biomedcentral.com)
Taken together, all these observations suggest that Tax could indirectly keep antisense transcription to low levels through its stimulation of sense transcription and viral production. (biomedcentral.com)
Cells1
Interestingly, transfection of a 5′ LTR-deleted proviral clone into 293T cells stimulates synthesis of antisense transcripts from the 3′ LTR [ 4 ], suggesting that decreased sense transcription may indeed result in an increased antisense transcription. (biomedcentral.com)
Small1
Using a small interfering RNA (siRNA) library and an HBV/NanoLuc (NL) reporter virus, we screened to identify anti-HBV host factors. (bvsalud.org)