Also was evaluated expression level of stress-related genes glucocorticoid and mineralocorticoid receptors (Nr3c1 and Nr3c2) as well as Nr1d1, which encodes a transcription factor REVERBО±, which regulates sociability and anxiety-related behavior. (icgbio.ru)
The expression of stress-related genes Nr3c1 and Nr3c2 was unchanged in both groups. (icgbio.ru)
4-97 years) to investigate the relationship between the thickness of cerebral cortex and the expression of the glucocorticoid- and the mineralocorticoid-receptor genes (NR3C1 and NR3C2, respectively), obtained from the Allen Human Brain Atlas. (uai.cl)
In all participants, cortical thickness correlated negatively with the expression of both NR3C1 and NR3C2 across 34 cortical regions. (uai.cl)
These variations do not reflect age-related changes in NR3C1 and NR3C2 expression, as observed in 5 databases of gene expression in the human cerebral cortex (502 donors). (uai.cl)
Based on the co-expression of NR3C1 (and NR3C2) with genes specific to neural cell types, we determine the potential involvement of microglia, astrocytes, and CA1 pyramidal cells in mediating the relationship between corticosteroid exposure and cortical thickness. (uai.cl)
The scientists also measured methylation of the promoter regions for the GR (NR3C1 and NR3C2), MR (MTNR1A and MTNR1B), EPAC (RASGRF1 and RASGRF2), and DR (DRD1 and DRD2) genes. (dentist-in-greece.com)
Genes1
The expression network of three candidate genes ( ARHGAP10, NR3C2, and EDNRA) regulating dose transcription was constructed by RNA sequencing. (bvsalud.org)
Mineralocorticoid1
As a result, changes in the gene sequence NR3C2, located on the long arm of chromosome 4 (4q31.1), the mineralocorticoid receptor encoding can change blood pressure by impaired renal absorption of salt. (ivami.com)
Exons2
in IVAMI perform detection of mutations associated with early onset hypertension, by complete PCR amplification of the exons of the gene NR3C2, and subsequent sequencing. (ivami.com)
qRT-PCR analysis continues to be performed using primers for exons 6 and 7 from the Nr3c2 coding series. (scienceexhibitions.org)
Gene2
A particular mutation in the gene can cause hypertension NR3C2 early onset with severe exacerbation during pregnancy. (ivami.com)
Three Brothers With Autism Carry a Stop-Gain Mutation in the HPA-Axis Gene NR3C2. (nih.gov)
Targets1
Compare with the compound-target network and component-target network, 6 kernel targets were screened, including AR, CHRM2, ESR1, NR3C1, NR3C2 and PGR, which was considered as potential markers and might play important roles in the process of GLE treatment. (researcher-app.com)
ESR11
Moreover, qRT-PCR data demonstrated the expression levels of NR3C1, NR3C2 and AR are up-regulated and PGR, ESR1 and CHRM2 are down-regulated. (researcher-app.com)
Expression1
From childhood through early adulthood, the profile similarity (between NR3C1/NR3C2 expression and thickness) increased with age. (uai.cl)
HUMAN1
With GeneMedi's target-insight database-GM ITD database, the NR3C2 target is also connected to human indications/diseases/conditions/MOA. (genemedi.net)
Cell3
Pre-made anti-NR3C2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). (genemedi.net)
The anti-NR3C2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. (genemedi.net)
A) Quantification of Nr3c2 mRNA appearance in tissues and cell lysates. (scienceexhibitions.org)
Products1
The page also collects GeneMedi's different modalities and formats products for NR3C2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. (genemedi.net)
Mineralocorticoid receptor gene3
The mineralocorticoid receptor gene (NR3C2) is linked to and associated with polycystic ovarian syndrome in Italian families. (bvsalud.org)
Thus, we aimed to investigate the potential pathogenetic role of the mineralocorticoid receptor gene (NR3C2) as the encoded NR3C2 product binds aldosterone and plays a role in folliculogenesis, fat metabolism , and insulin resistance . (bvsalud.org)
Functional polymorphisms of the mineralocorticoid receptor gene NR3C2 are associated with diminished memory decline: Results from a longitudinal general-population study. (cdc.gov)
Nuclear receptor1
Here we report evidence of a novel MIF-driven signaling pathway that inhibits the orphan nuclear receptor NR3C2, a previously undescribed tumor suppressor that impacts aggressiveness and survival in PDAC. (nih.gov)
MRNA1
In Study 2, we measured Nr3c2 mRNA levels in the PFC and CeA of dependent and nondependent rats and the correlates with ethanol drinking during acute withdrawal. (nih.gov)
Genes2
Nr3c2 is particularly interesting because it is not expressed to the same extent throughout the brain, like many other autism-linked genes are. (nih.gov)
In Study 1, we investigated the relationship between plasma aldosterone levels, ethanol self-administration and the expression of CYP11B2 and MR (NR3C2) genes in the prefrontal cortex area (PFC) and central nucleus of the amygdala (CeA) in monkeys. (nih.gov)
Variants1
We tested the NR3C2 variants for linkage and linkage disequilibrium to the PCOS phenotype by using parametric analysis . (bvsalud.org)
Functional1
Functional analysis showed that NR3C2 inhibited epithelial-to-mesenchymal transition and enhanced sensitivity to the gemcitabine, a chemotherapeutic drug used in PDAC standard of care. (nih.gov)
Levels3
PDAC tumors expressing high levels of MIF displayed elevated levels of miR-301b and reduced levels of NR3C2. (nih.gov)
Additionally, reduced levels of NR3C2 expression correlated with poorer survival in multiple independent cohorts of PDAC patients. (nih.gov)
Low Nr3c2 expression levels in the CeA were significantly associated with increased anxiety-like behavior and compulsive-like drinking in dependent rats. (nih.gov)
Plays1
Postdoctoral fellow Katharine McCann, Ph.D., lead author of the study, said that Nr3c2 plays a key role in hormonal responses to a stressful experience. (nih.gov)
Report1
Here, we report multiple crystal structures of MR (NR3C2) bound to both agonist and antagonists. (nih.gov)
Target1
Taken together, our results offer a preclinical proof-of-principle for candidate therapies to target a newly described MIF-miR-301b-NR3C2 signaling axis for PDAC management. (nih.gov)