• This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. (nih.gov)
  • Homo sapiens secretory carrier membrane protein 2 (SCAMP2), transcript variant 2, mRNA. (origene.com)
  • β-Ketoacyl-(acyl carrier protein) reductase (FabG) catalyzes the key reductive reaction in the elongation cycle of fatty acid synthesis (FAS), which is a vital metabolic pathway in bacteria and a promising target for new antibiotic development. (rcsb.org)
  • Acyl carrier proteins are critical components of fatty acid and polyketide biosynthesis. (rsc.org)
  • Selectivity for the holo over apo -form of acyl carrier proteins is demonstrated indicating that only the phosphopantetheine - thiol is modified. (rsc.org)
  • The α-subunits of the oxaloacetate and methylmalonyl-CoA decarboxylases are homologous to many biotin-containing enzymes including (1) pyruvate carboxylases, (2) homocitrate synthases, (3) biotin carboxyl carrier proteins, (4) isopropylmalate synthases and (5) acyl-CoA carboxylase. (tcdb.org)
  • beta-Ketoacyl-acyl carrier protein synthetase. (brenda-enzymes.org)
  • The encoded protein is a transmembrane protein located in the mitochondrial inner membrane and catalyzes the transport of phosphate ions across it for the purpose of oxidative phosphorylation. (wikipedia.org)
  • In the final steps of oxidative phosphorylation, this protein catalyzes the uptake of a phosphate ion with a proton across the mitochondrial inner membrane. (wikipedia.org)
  • Mitochondrial protein degradation is not triggered by loss of mitochondrial membrane potential or oxidative stress. (elifesciences.org)
  • PROJECT SUMMARYFor decades, NRAMP1 (for natural resistance-associated macrophage protein 1, renamed SLC11A1 forsolute carrier protein family 11, member 1) has been characterized as a divalent cation/H+ antiporter in thephagosomal membrane of macrophages that pumps iron and manganese out of the vacuole. (usda.gov)
  • The cytoplasmic domain is essential for transport function of the integral membrane transport protein SLC4A11. (genscript.com)
  • We conclude that SLC4A11 is a rare integral membrane protein in which the CD has strong associations with the integral MD, which contributes to membrane transport function. (genscript.com)
  • The β-subunits possess 9 transmembrane α-helical spanners (TMSs), and the protein may dip into the membrane twice between TMSs III and IV. (tcdb.org)
  • Serotonin Plasma Membrane Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
  • This graph shows the total number of publications written about "Serotonin Plasma Membrane Transport Proteins" by people in this website by year, and whether "Serotonin Plasma Membrane Transport Proteins" was a major or minor topic of these publications. (musc.edu)
  • Below are the most recent publications written about "Serotonin Plasma Membrane Transport Proteins" by people in Profiles. (musc.edu)
  • ZIP4 is a member of the Zrt-/Irt-like protein (ZIP) family, and it is a histidine-rich transmembrane protein that is specifically expressed on the apical side of enterocytes in the small intestine, as well as in the kidney, and is responsible for zinc absorption. (medscape.com)
  • RFC proteins possess 12 putative transmembrane a-helical spanners (TMSs) and evidence for a 12 TMS topology has been published for the human RFC. (nih.gov)
  • 1] "The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein. (tcdb.org)
  • Description: A sandwich ELISA kit for detection of Solute Carrier Family 1, Member 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (glideruniversity.org)
  • This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. (cancerindex.org)
  • Ataxia-telangiectasia is caused by mutations in the gene that encodes ataxia-telangiectasia-mutated (ATM) protein. (msdmanuals.com)
  • The Reduced Folate Carrier (RFC) Family (TC 2.A.48) Members of the RFC family mediate the uptake of folate, reduce folate, derivatives of reduced folate and the drug, methotrexate. (nih.gov)
  • The actions of the proteins that control the uptake, storage, and distribution of zinc, the zinc transporters, are under intense investigation due to their emerging role in type 2 diabetes. (hindawi.com)
  • These proteins are highly conserved across all kingdoms of life and thus likely share a common transport mechanism. (nature.com)
  • The Atg12 protein in yeast is an indispensable polypeptide in the highly conserved ubiquitin-like conjugation system operating in the macroautophagy/autophagy pathway. (bvsalud.org)
  • They function as carriers to the cell surface in post-golgi recycling pathways. (nih.gov)
  • These findings suggest that these protein family members may function at the same site during vesicular transport rather than in separate pathways. (nih.gov)
  • Different family members are highly related products of distinct genes, and are usually expressed together. (nih.gov)
  • Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified. (guidetopharmacology.org)
  • Mammalian cells are devoid of folate biosynthesis and are therefore folate auxotrophs that take up folate vitamins primarily via the reduced folate carrier (RFC). (aspetjournals.org)
  • Although BBAP has a unique N terminus, the C-terminal region is highly homologous to that of DTX family members. (nih.gov)
  • Highly homologous prokaryotic SLC11 family members transport Mn 2+ into the cytoplasm 11 . (nature.com)
  • PHC contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. (wikipedia.org)
  • Members of the DTX (Deltex) family act as Notch signaling modifiers and may also regulate transcription through interactions with specific transcription factors. (nih.gov)
  • Herein, we report that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination. (nih.gov)
  • DTX family members homodimerize and heterodimerize in vivo, suggesting that physical interactions between various DTX family members modify E3 activity and/or substrate availability. (nih.gov)
  • ASOB2 has been identified as apolipoprotein D (apoD), a known member of the lipocalin family of carrier proteins. (medscape.com)
  • The SLC25A19 gene provides instructions for producing a protein that is a member of the solute carrier (SLC) family of proteins. (medlineplus.gov)
  • Proteins in the SLC family transport various compounds across the membranes surrounding the cell and its component parts. (medlineplus.gov)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Solute Carrier Family 1, Member 5 (SLC1A5) in Tissue homogenates, cell lysates and other biological fluids. (glideruniversity.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Solute Carrier Family 1, Member 5 (SLC1A5) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (glideruniversity.org)
  • Proteins of the RFC family are so-far restricted to animals. (nih.gov)
  • Its crystal structure reveals a previously unknown outward-facing state of the protein family. (nature.com)
  • Whereas family members poorly discriminate between different divalent transition-metal ions, they efficiently select against Ca 2+ and Mg 2+ , which are both several orders of magnitude more abundant 4 , 5 . (nature.com)
  • Orthologous to human SLC7A15P (solute carrier family 7 member 15, pseudogene). (jax.org)
  • Rattus norvegicus solute carrier family 4 member 11 (Slc4a11), mRNA. (genscript.com)
  • Consequently, NaT-DC family members may be present in archaea as well as bacteria. (tcdb.org)
  • Here we reviewed the research progress of PIN protein in Arabidopsis thaliana and cereal crops from the aspects of protein structure, activity regulation and functional verification to provide new ideas and clues for exploring the auxin polar transport mediated by PIN protein family. (chinbullbotany.com)
  • Members of the SLC45 family remain to be fully characterised. (guidetopharmacology.org)
  • Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O. (2014) Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. (guidetopharmacology.org)
  • A multifunctional role of Atg8-family proteins (Atg8 from yeast and human LC3 and GABARAP subfamilies, all referred to here as ATG8s) in macroautophagy/autophagy is carried out by two protein domains, the N-terminal helical domain (NHD) and ubiquitin-like (UBL) domain. (bvsalud.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Solute Carrier Family 30 Member 7 (SLC30A7) in samples from tissue homogenates or other biological fluids. (isogem.org)
  • Acrodermatitis enteropathica is an autosomal recessive disorder occurring as a result of mutations in the SLC39A4 ( solute carrier family 39 member A4) gene located on band 8q24.3. (medscape.com)
  • Genetic counseling is recommended for family members of parents with the congenital form of acrodermatitis enteropathica. (medscape.com)
  • WF upregulated (1.4 to 1.7-fold) the mRNA transcripts for interferon-gamma (Ifng), inducible nitric oxide synthase (Nos2), matrix metalloproteinase 9 (Mmp9), dopamine D2 receptor (Drd2), and the solute carrier family 18 member A2 (Slc18a2 / Vmat2) in FCT after 1 d, suggestive of neuroinflammation and altered monoamine neurotransmitter signaling. (cdc.gov)
  • Recent studies suggest that infants and children with a history of convulsions in first-degree family members (i.e. siblings and parents) have a 3:2 fold increased risk for neurologic events compared DTP vaccine and permanent neurologic damage. (who.int)
  • Using a yeast two-hybrid screen for BAL-binding partners, we have now identified a novel protein termed BBAP (B-lymphoma- and BAL-associated protein). (nih.gov)
  • These findings provide evidence that the IDPR is an indispensable part of the Atg12 protein from yeast. (bvsalud.org)
  • The enzyme transfers CO 2 from glutaconyl-CoA to a biotin carrier protein (the γ-subunit) that is subsequently decarboxylated by the carboxybiotin decarboxylation site within the Na + pumping beta subunit (Gcdβ). (tcdb.org)
  • No significant cross-reactivity or interference between Mitochondrial Uncoupling Protein 2 (UCP2) and analogues was observed. (biomatik.com)
  • All known individuals with Amish lethal microcephaly have a mutation in which the protein building block (amino acid) alanine is substituted for the amino acid glycine at position 177 of the SLC25A19 protein, written as Gly177Ala or G177A. (medlineplus.gov)
  • A major deletion in the IDPR disrupts intactness of the UBL domain at the unconjugated C terminus, and a mutation in the predicted α0 helix in the IDPR prevents Atg12 from binding to Atg7 and Atg10, which ultimately affects the protein function in the ubiquitin-like conjugation cascade. (bvsalud.org)
  • There exist two transcript variants of this protein, PHC-A and PHC-B, which differ by 13 amino acids. (wikipedia.org)
  • Zinc has "mimetic" activity where it is involved in a range of functions including insulin receptor signal transduction, insulin storage, secretion and tissues/organelle distribution, and inhibition of protein tyrosine phosphatases [ 5 - 8 ]. (hindawi.com)
  • Thus, the proteins that transport zinc likely facilitate cell signaling processes that contribute to glycemic control in peripheral tissues by modulating cytosolic zinc concentrations. (hindawi.com)
  • Given the low plasma concentration of zinc and its importance in cellular signaling, it is essential that the availability and distribution of "free" zinc (free zinc is used to differentiate zinc involved in cell signaling from zinc that tightly bound to protein and therefore thermodynamically unavailable) are tightly controlled [ 6 ]. (hindawi.com)
  • The etiopathogenesis of the zinc deficiency occurs as a result of loss-of-function mutations of the zinc-ligand binding protein ZIP4 encoded by the SLC39A4 ( solute carrier 39A) gene located on band 8q24.3. (medscape.com)
  • The most abundant of these acids is (E)-3-methyl-2-hexanoic acid (E-3M2H), which is brought to the skin surface bound by 2 apocrine secretion odor-binding proteins, ASOB1 and ASOB2. (medscape.com)
  • These sequences represent the protein coding region of the Slc4a11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
  • GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. (genscript.com)
  • To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (origene.com)
  • The direction of auxin flow between cells is closely related to the polar localization of PIN proteins in cells. (chinbullbotany.com)
  • Here we report the findings of structural, enzymatic, and binding studies of the FabG protein found in the causative agent of cholera, Vibrio cholerae (vcFabG). (rcsb.org)
  • B)Structural model of PIN protein with a short HL. (chinbullbotany.com)
  • 2] "Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues. (tcdb.org)
  • We have structurally characterized the final peptidyl carrier protein domain of the teicoplanin non-ribosomal peptide synthetase machinery: this domain is believed to mediate the interactions with tailoring Oxy enzymes in addition to its function as a shuttle for intermediates between multiple non-ribosomal peptide synthetase domains. (rcsb.org)
  • The structures exhibit the same general fold as the majority of known carrier protein structures, in spite of the complex biosynthetic role that PCP domains from the final non-ribosomal peptide synthetase module must play in glycopeptide antibiotic biosynthesis. (rcsb.org)
  • Mitochondrial proteins are degraded by autophagy in aged cells. (elifesciences.org)
  • Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). (medsci.org)
  • Using established molecular biology techniques, Rubius's scientists can engineer progenitor cells taken from human bone marrow and grow blood cells that produce specific therapeutic proteins on their surface or inside the cell. (technologyreview.com)
  • Lodish, a scientific cofounder and member of Rubius's board of directors, says engineering red blood cells to produce the desired enzyme "answers both problems. (technologyreview.com)
  • It takes only a few weeks to grow cells that produce a new protein of interest-a process Kahvejian calls "rapid prototyping. (technologyreview.com)
  • Sickle-cell disease (SCD) is a genetic condition in which the red blood cells contain haemoglobin S (HbS), an abnormal form of the oxygen-carrying protein. (who.int)
  • Mutations in this gene can cause mitochondrial phosphate carrier deficiency (MPCD), a fatal disorder of oxidative phosphorylation symptomized by lactic acidosis, neonatal hypotonia, hypertrophic cardiomyopathy, and death within the first year of life. (wikipedia.org)
  • Mutations in this gene can cause mitochondrial phosphate carrier deficiency (MPCD), a fatal disorder of oxidative phosphorylation. (wikipedia.org)
  • The encoded protein (PHC) catalyzes the transport of phosphate from the cytosol into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. (wikipedia.org)
  • The polar transport of auxin mainly depends on three transporters: AUX/LAX, PIN and ABCB protein families. (chinbullbotany.com)
  • About 98% of estradiol is bound to transport proteins (SHBG and albumin). (cdc.gov)
  • The development of pneumococcal conjugate vaccines, in which each of the selected bacterial capsular polysaccharides is coupled to a protein carrier molecule, has been a major advance in the prevention of invasive pneumococcal disease. (who.int)
  • These structures thus support the hypothesis that it is subtle rearrangements, rather than dramatic conformational changes, which govern carrier protein interactions and selectivity during non-ribosomal peptide synthesis. (rcsb.org)
  • The biosynthesis of the glycopeptide antibiotics, of which teicoplanin and vancomycin are representative members, relies on the combination of non-ribosomal peptide synthesis and modification of the peptide by cytochrome P450 (Oxy) enzymes while the peptide remains bound to the peptide synthesis machinery. (rcsb.org)
  • The SLC45A2 gene is thought to encode a transporter protein that mediates melanin synthesis. (guidetopharmacology.org)