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  • embryonic stem
  • among the miRNAs that are highly expressed in undifferentiated embryonic stem cells, the miR-520 cluster may be closely involved in hES cell function and its relevance to chromatin structure warrants further study. (biomedcentral.com)
  • translational
  • miRNAs cause the translational repression or cleavage of target messages ( Doench and Sharp 2004 ). (biology-online.org)
  • Recent experiments show some correlation between the level of translational repression and the free energy of binding of the first eight nucleotides in the 5′ region of the miRNA ( Doench and Sharp 2004 ). (biology-online.org)
  • Here, we describe a sequential homeostatic synaptic depression mechanism in primary hippocampal neurons involving miRNA‐dependent translational regulation. (embopress.org)
  • To our knowledge, this is the first study to apply a high-throughput sequencing approach to the investigation of liver microRNAs (miRNAs) in NAFLD-related liver damage,' DiStefano said the study's senior author Johanna DiStefano from Translational Genomics Research Institute (Tgen) in Arizona, US. (mid-day.com)
  • From which, 941 (77.19%) were predicted to be the subject of miRNA cleavage and 278 (22.81%) scaffolds were regulated via translational repression of mRNA. (omicsonline.org)
  • significantly
  • Global miRNA and mRNA expression was significantly reduced during lactation and the early stages of involution after weaning. (biomedcentral.com)
  • Breast cancer-associated miRNAs were significantly enriched in these clusters. (biomedcentral.com)
  • Interestingly, miR-22 and miR-125 are significantly up-regulated in cells grown under low-folate conditions. (uib.no)
  • We identified three significantly associated mRNA-miRNA pairs: BCL2 was positively associated with miR-16 and SMAD4 was positively associated with miR-567 in the CRC tissue, while MSH6 was positively associated with miR-142-5p in the normal tissue. (hindawi.com)
  • We present additional evidence that RNAs crosslinked to Ago2 are significantly enriched in a G-rich motif in a miRNA-independent manner, as it is present in Ago2-CLIP libraries from Dicer wild-type and Dicer null mESCs. (mit.edu)
  • PM 10 exposure was significantly associated with elevated fibrinogen levels, and five of the nine downregulated EV-miRNAs were mediators between PM 10 exposure and fibrinogen levels. (biomedcentral.com)
  • Results: miR-34a, miR-99a, miR-143 and miR-380-5p were significantly down-regulated in tumors compared to controls. (koreascience.or.kr)
  • Interestingly, RNAseq analysis uncovered 27 significantly altered miRNAs, of which 11 were upregulated and 16 were downregulated in Nrf2 −/− hearts. (biomedcentral.com)
  • This miRNA was significantly elevated in the serum of RA patients as well as patients with other forms of chronic inflammatory arthritis. (abcam.com)
  • assay
  • The research team then adapted NanoString Technologies' nCounter assay for the high-throughput quantification of 3' miRNA variants. (fredhutch.org)
  • miR-4443 was found to directly regulate TRAF4 and NCOA1, as validated by a reporter assay. (biomedcentral.com)
  • Advantages of the miRNA assay approach used in this study is that it enables a fast screening of mature miRNA regulations in numerous samples, even with limited sample amounts. (jove.com)
  • tissues
  • Taken together, ADAR2 constitutes a potential candidate for therapeutic modulation of angiogenesis and inflammation in ischemic tissues. (ahajournals.org)
  • Many miRNAs are also ubiquitously expressed in a variety of embryonic and adult tissues. (mit.edu)
  • Extracellular vesicles (EVs), which travel in body fluids and transfer microRNAs (miRNAs) between tissues, might play an important role in PM-induced cardiovascular risk. (biomedcentral.com)
  • Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. (springer.com)
  • functionally
  • While genome-wide association studies (GWAS) have made significant advances in our understanding of mutations and their related genes with potential involvement in the etiology of CL, it remains unknown how these genes are functionally regulated and interact with each other in lip development. (springer.com)
  • Pathway
  • Our findings suggest that miR-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 and NCOA1 downstream of MEK-C/EBP-mediated leptin and insulin signaling, and that insulin and/or leptin resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC. (biomedcentral.com)
  • The neuronal activity regulated miR‐134/Pum2/Plk2 pathway mediates synaptic depression in primary hippocampal neurons by inhibiting the AMPA‐type glutamate receptor GluA2. (embopress.org)
  • Our subnetwork analysis pinpointed two candidate miRNAs, hsa-mir-27b and hsa-mir-497 , activating the Wnt pathway that was associated with CL. (springer.com)
  • known miRNA
  • 40 million tags were mapped to known miRNA hairpin sequences as deposited in miRBase version 16, calling 403 generic miRNAs as appreciably expressed. (jove.com)
  • Given a search query, candidate homologs from different species are tested for their known miRNA properties, such as secondary structure, energy and alignment and conservation, in order to asses their fidelity. (biomedcentral.com)
  • mechanism
  • This impressive body of work illustrates that 3' nucleotide addition is a much more common and biologically meaningful mechanism of generating miRNA transcriptome complexity than previously recognized. (fredhutch.org)
  • The mechanism and functional consequences of this miRNA co-regulation provide new avenues for research into mammary gland biology and generate candidates for functional validation. (biomedcentral.com)
  • mechanisms
  • Therefore, limiting AID levels in the nucleus protects the B cell genome from mistargeted mutations, and this is regulated by multiple mechanisms. (antibodyassay.com)
  • Thus the mechanisms that regulate expression of NMI are of potential interest for understanding the etiology of breast tumor progression and metastasis. (biomedcentral.com)
  • Because of the known role of miR-182 in mechanisms related to liver cancer, we sought to investigate this miRNA in NAFLD-related liver damage by looking at relevant target genes,' the study's lead author Fatjon Leti, research associate at Tgen said. (mid-day.com)