Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. (wikipedia.org)
In this study, we report the synthesis, in silico molecular docking, and in vitro urease inhibition studies of a novel series of benzoxazole derivatives. (erdogan.edu.tr)
Derivatives5
Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. (wikipedia.org)
Benzoxazole derivatives are also of interest for optical brighteners in laundry detergents. (wikipedia.org)
These new derivatives, along with previously synthesized 2-(p-substituted-benzyl)-5-substituted-benzoxazoles, were evaluated for their antibacterial and antifungal activities against standard strains and drugresistant isolates in comparison with ampicillin, gentamicin sulfate, ofloxacin, vancomycin, fluconazole, and amphotericin B trihydrate. (degruyter.com)
A new series of pyranopyrazole based benzoxazole derivatives 2(a-h) were synthesized from reaction of compounds 1(a-h), o-aminophenol and carbon disulphide. (journalcra.com)
It was observed that pyranopyrazoles based benzoxazole derivatives exhibit potent antibacterial activity as compare to their starting analogues. (journalcra.com)
Compounds5
A series of 2-(p-substituted-benzyl)-5-[[4-(p-chloro/fluoro-phenyl)piperazin-1-yl]ace tamido] -benzoxazoles were synthesized in need of new compounds for the fight against microbial pathogens. (degruyter.com)
Among these, benzoxazole-based compounds are particularly attractive because of their wide range of pharmacological activities. (korea.ac.kr)
In this focus review, we highlight recent advancements in the development of benzoxazole-based pharmacologically active compounds since the year 2000. (korea.ac.kr)
The benzoxazole motif has emerged as a valuable scaffold in organic compounds, and these benzoxazole-based compounds have gained special attention in recent years because of their broad range of pharmacological activities. (korea.ac.kr)
However, natural benzoxazoles are rarely used because of the time it takes to organically produce the compounds and their unwanted properties, such as high toxicity, low potency and poor solubility. (tamu.edu)
Heterocyclic compound1
Benzoxazole is a heterocyclic compound composed of carbon, hydrogen, oxygen and nitrogen. (tamu.edu)
Tafamidis1
Synthetically created benzoxazoles are found in synthetic pharmaceuticals ranging from chlorzoxazone (a muscle relaxant) to tafamidis (for treating heart disease). (tamu.edu)
Antifungal2
Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. (wikipedia.org)
doi:10.1002/14356007.o15_013 Şener, E., Yalçin, İ. and Sungur, E.: QSAR of some antifungal benzoxazoles and oxazolo(4,5-b)pyridines against C. Albicans. (wikipedia.org)
Compound4
Benzoxazole is an aromatic organic compound with a molecular formula C7H5NO, a benzene-fused oxazole ring structure, and an odor similar to pyridine. (wikipedia.org)
PubChem Compound Summary for CID 9228, Benzoxazole. (vibratist.com)
Currently, natural methods for producing the compound benzoxazole occur very slowly, sometimes taking a week or longer," said Zhu. (tamu.edu)
Antimicrobial1
There is limited research on natural benzoxazoles, but they contain many qualities that show potential for future use in cancer, antiparasitic and antimicrobial treatments. (tamu.edu)
Tumor1
For example, some natural benzoxazoles show promising cytotoxic activity that fights against various tumor cell lines. (tamu.edu)
Catalytic1
2-(4-(trifluoromethyl)pyridin-2-yl)benzoxazole have been examined for their catalytic oxidative activities. (imist.ma)
Research1
Optimization and SAR research at the benzoxazole and tetrazole rings of JNJ4796 as new anti-influenza A virus agents, part 2. (bvsalud.org)
Activity1
In this study, we described the structure-activity relationship of the benzoxazole and tetrazole rings of JNJ4796. (bvsalud.org)
Development1
Dr. Xuejun Zhu, assistant professor in the Artie McFerrin Department of Chemical Engineering at Texas A&M University, alongside graduate student Huanrong Ouyang, and two undergraduate students, Joshua Hong and Jeshua Malroy are synthesizing natural benzoxazoles using E. coli in hopes of developing a more efficient, eco-friendly and cost-effective method of producing them for future drug development. (tamu.edu)
Rate1
By coupling the engineered E. coli with precursor-directed biosynthesis, a pathway is developed to produce natural benzoxazoles at a faster rate. (tamu.edu)
Found2
Desiring to extract and combat certain qualities of natural benzoxazoles, the researchers turned to the microbe, E. coli - - a bacterium found in the environment and within human and animal intestines. (tamu.edu)
From our study, we found we could produce three different types of benzoxazoles simultaneously," said Zhu. (tamu.edu)
Synthesis3
Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. (wikipedia.org)
This article reports the synthesis of poly(2,5-benzoxazole)/multiwalled carbon nanotubes (ABPBO/MWNT) composites by in situ polycondensation and their chemical and physical properties. (psu.edu)
7. Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors. (nih.gov)
Heterocyclic1
Horch T, Molloy EM, Bredy F, Haensch VG, Scherlach K, Dunbar KL, Franke J, Hertweck C (2022) Alternative benzoxazole assembly discovered in anaerobic bacteria provides access to privileged heterocyclic scaffold. (leibniz-hki.de)
Pyridines1
doi:10.1002/14356007.o15_013 Şener, E., Yalçin, İ. and Sungur, E.: QSAR of some antifungal benzoxazoles and oxazolo(4,5-b)pyridines against C. Albicans. (wikipedia.org)
Formula1
Benzoxazole is an aromatic organic compound with a molecular formula C7H5NO, a benzene-fused oxazole ring structure, and an odor similar to pyridine. (wikipedia.org)
Activity3
Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. (wikipedia.org)
In this study, we described the structure-activity relationship of the benzoxazole and tetrazole rings of JNJ4796. (bvsalud.org)
Particularly, changing for an isosteric benzoxazole (45b) resulted in around an 800-flip reduction in activity in comparison to 1. (conferencedequebec.org)
Description1
Description: UK 1, an unusual bis-benzoxazole metabolite isolated from Streptomyces sp. (postgenomeconsortium.com)