In this report , the synthesis of benzimidazole derivatives guided by structure-activity parameters is presented. (bvsalud.org)
Phenyl2
Report on the risk assessment of N,N-diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1H-benzimidazole-1-ethanamine (isotonitazene) in accordance with Article 5c of Regulation (EC) No 1920/2006 (as amended). (bmj.com)
A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. (tmu.edu.tw)
Compounds6
Then, all compounds were evaluated with regard to pancreatic lipase activity, and some of the 2-substituted perimidines, bisperimidine and bisbenzimidazole derivatives showed lipase inhibition at various concentrations. (erdogan.edu.tr)
CONCLUSION: The synthesized benzimidazole derivatives exhibit high activity, suggesting that further research on this family of compounds would be beneficial to finding a potent urease inhibitor. (elsevierpure.com)
1-Methy1-2-(2'-hydroxyphenyl)benzimidazole (1) and 1-Methy1-2-(2'-hydroxy-4'-methylphenyl)benzimidazole (2) compounds have been synthesized and characterized by XRD, IE-MS, FT-IR, UV Vis and H-1, C-13 NMR techniques. (deu.edu.tr)
The observation of other compounds revealed that the substitution of 6-nitro group in benzimidazole ring increases the antibacterial activity. (ijpsr.com)
Ten pharmacologically and synthetically important ( E )-3-(dimethylamino)-1-arylprop-2-en-1-ones (enaminones 4a-j ) were chosen as model compounds for this study. (hindawi.com)
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. (nih.gov)
Antifungal4
Benzimidazole derivatives are an important class of nitrogen containing heterocycles and were reported to possess a wide spectrum of biological properties such as antibacterial, analgesic, anti-inflammatory, antifungal and antimalarial activities. (ijpsr.com)
The antifungal activity of newly synthesized benzimidazole derivatives have been evaluated against Aspergillus niger and Aspergillus flavus the standard used is Clotrimazole and Amphotericin B. The antifungal data is given in the Data- 2. (ijpsr.com)
Benzimidazole and piperazine derivatives play an important role in biological field such as antibacterial, antiviral and antifungal activity. (ajrconline.org)
Benzimidazole and piperazine derivatives synthesized are screened for their antifungal potential. (ajrconline.org)
Inhibitors1
was performed in the absence and presence of imidazole and benzimidazole corrosion inhibitors. (scirp.org)
Antimicrobial1
In this study, 16 benzimidazole and indole derivatives were synthesized and tested for in vitro antimicrobial activity by tube dilution and disc diffusion susceptibility test methods. (academicjournals.org)
Heterocyclic1
Benzimidazole is a heterocyclic aromatic compound. (nlai.ir)
Triclabendazole1
Triclabendazole, a benzimidazole derivative, has become the drug of choice for the treatment of fascioliasis. (medscape.com)
Potent1
NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2, 3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride], is a mibefradil derivative that retains potent in vitro T-type calcium channel antagonist efficacy. (nih.gov)
Pyrazole1
2. A process for the synthesis of a pyrazole derivative: Inventor- Avijit Kumar Paul , Nikhil Kumar and Shubhangi. (nitkkr.ac.in)
Evaluation4
Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting Cannabinoid Receptor Type 1. (cienciavida.org)
10. Synthesis and antioxidant evaluation of some new pyrazolopyridine derivatives. (nih.gov)
18. Syntheses and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives. (nih.gov)
Synthesis, Characterization and Evaluation of substituted Benzimidazole hydrazine Carboxamide derivatives for Antiinflammatory activity. (ijtonline.com)
Bacteria1
A series of 2-(2-nitrophenyl)benzothiazole 7, 2-(2-nitrophenyl)benzoxazole 10 and 2-(2-nitrophenyl)benzimidazole 13 derivatives have been synthesised and assessed as indicators of nitroreductase activity across a range of clinically important Gram negative and Gram positive bacteria. (northumbria.ac.uk)
Activity7
The antibacterial activity of newly synthesized benzimidazole derivatives has been evaluated against Gram positive Staphylococcus aureus and Enterobacter cocci and Gram negative Escherichia coli and Shigella species by disc diffusion method. (ijpsr.com)
The 6-nitro derivative of benzimidazole shows good activity against Aspergillus niger and Aspergillus flavus. . (ijpsr.com)
1. Synthesis, tumor inhibitory and antioxidant activity of new polyfunctionally 2-substituted 5,6,7,8-tetrahydronaphthalene derivatives containing pyridine, thioxopyridine and pyrazolopyridine moieties. (nih.gov)
Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. (tmu.edu.tw)
Antiviral activity of benzimidazole derivatives. (nih.gov)
Antiviral activity of 2-phenylbenzimidazole derivatives. (nih.gov)
Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. (nih.gov)
Pyridine1
2. New pyridone, thioxopyridine, pyrazolopyridine and pyridine derivatives that modulate inflammatory mediators in stimulated RAW 264.7 murine macrophage. (nih.gov)
Inhibition1
Sirtuin Inhibition and Anti-Cancer Activities of Ethyl 2-benzimidazole" by K. Y. Yeong, M. I. H. Nor Azizi et al. (chapman.edu)
Inhibitor1
New benzimidazoles were synthesized based on the previously identified sirtuin inhibitor BZD9L1. (chapman.edu)
Chemistry1
Therefore, this review aims at compiling the chemistry of differently substituted benzimidazoles and some other methods. (nlai.ir)
Microwave2
This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. (erdogan.edu.tr)
A series of 5-nitrosubstituted benzimidazole and 6-nitro substituted benzimidazole derivatives were synthesized starting from iminoester hydrochloride and 4-nitro- o -phenylenediamine under microwave irradiation. (ajol.info)
Study1
Ten substituted ( E )-3-(dimethylamino)-1-arylprop-2-en-1-ones (enaminones) were selected for this comparative study. (hindawi.com)
Material1
An organometallic complex including a ligand having a structure of 5-(2-pyridinyl)-5H-benzimidazo[1,2-a]benzimidazole and a light-emitting material including the organometallic complex are provided. (justia.com)
Chemical1
The chemical name of pimobendan is 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazole-5-yl]-5-methyl-3(2H)-pyridazinone. (canadapharmacy.com)
Highly1
Related benzimidazole derivatives have been reported to be highly selective agonists for the CB2 receptor. (wikipedia.org)
Shown1
The corrin ring with a central cobalt atom is shown in red and the benzimidazole unit in blue. (medscape.com)