Heterocyclic amidine derivatives have been synthesized by condensation of 2-cyanopyrazine, 4-cyanopyridine and 2-cyanopyridine with furfurylamine, histamine, 1-(3-aminopropyl)imidazole, 4-picolylamine, 2-picolylamine, and tryptamine respectively, in the presence of sodium methoxide as well as via microwave irradiation in good yields. (csircentral.net)
Cyclic amidine2
Imidazolines contain a cyclic amidine. (wikipedia.org)
Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. (ntu.edu.sg)
Aryl1
This disclosure relates to aryl amidines of Formula I and their use as fungicides. (sumobrain.com)
React2
Among others they react with amines giving amidines as the products. (springer.com)
Amidines react with diphenylamine-2,2'-dicarbonyl chloride to yield polyheterocycles. (heterocycles.jp)
Moiety3
b) DFMO enhances the polyamine uptake system in tumor cells, increasing the entry of tetracyclic amidines bearing a putrescine moiety as well as their accessibility to final DNA-binding sites. (curehunter.com)
The single-crystal structures confirmed the presence of a primary amine group in the amidine moiety. (springer.com)
Moreover, the amidine group may be a perfect linker unit that could connect two pharmacophores, e.g., the sulfanilamide moiety and the pyridine or pyrazine system. (springer.com)
Analogs2
The present disclosure provides a group of amidine analogs and their pharmaceutically acceptable salts that are useful for treating a bacterial or fungal infection. (sumobrain.com)
Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs. (expasy.org)
Amides1
Dimethylformamide acetal reacts with primary amines to give amidines: Me2NC(H)(OMe)2 + RNH2 → Me2NC=NHR + 2 MeOH Amidines are much more basic than amides and are among the strongest uncharged/unionized bases. (wikipedia.org)
Inhibitors1
A hydrogen bond unique to Ser190 protease-arylamidine complexes between O gamma(Ser190) and the inhibitor amidine confers an intrinsic preference for such inhibitors toward Ser190 proteases over Ala190 counterparts. (rcsb.org)
Functional group2
Amidines are organic compounds with the functional group RC(NR)NR2, where the R groups can be the same or different. (wikipedia.org)
The amidine functional group is an important structural element of compounds with established pharmacological activity. (springer.com)
Compound3
Treatment of the resulting compound with ammonia then completes the conversion to the amidine. (wikipedia.org)
Provided in the present invention are an amidine derivative compound as represented by formula I, and a preparation method therefor and the use thereof. (sumobrain.com)
The amidine derivative compound of the present invention has Nav1.8 selective inhibi. (sumobrain.com)
Examples of amidines include: DBU diminazene benzamidine Pentamidine Paranyline A common route to primary amidines is the Pinner reaction. (wikipedia.org)
The −OH group is replaced by an −NH2 group and the =O group is replaced by =NR, giving amidines the general structure RnE(=NR)NR2. (wikipedia.org)
Type3
Carboxamidines are frequently referred to simply as amidines, as they are the most commonly encountered type of amidine in organic chemistry. (wikipedia.org)
This study reports an effective amidine-type n-dopant of 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) that can universally dope electron acceptors, including PC61BM, N2200, and ITIC, by mixing the dopant with the acceptors in organic solvents or exposing the acceptor films in the dopant vapor. (researcher-app.com)
An effective solution-processed amidine-type n-dopant of 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU), which can universally dope electron acceptor materials, including PC61BM, N2200, and ITIC, is reported. (researcher-app.com)
Research1
The programme of research that constitutes AMIDiNe will address the increasingly problematic management of electrical load on distribution networks as the UK transitions to a low carbon energy system. (amidine.net)
Form1
The oxoacid from which an amidine is derived must be of the form RnE(=O)OH, where R is a substituent. (wikipedia.org)