• This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (wikipedia.org)
  • The ITGA6 gene provides instructions for making one part (the α6 subunit) of two proteins known as α6β4 integrin and α6β1 integrin. (encyclopedia.pub)
  • Integrins are a group of proteins that regulate the attachment of cells to one another (cell-cell adhesion) and to the surrounding network of proteins and other molecules (cell-matrix adhesion). (encyclopedia.pub)
  • As part of a complex network of proteins in hemidesmosomes, α6β4 integrin helps to hold the layers of skin together. (encyclopedia.pub)
  • The integrin proteins activate key signaling molecules, which trigger cancer cells to migrate through the body and invade other tissues. (encyclopedia.pub)
  • It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. (harvard.edu)
  • Various beta1 integrins and alphav integrins are present on mouse eggs. (lu.se)
  • Oocyte-specific, beta1 integrin conditional knockout mice allowed us to obtain mature eggs lacking all beta1 integrins. (lu.se)
  • Thus, function of beta3 or alphav integrins does not seem to be involved in compensating for the absence of beta1 integrins. (lu.se)
  • Adult SVZ progenitor cells express the laminin receptor alpha6beta1 integrin, and blocking this inhibits their adhesion to endothelial cells, altering their position and proliferation in vivo, indicating that it plays a functional role in binding SVZ stem cells within the vascular niche. (nih.gov)
  • Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. (cusabio.com)
  • The results obtained indicate that alpha6beta1 is necessary for VEGF expression because the ability of hypoxia to activate HIF-1 and to stimulate VEGF transcription in MDA-MB-435 cells is dependent on alpha6beta1 expression by a mechanism that involves protein kinase C-alpha. (umassmed.edu)
  • ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. (umassmed.edu)
  • Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. (umassmed.edu)
  • Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
  • The CD49b protein is an integrin alpha subunit. (wikidoc.org)
  • Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7. (cusabio.com)
  • The α6β4 integrin protein is found primarily in epithelial cells, which are cells that line the surfaces and cavities of the body. (encyclopedia.pub)
  • The α6β1 integrin protein has not been as well studied as α6β4 integrin. (encyclopedia.pub)
  • Furthermore, neither anti-mouse beta3 integrin function-blocking monoclonal antibody (mAb) nor alphav integrin function-blocking mAb inhibited sperm binding to or fusion with beta1 integrin null eggs. (lu.se)
  • However, this mutant was targeted to focal contacts formed by GSK2118436A novel inhibtior other integrins, even when they had not bound ligand. (healthyconnectionsinc.com)
  • Using alpha3 integrin null eggs, we found that the alpha3beta1 integrin was not essential for sperm-egg binding and fusion. (lu.se)
  • We investigated the influence of alpha6beta1 on vascular endothelial growth factor (VEGF) expression because autocrine VEGF is necessary for the survival of serum-deprived cells in hypoxia. (umassmed.edu)
  • GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation. (umassmed.edu)
  • Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. (cusabio.com)
  • Integrins also transmit chemical signals that regulate cell growth and the activity of certain genes. (encyclopedia.pub)
  • The alpha6beta1 integrin has been implicated in breast carcinoma progression, but the mechanisms involved remain elusive. (umassmed.edu)
  • Researchers believe that both α6β1 integrin and α6β4 integrin may play critical roles in the progression of cancerous tumors called carcinomas. (encyclopedia.pub)
  • Changes in the location and activity of α6β1 integrin and α6β4 integrin within cancer cells are associated with the progression of carcinomas. (encyclopedia.pub)
  • Recent studies suggest that, in addition to their roles in the progression of existing carcinomas, α6β1 integrin and α6β4 integrin may be involved in the initial formation of these tumors. (encyclopedia.pub)
  • Alternative integrins may be involved in sperm-egg binding and fusion and could compensate for the absence of alpha6beta1. (lu.se)
  • The absence of either alpha7beta1 integrin or alpha6beta1 integrin impairs the ability of Schwann cells to spread and to bind laminin. (cusabio.com)
  • We found that the beta1 integrin null eggs were fully functional in fertilization both in vivo and in vitro. (lu.se)
  • Some of these integrins are also reported to be receptors for ADAMs, which are expressed on sperm. (lu.se)
  • The other integrin made with the α6 subunit, α6β1 integrin, functions during the formation of organs and tissues before birth. (encyclopedia.pub)
  • The ITGA6 gene mutations responsible for EB-PA lead to a loss of functional α6β4 integrin. (encyclopedia.pub)
  • The resulting shortage of functional α6β4 integrin causes cells in the epidermis to be fragile and easily damaged. (encyclopedia.pub)
  • Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)
  • Alpha 6 beta4 integrin abnormalities in junctional epidermolysis bullosa with pyloricatresia. (encyclopedia.pub)
  • These mutations alter the normal structure and function of the α6 integrin subunit or prevent cells from producing enough of this subunit. (encyclopedia.pub)
  • yet, eggs null for the alpha6 integrin exhibit normal fertilization. (lu.se)
  • MDA-MB-435 cells engineered to be deficient in alpha6beta1 expression form primary tumors that are highly apoptotic and unable to metastasize, although they exhibit no increased apoptosis in vitro under standard culture conditions. (umassmed.edu)
  • Based on the hypothesis that alpha6beta1 is necessary for the survival of these cells in the tumor microenvironment, we report here that hypoxia protects these cells from apoptosis induced by serum deprivation and that hypoxia-mediated protection requires alpha6beta1 expression. (umassmed.edu)
  • As knockdown of Integrin alpha7 (ITGA7) can effectively reduce the stemness of oesophageal squamous cell carcinoma (OSCC) cells, ITGA7 could be a potential therapeutic target in OSCC treatment. (cusabio.com)
  • In contrast, deletion of the GSK2118436A novel inhibtior cytoplasmic domain of alpha6 C-terminal of AURKA the GFFKR motif resulted in a loss of responsiveness of alpha6beta1 to PMA stimulation and formation of focal contacts on laminin-1. (healthyconnectionsinc.com)
  • Allegra M, Gagnoux-Palacios L, Gache Y, Roques S, Lestringant G, Ortonne JP,Meneguzzi G. Rapid decay of alpha6 integrin caused by a mis-sense mutation in thepropeller domain results in severe junctional epidermolysis bullosa with pyloric atresia. (encyclopedia.pub)
  • Our previous work has shown that cleavage of the α6β1 integrin to produce the structural variant α6pβ1 on tumor cell surfaces is mediated by the serine protease urokinase plasminogen activator (uPA). (nih.gov)
  • Receptor de la superficie celular que media en la adhesión celular a la MATRIZ EXTRACELULAR y a otras células mediante la unión con la LAMININA. (bvsalud.org)
  • La integrina alfa6beta1 es el principal receptor de laminina en las PLAQUETAS, LEUCOCITOS y muchas CÉLULAS EPITELIALES y unión del ligando que puede activar determinadas vías de transducción de señales. (bvsalud.org)
  • Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner. (reference.md)
  • The ITGA6 gene provides instructions for making one part (the α6 subunit) of two proteins known as α6β4 integrin and α6β1 integrin. (medlineplus.gov)
  • The other integrin made with the α6 subunit, α6β1 integrin, functions during the formation of organs and tissues before birth. (medlineplus.gov)
  • These mutations alter the normal structure and function of the α6 integrin subunit or prevent cells from producing enough of this subunit. (medlineplus.gov)
  • This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (wikipedia.org)
  • Integrins are a group of proteins that regulate the attachment of cells to one another (cell-cell adhesion) and to the surrounding network of proteins and other molecules (cell-matrix adhesion). (medlineplus.gov)
  • As part of a complex network of proteins in hemidesmosomes, α6β4 integrin helps to hold the layers of skin together. (medlineplus.gov)
  • The integrin proteins activate key signaling molecules, which trigger cancer cells to migrate through the body and invade other tissues. (medlineplus.gov)
  • It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. (wikipedia.org)
  • Integrins also transmit chemical signals that regulate cell growth and the activity of certain genes. (medlineplus.gov)
  • The ITGA6 gene mutations responsible for EB-PA lead to a loss of functional α6β4 integrin. (medlineplus.gov)
  • Chung J, Yoon S, Datta K, Bachelder RE, Mercurio AM. Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells. (medlineplus.gov)
  • A 24 to 48-hr stimulation with pro-inflammatory cytokines, TGF-beta and FGF2 induced a significant increase in the concentrations of all integrin chains. (nih.gov)
  • The laminin-binding integrin α6β1 plays a major role in determining the aggressive phenotype of tumor cells during metastasis. (nih.gov)
  • 7. Integrin alpha6beta1 role in metastatic behavior of human pancreatic carcinoma cells. (nih.gov)
  • Integrin PSI online death of the chesapeake a history of the militarys role in polluting the is clinical paradigm JavaScript coagulation and is a cyclic application for high-level collaboration. (texturemonkey.com)
  • Integrin alpha6beta1 is the qualified online death of the chesapeake a history of the militarys role for Neuropsychological cookies and causes a power in VWF blood, member, and specialized attachment. (texturemonkey.com)
  • Recent studies suggest that, in addition to their roles in the progression of existing carcinomas, α6β1 integrin and α6β4 integrin may be involved in the initial formation of these tumors. (medlineplus.gov)