• The US Food and Drug Administration (FDA) approved pembrolizumab (Keytruda) in the adjuvant setting for patients with stage IB-IIIA non-small cell lung cancer (NSCLC) following resection and platinum-based chemotherapy. (medscape.com)
  • Among the 1010 patients who received adjuvant platinum-based chemotherapy, the median DFS was 58.7 months in the pembrolizumab arm (n = 506) and 34.9 months in the placebo arm (hazard ratio, 0.73). (medscape.com)
  • In an exploratory subgroup analysis of the 167 patients who did not receive adjuvant chemotherapy, the DFS hazard ratio was 1.25. (medscape.com)
  • On October 16, 2023, the Food and Drug Administration approved pembrolizumab (Keytruda, Merck) with platinum-containing chemotherapy as neoadjuvant treatment, and with continuation of single-agent pembrolizumab as post-surgical adjuvant treatment for resectable (tumors ≥4 cm or node positive) non-small cell lung cancer (NSCLC). (fda.gov)
  • Patients were randomized (1:1) to either pembrolizumab or placebo, with platinum-based chemotherapy, every 3 weeks for 4 cycles (neoadjuvant treatment) followed by either continued single-agent pembrolizumab or placebo, every 3 weeks for up to 13 cycles (adjuvant treatment). (fda.gov)
  • No suitable evidence was found to determine the role of adjuvant chemotherapy, when compared with placebo or any other or no adjuvant treatment, in the management of adenocarcinoma of the small intestine. (cochrane.org)
  • There is a need for high quality randomised controlled trials to evaluate the effectiveness of adjuvant chemotherapy in the management of adenocarcinoma of the small intestine. (cochrane.org)
  • The rare nature of adenocarcinomas of the small intestine has led to a paucity of information about the benefits of adjuvant chemotherapy but there are reports of overall better survival for those patients that receive combination treatment. (cochrane.org)
  • Phase III randomised controlled trials comparing post-operative adjuvant chemotherapy for adenocarcinoma of the small intestine with other adjuvant therapies, placebo or no adjuvant treatment. (cochrane.org)
  • Singhal N, Singhal D. Adjuvant chemotherapy for small intestine adenocarcinoma. (cochrane.org)
  • And there's also a second study that's ongoing, which is looking at adjuvant pembrolizumab [Keytruda] in exactly the same population, high-risk non-muscle-invasive urothelial carcinoma with or without neoadjuvant chemotherapy. (medpagetoday.com)
  • If your cancer treatment plan includes adjuvant chemotherapy or neoadjuvant chemotherapy, that means you will be receiving both chemotherapy and surgery to treat your cancer. (rockymountaincancercenters.com)
  • Adjuvant chemotherapy is administered after surgery to kill any remaining cancer cells with the goal of reducing the chances of recurrence. (rockymountaincancercenters.com)
  • When are Neoadjuvant Chemotherapy and Adjuvant Chemotherapy Used? (rockymountaincancercenters.com)
  • Adjuvant chemotherapy and neoadjuvant chemotherapy are frequently used in the treatment of breast, colon, lung, bladder, and prostate cancers. (rockymountaincancercenters.com)
  • Or, she may receive adjuvant chemotherapy after breast surgery to kill any cancer cells that may have been too small to detect during surgery to keep them from growing and spreading. (rockymountaincancercenters.com)
  • If your treatment plan includes adjuvant chemotherapy, you'll likely begin treatments within 30 days following surgery. (rockymountaincancercenters.com)
  • Some adjuvant chemotherapy is administered in a few treatment cycles while others are administered for up to 10 years. (rockymountaincancercenters.com)
  • The side effects of adjuvant and neoadjuvant chemotherapy are the same as when chemotherapy is the only treatment. (rockymountaincancercenters.com)
  • The adjuvant therapies do not give early insight into how a patient does with a particular form of chemotherapy or radiation therapy. (differencebetween.net)
  • Additionally, many early lung cancer cases recur after surgery, despite modern treatment approaches including adjuvant chemotherapy and immunotherapy. (outsourcing-pharma.com)
  • This international, multicenter, randomized, double-blind phase III study intends to recruit 680 patients who have received radical gastrectomy (R0 resection, D2 or more extended lymphadenectomy) with postoperative pathological stage II or III (AJCC Cancer Staging Manual, 8th Edition) gastric or EGJ adenocarcinoma to evaluate the efficacy and safety of JS001 combined with postoperative adjuvant chemotherapy versus placebo combined with postoperative adjuvant chemotherapy. (centerwatch.com)
  • 2,3 In the trial, 682 patients with complete tumor resection, with or without prior adjuvant chemotherapy, were randomly assigned to receive oral osimertinib at 80 mg once daily (n = 339) or placebo (n = 343) following recovery from surgery and standard adjuvant chemotherapy, if given. (ascopost.com)
  • and 60% received adjuvant chemotherapy prior to randomization, including 27% with stage IB, 70% with stage II, and 79% with stage IIIA disease. (ascopost.com)
  • Patient who undergo upfront surgery can qualify for adjuvant chemotherapy based on gene expression profiling such as the Oncotype DX, MammaPrint, or Prosigna. (medscape.com)
  • A large proportion of breast cancer patients are treated with adjuvant chemotherapy after the primary operation, but some will recur in spite of this treatment. (lu.se)
  • Given the unique trial design of SweBCG91-RT, where adjuvant endocrine and chemotherapy were largely unadministered, we sought to evaluate the potential of transcriptomic profiling for identifying patients who may be spared adjuvant endocrine therapy. (lu.se)
  • Ninety-two percent of patients were untreated by both adjuvant endocrine therapy and chemotherapy. (lu.se)
  • However, an important role exists for the use of chemotherapy and/or radiation therapy in an adjuvant or neoadjuvant setting, and in the treatment of patients with unresectable disease. (medscape.com)
  • Following the failure of TKIs in the adjuvant setting, pembrolizumab (Keytruda) was studied in the phase 3 KEYNOTE-564 trial (NCT03142334), randomizing 994 patients 1:1 to 1 year of adjuvant immunotherapy vs placebo. (onclive.com)
  • Immunomodulatory nanoparticles as adjuvants and allergen-delivery system to human dendritic cells: Implications for specific immunotherapy. (lu.se)
  • Novel adjuvants and antigen-delivery systems with immunomodulatory properties that shift the allergenic Th2 response towards a Th1 or regulatory T cell response are desired for allergen-specific immunotherapy. (lu.se)
  • Thus, gamma-PGA NPs are promising as sophisticated adjuvants and allergen-delivery systems in allergen-specific immunotherapy. (lu.se)
  • The current approval expands the use of pembrolizumab to the adjuvant setting. (medscape.com)
  • Cite this: FDA OKs Pembrolizumab for Adjuvant Treatment of NSCLC - Medscape - Jan 27, 2023. (medscape.com)
  • Neoadjuvant pembrolizumab therapy given to patients with stage III or IV resectable melanoma provides superior 2-year event-free survival in comparison to using only adjuvant therapy according to the findings of randomised, Phase II trial by US researchers. (hospitalhealthcare.com)
  • In a randomised, placebo-controlled trial of patients with completely resected stage III melanoma, adjuvant treatment with the programmed death 1 (PD-1) inhibitor, pembrolizumab, significantly improved recurrence-free survival compared to placebo . (hospitalhealthcare.com)
  • However, the added value of using neoadjuvant pembrolizumab therapy in patients with either stage III or IV resectable melanoma compared to adjuvant treatment alone has not been tested. (hospitalhealthcare.com)
  • Participants were randomised 1:1 to either three doses of neoadjuvant pembrolizumab, surgery followed by 15 doses of adjuvant pembrolizumab or to surgery followed by pembrolizumab for approximately 1 year (adjuvant-only group). (hospitalhealthcare.com)
  • After 2 years, event-free survival occurred in 72% (95% CI 64 - 80) of those given neoadjuvant pembrolizumab compared to 49% (95% CI 41 - 59) in the adjuvant only group. (hospitalhealthcare.com)
  • The authors concluded that giving pembrolizumab both before and after surgery resulted in significantly longer event-free survival compared to adjuvant therapy alone. (hospitalhealthcare.com)
  • consequently, these patients are classified as high risk and should be considered for adjuvant therapy. (medscape.com)
  • The global vaccine adjuvants market is segmented on the basis of region into North America, Europe, Asia Pacific, Latin America, and Middle East and Africa. (pharmiweb.com)
  • According to Visiongain analysis, global Vaccine Adjuvants market is estimated to be valued at US$ xx million in 2020. (pharmiweb.com)
  • According to Visiongain analysis, key players are forming various strategies such as acquisitions, mergers, partnerships, collaborations, and launching new products to strengthen their position in the global vaccine adjuvants market. (pharmiweb.com)
  • The global Vaccine Adjuvants Market was valued at USD 585.3 million in 2019 and is expected to reach U SD 1,305.7 million by 2027 , growing at a CAGR of 10.68% during 2020-2027 according to a new study by Polaris Market Research. (medgadget.com)
  • Ziller V, Kalder M, Albert US, Holzhauer W, Ziller M, Wagner U, Hadji P (2009) Adherence to adjuvant endocrine therapy in postmenopausal women with breast cancer. (springer.com)
  • Toxicity of adjuvant endocrine therapy in postmenopausal breast cancer patients: A systematic review and meta-analysis. (ons.org)
  • Specifically, the term can refer to: Adjuvant therapy in cancer management Analgesic adjuvant in pain management Immunologic adjuvant in vaccines This article includes a list of related items that share the same name (or similar names). (wikipedia.org)
  • An adjuvant is an ingredient used in some vaccines that helps create a stronger immune response in people receiving the vaccine. (cdc.gov)
  • In other words, adjuvants help vaccines work better. (cdc.gov)
  • Some vaccines that are made from weakened or killed germs contain naturally occurring adjuvants and help the body produce a strong protective immune response. (cdc.gov)
  • Adjuvants have been used safely in vaccines for decades. (cdc.gov)
  • In all cases, vaccines containing adjuvants are tested for safety and effectiveness in clinical trials before they are licensed for use in the United States, and these vaccines are continuously monitored by CDC and FDA once they are approved. (cdc.gov)
  • Several different adjuvants are used in U.S. vaccines. (cdc.gov)
  • Aluminum-containing adjuvants are vaccine ingredients that have been used in vaccines since the 1930s. (cdc.gov)
  • The purpose of adding adjuvants into vaccines is to boost the immune system response and to allow for fewer doses or lesser quantities of the vaccine to be administered. (news-medical.net)
  • Since then numerous vaccines, such as hepatitis A, hepatitis B, diphtheria-tetanus, Haemophilus influenza type b, and pneumococcal vaccines have been developed with the use of aluminum adjuvants. (news-medical.net)
  • Today, a number of different kinds of adjuvants have been discovered and successfully used to develop new vaccines. (news-medical.net)
  • Since the discovery of aluminum's function of an adjuvant back in 1926, many more substances have been recognized as adjuvants and used to create a variety of vaccines. (news-medical.net)
  • The funds will be used to advance its adjuvant platform of cationic-lipid DNA complexes, which are designed to improve the quality and quantity of immune responses achievable with vaccines, along with its adjuvanted vaccine pipeline. (genengnews.com)
  • The adjuvant is in preclinical investigations being conducted with the CDC in pandemic influenza vaccines. (genengnews.com)
  • Supports the elaboration of novel adjuvant, antigen-sparing and multivalent technologies that can bolster the effectiveness and scope of vaccines based on adaptive or innate immunological response. (archives.gov)
  • Vaccines have proven to be the most effective method of preventing infectious diseases, yet many problems still exist including multi-dose administration, poor immunogenicity of vaccine antigens, and undesirable side effects of immunization with adjuvants which can all lead to poor patience compliance and poor vaccine efficacy. (aiche.org)
  • In this thesis, we show that the immunogenicity and protective capacity of influenza vaccines can be significantly potentiated by the incorporation of the adjuvant GPI-0100 in the vaccine. (rug.nl)
  • Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. (flutrackers.com)
  • Adjuvant is defined as a substance which in combination with vaccine invigorates antigen specific immune reactions to increase specificity and immunogenicity of marketed vaccines administered in any individual. (medgadget.com)
  • Adjuvant imparts beneficial effects to vaccines in several ways such as increasing its potency to grasp the higher degree of immunogenicity, reducing the number of repeated vaccinations, antigen dose reduction, widening antibody responses of the individual, and inducing T-cell responses. (medgadget.com)
  • This will bring both industry experts and stakeholders working in the areas of vaccine research and development and adjuvant research to reduce side effects and efficacy of new developing vaccines. (medgadget.com)
  • Title : Relative merits of aqueous and adjuvant influenza vaccines when used in a two-dose schedule Personal Author(s) : Hennessy, Albert V.;Davenport, Fred M. (cdc.gov)
  • Twenty-nine of 60 patients were treated with adjuvant radiotherapy. (nih.gov)
  • Adjuvant radiotherapy reduced the risk of distant failure and death in patients with disease confined to the uterus but did not impact distant recurrence or survival in stage III patients. (nih.gov)
  • Because the definitive treatment of cutaneous melanoma is surgery, medical management is reserved for adjuvant therapy of patients with advanced melanoma. (medscape.com)
  • Interferon alfa-2b was approved in 1995 for adjuvant treatment after excision in patients who are free of disease but are at high risk for recurrence. (medscape.com)
  • Merck and Moderna announced the initiation of the pivotal phase III, randomized V940-001 clinical trial evaluating V940 (mRNA-4157), an investigational individualized neoantigen therapy (INT), in combination with Keytruda-Merck's antiprogrammed death receptor-1 (PD-1) therapy-as an adjuvant treatment in patients with resected high-risk (stage IIB-IV) melanoma. (uspharmacist.com)
  • Based on data from the phase IIb KEYNOTE-942/mRNA-4157-P201 study, the FDA and European Medicines Agency granted Breakthrough Therapy Designation and the Priority Medicines (PRIME) scheme, respectively, for V940 (mRNA-4157) in combination with Keytruda for the adjuvant treatment of patients with high-risk melanoma. (uspharmacist.com)
  • And when that study was initially presented, there was a minimum follow-up of 5.9 months, and at that time there was an improvement in disease-free survival with adjuvant nivolumab [Opdivo] versus placebo in both the intent-to-treat population and in patients with tumors with high PD-L1 expression, ultimately leading to FDA approval of adjuvant nivolumab in that space. (medpagetoday.com)
  • There is, of course, another trial being planned through the Intergroup, which you are involved in, Matt, which is looking at adjuvant nivolumab versus nivolumab plus relatlimab, the LAG-3 inhibitor, in patients who are ctDNA positive. (medpagetoday.com)
  • Results - Of the 397 patients included, 75.3% received adjuvant treatment (27.2% CRT, 48.1% CTX) and 24.7% received OBS. (ices.on.ca)
  • Among patients receiving adjuvant treatment, positive margins and a low comorbidity burden were associated with CRT compared with CTX. (ices.on.ca)
  • The small molecule drug alectinib (Alecensa) developed by the big pharma company Roche has improved disease-free survival in patients with a specific form of non-small cell lung cancer (NSCLC) when delivered as an adjuvant therapy in a phase 3 trial. (outsourcing-pharma.com)
  • The objective of this review is to provide a scientific opinion on the indications for Ginkgo biloba as an adjuvant therapy for normal tension glaucoma patients and for high tension glaucoma patients progressing despite a normalized IOP. (molvis.org)
  • Roy S. Herbst, MD, PhD, discusses findings from the overall survival analysis of the phase 3 ADAURA trial of adjuvant osimertinib in patients with stage IB to IIIA resected non-small cell lung cancer harboring EGFR mutations. (onclive.com)
  • assistant dean for translational research, Yale School of Medicine, discusses findings from the overall survival (OS) analysis of the phase 3 ADAURA trial (NCT02511106) of adjuvant osimertinib (Tagrisso) in patients with stage IB to IIIA resected non-small cell lung cancer (NSCLC) harboring EGFR mutations. (onclive.com)
  • These DFS data supported the 2020 FDA approval of adjuvant osimertinib in patients with EGFR -mutant NSCLC. (onclive.com)
  • In total, 313 patients with a median age of 63 years (35% female) were randomised to either neoadjuvant (154) or adjuvant only therapy. (hospitalhealthcare.com)
  • San Francisco-based Genentech, a member of the Roche group, is developing giredestrant as a potential adjuvant treatment in patients with ER-positive, HER2-negative early breast cancer, as well as first-line treatment for ER-positive metastatic breast cancer and ER-positive, HER2-negative metastatic breast cancer. (managedhealthcareexecutive.com)
  • THURSDAY, April 1, 2021 (HealthDay News) - Among patients with resected esophageal or gastroesophageal junction cancer who have received neoadjuvant chemoradiotherapy, disease-free survival is significantly longer with nivolumab adjuvant therapy versus placebo, according to a study published in the April 1 issue of the New England Journal of Medicine . (physiciansweekly.com)
  • Androgens as adjuvant treatment in postmenopausal female patients with rheumatoid arthritis. (bmj.com)
  • The primary goal of adjuvant treatments is to minimise the recurrence rate of radically operated patients who are at high risk of recurrence and, possibly, to enhance survival.Recently published practice-changing outcomes with immune checkpoint inhibitors and targeted treatments in stage III/IV melanoma patients following surgical full resection have drastically altered the landscape of adjuvant therapy. (physiciansweekly.com)
  • On December 18, 2020, osimertinib was approved for adjuvant therapy after tumor resection in patients with non-small cell lung cancer (NSCLC) with tumors with EGFR exon 19 deletions or exon 21 L858R mutations, as detected by a U.S. Food and Drug Administration (FDA)-approved test. (ascopost.com)
  • Osimertinib was approved for adjuvant therapy after tumor resection in patients with NSCLC with tumors with EGFR exon 19 deletions or exon 21 L858R mutations. (ascopost.com)
  • Patients at high risk for recurrence should be evaluated for adjuvant treatment with CDK4/6 inhibitors. (medscape.com)
  • Patients with invasive breast cancer that is ER+ or progesterone receptor positive (PR+) should be considered for adjuvant endocrine therapy with tamoxifen or aromatase inhibitors (AIs). (medscape.com)
  • We have investigated to what extent cDNA microarray measurements could distinguish the likelihood of recurrences after adjuvant CMF (cyclophosphamide, methotrexate and 5-fluorouracil) treatment of premenopausal, lymph node positive breast cancer patients, and have also compared with the corresponding performance using conventional clinical variables. (lu.se)
  • Within the MET141 low-risk subgroup (lowest 25th percentile of scores), 95% of patients were free of metastasis at 15 years, even in the absence of adjuvant endocrine therapy. (lu.se)
  • Conclusions: Transcriptomic profiling identifies patients with an excellent outcome without any systemic adjuvant therapy in clinically low-risk patients of the SweBCG91-RT and METABRIC cohorts. (lu.se)
  • Agents used in adjuvant therapy include aromatase inhibitors that decrease estrogen production and selective estrogen receptor modulators (SERMs), such as tamoxifen, that block estrogen from binding to receptors. (managedhealthcareexecutive.com)
  • Winer EP, Hudis C, Burstein HJ, Wolff AC, Pritchard KI, Ingle JN, Chlebowski RT, Gelber R, Edge SB, Gralow J et al (2005) American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: status report 2004. (springer.com)
  • And we also see improvements in secondary and exploratory endpoints with adjuvant nivo versus placebo, including distant metastases-free survival and progression-free survival too. (medpagetoday.com)
  • Right, so the other key trial that has been presented is the adjuvant atezolizumab [Tecentriq] trial , which was not placebo controlled. (medpagetoday.com)
  • In the primary DFS analysis of ADAURA, published in October 2020, adjuvant osimertinib led to a statistically significant DFS improvement compared with placebo. (onclive.com)
  • Nivolumab adjuvant therapy showed superior efficacy over placebo in the primary end point of disease-free survival," the authors write. (physiciansweekly.com)
  • The role of adjuvant radiotherapy in the setting of uterine carcinosarcoma has not been clearly established. (nih.gov)
  • Local failure represents a significant site of failure in the absence of adjuvant radiotherapy. (nih.gov)
  • Details of the safety of the neoadjuvant and adjuvant phases are described in the above drug label link. (fda.gov)
  • BACKGROUND: Oncological outcome after radical radiotherapy (RRT) combined with neoadjuvant and adjuvant androgen suppression therapy (AST) may differ according to type of AST. (lu.se)
  • Time to Pca death according to type of neoadjuvant and adjuvant AST was assessed by use of. (lu.se)
  • Time to Pca death according to type of neoadjuvant and adjuvant AST was assessed by use of Kaplan-Meier plots and Cox proportional hazard models adjusted for putative confounders. (lu.se)
  • The new report on 2020 Vaccine Adjuvants Market analysis, size, share, growth, trends and forecasts, focuses on customers research requirements and try to provide in-depth details on market trends. (medgadget.com)
  • European Union (EU) through EU programme Horizon 2020, has formed ENOVA, a network on vaccine adjuvants. (medgadget.com)
  • In February 2020, GSK and Coalition for Epidemic Preparedness Innovations (CEPI) collaborated to ease the out nCOV vaccine development with GSK's vaccine adjuvant platform for other players in vaccine development. (medgadget.com)
  • Multiple options for adjuvant treatment of node-positive melanoma have become available. (medscape.com)
  • Ginsenosides extracted from ginseng, which is derived from the roots and rhizomes of Panax ginseng C. A. Meyer, have been used in China as an adjuvant in the treatment of diabetes mellitus. (frontiersin.org)
  • Rg1, Rg3, Rb1, and compound K demonstrated the most promising therapeutic prospects as potential adjuvant medicines for the treatment of diabetes. (frontiersin.org)
  • SAN ANTONIO-In the treatment of breast cancer, cardiomyopathy has represented a possible barrier to the use of trastuzumab (Herceptin) in the adjuvant setting. (cancernetwork.com)
  • Background - In the present study, we aimed to describe, at the population level, patterns of adjuvant treatment use after curative-intent resection for pancreatic adenocarcinoma (PCC) and to identify independent predictors of adjuvant treatment use. (ices.on.ca)
  • Logistic regression analyses were used to identify independent predictors of adjuvant treatment versus OBS, and CTX versus CRT. (ices.on.ca)
  • Although the likelihood of receiving adjuvant treatment increased from 2005 to 2010 (p = 0.002), multivariate analysis revealed widespread variation between the treating hospitals (p = 0.001), and even between high-volume hepatopancreatobiliary hospitals (p = 0.0006). (ices.on.ca)
  • Younger age, positive lymph nodes, and positive surgical resection margins predicted an increased likelihood of receiving adjuvant treatment. (ices.on.ca)
  • Conclusions - Interinstitutional medical practice variation contributes significantly to differential patterns in the rate of adjuvant treatment for PCC. (ices.on.ca)
  • Adjuvant therapy is any treatment used after a cancerous tumor has been surgically removed. (differencebetween.net)
  • Adjuvant therapy is any type of treatment done after tumor removal. (differencebetween.net)
  • Adjuvant therapy has the disadvantage that the treatment can weaken the person further because of the side effects. (differencebetween.net)
  • Adjuvant and neoadjuvant therapy are both used in the treatment of certain types of cancer. (differencebetween.net)
  • In addition, the incidence of treatment-related adverse events of grades 3 or higher was similar between the two groups (12 vs 14%, neoadjuvant vs adjuvant). (hospitalhealthcare.com)
  • The recommended osimertinib dose for adjuvant treatment of early-stage NSCLC is 80 mg once daily until disease recurrence, unacceptable toxicity, or for up to 3 years. (ascopost.com)
  • Influence of patient and treatment factors on adherence to adjuvant endocrine therapy in breast cancer. (ons.org)
  • Quality of life of postmenopausal women in the ATAC ("Arimidex," tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for early breast cancer. (ons.org)
  • Postmenopausal women at high risk for recurrence can be evaluated for adjuvant treatment with a bisphosphonate. (medscape.com)
  • When radiation is delivered after surgery is performed, it is called adjuvant (additional) treatment. (medlineplus.gov)
  • This study highlights the present status of the field and explains novel methods, while also chronicling the history of adjuvant therapy in melanoma and looking ahead to future initiatives. (physiciansweekly.com)
  • Despite the benefit of adjuvant hormonal therapy (HT) on mortality among women with breast cancer (BC), many women are non-adherent with its use. (springer.com)
  • Compared with the reference RRT combined with neoadjuvant CAB/adjuvant GnRH, risk of Pca death for men treated with CAB/bicalutamide and conventionally fractionated external beam radiotherapy (CF-EBRT) was hazard ratio (HR) 0.73 (95% CI: 0.50-1.04), hypofractionated EBRT (HF-EBRT), HR 1.35 (95% CI: 0.65-2.81) and EBRT with high dose rate brachytherapy (EBRT-HDRBT), HR 0.85 (95% CI: 0.37-1.95). (lu.se)
  • I think that a DFS improvement in the adjuvant checkpoint inhibitor setting is highly likely to translate to improved survival. (medpagetoday.com)
  • Ronan J. Kelly, M.B., B.Ch., from the Charles A. Sammons Cancer Center at Baylor University Medical Center in Dallas, and colleagues conducted a phase 3 trial to assess a checkpoint inhibitor as adjuvant therapy in adults with resected stage II or III esophageal or gastroesophageal junction cancer. (physiciansweekly.com)
  • Aluminum, one of the most commonly used adjuvants, was first discovered to have adjuvant properties back in 1926. (news-medical.net)
  • Clover's COVID-19 vaccine candidate is the combination of SCB-2019 and two adjuvants, Dynavax's CpG 1018 advanced adjuvant and aluminum hydroxide (alum). (biospace.com)
  • Clinical trials over the past ten years have contributed an enormous amount of new information about adjuvant therapies,' said panel chair Patricia Eifel, professor of radiation oncology at M.D. Anderson Cancer Center in Houston. (pharmexec.com)
  • Adjuvant therapy is any therapeutic method used after surgical resection of a cancerous tumor. (differencebetween.net)
  • So in clinical practice, Guru, are you using adjuvant nivolumab? (medpagetoday.com)
  • Yes, I am using adjuvant nivolumab, although survival has not been presented in the study, and in Europe as we know, nivolumab was approved only in the PD-L1-high population as opposed to the U.S. where it's approved in the overall population regardless of PD-L1 status. (medpagetoday.com)
  • Roche is aiming to develop the drug in earlier stages of the disease as an adjuvant therapy following surgical removal of the tumor. (outsourcing-pharma.com)
  • The random stratification factors include adjuvant chemotherapeutic regimens (XELOX versus SOX) and tumor anatomical sites (gastric adenocarcinoma versus gastroesophageal junction adenocarcinoma). (centerwatch.com)
  • The adjuvant complex self-assembles with disease-specific antigens and induces antibody- and cell-mediated immune responses, particularly induction of CD4+ and CD8+ T lymphocytes. (genengnews.com)
  • Research on adjuvant-based oral vaccine delivery systems. (archives.gov)
  • Therefore, this research is focused on the rational design of pathogen-mimicking adjuvants for vaccine delivery by utilizing flow cytometry and confocal microscopy in concert with materials informatics to identify key properties responsible for nanoparticle uptake and downstream activation of murine bone marrow derived dendritic cells (BMDCs). (aiche.org)
  • Coupled with the platform for each hospital, Adjuvant Informatics is building a centralized data store for clinical anaesthesia "allowing hospitals to make comparisons between their own patient outcomes - such as side effects and length of stay" with those of other hospitals. (davidcrow.ca)
  • A meta-analysis of clinical studies in which melatonin was applied as an adjuvant drug in the therapy of various tumors pointed to some effects of its administration. (unboundmedicine.com)
  • American Society of Clinical Oncology clinical practice guideline: Update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer. (ons.org)
  • Purpose: There is currently no molecular signature in clinical use for adjuvant endocrine therapy omission in breast cancer. (lu.se)
  • The phase 3 lidERA Breast Cancer trial is evaluating the safety and efficacy of adjuvant giredestrant versus physician's choice of therapy in adults with ER-positive, HER2-negative early breast cancer. (managedhealthcareexecutive.com)
  • Partridge AH, LaFountain A, Mayer E, Taylor BS, Winer E, Asnis-Alibozek A (2008) Adherence to initial adjuvant anastrozole therapy among women with early-stage breast cancer. (springer.com)
  • This review summarizes the most relevant data relating to the potential role of melatonin (pineal secretory product) as an adjuvant therapy of tumors. (unboundmedicine.com)
  • Dziegiel P, Podhorska-Okolow M, Zabel M. Melatonin: adjuvant therapy of malignant tumors. (unboundmedicine.com)
  • An adjuvant is a substance that enhances the immune system's response to the presence of an antigen. (news-medical.net)
  • Studies have revealed that adjuvants are likely to influence mechanisms such as the induction of cytokines and chemokines, the formation of depot, the promotion of antigen transportation to drain the lymph nodes, and the enhancement of antigen uptake and presentation. (news-medical.net)
  • To do this adjuvants boost the activation of antigen-presenting cells, cells of the immune system that encompass foreign substances and break them up, presenting the resulting particles to the immune system's T cells. (news-medical.net)
  • Finally, adjuvants can induce the slow release of an antigen. (news-medical.net)
  • The depot effect refers to the process by which adjuvants can regulate the rate of antigen release into the bloodstream. (news-medical.net)
  • To achieve this, the adjuvant is enclosed within a polymer along with an antigen. (news-medical.net)
  • Second, the adjuvant is able to increase the adaptability of the recalled cells to give improved specificity to the new vaccine antigen. (nature.com)
  • Adjuvants can enhance vaccine immunogenicity, allowing a reduction in the quantity of antigen per dose and a consequent increase in the number of doses that can be manufactured in a given time-period. (nature.com)
  • The combination of iBio's VLP antigen with the latter adjuvant expected to offer promising efficacy and safety characteristics. (medgadget.com)
  • 7.5, 3.8, 1.9 μg/dose with adjuvant or 15 μg without adjuvant. (cdc.gov)
  • In pharmacology, an adjuvant is a drug or other substance, or a combination of substances, that is used to increase the efficacy or potency of certain drugs. (wikipedia.org)
  • In addition, targeted therapy such as that used to block human epidermal growth factor receptor 2 (HER2) is often used as an adjuvant therapy in women with breast cancer. (differencebetween.net)
  • Adjuvants help the body to produce an immune response strong enough to protect the person from the disease he or she is being vaccinated against. (cdc.gov)
  • Newer adjuvants have been developed to target specific components of the body's immune response, so that protection against disease is stronger and lasts longer. (cdc.gov)
  • Research has revealed that adjuvants are likely generating immuno-competent environments at the location of the vaccine injection through the activation of an innate immune response. (news-medical.net)
  • When adjuvants are added into a vaccine they work in four distinct ways to boost the immune response. (news-medical.net)
  • We used high-throughput B cell receptor sequencing of plasma cells produced following AS03-adjuvanted and non-adjuvanted 2009 pandemic H1N1 vaccination, as well as pre-pandemic seasonal influenza vaccination to elucidate the effect of the adjuvant on the humoral immune response. (nature.com)
  • Risk of Pca death was increased for men with monotherapy neo-/adjuvant bicalutamide in combination with CF-EBRT or EBRT-HDRBT. (lu.se)
  • Rising demand for sustainable crop protection products will be the key growth enabler for the agricultural adjuvants market. (prsync.com)
  • Rising research & development activities in the agricultural adjuvants market could further help in making products that are less harmful for the environment. (prsync.com)
  • Agricultural utility adjuvant is a significant product type in the market. (prsync.com)
  • Organosilicone is a key chemical group segment in the agricultural adjuvants market. (prsync.com)
  • Oilseeds & pulses are a significant crop type segment of the agricultural adjuvants market. (prsync.com)
  • North America agricultural adjuvants market value is likely to reach around USD 800 million by 2025. (prsync.com)
  • WAUKEGAN, ILL. (January 24, 2022) - Justin Hoeppner has joined Precision Laboratories' team as the Technical Development Manager for the agricultural adjuvant business. (precisionlab.com)
  • Hoeppner will also provide technical support for the agricultural adjuvant business. (precisionlab.com)
  • Adjuvant aromatase inhibitor therapy is used to treat women with certain forms of breast cancer. (differencebetween.net)
  • Five years of follow-up (or adjuvant) therapy has been the standard for reducing breast cancer relapse and mortality. (managedhealthcareexecutive.com)
  • Adjuvant Informatics builds tools to help clinicians and hospital administrators manage information related to patient pain. (davidcrow.ca)
  • Adjuvant Informatics sells an enterprise software solution to hospitals to help them manage their patient pain information. (davidcrow.ca)
  • There are benefits for a patient to have adjuvant therapy. (differencebetween.net)
  • Scientists theorize that adjuvants may act through a number of mechanisms to have the impact of enhancing the immune system response. (news-medical.net)
  • We show that the adjuvant functions through two mechanisms. (nature.com)
  • In this review we use influenza vaccine as a model in a discussion of the different mechanisms of action of the available adjuvants. (smw.ch)
  • In this purview, they act as endogenous adjuvants to ignite evolving immune responses , promote the transition of allergic disease into chronic illness and disrupt the development of active mechanisms of tolerance to ingested foods . (bvsalud.org)
  • So we're going to start by talking about adjuvant immune checkpoint blockade in bladder cancer, and at ASCO GU this year we saw the updated results from the CheckMate-274 study . (medpagetoday.com)
  • Advantages of adjuvant therapy include the fact that it helps to prevent cancer returning and kills off any remaining cancer cells. (differencebetween.net)
  • Adjuvant therapy helps decrease the risk of cancer returning, and in cases of terminal diseases, helps with pain control. (differencebetween.net)
  • If its development as an adjuvant proceeds to plan, Alecensa could become the first approved ALK inhibitor for early-stage ALK-positive lung cancer. (outsourcing-pharma.com)