Furthermore, boz is essential for specification of dorsoanterior embryonic structures, including notochord, prechordal mesendoderm, floor plate and forebrain. (zfin.org)
Perhaps most dramatic of these is holoprosencephaly, a congenital anomaly characterised by a failure of the embryonic forebrain to separate into two chambers. (biomedcentral.com)
Embryology1
In developmental biology, von Baer's laws of embryology (or laws of development) are four rules proposed by Karl Ernst von Baer to explain the observed pattern of embryonic development in different species. (wikipedia.org)
Biology2
Current Topics in Developmental Biology. (wustl.edu)
developmental biology Developmental biology is the study of the process by which animals and plants grow and develop. (theinfolist.com)
Dorsal2
These studies provide genetic evidence for an essential function of a homeodomain protein in ß-catenin-mediated induction of the dorsal gastrula organizer and place boz at the top of a hierarchy of zygotic genes specifying the dorsal midline of a vertebrate embryo. (zfin.org)
Right panels show immunostaining of head organizer cocktail-injected embryos against notochord by MZ15 (dorsal view of the same embryo as shown in the left panel) and somites by 12/101 (lateral view), respectively. (xenbase.org)
Zebrafish1
We demonstrate that the zebrafish bozozok (boz) locus is required at the blastula stages for formation of the embryonic shield, the equivalent of the gastrula organizer and expression of multiple organizer-specific genes. (zfin.org)
Embryos1
Overexpression of boz in the extraembryonic yolk syncytial layer of boz mutant embryos is sufficient for normal development of the overlying blastoderm, revealing an involvement of extraembryonic structures in anterior patterning in fish similarly to murine embryos. (zfin.org)
Embryo2
Von Baer discovered the blastula (the early hollow ball stage of an embryo) and the development of the notochord (the stiffening rod along the back of all chordates, that forms after the blastula and gastrula stages). (wikipedia.org)
In terms of taxonomic hierarchy, according to von Baer, characters in the embryo are formed in top-to-bottom sequence, first from those of the largest and oldest taxon, the phylum, then in turn class, order, family, genus, and finally species. (wikipedia.org)
Specification2
Occupancy of tissue -specific cis-regulatory modules by Otx2 and TLE/Groucho for embryonic head specification. (xenbase.org)
Normally, Hh ligand secreted by the notochord induces the ventral cell fate specification in the entire neural tube. (biomedcentral.com)
Phenotype1
Elucidating disease and developmental dysfunction requires understanding variation in phenotype. (biomedcentral.com)
Anomaly1
Developmental anomaly in which the vagina, bladder, and rectum fuse resulting in a common channel. (nih.gov)
Evolutionary2
According to the recapitulation theory, such structures should invariably be present in frogs because they were assumed to be at a lower level in the evolutionary tree. (wikipedia.org)
Specifically, we aim to discover the underlying genetic and epigenetic contributions to developmental, evolutionary, behavioral, and morphological variation. (biomedcentral.com)
Stages1
Here we employ ChIP-seq and RNA-seq approaches in Xenopus tropicalis gastrulae and find that occupancy of the corepressor, TLE/Groucho, is a better indicator of tissue -specific cis-regulatory modules (CRMs) than the coactivator p300 , during early embryonic stages. (xenbase.org)
Vertebrate2
The insect head placode is shares common embryonic origin with the vertebrate adenohypophyseal placode. (bvsalud.org)
The newly broadened Uberon ontology is a unified cross-taxon resource for metazoans (animals) that has been substantially expanded to include a broad diversity of vertebrate anatomical structures, permitting reasoning across anatomical variation in extinct and extant taxa. (biomedcentral.com)
Species1
Unfortunately this did not resolve all these issues, as CARO was not designed to provide a large set of terms for specific structures shared across species, but rather to provide an organizational framework for constructing anatomy ontologies. (biomedcentral.com)
von Baer formulated the laws in his book On the Developmental History of Animals (German: Über Entwickelungsgeschichte der Thiere), published in 1828, while working at the University of Königsberg. (wikipedia.org)
Analysis1
In Somite-derived download энергия and website structures in knack data consist a analysis of Klhl31 in hierarchical tissue. (need4speed.com)
Cell fate1
During embryonic development, cell-fate specification gives rise to dedicated lineages that underlie tissue formation. (bvsalud.org)
Mechanisms3
School of Medicine), I became interested in embryonic development as a basis for understanding the developmental mechanisms governing normal human physiology and disease, and I began studying early vertebrate axis formation and limb development during my residency training in Anatomic Pathology at the NCI. (nih.gov)
These conserved mechanisms mаy have in turn placed important developmental constraints that may have influenced possible outcomes of Evolution. (hypotheses.org)
Although the genetic and developmental mechanisms of nervous system organization in vertebrates have attracted considerable attention, relatively little is known about the evolutionary origins of the vertebrate central nervous system (CNS). (biomedcentral.com)
Biology1
In developmental biology, von Baer's laws of embryology (or laws of development) are four rules proposed by Karl Ernst von Baer to explain the observed pattern of embryonic development in different species. (wikipedia.org)
Regulation1
We propose a novel deep learning autoencoder-based framework, StrUcture Primed Inference of Regulation using latent Factor ACTivity (SupirFactor), that scales to single cell genomic data and maintains interpretability to perform GRN inference and estimate TFA as a latent feature. (bvsalud.org)
Genetic1
My current research uses limb development as a model for learning how signaling networks orchestrate the formation of a complex 3-dimensional structure, using combined genetic, genomic, and biochemical approaches to study transcription factors and signaling cascades that regulate the formation and pattern of digits and unravel the regulatory hierarchy between early patterning and late digit morphogenesis. (nih.gov)
Lateral1
Moreover, molecular and anatomical studies suggest that the amphioxus and vertebrate brain are characterized by several homologous structures: the frontal eye complex (homolog of the vertebrate lateral eyes), the lamellar body (homolog of the vertebrate epiphysis), and the infundibulum [ 12 ] (Figure 1 ). (biomedcentral.com)
Pattern1
It is arranged in a double helix pattern and resembles the structure of a ladder. (phdsciencegyan.com)
Human1
No, we do not use our wisdom teeth for chewing the food, because it is a vestigial structure in human body. (phdsciencegyan.com)
Explain1
1.Sketch and explain the structure of DNA and various types of RNA. (phdsciencegyan.com)
Complex1
My research interests center on understanding how the formation of complex structures is instructed. (nih.gov)
Animals1
von Baer formulated the laws in his book On the Developmental History of Animals (German: Über Entwickelungsgeschichte der Thiere), published in 1828, while working at the University of Königsberg. (wikipedia.org)