• Noscapine (also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane) is a benzylisoquinoline alkaloid, of the phthalideisoquinoline structural subgroup, which has been isolated from numerous species of the family Papaveraceae (poppy family). (wikipedia.org)
  • Beschreibung Noscapine.HCl Product reference number NOS-285-HC Full chemical name Narcotine.HCl Formula C22H23NO7.HCl Molecular weight 449.89 CAS Number 912-60-7 Supplied as hydrochloride salt Appearance white to off-white cry. (lipomed-shop.com)
  • Noscapine (narcotine). (stonecottagegardens.com)
  • Fass environmental information for noscapine from Spasmofen (codeine, methylscopolamine, morphine, noscapine, papaverine) from Meda (downloaded 2019-04-02). (janusinfo.se)
  • Extra chemicals such as morphine, noscapine and acetylcodeine were present in the fingerprints of those who had actually taken heroin, due to the way the drug breaks down inside the body. (medicaldevice-network.com)
  • Noscapine hydrochloride (Cat. (tocris.com)
  • Noscapine hydrochloride is an opioid alkaloid with several actions. (tocris.com)
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  • The biosynthesis of noscapine in P. somniferum begins with chorismic acid, which is synthesized via the shikimate pathway from erythrose 4-phosphate and phosphoenolpyruvate. (wikipedia.org)
  • Finally, an NAD+-dependent short-chain dehydrogenase (NOS) oxidizes the hemiacetal to a lactone, completing noscapine biosynthesis. (wikipedia.org)
  • The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine. (expasy.org)
  • Noscapine, and its synthetic derivatives called noscapinoids, are known to interact with microtubules and inhibit cancer cell proliferation The lactone ring is unstable and opens in basic media. (wikipedia.org)
  • Intervention 1: Intervention group: Patients receive Noscapine Syrup (Noscough®) 20 cc every 6 hours for 5 days. (who.int)
  • Noscapine is often used as an antitussive medication. (wikipedia.org)
  • Pretreatment with rimcazole, a σ-specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapine. (wikipedia.org)
  • Paratusin Obat Untuk Apa - PARATUSIN adalah obat yang mengandung noscapine, chlorpheniramine maleate, glyceryl guaiacolate, paracetamol dan phenylpropanolamine HCl. (missnutrition.info)
  • Transgenic arcAβ mice, and non-transgenic littermates of 14 months-of-age were either treated with the bradykinin receptors 1 and 2 blocker noscapine or received normal drinking water as control over 3 months ( = 8-11/group) and all mice were assessed using fMRI at the end of the treatment period. (uzh.ch)
  • Noscapine (NOS) has several anti-inflammatory, anti-angiogenic, and anti-fibrotic effects, but its low solubility and large size results in its lower efficacy in the clinic. (bvsalud.org)
  • Researchers found that noscapine, which has been used in cough medication for nearly 50 years, reduced tumor growth in mice by 60% and limited the spread of tumors by 65% without causing harmful side effects. (science20.com)
  • Since noscapine is approved for use in many countries as a cough suppressant, however, it is available to doctors to prescribe for other uses as well. (science20.com)
  • Because noscapine has been used as a cough-suppressant for nearly half a century, it already has an extensive safety record. (science20.com)
  • As a natural substance, noscapine cannot be patented, which has limited the potential for clinical trials. (science20.com)
  • A synthetic derivative of noscapine has been patented but has not yet reached the clinical testing phase. (science20.com)
  • Dr. Barken used noscapine to treat a handful of prostate cancer patients before retiring from clinical practice. (science20.com)
  • citation needed] Noscapine should not be taken in conjunction with warfarin as the anticoagulant effects of warfarin may be increased. (wikipedia.org)
  • Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A. J Biol Chem. (harvard.edu)
  • Preparation and characterization of solid lipid nanoparticles encapsulated noscapine and evaluation of its protective effects against imiquimod-induced psoriasis-like skin lesions. (bvsalud.org)
  • In each block, 2 patients will be assigned to noscapine group and 2 patients will be assigned to control group, Blinding description: Patients included to the study are randomized to two groups of drug and control (noscapine syrup and diphenhydramine syrup) by a randomizer (nurse) according to the randomization list taken from www.sealedenvelope.com. (who.int)
  • Noscapine is a naturally-occurring substance, a non-addictive derivative of opium. (science20.com)
  • No toxic side effects were observed in the laboratory study of noscapine. (science20.com)
  • Nausea Vomiting Loss of coordination Hallucinations (auditory and visual) Loss of sexual drive Swelling of prostate Loss of appetite Dilated pupils Increased heart rate Shaking and muscle spasms Chest pains Increased alertness Loss of any sleepiness Loss of stereoscopic vision Noscapine can increase the effects of centrally sedating substances such as alcohol and hypnotics. (wikipedia.org)
  • Noscapine is effective without the unpleasant side effects associated with other common prostate cancer treatments. (science20.com)
  • Noscapine can increase the effects of centrally sedating substances such as alcohol and hypnotics . (cloudfront.net)
  • Risk of environmental impact of noscapine cannot be excluded, since no ecotoxicity data are available. (janusinfo.se)
  • Perfusion MRI using an arterial spin labeling technique showed regional hypoperfusion in arcAβ compared to non-transgenic controls, which was alleviated by noscapine treatment. (uzh.ch)
  • Similarly, measuring cerebral blood volume changes upon pharmacological stimulation using vessel dilator acetazolamide revealed recovery of regional impairment of cerebral vascular reactivity in arcAβ mice upon noscapine treatment. (uzh.ch)
  • Noscapine has previously been studied as a treatment for breast, ovarian, colon, lung and brain cancer and for various lymphomas, chronic lymphocytic leukemia and melanoma. (science20.com)
  • Rogosnitzky, director of research at MedInsight Research Institute, points out the significant advantages that noscapine could present as a treatment for prostate cancer. (science20.com)
  • Immunohistological stainings for Aβ deposition (6E10) and related microgliosis (Iba1) in the cortex and hippocampus were found comparable between noscapine-treated and untreated arcAβ mice. (uzh.ch)
  • In addition, levels of soluble and insoluble Aβ, Aβ, Aβ were found to be similar in brain tissue homogenates of noscapine-treated and untreated arcAβ mice using electro-chemiluminescent based immunoassay. (uzh.ch)
  • This graph shows the total number of publications written about "Noscapine" by people in Harvard Catalyst Profiles by year, and whether "Noscapine" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Noscapine" by people in Profiles. (harvard.edu)
  • indicates that noscapine has low potential for bioaccumulation. (janusinfo.se)