Normal and neoplastic cells are cells. Medical search. Frequent questions

For childhood neoplasms, it is safe to assume that cancer is the product of degeneration in a neoplastic sense of tissues undergoing very rapid proliferation and differentiation, in which proliferative and differentiative programs are being disturbed by increasingly early (maternal-fetal) exposure to a growing number of environmental stressors and pollutants. (frontiersin.org)
This results in differentiation, survival and proliferation of the erythroid cell. (wikipedia.org)
An accompanying proliferation of erythroid cells and megakaryocytes usually is present. (medscape.com)
In: Chemically induced cell proliferation: Implications for risk assessment. (cdc.gov)
Additionally, moderate proliferation of the fibrous connective tissue and the myoepithelial cells near the proliferating acini was evident. (scielo.br)
Knockdown of CASP5 greatly inhibited GBM proliferation and resulted in G1 cell cycle arrest along with higher apoptosis ratios in vitro and in vivo, while overexpression led to the opposite phenomenon. (cancerindex.org)
Inhibits topoisomerase II and causes DNA strand breakage, causing cell proliferation to arrest in late S or early G 2 portion of cell cycle. (medscape.com)
Inhibits DNA synthesis and, thus, cell proliferation, by causing DNA cross-links and denaturation of double helix. (medscape.com)
FOXP2 mRNA was expressed in bone marrow samples from 96% of MM patients (24/25), 66.7% of patients with the pre-neoplastic plasma cell proliferation monoclonal gammopathy of undetermined significance (MGUS) (6/9), but not in reactive plasma cells. (ox.ac.uk)
γ-secretase inhibitors (GSIs) have been recently proposed as chemopreventive agents in gastrointestinal neoplasia, because they lead, through inhibition of the Notch signaling pathway, to goblet cell conversion in some intestinal adenomas of the Apc Min mice, and halt epithelial cell proliferation. (biologists.com)
The patient underwent a second TSS, and histology of the specimen revealed neoplastic proliferation of astrocytes and spindle-shaped cells with fascicles. (ajnr.org)
We investigated the effects of LTD4 in bringing about changes in survival, proliferation and migration of these cells, all of which are hallmarks of cancer. (lu.se)
We observed that stimulation of intestinal epithelial cell line, Int 407 with LTD4 led to enhanced cell survival and proliferation through the activation of series of signaling cascades like Ras, Erk-1/2, p90RSK, and CREB. (lu.se)
We also show that Int 407 cells produce CysLTs and blocking this autocrine signaling using three different CysLT1 receptor antagonists for longer time points led to attenuation in cell proliferation and induction of apoptosis in the cells. (lu.se)
In the skin, nAChRs regulate the activity of genes involved in the growth and division (proliferation), maturation (differentiation), and survival of cells. (medlineplus.gov)
Similarly, depletion in the STRIPAK component STRIP1 affects activation of GCKIII kinases and cell cycle disruption through elevated expression of cyclin dependent kinase inhibitors p21 and p27, enhanced levels of which lead to a protective effect from therapeutic treatments and increased proliferation. (lu.se)

Erythropoietin was reported to have a range of actions beyond stimulation of erythropoiesis including vasoconstriction-dependent hypertension, stimulating angiogenesis, and promoting cell survival via activation of EPO receptors resulting in anti-apoptotic effects on ischemic tissues. (wikipedia.org)
The development of novel therapy against target critical and specific to the cancer cells but not to the normal tissues is expected to be efficacious and minimize damage to healthy cells. (inknowvation.com)
however, the expression in normal and malignant adult tissues has not been examined in detail. (nature.com)
Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
Using tissue microarrays and full tissue sections of normal and 448 neoplastic tissues, HE4 immunoreactivity was found in normal glandular epithelium of the female genital tract and breast, the epididymis and vas deferens, respiratory epithelium, distal renal tubules, colonic mucosa, and salivary glands, consistent with HE4 gene expression. (nature.com)
Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
LncRNA CASP5 have been found to be up-regulated in GBM tissues compared with normal tissues in a microarray-based lncRNA profiling study. (cancerindex.org)
We examined the expression level of lncRNA CASP5 in GBM tissues as well as GBM cell lines. (cancerindex.org)
We observed that lncRNA CASP5 was highly expressed in GBM tissues and cell lines. (cancerindex.org)
Cells Tissues Organs (2001) 169 (4): 347-354. (karger.com)
FOXP2 mRNA and protein expression were characterised in normal human tissues, haematological cell lines and multiple myeloma (MM) patients' samples. (ox.ac.uk)
The developer defines antineoplastons as "substances produced by the living organism that protect it against development of neoplastic growth by a nonimmunological process which does not significantly inhibit the growth of normal tissues . (cancer.gov)
Nicotinic acetylcholine receptors are best known for their role in chemical signaling between nerve cells, but they are also found in other tissues. (medlineplus.gov)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

The colonic mucosa is constantly challenged by a series of carcinogenic factors able to generate mucosal foci of mutated dysplastic cells called adenomas, lesions that may eventually progress to invasive carcinoma. (iiarjournals.org)
Pancreatic ductal adenocarcinoma evolves from a progressive cascade of cellular, morphological and architectural changes from normal ductal epithelium through pre-neoplastic lesions termed PanIN (Pancreatic Intraepithelial Neoplasia). (proteinlounge.com)
[ 5 ] The investigators found "an arbitrary continuum of morphologic structure links normal [TDLUs] and/or lobules to the entire group of dysplastic, metaplastic, hyperplastic, anaplastic, and neoplastic human mammary lesions, with the exception of intraductal papillomas and rarely occurring hyperplasias of larger ducts. (medscape.com)

Prof Weissman is an expert in the fields of hematopoiesis, leukemia, and hematopoietic stem cells (HSC), and most recently, the clonal events leading from HSC to leukemia stem cells. (edu.hk)
Normal and neoplastic hematopoiesis : proceedings of the UCLA Symposium held at Steamboat Springs, Colorado, March 27-April 1, 1983 / editors, David W. Golde, Paul A. Marks. (who.int)

We have recently shown that myeloid leukaemias in mouse and human are often driven by rare leukaemia (cancer) stem cells which are at the progenitor stage of differentiation, but have activated the self-renewing cell division pathway normally used only by HSCs. (edu.hk)
Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, proerythroblast and basophilic erythroblast subsets in the differentiation. (wikipedia.org)
FOXP2 mRNA and protein were absent in mononuclear cells from different anatomical sites, lineages and stages of differentiation. (ox.ac.uk)
For the developer, cell differentiation is the key to cancer therapy. (cancer.gov)
Antineoplastons are the surveillance system that directs cancer cells into normal channels of differentiation . (cancer.gov)
The notion of controlling tumor growth through a naturally occurring biochemical mechanism in the body that directs cancer cells into normal channels of differentiation is one of the theoretical foundations of antineoplaston therapy. (cancer.gov)
The proposed components in the body that correct the differentiation problems of abnormal cells and send them into normal pathways have been given the name "antineoplastons" by the developer. (cancer.gov)
Functional network analysis revealed that MRPL19 may be associated with the cell cycle, cell adhesion molecules, spliceosome, and T-helper cell differentiation and was regulated by several microRNA and the E2F family. (bvsalud.org)

Transformation assay of established cell lines : mechanisms and application, proceedings of a workshop organized by IARC in collaboration with the US National Cancer Institute and the US Environmental Protection Agency, held in Lyon, 15-17 February 1984 / editors, T. Kakunaga, H. Yamasaki. (who.int)
In this context, in the present study, we examined if exposure of non-transformed intestinal cells to LTD4, a well known inflammatory mediator would make the cells more sensitive to transformation. (lu.se)
All these results indicate that this inflammatory mediator could be implicated in the inflammation-induced neoplastic transformation through CysLT1R and the downstream signaling cascades. (lu.se)
Our previous research suggests that IONPs may induce a neoplastic-like cellular transformation, likely due to particle dissolution, release of free iron ions, and disruption of iron homeostasis. (cdc.gov)
We hypothesized that an amorphous silica coating (SiO2-nFe2O3) would ablate iron homeostasis disruption induced by an uncoated but otherwise identical particle (nFe2O3), and would therefore reduce nFe2O3-induced subsequent neoplastic-like cellular transformation and oxidative stress. (cdc.gov)
The cells were continuously treated at 0.6 microg/cm2 to SiO2-nFe2O3 or nFe2O3 for six months, and were evaluated for oxidative stress, epithelial to mesenchymal transition (EMT), and neoplastic-like cellular transformation throughout. (cdc.gov)

Glioblastomas are intrinsic brain tumors believed to originate from neuroglial stem or progenitor cells. (frontiersin.org)
In brief, frozen sections of profiled tumors were examined by hematoxylin-and-eosin, and areas rich in neoplastic cells were cut from the frozen blocks. (nature.com)
Glial cell tumors and pituitary tumors occur commonly in brachycephalic breeds, whereas meningiomas occur most frequently in dolichocephalic breeds. (vin.com)
Local extension in cats may be either from tumors such as squamous cell carcinoma of the middle ear cavity, or from nasal adenocarcinoma. (vin.com)
Primary brain tumors originate from cells normally found within the brain and meninges. (vin.com)
Brain tumors cause cerebral dysfunction through infiltration of normal brain tissue, compression of adjacent structures, disruption of cerebral circulation, and local necrosis. (vin.com)
Gestational trophoblastic tumors are sensitive to many antineoplastic agents, especially those that act in the S phase or the M phase of the cell cycle. (medscape.com)
The association of Klinefelter syndrome and mediastinal nonseminomatous germ cell tumors is now well recognized. (health.am)
Four of 22 consecutive patients (18%) treated at Indiana University for primary mediastinal germ cell tumors had karyotypic confirmation of Klinefelter syndrome, and an additional patient had clinical features. (health.am)
The average age of patients with Klinefelter syndrome who develop extragonadal germ cell tumors is approximately 18 years, 10 years younger than the median age of those developing this tumor in the absence of Klinefelter syndrome. (health.am)
Increasing evidence indicates that many individuals who develop germ cell tumors have underlying germ cell defects. (health.am)
Many patients with extragonadal germ cell tumors have histories of infertility, and testicular biopsy in these patients shows various abnormalities, including decreased spermatogenesis, peritubular fibrosis, and interstitial edema. (health.am)
In addition, patients who are successfully treated for extragonadal germ cell tumors have a markedly increased risk of developing a subsequent testicular germ cell tumor. (health.am)
These data suggest that either a congenital or an acquired germ cell defect contributes not only to defective spermatogenesis but also to the development of extragonadal germ cell tumors. (health.am)
Hematologic Neoplasia A unique association between mediastinal nonseminomatous germ cell tumors and a variety of hematologic neoplasms is now well described. (health.am)
In a series of 635 patients with extragonadal germ cell tumors, 17 patients developed hematologic malignancies at a median of 6 months after the extragonadal germ cell tumor was diagnosed. (health.am)
All hematologic neoplasms developed in the 287 patients with mediastinal nonseminomatous germ cell tumors, for a 2% incidence in this group. (health.am)
Foci of malignant lymphoblasts have been recognized histologically in several mediastinal germ cell tumors. (health.am)
However, the specific association of leukemias and other hematologic neoplasms with mediastinal nonseminomatous germ cell tumors, rather than with all germ cell tumors, remains unexplained. (health.am)
In addition to hematologic neoplasia, several cases of idiopathic thrombocytopenia in association with mediastinal nonseminomatous germ cell tumors have been reported. (health.am)
Bronchial carcinoids (BC) are rare tumors originating from endocrine cells dispersed in the respiratory epithelium. (endocrine-abstracts.org)
Pancreatic adenocarcinoma, the malignant neoplasm of the exocrine duct cells, accounts for more than ninety percent of all pancreatic tumors (Ref.1). (proteinlounge.com)
However, the new classification applies to small cell lung carcinoma (SCLC) and bronchopulmonary carcinoid tumors as well. (medscape.com)
The biosynthesis and storage of catecholamines in chromaffin cell tumors may differ from the biosynthesis and storage in the normal medulla. (medscape.com)

Background: Colonic crypts with normal epithelial lining displaying corrupted shapes (called non-dysplastic crypts with corrupted shapes, NDCs) were earlier recorded underneath the adenomatous glands of conventional colon adenomas in rats. (iiarjournals.org)
Nineteen out of the 22 control colon segments had normal crypts and the remaining three had occasional NDCs (mean=3.7, range=2-5). (iiarjournals.org)
We demonstrate that DBZ elicits a homogeneous goblet cell conversion all along the mouse intestinal tract, associated with an overexpression of the gene Muc2 without ectopic expression of the gastric genes Muc5ac and Muc6 , and with the emergence of lysozyme-positive 'intermediate cells' in the colon. (biologists.com)
Furthermore, DBZ treatment induces a heterogeneous reorganization of the crypt structural-proliferative units along the intestinal tract and of the stem cell niche in the colon, without disturbing the apoptotic compartment. (biologists.com)

Leukemias are a group of heterogeneous neoplastic disorders of white blood cells. (medscape.com)
Glioblastomas contain chromosomally heterogeneous cells. (msdmanuals.com)

Cancer-free prospectively purified HSCs regenerate the haematopoietic system of patients as rapidly as a marrow or mobilized blood transplant, but without the risk of re-seeding the body with cancer cells. (edu.hk)
11 To clarify this issue for lymphocyte predominant HL we quantitatively examined the expression of AID in the L&H cells of six patients with lymphocyte predominant HL at the transcription level, because suitable antibodies for immunohistochemistry are not yet available. (bmj.com)
Surgical excision is the main treatment for patients with Hürthle cell carcinoma. (medscape.com)
thus, radioactive iodide treatment, which is the most useful nonsurgical therapy for recurrent well-differentiated thyroid carcinoma, is not always useful in patients with Hürthle cell carcinoma. (medscape.com)
Nevertheless, radioactive iodide treatment is used for most patients with Hürthle cell cancers after total and near-total thyroidectomy and in the treatment of patients with recurrent and metastatic Hürthle cell carcinoma. (medscape.com)
Jillard et al reported that post-thyroidectomy 131 I therapy improves survival in patients with Hürthle cell carcinoma. (medscape.com)
[ 35 , 36 ] Retinoic acid therapy also may be considered in patients with Hürthle cell carcinoma that does not take up radioactive iodide, although this is not yet a standard form of therapy. (medscape.com)
More importantly, several patients have had an identical chromosomal abnormality (an isochromosome of the short arm of chromosome 12) in the neoplastic cells from the mediastinal germ cell tumor and the hematologic neoplasm, providing strong evidence for a common origin. (health.am)
GH is produced by normal and neoplastic endometrial cells and elevated levels have been observed in endometrial epithelium of patients with endometriosis and endometrial adenocarcinoma (EA). (endocrine-abstracts.org)
CT of the chest alone is sufficient for stagin patients with pure ground glass opacities and an otherwise normal study, adn for patients with perpheral IA diease. (medscape.com)
Serum sCD40Lshowed statistically-significant high levels in HCV-HCC patients compared to HCV-cirrhotic patients and normal controls (P (who.int)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)

Probable driver mutations were present in around 1% of normal colorectal crypts in middle-aged individuals, indicating that adenomas and carcinomas are rare outcomes of a pervasive process of neoplastic change across morphologically normal colorectal epithelium. (cam.ac.uk)
In addition, the normal systematic arrangement of the different layers of the epithelium is lost (this is called a loss of polarity) as the cells become cancerous. (iarc.fr)
CIN1 is the earliest form of CIN, in which the neoplastic cells are limited to the lower third of the thickness of the cervical epithelium. (iarc.fr)
Introduction: It is known that growth hormone (GH) may influence neoplastic development of endometrial epithelium. (endocrine-abstracts.org)
Germ cell movement within the epithelium is vital because germ cells, if induced to release into the tubule lumen prematurely, will be unable to fertilize the ovum. (proteinlounge.com)
On the other hand, if germ cells are forced to remain attached to the seminiferous epithelium for a period of time longer than necessary to complete their development, they will degenerate and eventually be phagocytosed by Sertoli cells and for this, proper regulation of germ cell migration in the seminiferous epithelium and at blood-testes barrier (abbreviated as BTB) is essential (Ref.1). (proteinlounge.com)

However, Glioma cells have the ability to invade as single cells through the unique environment of the normal CNS (Central Nervous System). (proteinlounge.com)
this metabolite can modify DNA methylation of normal neural and glial progenitor cells causing them to produce neoplastic glioma cells. (msdmanuals.com)

Inset-The labeling of the neoplastic cells was cytoplasmic and appeared granular. (avma.org)
The neoplastic cells present in CIN have a higher nuclear cytoplasmic ratio compared with normal cells, an irregular nuclear membrane, dense chromatin in the nucleus, and mitotic figures. (iarc.fr)

Underlying the oral mucosa (arrow), there is a multinodular mass of polygonal neoplastic cells arranged in packets and trabeculae that replace the normal subepithelial stroma (asterisk). (avma.org)

The best available evidence suggests that glioblastomas originate from cells that give rise to glial cells. (bmj.com)
The cellular composition of the neurohypophysis is that of specialized glial cells (pituicytes) together with their axons. (ajnr.org)
The posterior pituitary, being part of the neurohypophysis, harbors specialized glial cells named "pituicytes. (ajnr.org)
They are modified glial cells of empendymal cell lineage located in the neurohypophysis and pituitary stalk. (ajnr.org)
Transformed glial cells share the common attributes of the invasion process, including cell adhesion to ECM (Extracellular Matrix) components, cell locomotion, and the ability to remodel extracellular space. (proteinlounge.com)

The specific aims are: 1) Determine the efficacy and potency of anti-human GP88 monoclonal antibody AG1 in mono-therapy for non small cell carcinoma in nude mice xenograft models. (inknowvation.com)
The present application proposes feasibility studies to investigate if this agent can be inhibit lung cancer, particularly on small cell lung carcinoma. (inknowvation.com)
Hürthle cell carcinoma is considered a radiosensitive tumor. (medscape.com)
The previous editions of TNM staging only apply to non-small cell lung carcinoma (NSCLC). (medscape.com)

To test this hypothesis, we used an occupationally relevant low dose/long term exposure in vitro model system which utilized a normal human bronchial epithelial cell line (Beas2B). (cdc.gov)

6 Recent studies of AID protein expression using western blot analysis showed that AID expression is largely restricted to normal and transformed GC B cells and correlates well with the expression of AID transcripts. (bmj.com)
7 Several studies analysing AID expression and mutation patterns in V gene rearrangements in various B cell non-HLs showed that, although somatic hypermutation activity is strictly dependent on AID, the expression of this protein does not necessarily indicate ongoing somatic hypermutation. (bmj.com)
However, FOXP2 mRNA and protein was detected in several lymphoma (8/20) and all MM-derived cell lines (n = 4). (ox.ac.uk)
There were foci of eosinophilia, stellate cytoplasm, and occasional gemistocytic morphology, and many cells were positive for glial fibrillary acidic protein (GFAP). (ajnr.org)
This protein is found in skin cells and other cells that line the surfaces and cavities of the body. (medlineplus.gov)
In this compiled work, we elaborate on the effect of protein expression alterations and their resulting effect on recurrence capability of cells. (lu.se)

However, our understanding of the earliest phases of colorectal neoplastic changes-which may occur in morphologically normal tissue-is comparatively limited, as for most cancer types. (cam.ac.uk)

In addition, the myoepithelial cells exhibited diffuse nuclear immunoreactivity for p63. (scielo.br)

High level erythropoietin receptor expression is localized to erythroid progenitor cells. (wikipedia.org)

9 The exact number and nature of genetic alterations and deregulated signalling pathways required for tumorigenesis remains an issue of debate, 10 although it is now clear that central nervous system (CNS) carcinogenesis requires multiple disruptions to the normal cellular circuitry. (bmj.com)
It is strongly recommended that when using a reagent for the first time, users compare the spillover on cell and CompBead to ensure that BD Comp beads are appropriate for your specific cellular application. (bdbiosciences.com)
This mass was resected via a transspenoidal approach, and histology revealed a moderately cellular astrocytomas with compact fibrillated cells in a fascicular pattern. (ajnr.org)
Sertoli-Germ (Spermatid)-cell interactions affect spermatogenesis at the molecular, cellular and biochemical levels. (proteinlounge.com)

The synthetic Compound 5 is capable of sensitizing chemoresistant tumor cells overexpressing Magmas to proapoptotic stimuli, indicating that this molecule may be useful to overcome tumor chemoresistance. (endocrine-abstracts.org)
a perivascular arrangement of tumor cells resulting in a palisading effect may be seen. (medscape.com)
Summary: Astrocytoma, or pituicytoma, of the posterior pituitary is a relatively rare entity consisting of poorly characterized glial tumor cells. (ajnr.org)

In leukemias, a clone of malignant cells may arise at any stage of maturation, that is, in the lymphoid, myeloid, or pluripotential stage. (medscape.com)
and 3) the molecular basis of diseases that involve spectrin or any of its associated proteins, including contributions of the cortical cytoskeleton to the phenotypic alterations of malignant cells and the molecular pathology of acquired and inherited disorders involving this structure. (yale.edu)
Additionally, MRPL19 knockdown in LUAD cells substantially reduced cell growth, migration, and invasion of malignant cells. (bvsalud.org)

Erythropoietin has its primary effect on red blood cell progenitors and precursors (which are found in the bone marrow in humans) by promoting their survival through protecting these cells from apoptosis, or cell death. (wikipedia.org)
Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. (cancerindex.org)
In most cases, dying cells during development exhibit generalized morphological features typical of apoptosis. (karger.com)
Two morphological types of cell death were found: apoptosis which was characterized by round or semilunar nuclear chromatin condensations, condensation and shrinkage of the cytoplasm and formation of apoptotic bodies, and cell death without the morphological features of apoptosis which was characterized by pyknotic nuclear chromatin condensations, vacuolated cytoplasm and the formation of numerous intercellular spaces. (karger.com)
According to our findings, apoptosis seems to be the most frequently observed type of PCD, but it is not the exclusive type of morphological cell death during the development of axial structures in human embryos. (karger.com)

Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

An inhibition of the normal development of hematopoietic cell elements occurs. (medscape.com)
Acute myelogenous leukemia (AML) is a group of neoplastic disorders of the hematopoietic precursor cells of the bone marrow. (medscape.com)

Central to the integrated function of multicellular organisms is cell contact mediated signaling and the spatial organizations of specialized membrane-surface domains. (yale.edu)

nFe2O3 transformed cells also possess a pro-inflammatory phenotype, including increased oxidative stress, EMT marker proteins, and changes in select inflammatory cytokines. (cdc.gov)

Inset-Neoplastic cells contain abundant granular eosinophilic cytoplasm with centrally placed small round nuclei and 1 to 2 nucleoli. (avma.org)
The rapidly dividing abnormal cells cannot accumulate glycogen, and the cytoplasm remains intact. (iarc.fr)

Our previous work with histone deacetylases (HDACs), key epigenetic modifiers in normal and neoplastic cells, has demonstrated the essential role of HDAC3 in suppressing RMS tumor growth. (curesarcoma.org)
On one hand, it is clear that epigenetic alterations accumulate with age, leading to disrupted cell function and tissue pathology. (irbbarcelona.org)

Flow cytometric evaluation of normal and neoplastic B cells. (bdbiosciences.com)

1 Analysis of V gene rearrangements in single L&H cells revealed the presence of somatic mutations with intraclonal diversity in functional monoclonal V gene rearrangements, in line with a GC B cell origin. (bmj.com)

The lymphocytic and histiocytic (L&H) cells of lymphocyte predominant Hodgkin lymphoma (HL) originate from germinal centre B cells and carry mutated V gene rearrangements, usually with intraclonal diversity. (bmj.com)
Intraclonal diversity in V gene rearrangements as a result of active somatic hypermutation is a typical feature of GC B cells. (bmj.com)
Through gene expression and proteomic profiling of HDAC3-deficient RMS cells, we have identified candidate genes functioning downstream of or interacting with HDAC3. (curesarcoma.org)
We proposed to complete targeting of the identified gene target set in a panel of RMS cell lines and characterize their effects on human xenografts in vivo. (curesarcoma.org)
Magmas, a gene encoding for the mitochondrial import inner membrane translocase subunit, Tim16, protects different cell lines from the antitumoral effects of several pro-apoptotic stimuli (i.e. chemicals and chemotherapeutic agents). (endocrine-abstracts.org)

In normal brain tissue, the following metabolites were identified: NAA at 2.0 ppm, Pcr-Cr at 3.0 ppm and Cho at 3.2 ppm. (nih.gov)
The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of Gliomas and contributes to the failure of current therapeutic modalities (surgery, radiation and chemotherapy). (proteinlounge.com)

In the fifth week of fetal development, neuroblastic cells migrate from the thoracic neural crest to form the sympathetic chains and preaortic ganglia. (medscape.com)

However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)

Abstract: Stem cells are cells that at the single cell level both self-renew and give rise to differentiated progeny. (edu.hk)

These results represent a novel mechanism by which alkylphospholipids modulate transcription, and may contribute to the discovery of new signal transduction pathways crucial for normal and neoplastic cell cycle control. (conicet.gov.ar)
This suggest that LTD4 signaling through CysLT1 receptor is some how crucial for normal maintenance of intestinal epithelial cells. (lu.se)

Acute lymphocytic leukemia (ALL) is a malignant clonal disorder of the bone marrow lymphopoietic precursor cells. (medscape.com)
Cytofluorometric detection of B cell clonal excess: a new approach to the diagnosis of B cell lymphoma. (bdbiosciences.com)
Sequencing normal colorectal cells provides quantitative insights into the genomic and clonal evolution of cancer. (cam.ac.uk)

FOXP2 represents the first transcription factor whose expression consistently differentiates normal and abnormal plasma cells and FOXP2 target genes are implicated in MM pathogenesis. (ox.ac.uk)
The abnormal cells have the classic features of HPV infection. (iarc.fr)
At the molecular level, abnormal cells that are potential cancer cells need to be "switched" to normal mode. (cancer.gov)
Groups of abnormal cells can arise under the influence of carcinogenic factors from outside or inside the body. (cancer.gov)
The body must have a mechanism for dealing with these abnormal cells, or the organism will not live very long. (cancer.gov)

it stimulates red blood cell production (erythropoiesis) in the bone marrow. (wikipedia.org)
The time for 1 cell division is prolonged with respect to that of normal bone marrow blast cells. (medscape.com)
The bone marrow is gradually replaced by blast cells. (medscape.com)

This review will focus on information that begins to emerge regarding the role of cell competition in liver physiology and pathology. (wjgnet.com)

First, radioactive iodide destroys any remaining normal thyroid tissue, thereby enhancing the sensitivity of subsequent 131 I total-body scanning and increasing the specificity of measurements of serum thyroglobulin for the detection of persistent or recurrent disease. (medscape.com)

A comparative marker study of large cell lymphoma, Hodgkin's disease, and true histiocytic lymphoma in paraffin-embedded tissue. (bdbiosciences.com)

The pituitary gland is unique because of its dual embryologic cell lineage. (ajnr.org)
On the basis of these facts, it is understandable that the hypophyseal stalk or posterior pituitary can be a host to all the neoplastic processes that originate from the glial cell series. (ajnr.org)

The immune infiltration analysis revealed a correlation between MRPL19 expression and the extent of B cells, CD4+ T cells, and dendritic cells' infiltration in LUAD. (bvsalud.org)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

The distribution of neoplastic and normal B-lymphoid cells in nodular lymphomas: use of an immunoperoxidase technique on frozen sections. (bdbiosciences.com)

therefore, the association with mediastinal germ cell tumor seems specific. (health.am)
Recent evidence indicates that the hematologic neoplasms in this setting are not treatment related, but rather arise from clones of malignant lymphoblasts or myeloblasts contained within the mediastinal germ cell tumor. (health.am)

Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed. (bmj.com)
The tumour microenvironment (TME) contains several other cell types apart from cancer cells which play a role not only in the regulation of the environment but in response to treatments. (lu.se)

As alkylating agent, mechanism of action of active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells. (medscape.com)

Similar cancer stem cells have been isolated in other tumours. (edu.hk)
In recent years his work has included studying the potential of CD47 as a cancer therapeutic and identifying cancer stem cells from a variety of blood and solid cancers. (edu.hk)
We explore signalling alterations resulting in cancer stem cells as well as cell cycle arrest and cell fate determination. (lu.se)

In 2010, there were 222,520 new cases of lung cancer diagnosed in the US, 85% being non small cell lung cancer (NSCLC) and 157,300 lung cancer related deaths. (inknowvation.com)
Transbronchial lung biopsy microscopic slide of a) lung tissue showing a granulomatous inflammation with giant cell reaction and b) lung tissue under polarised light (birefringed crystalline material). (ersjournals.com)

Furthermore, the migration and invasion ability of GBM cells were significantly decreased after CASP5 down-regulation, while increased migration and invasion can be observed after CASP5 up-regulation. (cancerindex.org)
LTD4 stimulation also led to significant enhancement of cell migration in a PI3K and Rac-dependent manner. (lu.se)

While pursuing this goal, it is also effective in selecting against altered/defective cells with putative (pre)-neoplastic potential, thereby edging the risk of cancer development. (wjgnet.com)

Even some cancers seem to be unable to significantly do damage that permanently impairs genetic function given the healthy clone obtained out of a cancer cell. (fightaging.org)
Colorectal cancers exhibit substantially increased mutational burdens relative to normal cells. (cam.ac.uk)

His research also encompasses the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems. (edu.hk)
The Tumor Immune Estimation Resource (TIMER) was employed to assess the connection between MRPL19 expression and infiltrated immune cells in LUAD. (bvsalud.org)

Genomic instability creates a permissive state in which a potential cancer cell is allowed to acquire enough mutations to become a cancer cell. (proteinlounge.com)

Programmed cell death (PCD) is a widespread phenomenon in the development of vertebrates. (karger.com)
Apoptotic death occurred during the 5th week of normal development in all the axial structures. (karger.com)
A light and electron microscopic study of naturally occurring and induced cell loss during development. (karger.com)
Intriguing analogies between liver repopulation and carcinogenesis will be briefly discussed and the potential dual role of cell competition, as a barrier or a spur to neoplastic development, will be considered. (wjgnet.com)

The neoplastic cell is a hypoproliferative, immunologically incompetent small lymphocyte. (medscape.com)
L&H cells from lymphocyte predominant HL cases and centroblasts from lymphadenites were micromanipulated and analysed for AID expression by quantitative real time polymerase chain reaction. (bmj.com)
The lymphocytic and histiocytic (L&H) cells of lymphocyte predominant HL express B cell markers and also the germinal centre (GC) marker BCL6, indicating that they are derived from GC B cells. (bmj.com)
In the United States, opportunistic infections continue to produce morbidity and mortality among the estimated 650,000-900,000 persons who are infected with HIV, especially among the estimated 200,000-250,000 persons who are severely immunosuppressed (i.e., persons who have a CD4+ T-lymphocyte count of less than 200 cells/uL) (6-10). (cdc.gov)

We have shown previously that perifosine induces p21(waf1/cip1) in a p53-independent fashion and that induction of p21(waf1/cip1) is required for the perifosine-induced cell cycle arrest because cell lines lacking p21(waf1/cip1) are refractory to perifosine. (conicet.gov.ar)

The tripartite DENN (after differentially expressed in neoplastic versus normal cells) domain is found in several proteins involved in Rab-mediated processes or regulation of MAPKs (Mitogen-activated preotein kinases) signaling pathways. (embl.de)

It is evident that some stem cell clones acquire somatic mutations that endow them with a self-renewal advantage, leading to their expansion and tissue-takeover in old age. (irbbarcelona.org)

It is also inconsistent with the low levels of EPO receptors on those cells. (wikipedia.org)
About 50% of the proliferating epithelial cells showed positive nuclear labeling for estrogen and progesterone receptors, and approximately one-third were positive for Ki-67. (scielo.br)
Like other Ly6/uPAR-related proteins, SLURP-1 folds into a particular shape and is thought to attach (bind) to other proteins called receptors to carry out signaling within cells. (medlineplus.gov)

AML is not a disorder of rapidly proliferating neoplastic cells. (medscape.com)

Junctional activity among the neoplastic cells is not evident. (avma.org)

Anatomy38

Organisms18

Diseases88

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes37

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care2

Proliferation16

Tissues14

Lesions3

Hematopoiesis2

Differentiation8

Transformation6

Tumors24

Colon4

Heterogeneous2

Patients12

Epithelium6

Glioma2

Cytoplasmic2

Polygonal1

Glial cells5

Carcinoma4

Epithelial cell line1

Protein6

Morphologically1

Immunoreactivity1

Progenitor cells1

Cellular4

Tumor Cells3

Malignant cells3

Apoptosis5

Induce1

Hematopoietic2

Integrated function of multicellul1

Inflammatory1

Cytoplasm2

Epigenetic2

Cytometric1

Monoclonal1

Gene5

Brain tissue2

Neural1

Carcinomas1

Abstract1

Crucial for normal2

Clonal3

Abnormal5

Bone3

Pathology1

Subsequent1

Lymphoma1

Pituitary2

Dendritic cells2

Nodular1

Germ2

Tumour microenvironment2

Growth1

Cancer stem3

Lung2

Migration2

Defective1

Cancers2

Immune2

Genomic1

Development4

Lymphocyte4

Cycle arrest1

Processes1

Somatic mutations1

Receptors3

Rapidly1

Evident1