Norepinephrine and dopamine inhibiting auto receptors. Medical search. Frequent questions

We conclude that sympathetic neurons possess β1 autoreceptors that regulate axon outgrowth negatively. (tech-strategy.org)
Activation of 5-HT1A receptors in the medial prefrontal cortex enhances the activity of Ventral tegmental area (VTA) DA neurons and mesocortical DA release. (psychscenehub.com)
5-HT7 receptors innervate GABA neurons in the raphe nucleus and act as negative feedback. (psychscenehub.com)
Neurons that are activated by norepinephrine project bilaterally (send signals to both sides of the brain) from the locus ceruleus along distinct pathways to many locations, including the cerebral cortex, limbic system, and the spinal cord . (newworldencyclopedia.org)
Norepinephrine is a neurotransmitter in the central nervous system and sympathetic nervous system where it is released from noradrenergic neurons during synaptic transmission. (newworldencyclopedia.org)
Progressive loss of nigrostriatal dopamine (DA) neurons is the neuropathological hallmark of Parkinson's disease (PD). (jneurosci.org)
Preliminary evidence suggests that the dopamine transporter couples to L-type voltage-gated calcium channels (particularly Ca v 1.2 and Ca v 1.3 ), which are expressed in virtually all dopamine neurons. (cloudfront.net)
[11] As a result of DAT-Ca v coupling, DAT substrates that produce depolarizing currents through the transporter are able to open calcium channels that are coupled to the transporter, resulting in a calcium influx in dopamine neurons. (cloudfront.net)
In the brain, dopamine functions as a neurotransmitter -a chemical released by neurons (nerve cells) to send signals to other nerve cells. (alchetron.com)
Parkinson's disease , a degenerative condition causing tremor and motor impairment, is caused by a loss of dopamine-secreting neurons in an area of the midbrain called the substantia nigra . (alchetron.com)
Dopamine is synthesized in a restricted set of cell types, mainly neurons and cells in the medulla of the adrenal glands. (alchetron.com)
A pathological feature of Parkinson's disease (PD) is the progressive loss of dopaminergic neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD brains. (biomedcentral.com)
The cause of degeneration of nigrostriatal dopamine (DA) neurons in idiopathic Parkinson's disease (PD) is still unknown. (jneurosci.org)

SNRIs can be contrasted with the selective serotonin reuptake inhibitors (SSRIs) and norepinephrine reuptake inhibitors (NRIs), which act upon single neurotransmitters. (wikipedia.org)
Imipramine was found to affect numerous neurotransmitter systems and to block the reuptake of norepinephrine and serotonin from the synapse, therefore increasing the levels of these neurotransmitters. (wikipedia.org)
Throughout the 1960s and 1970s, the catecholamine hypothesis of emotion and its relation to depression was of wide interest and that the decreased levels of certain neurotransmitters, such as norepinephrine, serotonin, and dopamine might play a role in the pathogenesis of depression. (wikipedia.org)
Symptoms may occur because concentrations of neurotransmitters, such as norepinephrine and serotonin, are insufficient, leading to downstream changes. (wikipedia.org)
Older and less selective antidepressants like TCAs and MAOIs inhibit the reuptake or metabolism of norepinephrine and serotonin in the brain, which results in higher concentrations of neurotransmitters. (wikipedia.org)
Furthermore, neurotransmitters like serotonin, dopamine, gaba, histamine, acetylcholine and others are also used to down-regulate norepinephrine, which is an excitatory neurotransmitter that can be toxic to the brain in excess and overstimulates the lower more primitive sections of the brain that are responsible for increasing impulsivity. (holistichelp.net)
As such, dopamine is the simplest possible catecholamine , a family that also includes the neurotransmitters norepinephrine and epinephrine. (alchetron.com)
Antidepressants used to treat anxiety, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs), work by increasing levels of certain neurotransmitters in the brain, especially serotonin. (medical-actu.com)

Along with epinephrine (adrenaline), another hormone secreted by the adrenal medulla, norepinephrine underlies the fight-or-flight response to physical or mental stress , directly increasing heart rate, triggering the release of glucose from energy stores, and increasing skeletal muscle readiness, among other actions. (newworldencyclopedia.org)
Like epinephrine, norepinephrine also belongs to the family of compounds called catecholamine , a sympathomimetic monoamine derived from the amino acid tyrosine . (newworldencyclopedia.org)
The most abundant catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine. (newworldencyclopedia.org)
Norepinephrine can be converted to epinephrine. (newworldencyclopedia.org)
Norepinephrine and epinephrine are the two main hormones excreted by the adrenal medulla . (newworldencyclopedia.org)
The adrenal glands are chiefly responsible for regulating the stress response through the synthesis of corticosteroids and catecholamines (chiefly norepinephrine and epinephrine), including cortisol released in the adrenal cortex. (newworldencyclopedia.org)
While epinephrine is mainly released from the adrenal medulla, norepinephrine has another major source-nerve endings. (newworldencyclopedia.org)
It is formed as an intermediate during the formation of norepinephrine and epinephrine [ 20 ]. (biomedcentral.com)
Outside the brain, phentermine stimulates the release of hormones epinephrine and norepinephrine which breaks down fat cells. (zovon.com)
It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. (lookformedical.com)

Appropriately we attemptedto demonstrate the experience of the receptors with the addition of the β1 agonist dobutamine to your ethnicities. (tech-strategy.org)
It is a serotonin modulator and stimulator because although it has SERT inhibition properties, it is also a serotonin receptor agonist and antagonist. (psychscenehub.com)
Vortioxetine acts as an agonist at the 5-HT1A receptor, an autoreceptor for serotonergic neurotransmission at the presynaptic end . (psychscenehub.com)
3. 5-HT1A agonist activity at postsynaptic receptors. (psychscenehub.com)
APO, a direct acting DA receptor agonist, decreases prolactin (PRL) and stimulates growth hormone (GH), adrenocorticotropic hormone (ACTH) and cortisol secretion. (mdpi.com)
It has recently been demonstrated that prenatal exposure to the cannabinoid receptor 1 agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone (WIN 55,212-2) produces memory deficit in adulthood, an effect associated with a reduced functionality of the glutamatergic system. (researchgate.net)
A selective D1 dopamine receptor agonist used primarily as a research tool. (lookformedical.com)
A dopamine D2/D3 receptor agonist. (lookformedical.com)

Partial agonism toward the 5-HT1B receptors also increases the release of 5-HT, glutamate, acetylcholine and histamine. (psychscenehub.com)
5-HT3 antagonism can lead to increases in serotonin, dopamine, norepinephrine, acetylcholine, and histamine, which may explain the pro-cognitive effects of vortioxetine. (psychscenehub.com)
SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs. (illumina.com)
Both have a fairly long list of receptors to which they can bind: SERT, NET, 5-HT receptors, α receptors, σ receptors, dopamine receptors, histamine receptors, and muscarinic acetylcholine receptors. (stackexchange.com)

This is followed by decarboxylation into the neurotransmitter dopamine. (newworldencyclopedia.org)
Norepinephrine also has another major role beyond that of a hormone in that it acts as a neurotransmitter. (newworldencyclopedia.org)
The dopamine transporter ( DAT ) also ( sodium-dependent dopamine transporter ) is a membrane-spanning protein coded for in the human by the SLC6A3 gene , (also known as DAT1 ), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol . (cloudfront.net)
DAT is an integral membrane protein that removes dopamine from the synaptic cleft and deposits it into surrounding cells, thus terminating the signal of the neurotransmitter. (cloudfront.net)
Studies using electrophysiology and radioactive-labeled dopamine have confirmed that the dopamine transporter is similar to other monoamine transporters in that one molecule of neurotransmitter can be transported across the membrane with one or two sodium ions. (cloudfront.net)
[11] since DAT phosphorylation by CAMKII results in dopamine efflux in vivo , activation of transporter-coupled calcium channels is a potential mechanism by which certain drugs (e.g., amphetamine ) trigger neurotransmitter release. (cloudfront.net)
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. (lookformedical.com)
These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. (lookformedical.com)

Venlafaxine blocks the neuronal reuptake of serotonin, noradrenaline, and, to a lesser extent, dopamine in the central nervous system. (wikipedia.org)
It also indirectly increases the release of dopamine and noradrenaline, particularly in the prefrontal cortex and hippocampus. (psychscenehub.com)
In this process, serotonin may interact antagonistically with noradrenaline (norepinephrine) and its α 2 -noradrenergic receptors that normally function to enhance carbohydrate intake at the onset of the natural feeding cycle. (springer.com)

Similar dopamine antagonist drugs are also some of the most effective anti-nausea agents . (alchetron.com)
Quetiapine is an α 2A antagonist, so that's a secondary mechanism by which quetiapine would affect norepinephrine levels. (stackexchange.com)
Doxepin has a high affinity for the H1 receptor, making it a selective H1 antagonist at low dose and it has been shown to display sedating properties. (studylib.net)

specifically, they inhibit the reuptake of serotonin and norepinephrine. (wikipedia.org)
Citalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT 1A autoreceptors. (illumina.com)
It is a drug which decreases the reuptake of serotonin, dopamine, and norepinephrine in the brain, thereby enhancing the feeling of satiety. (zovon.com)

Norepinephrine synthesis suppression by α-methyl p-tyrosine also improved sprouting and concurrent CEP-28122 dobutamine administration decreased it confirming that locally synthesized norepinephrine inhibits outgrowth via β1 adrenoceptors. (tech-strategy.org)
In cultures where NE synthesis was inhibited neurite outgrowth was increased to an extent similar to that seen with βAR blockade indicating that NE synthesized in CEP-28122 culture does indeed act to inhibit outgrowth. (tech-strategy.org)
It decreases the inflammatory response by inhibiting proinflammatory cytokine synthesis and secretion. (buypeptidesonlineusa.com)
The dark colored MELANIN is a by-product of dopamine synthesis. (lookformedical.com)

In vitro studies show that citalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. (illumina.com)
Most types of rewards increase the level of dopamine in the brain, and many addictive drugs increase dopamine neuronal activity. (alchetron.com)

Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? (jneurosci.org)

These results could be reproduced by computer modeling of the border zone based on our knowledge of β-adrenergic receptor signaling pathways and their influence on intracellular calcium handling and ion channels. (frontiersin.org)
This nucleus is the origin of most norepinephrine pathways in the brain. (newworldencyclopedia.org)
In combination with adaptive postsynaptic pathways, this leads to a persistent pathological signal, in particular, in pathways regulated by high-affinity receptors. (jneurosci.org)
The brain includes several distinct dopamine pathways, one of which plays a major role in reward-motivated behavior . (alchetron.com)
Other brain dopamine pathways are involved in motor control and in controlling the release of various hormones. (alchetron.com)
These pathways and cell groups form a dopamine system which is neuromodulatory. (alchetron.com)
Lots of adrenergic receptors (ARs) are widely present across the auditory pathways and are positioned to affect auditory and vestibular functions. (bvsalud.org)
This effect was associated with decreased activation of pathways linked to neurotrophin and glutamate receptor signaling. (researchgate.net)

Dopamine (contracted from 3,4- d ihydr o xy p henethyl amine ) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body. (alchetron.com)

Soon after its development, iproniazid and related substances were shown to slow enzymatic breakdown of serotonin, dopamine, and norepinephrine via inhibition of the enzyme monoamine oxidase. (wikipedia.org)
In contrast with several other antidepressant drugs, venlafaxine can induce a rapid onset of action mainly due to a subsequent norepinephrine reuptake inhibition. (wikipedia.org)
Part of the reason we see some of this is serotonin as well as dopamine have negative feedback inhibition and auto inhibition. (biocompatibledentist.org)

This phenomenon appears with moderate denervation (50-80%), and affects mainly signaling by high-affinity DA receptors (e.g., high-affinity D 2 - and D 3 -type receptors). (jneurosci.org)
Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells. (lookformedical.com)

General reference Several drug classes and drugs can be used to treat depression: Selective serotonin reuptake inhibitors (SSRIs) Serotonin modulators (5-HT2 blockers) Serotonin-norepinephrine reuptake inhibitors. (msdmanuals.com)
SSRIs are selective to the 5-HT system but not specific for the different 5-HT receptors. (msdmanuals.com)
Antidepressants are also used to treat anxiety, including selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and sertraline, and serotonin norepinephrine reuptake inhibitors (SNRIs) such as than venlafaxine and duloxetine. (medical-actu.com)

Endocannabinoids can affect multiple cellular targets, such as cannabinoid (CB) receptors, transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and peroxisome proliferator-activated receptor ${\gamma}$ ( $PPAR{\gamma}$ ). (koreascience.kr)
It selectively blocks the cannabinoid receptor CB1, which belongs to the endogenous cannabinoid system found throughout the body involved in controlling different physiological processes, like appetite. (zovon.com)

In summary, vortioxetine is a 5-HT modulator and stimulator which also potentiates the neurotransmission of the noradrenergic, dopaminergic, cholinergic, histaminergic, glutamatergic and gamma-aminobutyric acid (GABA)ergic systems through actions on 5-HT receptors. (psychscenehub.com)

However, many antidepressants also act on serotonin receptors, known as 5-hydroxytryptamine (5-HT) receptors. (psychscenehub.com)
Under normal conditions, the serotonin receptors are activated by synaptic serotonin and are involved in excitatory and inhibitory neurotransmission. (psychscenehub.com)
This phenomenon is mediated by serotonin and possibly serotonin receptors, in contrast to serotonin autoreceptors which potentiate feeding possibly by inhibiting serotonin release. (springer.com)

In the most widely accepted model for monoamine transporter function, sodium ions must bind to the extracellular domain of the transporter before dopamine can bind. (cloudfront.net)
Citalopram does not inhibit monoamine oxidase. (illumina.com)

Dopamine underlies several aspects of cognition, including reward, and DAT facilitates regulation of that signal. (cloudfront.net)

Dopamine reuptake via DAT provides the primary mechanism through which dopamine is cleared from synapses , although there may be an exception in the prefrontal cortex , where evidence points to a possibly larger role of the norepinephrine transporter . (cloudfront.net)

2005 and membrane stabilization may inhibit axon outgrowth (Ibarretxe et al. (tech-strategy.org)
DAT is a symporter that moves dopamine across the cell membrane by coupling the movement to the energetically-favorable movement of sodium ions moving from high to low concentration into the cell. (cloudfront.net)
The driving force for DAT-mediated dopamine reuptake is the ion concentration gradient generated by the plasma membrane Na + /K + ATPase . (cloudfront.net)
Once dopamine binds, the protein undergoes a conformational change, which allows both sodium and dopamine to unbind on the intracellular side of the membrane. (cloudfront.net)
In order to get the binding and the changes that we need in that dopamine receptor, again, we need GTP.Â GTP is generated by the methylation cycle or supporting with nucleotide bases, and the other types of receptors in the membrane utilize protein kinase C which, again, is tied together with aggression. (biocompatibledentist.org)

By preventing reuptake of 5-HT presynaptically, SSRIs result in more 5-HT to stimulate postsynaptic 5-HT receptors. (msdmanuals.com)

Here we show that agonists of α2-adrenergic receptors (α2-AR) have very strong anti-tumour activity when used as monotherapies in multiple immunocompetent tumour models, including ICB-resistant models, but not in immunodeficient models. (bvsalud.org)

Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters. (lookformedical.com)

Antagonism of the 5-HT7 receptor potentiates the effect of the SERT blockade by increasing the release of serotonin from the raphe nucleus. (psychscenehub.com)
antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. (illumina.com)

When 5-HT stimulates these 5-HT7 receptors, inhibitory GABA is released, activating a brake on further 5-HT release. (psychscenehub.com)
Looking at the relationship between stress and GABA levels, again, the impact that stress has on dopamine and norepinephrine levels. (biocompatibledentist.org)

They detect serotonin in the synapse, and when it builds up, it binds to the autoreceptors, which shut down serotonin release. (psychscenehub.com)

An autoreceptor acts as a brake on serotonergic transmission. (psychscenehub.com)

As a stress hormone, norepinephrine affects parts of the human brain where attention and responding actions are controlled. (newworldencyclopedia.org)
The chronic administration of citalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. (illumina.com)
If inhibited, it may increase the amount of norepinephrine in the brain. (stackexchange.com)
aged 20-50) to perform direct quantification of regional alpha 2 adrenergic receptors' (α2-ARs) availability in the living human brain. (bvsalud.org)
Thus, the brain sites and receptors involved have been identified, and a possible physiological role of endogenous serotonin in controlling natural patterns of eating and nutrient selection has been defined. (springer.com)
Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. (lookformedical.com)

In addition, the transporter may contribute to dopamine release when the neuron depolarizes. (cloudfront.net)

We hypothesize that the border zone is most vulnerable to alternans, that β-adrenergic receptor stimulation can suppresses this, and investigate the consequences in terms of arrhythmogenic mechanisms. (frontiersin.org)
β-Adrenergic receptor stimulation with norepinephrine (1 μmol/L) attenuated alternans by 60 [52-65]% [interquartile range] and this was reversed with metoprolol (10 μmol/L, p = 0.008). (frontiersin.org)
Simulations also demonstrated that β-adrenergic receptor stimulation in this specific region reduced the formation of conduction block and the probability of premature ventricular activation propagation. (frontiersin.org)
While high levels of overall cardiac sympathetic drive are a negative prognostic indicator of mortality following MI and during heart failure, β-adrenergic receptor stimulation in the infarct border zone reduced spatially heterogeneous alternans, and prevented conduction block and propagation of extrasystoles. (frontiersin.org)
In this study, a rat model of noise-induced hearing loss was developed to investigate the expression of α2A-adrenergic receptor (AR) after acoustic trauma, then, we investigated the expression of α2A-AR in the developing rat cochlea using immunofluorescence, qRT-PCR, and Western blotting. (bvsalud.org)
Beta-blockers, on the other hand, work by blocking beta-adrenergic receptors in the body, which can reduce the physical symptoms of anxiety such as heart palpitations and sweating. (medical-actu.com)

In 1993, a new drug was introduced to the US market called venlafaxine, a serotonin-norepinephrine reuptake inhibitor. (wikipedia.org)

This left me with the most likely interaction: methylphenidate is an NDRI, so it fairly strongly blocks the norepinephrine transporter (NET), and norquetiapine also has a strong blocking effect on NET. (stackexchange.com)

5-HT1D receptors are autoreceptors located on the presynaptic axon terminal and act as negative feedback on the 5-HT release. (psychscenehub.com)

Serotonin-norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant medications used to treat major depressive disorder (MDD), anxiety disorders, obsessive-compulsive disorder (OCD), social phobia, attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms. (wikipedia.org)

They stimulate 5-HT 1 receptors, with antidepressant and anxiolytic effects, but they also stimulate 5-HT 2 receptors, commonly causing anxiety, insomnia, and sexual dysfunction, and 5-HT 3 receptors, commonly causing nausea and headache. (msdmanuals.com)

Cell surface receptors that bind to ACETYLGLUCOSAMINE. (lookformedical.com)

The two mechanisms described above appear at stages of denervation where tonic DA levels and tonic receptor occupancy appear normal. (jneurosci.org)
There is evidence that schizophrenia involves altered levels of dopamine activity, and most antipsychotic drugs used to treat this are dopamine antagonists which reduce dopamine activity. (alchetron.com)
Stress can play a role in attention, and, again, high levels in norepinephrine can trigger on attention and behavior. (biocompatibledentist.org)
So, a lack of nitric oxide can cause aggressive behavior, and we already talked about the relationship between nitric oxide synthase and BH4 levels and also a lack of 5HTP receptor function can play a role.Â So, balance and moderation, whether weâ€™re talking about BH4, NOS, or serotonin. (biocompatibledentist.org)

Antidepressants that have dual mechanisms of action inhibit the reuptake of both serotonin and norepinephrine and, in some cases, inhibit with weak effect the reuptake of dopamine. (wikipedia.org)
What I suspect the interaction is referring to is that both drugs increase norepinephrine through one or more mechanisms (e.g. by inhibiting reuptake and/or increasing production) leading to a potential scenario where a person who takes both drugs may end up having far too much norepinephrine. (stackexchange.com)

Prior work suggests norepinephrine (NE) signaling in the bed nucleus of the stria terminalis (BNST) could have a role in mediating these phenotypes. (nature.com)
This study provides direct evidence for the expression of α2A-AR in HCs, SGNs, and the SV of the cochlea, indicating that norepinephrine might play a vital role in hearing function within the cochlea through α2A-AR. (bvsalud.org)
The stimulation of the H1 receptor is thought to play an important role in mediating arousal. (studylib.net)

The 5-HT receptors are a group of receptors found throughout the central and peripheral nervous systems. (psychscenehub.com)
With the exception of the blood vessels, dopamine in each of these peripheral systems is synthesized locally and exerts its effects near the cells that release it. (alchetron.com)

DAT is implicated in a number of dopamine-related disorders, including attention deficit hyperactivity disorder , bipolar disorder , clinical depression , eating disorders , and substance use disorders . (cloudfront.net)
Restless legs syndrome and attention deficit hyperactivity disorder (ADHD) are associated with decreased dopamine activity. (alchetron.com)

However, there is no evidence that symptoms arise by low extracellular DA concentration or are associated with reduced D 2 receptor binding. (jneurosci.org)
Evidence for the associations between DAT and dopamine related disorders has come from a type of genetic polymorphism , known as a variable number tandem repeat , in the SLC6A3 gene, which influences the amount of protein expressed. (cloudfront.net)

Anorectic activities of serotonin uptake inhibitors: correlation with their potencies at inhibiting serotonin uptake in vivo and 3 H-mazindol binding in vitro. (springer.com)

Outside the central nervous system, dopamine functions primarily as a local chemical messenger. (alchetron.com)

However tyramine-induced mobilization of norepinephrine stores produced elevated ventricular contractility consistent with enhanced sympathetic neuroeffector properties. (tech-strategy.org)
Collectively these studies indicate that under normal culture conditions NE tonically CEP-28122 inhibits sympathetic neurite outgrowth via β1ARs. (tech-strategy.org)

It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE. (lookformedical.com)

Medications for depression affect the transmission of serotonin, norepinephrine, and dopamine. (wikipedia.org)
There are 7 general serotonin receptor classes and another 14 serotonin subtype receptors, most of which are implicated in depression and depressive-like behaviours. (psychscenehub.com)

For example, not enough serotonin and too much norepinephrine have both been linked to aggressive and violent behavior. (holistichelp.net)

The symptoms of excess norepinephrine mimic that of stress, which can lead to increased blood pressure, but it seems odd to refer to that as '[increasing the] toxicity of methylphenidate' - that phrasing implies that some aspect of methylphenidate is already inherently toxic, and that quetiapine somehow specifically amplifies that. (stackexchange.com)

Desensitisation of the presynaptic 5-HT1A receptor restores raphe firing to enhance 5-HT release. (psychscenehub.com)
By blocking these receptors, vortioxetine increases the release of serotonin. (psychscenehub.com)
The partial agonistic activity of vortioxetine at this autoreceptor increases serotonin release. (psychscenehub.com)
In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release. (cloudfront.net)

Several important diseases of the nervous system are associated with dysfunctions of the dopamine system, and some of the key medications used to treat them work by altering the effects of dopamine. (alchetron.com)
In this study, the effects of three endocannabinoids, N-arachidonoyl ethanolamine (AEA), N-arachidonoyl dopamine (NADA) and 2-arachidonoyl glycerol (2-AG), on adipogenesis in hBM-MSCs were evaluated. (koreascience.kr)

Anatomy42

Organisms11

Diseases11

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology6

Phenomena and Processes18

Technology, Industry, Agriculture3

Information Science2

Health Care7

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Neurons13

Neurotransmitters8

Epinephrine10

Agonist8

Histamine4

Neurotransmitter8

Noradrenaline3

Antagonist3

Reuptake of serotonin3

Synthesis4

Neuronal2

Parkinson's1

Pathways8

Catecholamine1

Inhibition3

High-affinity2

Selective3

Cannabinoid2

Dopaminergic1

Serotonin receptors3

Monoamine2

Underlies1

Prefrontal cortex1

Membrane5

SSRIs1

Agonists1

Opioid1

Antagonism2

Gaba2

Binds1

Serotonergic1

Brain6

Neuron1

Adrenergic6

Venlafaxine1

Transporter1

Axon1

SNRIs1

Antidepressant1

Bind1

Levels4

Mechanisms2

Role3

Peripheral2

Attention deficit2

Evidence2

Vivo1

Central nervou1

Sympathetic2

Protein1

Depression2

Behavior1

Symptoms1

Release4

Effects2