• The major urinary metabolite is conjugated oxazepam (3-hydroxynordiazepam), and smaller amounts of conjugated p-hydroxynordiazepam and nordiazepam are also found in the urine. (nih.gov)
  • These tests typically identify BZDs that are metabolized to nordiazepam (desmethyldiazepam) or oxazepam. (medscape.com)
  • Diazepam is metabolized to the active metabolites nordiazepam (desmethyldiazepam) and temazepam, which are in turn metabolized to the active metabolite oxazepam. (nih.gov)
  • The active metabolites nordiazepam, oxazepam, and temazepam achieved levels that are expected to make only minor contributions to the threshold elevations. (cureepilepsy.org)
  • Nordiazepam, temazepam, and oxazepam are the most frequent valium 10mg pill metabolites. (xanaxuse.com)
  • In many cases, yes, Valium and other benzos like oxazepam and nordiazepam are tested for during routine roadside drug testing. (springhillrecovery.com)
  • The primary metabolite, nordiazepam, quickly appears in the blood stream. (nih.gov)
  • Pharmacokinetics of the placental transfer and distribution of clorazepate and its metabolite nordiazepam into the feto-placental unit and in the neonate. (drugs.com)
  • 0.005 mg/L) and its metabolite nordiazepam (0.033 mg/L). Death was attributed primarily to asphyxiation. (erowid.org)
  • Diazepam is excreted into breastmilk and it and its active metabolite, nordiazepam, accumulate in the serum of breastfed infants with repeated doses. (nih.gov)
  • Among benzodiazepine-related deaths in Florida , Valium (or its metabolite nordiazepam) is the second most likely to be present. (floridarehab.com)
  • Nordiazepam, also known as desmethyldiazepam or dealkylprazepam, belongs to the class of organic compounds known as 1,4-benzodiazepines. (nonpsychotoxic.com)
  • Clorazepate is a prodrug of nordiazepam (desmethyldiazepam) which is the primary active metabolite of diazepam. (drugs.com)
  • Since orally administered clorazepate dipotassium is rapidly decarboxylated to form nordiazepam, there is essentially no circulating parent drug. (nih.gov)
  • Plasma levels of nordiazepam increase proportionally with clorazepate dipotassium dose and show moderate accumulation with repeated administration. (nih.gov)
  • After a single 20 mg intramuscular dose of clorazepate in 7 women, milk nordiazepam levels ranged from 7.5 to 15.5 mcg/L at 2 days after the dose and 6 to 12 mcg/L at 4 days after the dose. (drugs.com)
  • 3,4] Concern has also been expressed that nordiazepam may compete with bilirubin for hepatic glucuronide conjugation in the neonate. (drugs.com)
  • Further tests are required to identify the exact substance as it could be either methamphetamine, ketamine, diazepam or nordiazepam. (phuketimes.it)
  • Nordiazepam has been found in infants' serum in levels higher than milk levels, indicating accumulation, and only slightly lower than adult therapeutic levels after diazepam use by the mother. (drugs.com)
  • Average milk levels of diazepam plus nordiazepam were 79 mcg/L after 4 days (total diazepam dosage130 mg) and 130 mcg/L after 6 days (total diazepam dosage 190 mg). (nih.gov)
  • Milk levels of diazepam and nordiazepam did not differ markedly between the collection times and ranged from 17 to 39 mcg/L for diazepam and 19 to 52 mcg/L for nordiazepam. (nih.gov)
  • The average of the pre- and post-feed diazepam milk levels were 185 and 307 mcg/L and average nordiazepam milk levels were 124 and 141 mcg/L on days 14 and 15 during maternal intake of diazepam 40 mg daily. (nih.gov)
  • The average of the pre- and post-feed diazepam milk levels were 200 and 158 mcg/L and average nordiazepam milk levels were 140 and 85 mcg/L on days 23 and 25 during maternal intake of diazepam 30 mg daily. (nih.gov)
  • On day 4, average infant serum levels were 172 mcg/L of diazepam and 243 mcg/L of nordiazepam. (nih.gov)
  • Because the half-life of diazepam and nordiazepam are long, timing breastfeeding with respect to the dose is of little or no benefit in reducing infant exposure. (nih.gov)
  • Breastmilk levels of 27 to 164 mcg/L of diazepam plus nordiazepam were found at various times between 9 days and 3.5 months postpartum during an irregular regimen of 6 to 10 mg daily of oral diazepam in 1 woman. (nih.gov)
  • Nordiazepam, the primary metabolite, quickly appears in the blood and is eliminated from the plasma with an apparent half-life of about 40 to 50 hours. (nih.gov)
  • For example, nordiazepam has a half-life of up to 100 hours. (xanaxuse.com)
  • Sedation in infants has been reported during maternal use of diazepam which has nordiazepam as its active metabolite. (drugs.com)
  • Toxicology tests conducted by Coroner Mitchell Sigal determined that the toxicology reports indicated that Sullivan suffered "acute polydrug intoxication due to combined effects of Oxycodone, Oxymorphone, Diazepam/Nordiazepam and ethanol. (q1057.com)
  • Total nordiazepam", i.e. the sum of clorazepate and its metabolite nordiazepam, was determined by gas-liquid chromatography in maternal blood, umbilical cord blood (both arterial and venous), amniotic fluid and in milk. (nih.gov)
  • The concentrations of clorazepate and its metabolite nordiazepam were determined by electron capture gas liquid chromatography. (nih.gov)
  • The primary metabolite, nordiazepam, quickly appears in the blood stream. (nih.gov)
  • Nordiazepam, the primary metabolite, quickly appears in the blood and is eliminated from the plasma with an apparent half-life of about 40 to 50 hours. (nih.gov)
  • Mull says a blood sample drawn at the scene shows Ericka Fouch had Nordiazepam, amphetamine, meth-amphetamine and THC or marijuana in her system. (wslmradio.com)
  • OMP inhibited the metabolism of DZ to its primary metabolites 4′-hydroxydiazepam, 3-hydroxydiazepam, and nordiazepam to different extents over a range of concentrations (0.3-150 μM), and a competitive inhibition model best fitted the data. (aspetjournals.org)
  • Nordiazepam was found in the milk and in the blood of neonates after breast-feeding had started. (nih.gov)
  • The Defendant's blood contained 220 ng/ml of Nordiazepam. (shubinlaw.com)