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  • NSAIDs
  • The tables below summarize results from a modest number of reports that collectively show no association between use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer disease dementia (AD) and total dementia. (alzrisk.org)
  • including traditional broad-spectrum NSAIDs like ibuprofen and naproxen, cyclooxygenase-2 [COX-inhibitors like celecoxib and rofecoxib, salicylates [aspirin]) and risk of either Alzheimer disease (AD) or all-cause dementia. (alzrisk.org)
  • Interest in a potential role of NSAIDs in AD prevention grew from a hypothesized role for inflammatory and vascular mechanisms in AD pathogenesis (see AlzRisk review of inflammatory biomarkers ). (alzrisk.org)
  • inflammation
  • The underlying cause of the disorder is not fully understood, but there have been several important findings: Abnormally low levels of prostaglandin E2 (PGE2), which is protective for the lungs, has been found in patients with aspirin-induced asthma and may worsen their lung inflammation. (wikipedia.org)
  • respiratory
  • In addition to the typical respiratory reactions, about 10% of patients with AERD manifest skin symptoms like urticaria and/or gastrointestinal symptoms such as abdominal pain or vomiting during their reactions to aspirin. (wikipedia.org)
  • ulcers
  • Use caution with a history of GI disease (bleeding or ulcers), concurrent therapy with aspirin, anticoagulants and/or corticosteroids, smoking, use of alcohol, the elderly or debilitated patients. (wikipedia.org)
  • cause
  • The most common cause of death following an aspirin overdose is cardiopulmonary arrest usually due to pulmonary edema. (wikipedia.org)
  • salicylate
  • The diagnosis of poisoning usually involves measurement of plasma salicylate, the active metabolite of aspirin, by automated spectrophotometric methods. (wikipedia.org)
  • formulation
  • Aspirin, either by itself or in a combined formulation, effectively treats certain types of a headache, but its efficacy may be questionable for others. (wikipedia.org)
  • tablets
  • Effervescent formulations of aspirin, such as Alka-Seltzer or Blowfish, relieve pain faster than aspirin in tablets, which makes them useful for the treatment of migraines. (wikipedia.org)
  • Arachidonic
  • The disorder is thought to be caused by an anomaly in the arachidonic acid metabolizing cascade which leads to increased production of pro-inflammatory cysteinyl leukotrienes, a series of chemicals involved in the body's inflammatory response. (wikipedia.org)
  • among
  • METHODS: We formulated a hypothesis from subgroup analyses in the Physicians' Health Study, a randomized double-blind placebo-controlled trial testing 325 mg of aspirin every other day among 22,071 apparently healthy US male physicians. (biomedsearch.com)
  • The term nonsteroidal distinguishes these drugs from steroids, which, among a broad range of other effects, have a similar eicosanoid-depressing, anti-inflammatory action. (wikipedia.org)
  • RESULTS
  • RESULTS: After 5 years, the blinded aspirin component was terminated early based on the unanimous recommendation of the Data and Safety Monitoring Board. (biomedsearch.com)
  • Agents
  • The two 15-HETE stereoisomers have intrinsic biological activities but, perhaps more importantly, can be further metabolized to a major class of anti-inflammatory agents, the lipoxins. (wikipedia.org)
  • study
  • Conclusions Our study suggests that aspirin may have potential as a chemopreventative agent for HNC however further investigation is warranted. (bmj.com)
  • However
  • However, within the last decade, studies have observed microscopic anatomical changes indicating that plantar fasciitis is actually due to a noninflammatory structural breakdown of the plantar fascia rather than an inflammatory process. (wikipedia.org)
  • The word Aspirin was Bayer's brand name, however their rights to the trademark were lost or sold in many countries. (wikipedia.org)
  • effects
  • A precursor to aspirin in the form of leaves from the willow tree has been used for its health effects for at least 2,400 years. (wikipedia.org)
  • dose
  • A high dose of aspirin (300mg and over) prevents the enzyme cyclo-oxygenase from producing these prostaglandins. (blogspot.com)
  • A lower dose of aspirin blocks cyclo-oxygenase too, but not enough to prevent prostaglandin production. (blogspot.com)
  • They conducted a randomized, controlled trials and concluded that a daily low dose of Aspirin for just 3 to 5 years is enough to lower risk of certain cancers, particularly bowel cancer in people who are at risk. (blogspot.com)
  • lower
  • At lower doses, aspirin prevents cyclo-oxygenase's role in the production of another chemical called thromboxane. (blogspot.com)