• Agents in common clinical use include: Prostaglandin analogs Parasympathomimetic (miotic) agents, including cholinergic and anticholinesterase agents Carbonic anhydrase inhibitors (oral and topical) Adrenergic antagonists (nonselective and selective Beta1-antagonists) Alpha 2 agonists Hyperosmotic agents Nitric oxide donators Rho kinase inhibitors When comparing people with primary open-angle glaucoma and ocular hypertension, medical intraocular pressure lowering treatment slowed down the progression of visual field loss. (wikipedia.org)
  • These include the alpha-2 adrenergic agonists clonidine and guanfacine, the nonselective beta-adrenergic agent propranolol, and most promising prazosin, which is an alpha-1 adrenergic receptor antagonist that blocks the actions of NE on alpha-1 receptors(Petrakis, 2016). (duepapers.net)
  • These agents compete with beta-adrenergic agonists for available beta-receptor sites. (medscape.com)
  • This chapter discusses two groups of drugs that affect the sympathetic nervous system-adrenergic agonists, or sympathomimetics , and adrenergic antagonists, also called adrenergic blockers or sympatholytics -along with their dosages and uses. (basicmedicalkey.com)
  • Intravenous (IV) adrenergic agonists and antagonists are high-alert medications because they can cause significant harm to a patient in the event of a medication error. (basicmedicalkey.com)
  • Drugs that stimulate the sympathetic nervous system are called adrenergic agonists, adrenergics, or sympathomimetics because they mimic the sympathetic neurotransmitters norepinephrine and epinephrine. (basicmedicalkey.com)
  • This usually requires combination therapy with the use of insulin secretagogues, insulin sensitizers (PPAR-gamma agonists), biguanides, alpha-glucosidase inhibitors, and ultimately exogenous insulin. (biomedcentral.com)
  • Ocuphire Pharma and Viatris Announce FDA Approval of RYZUMVI™ (Phentolamine Ophthalmic Solution) 0.75% Eye Drops for the Treatment of Pharmacologically-Induced Mydriasis Produced by Adrenergic Agonists (e.g. (ocuphire.com)
  • Recently, we showed that intrathecal (i.t.) α₁-agonists potentiate α₂-induced spinal antinociception in the rat by a δ-receptor mediated, enkephalin-dependent process. (mun.ca)
  • Nonselective beta-blockers block both beta receptors, whereas cardioselective beta-blockers bind to the beta-adrenoceptor and partially activate the receptor while preventing other receptor agonists from binding. (uspharmacist.com)
  • These include agonists capable of selectively activating β1-, β2- or β3-adrenoceptors, as well as antagonists selective for each of the three subtypes. (sigmaaldrich.com)
  • Albuterol (Ventolin, Proventil), terbutaline (Brethine, Brethaire) and metaproterenol (Metaprel, Alupent) are classified as β 2 -selective adrenergic agonists and as such reduce smooth muscle tone. (pharmacology2000.com)
  • Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. (lookformedical.com)
  • b2-Adrenoceptor protein density was decreased in b2-adrenoceptor agonists in the absence or presence of membrane aorta homogenates of Pnmt-KO mice, and this selective b1- or b2-adrenoceptor antagonists. (marysfamilymedicine.org)
  • Selective FP prostanoid receptor agonist believed to reduce IOP by increasing uveoscleral outflow. (medscape.com)
  • α receptor agonist causes an increase in blood pressure. (pharmacology2000.com)
  • Most β-adrenoceptor mediated actions involve stimulation of adenylyl cyclase via interaction of the agonist-receptor complex with G s . (sigmaaldrich.com)
  • Oxymetazoline is an example of a non-selective α-adrenergic receptor agonist. (pharmacology2000.com)
  • Isoproterenol (Isuprel, Isoprenaline) is a classical nonselective β-adrenergic agonist, with prominent actions at β 1 and β 2 receptors. (pharmacology2000.com)
  • Cirazoline is a full agonist at the α 1A adrenergic receptor , a partial agonist at both the α 1B and α 1D adrenergic receptors, [1] and a nonselective antagonist to the α 2 adrenergic receptor . (wikipedia.org)
  • The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. (lookformedical.com)
  • 1986) also founda diminished response to the nonselective b-adrenoceptor This work was supported by grants from Fundação Professor Ernesto agonist isoproterenol in human neonatal lymphocytes com- Morais [2012, Porto, Portugal] and Porto University [Grant IJUP2011-219]. (marysfamilymedicine.org)
  • A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults. (drugbank.com)
  • A serotonin receptor agonist used to treat migraines and cluster headaches. (drugbank.com)
  • A 5-HT1B/1D receptor agonist used to treat migraines. (drugbank.com)
  • Doxazosin mesylate is a quinazoline compound that is a selective alpha1-adrenergic antagonist. (medscape.com)
  • Adrenergic (non-selective blockade) in addition to its blockade of prorenin → renin conversion. (biomedcentral.com)
  • Potent, non-competitive and non-selective 5-HT 2 antagonist. (abcam.com)
  • Non-selective receptor antagonist. (abcam.com)
  • Selective alpha2-receptor that reduces aqueous humor formation and may increase uveoscleral outflow or inhibit inflow. (medscape.com)
  • Non-selective alpha-blocker medications have additional contraindications. (alldaychemist.com)
  • Non-selective alpha-blockers, including phentolamine and phenoxybenzamine, should not be taken when breastfeeding. (alldaychemist.com)
  • Non-selective alpha-blockers are discovered for short-term use. (alldaychemist.com)
  • In rats pretreated with the non-selective muscarinic-receptor antagonist atropine, BIMP significantly increased both heart rate and blood pressure. (inra.fr)
  • In rats treated with atropine plus hexamethonium, intravenous phentolamine (non-selective alpha-adrenergic receptor antagonist) plus propranolol (non-selective beta-adrenergic receptor antagonist) completely blocked the BIMP-induced increases in blood pressure and heart rate. (inra.fr)
  • β-Adrenoceptor antagonists, either non subtype-selective or selective for the β1-adrenoceptor, are widely used as antihypertensives, although the mechanism for this action is still not clearly understood. (sigmaaldrich.com)
  • this agent is a non-selective receptor blockers. (pharmacology2000.com)
  • An example of an 'irreversible' non-selective α-receptor blocker is phenoxybenzamine (Dibenzyline). (pharmacology2000.com)
  • Yohimbine is classified as a selective α 2 -adrenergic receptor antagonist. (pharmacology2000.com)
  • A beta-2 selective adrenergic antagonist. (lookformedical.com)
  • The was to characterize b-adrenoceptor-mediated relaxation selective b2-adrenoceptor antagonist ICI 118,551 [(6 and facilitation of norepinephrine release in the aorta of KO) mice. (marysfamilymedicine.org)
  • SSRIs are selective to the 5-HT system but not specific for the different 5-HT receptors. (msdmanuals.com)
  • A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. (drugbank.com)
  • It is an alpha1- and alpha2-adrenergic blocking agent that blocks circulating epinephrine and norepinephrine action, reducing hypertension that results from catecholamine effects on alpha receptors. (medscape.com)
  • For example, epinephrine binds to the β2 receptor on bronchial muscle which then activates adenylyl cyclase system releasing cAMP. (egpat.com)
  • epinephrine and isoproterenol might be expected to be effective bronchodilators because of their activity at 2 receptors. (pharmacology2000.com)
  • Beta-blockers bind to beta-adrenoceptors, which inhibit normal sympathetic effects that act through the receptors norepinephrine and epinephrine. (uspharmacist.com)
  • Beta-blockers inhibit the action of epinephrine and norepinephrine on beta-adrenergic receptors , decreasing heart rate and cardiac output. (pharmacologymentor.com)
  • In conclusion, epinephrine is crucial for b2- tritium overflow elicited by electrical stimulation in the adrenoceptor-mediated vasodilation and facilitation of nor- presence of increasing concentrations of nonselective b- or epinephrine release. (marysfamilymedicine.org)
  • At low doses, alpha-adrenergic receptor blockers may be used as monotherapy in the treatment of hypertension. (medscape.com)
  • As a result, concurrent diuretic therapy may be required to maintain the hypotensive effects of alpha-receptor blockers. (medscape.com)
  • Non dihydropyridine calcium channel blocker - antagonists are preferred over dihydropyridine calcium channel blockers - antagonists in CKD. (biomedcentral.com)
  • Nonselective beta-blockers (eg, timolol maleate, levobunolol) are controversial because as visual-field progression is possibly due to secondary aggravated nocturnal arterial hypotension. (medscape.com)
  • For instance, non-depolarising neuromuscular blockers like d-tubocurarine, pancuronium, vecuronium, atracurium and depolarising neuromuscular blocker like suxamethonium all act on nicotinic acetylcholine receptors (nAChR) which are of ionotropic receptors. (egpat.com)
  • Alpha-blockers are medicines to manage and treat hypertension (high blood pressure). (alldaychemist.com)
  • Alpha-blockers, also called alpha-adrenergic blockers, work by preventing a hormone called norepinephrine from tightening the muscles in the walls of arteries and veins. (alldaychemist.com)
  • Alpha-blockers drugs are also used to relax muscles in the urinary tract and may make the stone pass into the bladder quickly. (alldaychemist.com)
  • However, unwanted side effects may be experienced by people using alpha-blockers for kidney stones. (alldaychemist.com)
  • Nonselective alpha-blockers (alpha 1 and alpha 2) include phenoxybenzamine and phentolamine. (alldaychemist.com)
  • Alpha-blockers block the alpha receptors, which are present on cells in specific areas or organs in your body. (alldaychemist.com)
  • Before you take alpha antagonist drugs, inform your doctor of all the medications, such as beta-blockers, calcium channel blockers, or medications for erection disorders. (alldaychemist.com)
  • Alpha-blockers medications can increase or decrease the effects of other medicines you take. (alldaychemist.com)
  • However, studies have found that long-term usage of certain alpha-blockers can increase the risk of heart failure. (alldaychemist.com)
  • Alpha-blockers are contraindicated in individuals with hypersensitivity to alpha blockers or any of the components' formulations. (alldaychemist.com)
  • Caution should be taken when using alpha-blockers for hypertension in elderly patients or if previous cataract surgery. (alldaychemist.com)
  • How long you can take alpha blockers? (alldaychemist.com)
  • Alpha-blockers antagonize alpha-1 adrenergic receptors in vascular smooth muscle, causing vasodilation and reduced peripheral vascular resistance. (pharmacologymentor.com)
  • heavy f rmy bronchial asthma and chronic obstructive pulmonary disease (COPD) in history, - expressed peripheral circulatory disorders, Raynaud's syndrome, - metabolic acidosis, - pheochromocytoma (without the simultaneous use of alpha blockers), - simultaneous reception of monoamine oxidase inhibitors (MAO) (except of inhibitors MAO-B), - the age of 18 years (effectiveness and safety have not been established), - lactose intolerance, lactase deficiency or glucose-galactose syndrome malabsorption. (pharmru.com)
  • Careful preoperative treatment with alpha and beta blockers is required to control blood pressure and prevent intraoperative hypertensive crises. (medscape.com)
  • After primary treatment with an alpha-receptor blocker, propranolol hydrochloride may be used as adjunctive therapy if control of tachycardia becomes necessary before or during surgery. (medscape.com)
  • Results from using an in vitro tissue bath technique indicated that propranolol and preferential beta(2)-adrenoceptor antagonists (ICI-118,551 and butoxamine), in a concentration-dependent manner, blocked the relaxation induced by nicotine (100 microM) without affecting the relaxation elicited by transmural nerve stimulation (TNS, 8 Hz). (lookformedical.com)
  • Propranolol is a nonselective, beta-adrenergic receptor-blocking agent possessing no other autonomic nervous system activity. (ncats.io)
  • Propranolol exerts its antiarrhythmic effects in concentrations associated with beta-adrenergic blockade, and this appears to be its principal antiarrhythmic mechanism of action. (ncats.io)
  • Its drug action is transient and alpha-adrenergic blockade incomplete. (medscape.com)
  • Carvedilol, a molecule combining nonselective β-adrenoceptor blockade with α 1 -adrenoceptor blockade, has recently been shown to produce a dramatic reduction in the mortality/morbidity associated with congestive heart failure. (sigmaaldrich.com)
  • Reversible blockade suggests that the inhibitor dissociates from the receptor relatively easily. (pharmacology2000.com)
  • By analyzing specific amino acid mutations of the α 2A - receptor with respect to changes in PB binding, certain sites were identified that may serve as the molecular target for phenoxybenzamine-mediated receptor blockade. (pharmacology2000.com)
  • The net physiologic effect of beta-adrenergic blockade is usually advantageous and is manifested during exercise by delayed onset of pain and increased work capacity. (ncats.io)
  • It inhibits postsynaptic alpha-adrenergic receptors, resulting in the vasodilation of veins and arterioles and a decrease in total peripheral resistance and blood pressure. (medscape.com)
  • Since 2 receptors are activated at lower, physiological concentrations, vasodilation results. (pharmacology2000.com)
  • ARBs selectively block the binding of angiotensin II to its receptor, leading to vasodilation and reduced aldosterone secretion. (pharmacologymentor.com)
  • Distribution of adrenergic receptor subtypes and adrenergic receptor number are important factors in organ or cellular responses to adrenergic input. (pharmacology2000.com)
  • While it was initially thought that cardiac stimulation involved primarily the β1-adrenoceptor, it now appears that all of the receptor subtypes may be involved. (sigmaaldrich.com)
  • There are actually three human α 2 -adrenoreceptor subtypes and the amino acid sequences between them are highly conserved within the seven hydrophobic TM domains. (pharmacology2000.com)
  • Phenoxybenzamine (PB) has been used to probe α-adrenergic receptor subtypes. (pharmacology2000.com)
  • By preventing reuptake of 5-HT presynaptically, SSRIs result in more 5-HT to stimulate postsynaptic 5-HT receptors. (msdmanuals.com)
  • Clonidine activates another type of adrenergic receptor, designated α 2 . (pharmacology2000.com)
  • Activation of this receptor type centrally reduces sympathetic outflow, which is the proposed mechanism that accounts for antihypertensive actions noted following clonidine administration. (pharmacology2000.com)
  • Intra-ocular administration of nonselective β-adrenoceptor antagonists is a common treatment for glaucoma. (sigmaaldrich.com)
  • Fotil is a combination drug consisting of: Pilocarpine, a parasympathomimetic Timolol, a beta-adrenergic receptor antagonist Basic and clinical science course (2011-2012). (wikipedia.org)
  • Solution containing 2 mg/mL brimonidine tartrate and 5 mg/mL timolol. (nih.gov)
  • Drugs can bind to the various protein targets among which G-protein coupled receptors (GPCR) hold their flagship. (egpat.com)
  • Then, can we include all drugs acting on receptors into the list? (egpat.com)
  • Few of the drugs act on receptor coupled with ion channels again not fall into the list. (egpat.com)
  • These receptors, commonly called as ionotropic receptors, are not GPCR hence all drugs acting on these should be properly differentiated. (egpat.com)
  • Similar is the case with many drugs acting on these receptors. (egpat.com)
  • These alpha-blocker drugs may also be used to treat essential hypertension. (alldaychemist.com)
  • When you start taking alpha-antagonist drugs, you might develop low blood pressure or dizziness, making you faint when standing in a sitting or lying position. (alldaychemist.com)
  • Do alpha-blocker drugs interact with other medicines? (alldaychemist.com)
  • Some alpha-antagonist drugs may also interact with citrus juices, alcohol, or other foods. (alldaychemist.com)
  • Phenylephrine and methoxamine are examples of drugs that selectively activate α 1 -adrenergic receptors (adrenomimetic). (pharmacology2000.com)
  • Whereas the above two example drugs show α-adrenergic receptor selectivity (α 1 vs. α 2 ), oxymetazoline activates both α 1 and α 2 adrenergic receptors. (pharmacology2000.com)
  • Drugs that bind to and block the activation of ADRENERGIC BETA-2 RECEPTORS. (lookformedical.com)
  • Drugs that selectively bind to and activate beta-adrenergic receptors. (lookformedical.com)
  • Several randomized controlled trials have found that the alpha-1 blocker prazosin is effective in reducing symptoms of posttraumatic stress disorder (PTSD) among active-duty soldiers(Roundup, 2017). (duepapers.net)
  • The alpha 2 antagonist includes the medicines dioxin and yohimbine. (alldaychemist.com)
  • Benzyl derivative 11 showed excellent COX-2 inhibition with the IC50 value of 5.79 μM and SI value 7.96. (technoplus.ro)
  • Among the factors that may be involved in contributing to the antihypertensive action include: (1) decreased cardiac output, (2) inhibition of renin release by the kidneys, and (3) diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain. (ncats.io)
  • α receptor dominate in the cutaneous vascular beds. (pharmacology2000.com)
  • Both α and β adrenergic receptor are present in skeletal muscle vascular beds. (pharmacology2000.com)
  • Total peripheral vascular resistance at the beginning of the drug in the first 24 hours, is increased (as a result of reciprocal increase in the activity of alpha-adrenoceptor stimulation and removal of beta-2 adrenergic receptor), after 1-3 days returned to the initial value, and long-term use - is reduced. (pharmru.com)
  • What does receptor selectivity allow for? (brainscape.com)
  • These data indicate that μ- and δ-receptor selectivity was retained during infusion, consistent with the different cross-tolerance results to NE. (mun.ca)
  • The role and mechanism of action of α₁-adrenoceptors in adrenergic spinal antinociception is uncertain. (mun.ca)
  • The results of this study are consistent with the hypothesis that α₁-adrenoceptors facilitate the release of enkephalins in the spinal cord which, in turn, effect antinociception by a δ-receptor mechanism. (mun.ca)
  • Oral or intravenous calcium antagonists may cause atrioventricular conduction disturbances, left ventricular failure, and hypotension. (nih.gov)
  • Selectively blocks beta1-adrenergic receptors with little or no effect on beta2-receptors. (medscape.com)
  • Dobutamine is an example of a drug that selectively stimulates the heart via β 1 receptors, although dobutamine also has activity at α adrenergic receptors as well. (pharmacology2000.com)
  • It is common to take an alpha medicine indefinitely for conditions like enlarged prostate and hypertension. (alldaychemist.com)
  • 2 While studies have shown that the rates of hypertension in the elderly have not changed since 1999, the number of elderly affected continues to grow due to this aging population. (uspharmacist.com)
  • When hypertension effect develops after 2-5 days, stable operation is noted after 1-2 months. (pharmru.com)
  • In the MIRA-2 and MIRA-3 trials, a total of 553 subjects aged 12 to 80 years, who had mydriasis induced by instillation of phenylephrine or tropicamide or a combination of hydroxyamphetamine hydrobromide and tropicamide (Paremyd) were randomized. (ocuphire.com)
  • For example, if a particular cysteine residue located in the TM3 domain was changed to valine (by mutation), the receptor becomes resistant to phenoxybenzamine inactivation. (pharmacology2000.com)
  • This cysteine (at position 117) appears important in the association of phenoxybenzamine with receptor with PB likely covalently coupled to this amino acid. (pharmacology2000.com)
  • α receptor activation causes vasoconstriction. (pharmacology2000.com)
  • It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. (lookformedical.com)
  • It may be used to treat excessive beta-receptor stimulation in patients with inoperable metastatic pheochromocytoma. (medscape.com)
  • Stimulation of the beta 1 receptors increases myocardial contractility and heart rate. (basicmedicalkey.com)
  • [4] [5] However, in preliminary studies, through stimulation of α 2 adrenoceptors, working memory is comparatively improved. (wikipedia.org)
  • Blocking in low doses of beta 1-adrenergic receptors of the heart, stimulated by catecholamines reduces the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP), the current lowers intracellular calcium ions, inhibits all heart functions reduces atrioventricular (AV) conduction and excitability. (pharmru.com)
  • In the U.S., an estimated 100 million comprehensive eye exams take place each year that involve pharmacologically-induced mydriasis (or dilation) of the pupils 1 , which can last up 24 hours 2 . (ocuphire.com)
  • Side effects of pharmacologically-induced mydriasis include sensitivity to light (photophobia) 2 and blurred vision 2 , which may make it difficult to read, work and drive. (ocuphire.com)
  • Pharmacologically-induced mydriasis can last up to 24 hours in adults and children 2 . (ocuphire.com)
  • In atropine-treated rats, hexamethonium (antagonist of ganglionic nicotinic receptors) greatly attenuated the BIMP-induced increase in blood pressure without changing the BIMP-induced increase in heart rate. (inra.fr)
  • In subsequent cross-tolerance experiments, NE and DX dose-response curves were determined on days 1 and 2 PI for DADLE-pretreated rats, and on days 1-3 PI in MOR-pretreated rats. (mun.ca)
  • [3] Administration of cirazoline also seemed to present impairment in the spatial memory of monkeys through the activation of the same receptors that showed decreased food intake in rats. (wikipedia.org)
  • Noradrenaline bitartrate is an endogenous adrenergic hormone and neurotransmitter. (tocris.com)
  • Other adrenergic receptors are dopaminergic and are located in the renal, mesenteric, coronary, and cerebral arteries. (basicmedicalkey.com)
  • Furthermore, the possible roles of adrenergic and dopaminergic receptors were also studied. (technoplus.ro)
  • Our compounds were not active in dopaminergic and adrenergic pathways and so were acting centrally. (technoplus.ro)
  • Preoperatively, prepare patients with pheochromocytomas by treating them with an alpha-blocker or a tyrosine hydroxylase inhibitor, such as metyrosine, for 1-2 weeks, after which administration of a beta-blocker can be considered. (medscape.com)
  • Since all reactions are, by definition, reversible, those reactions in which the inhibitor and receptor complex is so stable that dissociation is unlikely are described as 'irreversible. (pharmacology2000.com)
  • A receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). (drugbank.com)
  • Imatinib is a 2-phenyl amino pyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. (keralapharmacist.com)
  • They stimulate 5-HT 1 receptors, with antidepressant and anxiolytic effects, but they also stimulate 5-HT 2 receptors, commonly causing anxiety, insomnia, and sexual dysfunction, and 5-HT 3 receptors, commonly causing nausea and headache. (msdmanuals.com)
  • The -Adrenergic Receptors and the Control of Adipose Tissue Metabolism and Thermogenesis. (sigmaaldrich.com)
  • The beta-3 adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS. (lookformedical.com)
  • Cervical vertebrae 1,2, …?Ca: Calcium?Ca: Cancer?Ca: Carcinoma?Ca: Cardiac arrest?Ca: Coronary artery?CA-125: A tumor marker for ovarian cancer?CAB: Cellulose acetate butyrate?CABG: Coronary artery bypass graft?CACI: Computer-Assisted Continuous Infusion?CAD: Coronary artery disease?CAG: ?CAH: Chronic active hepatitis?CAH: Congenital adrenal hyperplasia?calid. (kuwaitpharmacy.com)
  • The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS. (lookformedical.com)
  • The alpha 2 receptors are located in the postganglionic sympathetic nerve endings. (basicmedicalkey.com)
  • that is, of the 182 amino acids defining the TM domains of the human α 2A -adrenergic receptors, about 40% are identical with the human β 2 -adrenergic receptors. (pharmacology2000.com)
  • It is used primarily in animal and tissue experiments to characterize BETA-2 ANDRENERGIC RECEPTORS. (lookformedical.com)
  • However, in contrast to the prejunctional α 2 -adrenoceptors, these prejunctional receptors do not appear to have major physiologic significance. (sigmaaldrich.com)
  • Digitalis and calcium antagonists may have additive effects in prolonging atrioventricular conduction time. (nih.gov)
  • A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. (drugbank.com)