CollagenExtracellular matrix pGlycoproteinOsteocalcinMineralization processPeptidesGeneCartilageLipidsAntigenicGenesFragmentsCollagenousGlycosaminoglycanDegradationFibrosisEnzymesDepositionPolypeptideConnectiveStructuralMammalianMRNADisulfideFormationDomainMutantConcentrationsMatrixCellularDomainsImmuneDensitySubunitsCalcificationPresenceLarge
Collagen11
- It has a special configuration that gives particular elastic properties to protein: collagen fibers are located in the extracellular matrix and have the capacity to increase or reduce their volume according to the degree of compression to which they are subjected. (springer.com)
- Markers of bone resorption include collagen degradation products, non-collagenous proteins, osteoclastic enzymes, and osteocyte activity markers. (saveourbones.com)
- Two compounds, Compound 1 (1,4-dihydrophenanthrolin-4-one-3-carboxylic acid) and Compound 5 [8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenathrolin-4-one-3-carboxylic acid], with comparable potencies in vivo, were chosen to investigate the effect of the inhibition of the hydroxylation of newly synthesized uterine collagen on the turnover of this protein in vivo. (embl.de)
- Taken with the present results, this suggests that the potential use of inhibitors of prolyl 4-hydroxylase to control excessive collagen deposition in pathological fibrosis may be limited by the need to maintain continuous inhibition of collagen hydroxylation so as to facilitate intracellular degradation of the accumulated protein. (embl.de)
- In addition, type V collagen, proteoglycans and other non-collagenous proteins (serum proteins, phosphoproteins and Gla-proteins) are also secreted. (intelligentdental.com)
- Comparative analysis of the noncollagenous NC1 domain of type IV collagen: identification of structural features important for assembly, function, and pathogenesis. (ox.ac.uk)
- When bone is rapidly induced by recombinant human bone morphogenetic protein-2 (rhBMP-2), more noncollagenous proteins (NCPs) are accommodated among the collagen meshwork. (nii.ac.jp)
- The collagen in tendons are held together with proteoglycan (a compound consisting of a protein bonded to glycosaminoglycan groups, present especially in connective tissue) components including decorin and, in compressed regions of tendon, aggrecan , which are capable of binding to the collagen fibrils at specific locations. (handwiki.org)
- During the secretion of collagen type I, the osteoblasts also secret non-collagenous proteins (NCPs) that regulate the mineralization process. (tue.nl)
- There are a number of promising candidates, notably urinary C-terminal telopeptide of collagen type II and serum cartilage oligomeric protein, although none is sufficiently discriminating to differentiate between individual patients and controls (diagnostic) or between patients with different disease severities (burden of disease), predict prognosis in individuals with or without osteoarthritis (prognostic) or perform so consistently that it could function as a surrogate outcome in clinical trials (efficacy of intervention). (nordicbioscience.com)
- Binding to other ECM proteins such as collagen appears to depend on divalent cations. (utsouthwestern.edu)
Extracellular matrix p1
- It should play a role in the structural integrity of cartilage by its interaction with other extracellular matrix proteins and can be part of the interaction of the chondrocytes with the matrix and it is also a potent suppressor of apoptosis in chondrocytes. (wikipedia.org)
Glycoprotein2
- COMP is a non-collagenous glycoprotein and is belongs to the thrombospondin family of extracellular proteins. (prospecbio.com)
- Large, noncollagenous glycoprotein with antigenic properties. (bvsalud.org)
Osteocalcin8
- Osteocalcin is a small protein (49 amino acids) synthesized by mature osteoblasts, odontoblasts, and hypertrophic chondrocytes. (medscape.com)
- Over the past two decades, French geneticist and physician Gerard Karsenty has been studying the protein osteocalcin, which is found in high concentrations in the skeleton. (meltmethod.com)
- Osteocalcin, also known as bone gamma carboxyglutamic acid and contains protein (BGLAP), is a non-collagenous protein found in bone and dentin. (meltmethod.com)
- Osteocalcin is a messenger protein sent by the bone to the brain to regulate many crucial processes in the body. (meltmethod.com)
- Granted osteocalcin isn't the only hormone or protein that plays a role in regulating insulin, fertility, and brain function but it does seem to be a very relevant element in many brain functions and neurotransmission. (meltmethod.com)
- Bone gamma-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. (joplink.net)
- Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent g-carboxyglutamic acid residues. (joplink.net)
- Osteocalcin is a noncollagenous, 49 amino acid glutamate-rich polypeptide bone matrix protein with a molecular weight of about 5800 kDa. (medscape.com)
Mineralization process2
- A temporal correlation was established between quantified gene expression of DMP1 and IBSP, and the presence of hydroxyapatite, confirming the contribution of these proteins to the mineralization process. (sorbonne-universite.fr)
- The mineralization process of the extracellular matrix is controlled by the function of various inductive and reductive non-collagenous proteins, which initiate and control the formation and the growth of hydroxyapatite crystals. (intelligentdental.com)
Peptides2
- A variety of growth factors (GFs)-including bone morphogenetic protein (BMP), platelet-derived growth factor (PDGF), and peptides of the parathyroid hormone (PTH)-have been tested for local bone regeneration. (allenpress.com)
- Unlike other calcium supplements on the market, Ossopan consists of collagenous and non-collagenous proteins and peptides. (acuatlanta.net)
Gene2
- however, rabbit antibodies raised against the recombinant proteins encoded by the gene of mouse bullous pemphigoid antigen 2 (BP180) are capable of inducing blisters in newborn mice in a complement-dependent manner. (medscape.com)
- The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. (utsouthwestern.edu)
Cartilage2
- MATN3 protein may play a role in the formation of the extracellular filamentous networks and in the development and homeostasis of cartilage and bone. (wikipedia.org)
- Matrilin-1 is a non-collagenous cartilage matrix protein. (medjournal360.com)
Lipids1
- Among endogenous antioxidants, enzymes such as catalase, superoxide dismutase, and glutathione peroxidase are central to disabling free radicals, thereby preventing oxidative damage to cellular lipids, proteins, and nucleic acids. (bvsalud.org)
Antigenic1
- One antigenic site, comprising 14 amino acids of the BP180 noncollagenous (NC) 16A domain, was shown to be recognized by 60% of BP sera and by 63% of HG sera tested. (unboundmedicine.com)
Genes2
- On long term cultures human bone cells seeded on the osteoid-like matrix displayed a clear osteoblast phenotype as revealed by the osteoblast-like morphology, expression of specific protein such as alkaline phosphatase and expression of eight genes classically considered as osteoblast markers, including BGLAP, COL1A1, and BMP2. (sorbonne-universite.fr)
- Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)
Fragments1
- Utilize Nordic Bioscience's proprietary biomarker technology to measure specific protein fragments. (nordicbioscience.com)
Collagenous10
- A cell culture system is here proposed opening new integrative studies on biomineralization, improving our knowledge on the role played by non-collagenous proteins in bone. (sorbonne-universite.fr)
- The research done under the cooperative research agreement for the project titled 'The structure and function of non-collagenous bone proteins' represented the first phase of an ongoing program to define the structural and functional relationships of the principal noncollagenous proteins in bone. (psu.edu)
- Based on sequence analysis the BP180 Ag was predicted to be a transmembrane protein with a long extracellular collagenous domain. (unboundmedicine.com)
- Thus, the long, C-terminal collagenous domain of this basal keratinocyte protein projects into the basal lamina and may function as a site of interaction with an extracellular matrix component. (unboundmedicine.com)
- In this chapter we attempt to provide a general overview of the many new roles of this non-collagenous protein. (benthamscience.com)
- The non-collagenous matrix proteins may act as mediators of cell-matrix interactions, matrix maturation and mineralization. (intelligentdental.com)
- As a result of odontoblastic activity, some non-collagenous proteins are secreted and the density of the collagenous network increases before the dentin mineralization front. (intelligentdental.com)
- Non-collagenous proteins could be involved in the nucleation of calcium- and phosphate crystals (hydroxyapatite) and may also control the initial growth and orientation of the ionic nucleus. (intelligentdental.com)
- Increase in concentration, with the appearance of distinctive non-collagenous proteins. (wikimsk.org)
- Other biomarkers are related to non-collagenous proteins, inflammation and/or fibrosis. (nordicbioscience.com)
Glycosaminoglycan1
- Indeed, these cells have the capacity to synthesize matrix components, including proteins and glycosaminoglycan chains. (healthcoach.clinic)
Degradation1
- Biochemical monitoring of bone metabolism depends upon measurement of enzymes and proteins released during bone formation and of degradation products produced during bone resorption. (medscape.com)
Fibrosis2
- We analyzed liver fibrosis using several molecular and biochemical techniques (Q-PCR, Western blotting, and semi-quantitative immunohistochemistry on ECM proteins). (vin.com)
- Prolonged overexpression of TGF-β1 suppresses cell proliferation, is pro-apoptotic, and induces a deposition of ECM proteins, resulting in fibrosis in major organs such as the liver. (vin.com)
Enzymes1
- Osteoclastic enzymes are secreted by osteoclasts to break down bone matrix proteins. (saveourbones.com)
Deposition1
- Among persisting questions on bone calcification, a major one is the link between protein expression and mineral deposition. (sorbonne-universite.fr)
Polypeptide1
- A polypeptide substance comprising about one third of the total protein in mammalian organisms. (lookformedical.com)
Connective2
- Collagens are a big family of proteins, the main one forming connective tissue in all higher animals. (springer.com)
- Connective tissues contain a mixture of cells, proteins, complex polysaccharides and inorganic constituents. (springer.com)
Structural2
- SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
- We report comparative sequence analyses and structural predictions of the noncollagenous C-terminal globular NC1 domain (28 sequences). (ox.ac.uk)
Mammalian2
MRNA1
- Expression of mouse zonadhesin mRNA is evident only within the testis, and the protein is found exclusively on the apical region of the sperm head. (embl.de)
Disulfide1
- Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
Formation1
- 4. Express site-specific mutant proteins and domains of wild-type proteins to enhance likelihood of crystal formation for subsequent solution of structure. (psu.edu)
Domain4
- 73% (11/15) of BP sera and 100% (8/8) of HG sera reacted with at least one of three BP180 fusion proteins representing various portions of the NC16A domain. (unboundmedicine.com)
- Taxonomic distribution of proteins containing VWD domain. (embl.de)
- The complete taxonomic breakdown of all proteins with VWD domain is also avaliable . (embl.de)
- Click on the protein counts, or double click on taxonomic names to display all proteins containing VWD domain in the selected taxonomic class. (embl.de)
Mutant1
- To examine the role of OPN in vascular calcification, OPN mutant mice were crossed with matrix Gla protein (MGP) mutant mice. (silverchair.com)
Concentrations1
- The aim of this in vitro study was to optimize the concentrations of these 2 proteins. (karger.com)
Matrix2
- Gentle processing is used to retain the delicate protein matrix and organic factors. (acuatlanta.net)
- A pig sperm protein that binds to the extracellular matrix of the egg in a species-specific manner was recently identified and named zonadhesin (Hardy, D. M., and Garbers, D. L. (1995) J. Biol. (embl.de)
Cellular1
- Using a fluorescent sulfhydryl probe as well as a sulfhydryl inhibitor, one observes a strong cell density response, supporting the hypothesis that cellular redox potential could alter protein stability. (embl.de)
Domains3
- There are 25698 VWD domains in 12416 proteins in SMART's nrdb database. (embl.de)
- Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. (embl.de)
- Results Nineteen unrelated probands with isolated AI (no co-segregating features) had 17 heterozygous, potentially pathogenic COL17A1 variants, including missense, premature termination codons, frameshift and splice site variants in both the endo-domains and the ecto-domains of the protein. (bmj.com)
Immune1
- Although anatomy likes to cut things up and make systems seem separate and unique, there are many proteins like cytokins that also play a role in both our immune system and our nervous system. (meltmethod.com)
Density1
- This control is propagated through the alpha-subunit of prolyl 4-hydroxylase where protein levels were previously shown to rise fivefold with increasing cell density. (embl.de)
Subunits1
- The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)
Calcification1
- The role of posttranslational modifications and proteolytic processing has been studied in some detail, and OPN has been recognized as an integrin-binding protein that is involved in multiple biological processes such as arterial calcification, cardiovascular disease, inflammation and cancer. (benthamscience.com)
Presence1
- 5] Removal of the protein fraction appears to reduce the positive effects of the formula, highlighting the importance of its presence. (acuatlanta.net)
Large1
- VWF is a large multidomain protein. (embl.de)