Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered white blood cell count (leukopenia, most commonly of neutrophils) and thus causing neutropenia in the circulating blood. (wikipedia.org)
To be precise, neutropenia is the term normally used to describe absolute neutrophil counts (ANCs) of less than 500 cells per microlitre, whereas agranulocytosis is reserved for cases with ANCs of less than 100 cells per microlitre. (wikipedia.org)
Approximately 1 month into his hospital stay, the patient developed severe isolated neutropenia. (journalmc.org)
Many medications have been implicated as causal agents of neutropenia, but only one case has been reported describing isolated neutropenia induced by amiodarone [ 18 ]. (journalmc.org)
List medications that can cause neutropenia and thrombocytopenia, and state drugs that are useful for neutropenia. (ashp.org)
Granulocytopenia3
for these reasons, granulocytopenia is a more etymologically consistent term, and as such, is sometimes preferred to "agranulocytosis" (which can be misinterpreted as "agranulocyt-osis", meaning proliferation of agranulocytes (i.e. lymphocytes and monocytes). (wikipedia.org)
Agranulocytosis implies a more severe deficiency than granulocytopenia. (wikipedia.org)
Furthermore, amiodarone can induce immunological manifestations such as anti-amiodarone antibodies, lupus-like syndrome, immune-mediated thrombocytopenia, Coombs-positive hemolytic anemia (in canines), and vasculitis [ 12 - 17 ]. (journalmc.org)
16 Guest I, Sokoluk B, MacCrimmon J, Utrecht J. Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis. (thieme-connect.de)
Acute1
Prior studies reported high guideline adherence for secondary prevention medications (SPM) at hospital discharge in patients with acute myocardial infarction (AMI). (efim.org)
Clinically2
Agranulocytosis may be asymptomatic, or may clinically present with sudden fever, rigors and sore throat. (wikipedia.org)
In patients with clinically and biologically controlled disease, we aimed to assess how. (efim.org)
Blood3
In agranulocytosis, the concentration of granulocytes (a major class of white blood cells that includes neutrophils, basophils, and eosinophils) drops below 200 cells/mm3 of blood. (wikipedia.org)
7 Hummer M, Kurz M, Barnas C, Saria A, Fleischhacker W W. Clozapine-induced transient white blood count disorders. (thieme-connect.de)
a blood test used to measure the degree of anticoagulation in a patient taking warfarin. (ashp.org)
Human2
13 Claas F H, Abbott P A, Witvliet M D, D'Amaro J, Barnes P M, Krupp P. No direct clinical relevance of the human leucocyte antigen (HLA) system in clozapine-induced agranulocytosis. (thieme-connect.de)
15 Buchmann N, Strous R D, Ulman A M, Lerner M, Kotler M. Olanzapine-induced leukopenia with human leukocyte antigen profiling. (thieme-connect.de)
Class1
The development of modern second generation antipsychotics such as olanzapine, risperidone, quetiapine, amisulpride, ziprasidone or aripiprazol, however, makes it possible to use the positive effects of this class of drugs without the risks of a clozapine treatment. (thieme-connect.de)
Associated with antithyroid drug-induced agranulocytosis2
We aimed to identify genetic variants associated with antithyroid drug-induced agranulocytosis in a white European population. (scilifelab.se)
Three SNPs were strongly associated with antithyroid drug-induced agranulocytosis: rs652888 (OR 4·73, 95% CI 3·00-7·44, p=1·92 × 10(-11)) and rs199564443 (17·42, 7·38-41·12, p=7·04 × 10(-11)), which were independent of HLA-B*27:05, and rs1071816 (5·27, 3·06-9·10, p=2·35 × 10(-9)) which was in moderate linkage disequilibrium with HLA-B*27:05. (scilifelab.se)
Antithyroid drugs4
summarized the literature in 2002 and reported drug-induced neutropenia in a broad range of drug classes including antimicrobials, analgesics, antipsychotics and sedatives, anticonvulsants, antithyroid drugs, cardiovascular drugs, and antihistamines. (medscape.com)
Genome-wide association studies (GWASs) in ethnic Chinese people in Taiwan and Hong Kong have shown an association between agranulocytosis induced by antithyroid drugs and the HLA alleles HLA-B*38:02 and HLA-DRB1*08:03. (scilifelab.se)
Drug-specific analysis showed that the association with HLA-B*27:05 was largely driven by cases induced by antithyroid drugs. (scilifelab.se)
20181
We analyzed the data of 551,975 elderly patients with PD between 2002 and 2018. (frontiersin.org)
Granulocytopenia2
for these reasons, granulocytopenia is a more etymologically consistent term, and as such, is sometimes preferred to "agranulocytosis" (which can be misinterpreted as "agranulocyt-osis", meaning proliferation of agranulocytes (i.e. lymphocytes and monocytes). (wikipedia.org)
Agranulocytosis implies a more severe deficiency than granulocytopenia. (wikipedia.org)
Infection1
Although the reaction is generally idiosyncratic rather than proportional, experts recommend that patients using these drugs be told about the symptoms of agranulocytosis-related infection, such as a sore throat and a fever. (wikipedia.org)
Given these findings, a practical approach is to monitor white blood cell (WBC) count with a differential (including absolute neutrophil count) once a week in patients who are receiving vancomycin for more than 7 days. (medscape.com)
We did a GWAS in 234 European adults with any non-chemotherapy drug-induced agranulocytosis (absolute neutrophil count ≤0·5 × 10(9)/L [≤500/μL]) and 5170 population controls. (scilifelab.se)
Cases1
Cases with significant confounders and those in which authors provided minimal information about patients were also excluded. (medscape.com)
European1
In white European people, antithyroid drug-induced agranulocytosis was associated with HLA-B*27:05 and with other SNPs on chromosome 6. (scilifelab.se)
Terms1
In terms of TCAs users, compared with patients not receiving TCAs, current users had a lower risk of incident pneumonia (adjusted odds ratio [ aOR ] = 0.86, 95% CI = 0.82-0.90) and recent users (a OR = 0.83, 95% CI = 0.80-0.87). (frontiersin.org)
White1
In agranulocytosis, the concentration of granulocytes (a major class of white blood cells that includes neutrophils, basophils, and eosinophils) drops below 200 cells/mm3 of blood. (wikipedia.org)
ADMINISTRATION1
The Drug Enforcement Administration reported that, as of February 2010, 71% of seized cocaine lots coming into the US contained levamisole as a cutting agent. (wikipedia.org)
Risk3
To avoid one case of agranulocytosis, based on the possible risk reduction if all three SNPs are genotyped and carriers are treated or monitored differently from non-carriers, roughly 238 patients would need to be genotyped. (scilifelab.se)
The patients with Parkinson's disease (PD) are associated with a higher risk of pneumonia. (frontiersin.org)
The study investigated the risk of pneumonia associated with the use of antidepressants in elderly patients with PD. (frontiersin.org)
Data1
This study proposes a quantitative 2-stage procedure to detect potential drug-induced liver injury (DILI) signals in pediatric inpatients using an data warehouse of electronic health records (EHRs). (nih.gov)
Introduction1
[ 5-8 ] The first 2 case reports were published by Dangerfield and colleagues in 1960, shortly after the introduction of the drug. (medscape.com)