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  • tubulin
  • Microtubules nucleated from γ-tubulin ring complexes located at the centrosome regulate the localization of organelles, promote vesicular transport and direct cell migration. (biologists.org)
  • Microtubules are nucleated from γ-tubulin ring complexes (γ-TuRCs) present in the PCM ( Luders and Stearns, 2007 ). (biologists.org)
  • Expression of a construct encoding the ninein C-terminus displaced endogenous ninein and the γ-tubulin ring complex (γ-TuRC) from the centrosome, leading to microtubule nucleation and anchoring defects. (biologists.org)
  • Spc98p colocalizes with γ-tubulin at the nuclear surface where microtubules are nucleated on isolated tobacco nuclei and in living cells. (biologists.org)
  • Spc98p is not associated with γ-tubulin along microtubules. (biologists.org)
  • Microtubule nucleation involving Spc98p-containing γ-tubulin complexes could then be conserved among all eukaryotes, despite differences in structure and spatial distribution of microtubule organizing centers. (biologists.org)
  • Unlike γ-tubulin, plant Spc98p is not detected along MTs, suggesting that plant γ-tubulin may have a role that is independent of MT nucleation at these sites. (biologists.org)
  • We show that Spc98p and γ-tubulin colocalize at MT nucleation sites on the nuclear surface. (biologists.org)
  • Microtubules are semirigid tube-like polymers built up from tubulin subunits composed of a 1:1 heterodimer of α- and β-tubulin. (rupress.org)
  • Microtubules grow by the addition of GTP-bound αβ-tubulin heterodimers to their ends. (biochemistry.org)
  • A ) Microtubules are tubular filaments assembled from αβ-tubulin heterodimers arranged head-to-tail in 13 helically arranged protofilaments. (biochemistry.org)
  • Catastrophe, i.e. transition to shrinkage occurs when the GTP cap is lost and GDP-tubulin is exposed at the microtubule end. (biochemistry.org)
  • Therefore, free tubulin subunits would be expected to have better access to the plus end of a sliding microtubule, and a catastrophe by a subunit occlusion model seems unlikely. (sdbonline.org)
  • mitotic
  • Mitotic apparatus, which comprises hundreds of microtubules, plays an essential role in cell division, ensuring the correct segregation of chromosomes into each daughter cell. (spiedigitallibrary.org)
  • However, the discrimination of discrete microtubule filaments within the mitotic apparatus is beyond the capabilities of conventional light microscopic technologies. (spiedigitallibrary.org)
  • arrays
  • Microtubules form specialized arrays with important functions in cell division, cell migration, trafficking and cell morphogenesis. (grantome.com)
  • Radial arrays of centrosome-anchored microtubules are typical for proliferating and migrating animal cells. (grantome.com)
  • Formation of organized microtubule arrays is crucial for faithful chromosome segregation and cell differentiation, safeguarding cells against aneuploidy and cancer. (grantome.com)
  • To comprehend the events that underlie cell differentiation and development of tissue architecture, it is important to understand how diverse microtubule arrays are organized. (rupress.org)
  • radial
  • In cells with a radial microtubule system, a pivotal role in setting up asymmetry is attributed to the relative positioning of the centrosome and the nucleus. (nih.gov)
  • Drosophila
  • In this study, using transgenic Drosophila co-expressing human tau and Aβ, tau phosphorylation at AD-related Ser262/356 stabilized microtubule-unbound tau was found in the early phase of tau mismetabolism, leading to neurodegeneration. (sdbonline.org)