EDURANT is a human immunodeficiency virus type 1 (HIV-1) specific, non-nucleoside reverse transcriptase inhibitor (NNRTI) indicated in combination with other antiretroviral agents for the treatment of HIV-1infection in treatment-naïve patients 12 years of age and older and weighing at least 35 kg with HIV-1RNA less than or equal to 100,000 copies/mL ( 1.1 ). (guidelinecentral.com)
In contrast to the disappointing cross-resistance news with 1592, DuPont-Merck's new non-nucleoside reverse transcriptase inhibitor (NNRTI) DMP-266 (now with the generic name "efavirenz" and trade name "Sustiva"), seems to be active against the most common resistance mutation (Y181) associated with use of nevirapine and delavirdine, the two commercially available NNRTIs. (treatmentactiongroup.org)
Differentiating nucleoside RTIs that tight spot at the protein's dynamic site NNRTIs acts allosterically by connecting to an alternate site away from the dynamic site known as the NNRTI pocket. (allgenericcure.com)
RTIs bind the enzyme's active site, NNRTIs act allosterically by binding to a distinct site away from the active site known as the NNRTI pocket. (magicinepharma.com)
Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and has been shown to offer similar efficacy and a better tolerability profile with respect to central nervous system (CNS) side effects (including insomnia, depression and dizziness), rash, triglyceride elevations and severe vitamin D deficiency compared to the standard of care (efavirenz). (jnj.com)
Emtricitabine1
Emtricitabine (Trustiva):- a synthetic nucleoside analog of cytidine, is phosphorylated by cellular enzymes to form Emtricitabine (Trustiva) 5'-triphosphate. (magicinepharma.com)
Zalcitabine (2′-3′-dideoxycytidine, ddC), also called dideoxycytidine, is a nucleoside analog reverse-transcriptase inhibitor (NRTI) sold under the trade name Hivid. (wikipedia.org)
The aim was to study the mitochondrial toxicities in terms of peripheral neuropathy (PN), lipodystrophy (LD), hepatic steatosis, lactic academia (LA), and pancreatitis developing in AIDS cases on nucleoside analog reverse transcriptase inhibitors (NRTIs) based ART regimens. (ijstd.org)
Viral2
Both nucleoside and non-nucleoside RTIs hinder a similar objective, the opposite transcriptase protein, a crucial viral chemical that deciphers viral RNA into DNA. (allgenericcure.com)
Zalcitabine (2′-3′-dideoxycytidine, ddC), also called dideoxycytidine, is a nucleoside analog reverse-transcriptase inhibitor (NRTI) sold under the trade name Hivid. (wikipedia.org)
Potent1
Zalcitabine appears less potent than some other nucleoside RTIs, has an inconvenient three-times daily frequency and is associated with serious adverse events. (wikipedia.org)
Reverse6
EDURANT is a human immunodeficiency virus type 1 (HIV-1) specific, non-nucleoside reverse transcriptase inhibitor (NNRTI) indicated in combination with other antiretroviral agents for the treatment of HIV-1infection in treatment-naïve patients 12 years of age and older and weighing at least 35 kg with HIV-1RNA less than or equal to 100,000 copies/mL ( 1.1 ). (nih.gov)
Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection. (wikidoc.org)
RTIs inhibit activity of reverse transcriptase , a viral DNA polymerase enzyme that HIV needs to reproduce. (wikidoc.org)
RTIs block reverse transcriptase's enzymatic function and prevent completion of synthesis of the double-stranded viral DNA thus preventing HIV from multiplying. (wikidoc.org)