• In the intervening six decades, the bluegills became an invasive, species-destroying nightmare, crowding Japanese freshwater lakes and rivers and destroying native fish biodiversity, says Kenji Saitoh, a researcher at the country's Fisheries Resources and Education Agency. (nationalgeographic.com)
  • At that time, we had not experienced any serious invasive species problems and bluegill did not look dangerous according to its feeding habits, not being a fierce piscivore," says Nakai Katsuki, a Japanese research scientist at the Lake Biwa Museum who has studied invasive North American fish species in Japan's Shiga Prefecture since 1989. (nationalgeographic.com)
  • Now the Science for Citizens project has come up with a similar strategy for botany: a smartphone app that lets everyone track and report invasive species of plant. (bigthink.com)
  • One of North Queensland's most invasive species of pest fish may be tracked by its own DNA, in a new collaborative project between researchers from JCU and the Queensland Department of Agriculture, Fisheries and Forestry. (edu.au)
  • Professor Jerry said tilapia, a highly aggressive and invasive fish species originating from Africa, were becoming particularly prevalent in warm water habitats throughout North Queensland and were threatening to invade streams and rivers in the Gulf of Carpentaria. (edu.au)
  • Professor Jerry said the project, eDNA as a Surveillance Tool for Tilapia , would help to track the species' movements. (edu.au)
  • DNA technology has become so powerful over recent years that it is now possible to use eDNA as a detection and water body monitoring tool for a number of fish species, including that of invasive species. (edu.au)
  • Knowledge about species infectivity, tissue tropism, and cellular infectivity of different vectors is very important for assessing the BD of a cell and gene therapy product. (absorption.com)
  • They arrived with hopes the DNA Tracker would perform as it had dozens of times before in the laboratory - detecting invasive mussel DNA extracted from samples collected from plankton net tows - thereby proving its potential as an invaluable tool in the fight against aquatic invasive species, or AIS. (ksenam.com)
  • resistant to the antifungal agent fluconazole, which is concerning because fluconazole is frequently the first-line treatment for invasive Candida species infections in many countries. (cdc.gov)
  • The Nordic collections are used today primarily to clarify which species have been present at a certain place at a certain time, for example, to be able to study how changes in the environment and climate have affected the flora over the past 200 years and to document newly immigrated potentially invasive species. (lu.se)
  • A chip-based infection model developed by Jena researchers enables live microscopic observation of damage to lung tissue caused by the invasive fungal infection aspergillosis. (leibniz-gemeinschaft.de)
  • The team developed algorithms to track the spread of fungal hyphae as well as the response of immune cells. (leibniz-gemeinschaft.de)
  • In these cases, invasive aspergillosis usually occurs with fungal hyphae invading blood vessels. (leibniz-gemeinschaft.de)
  • For that, we need algorithms that can distinguish fungal hyphae or immune cells from tissue cells as well as the surrounding environment," explains Zoltán Cseresnyés, who is also a first author of the paper. (leibniz-gemeinschaft.de)
  • Although these immunocompromised infants are at increased risk during most of their hospital stay, they are at the highest risk of acquiring invasive fungal infections during the first weeks of life, when the most invasive therapies are performed and remain in place. (medscape.com)
  • Pathogenesis and invasive fungal infections in very low birth weight infants. (medscape.com)
  • Because most invasive fungal infections have high mortality rates, reducing the incidence of these diseases often relies on rapid and specific diagnostics, effective antifungal drugs, novel immunotherapeutic strategies, and adherence to infection control and sterility practices. (cdc.gov)
  • The FDA granted fast track status for DiscGenics' cell therapy for degenerative disc disease. (fdanews.com)
  • I am excited to be participating in the clinical evaluation of IDCT as a potential cell therapy to treat degenerative disc disease," mentioned Dr. Sakai in a press release. (drugdiscoverynews.com)
  • If the initiative succeeds, wildlife managers could use the same technique to rid the U.S. of damaging aquatic invasives such as the Asian carp. (nationalgeographic.com)
  • Environmental DNA, or eDNA, is the material that is floating around in the aquatic environment in the form of free-cells shed or excreted from aquatic organisms," he said. (edu.au)
  • Despite this decided trend, in 2004, 30,570 fresh invasive cervical cancer cases were diagnosed in 25 EU countries as prosperously as an estimated 10,520 unripe cases of cervical cancer in the USA. (daubnet.com)
  • 99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)
  • We harnessed non-invasive fluorescence imaging to sequentially follow in vivo material-mass loss to model the degradation of materials hydrolytically (PEG:dextran hydrogel) and enzymatically (collagen). (nature.com)
  • We developed a non-invasive imaging technique that tracks material erosion in vivo through a fluorescent tag covalently attached to components of model materials. (nature.com)
  • Materials erosion was calculated from the decay in total material fluorescence signal using non-invasive In Vivo Imaging System (IVIS). (nature.com)
  • Researchers from Kings College London and University College London have been awarded £500,000 from Cancer Research UK's Multidisciplinary Project Award, to develop a novel PET imaging reagent for Chimeric Antigen Receptor (CAR) T-cell in vivo tracking. (kcl.ac.uk)
  • The new construct can serve for monitoring delivery and differentiation of cells in vivo in cellular based therapy. (yedarnd.com)
  • Cell and gene therapy development requires a comprehensive understanding of the unique aspects of these products in relation to their in vivo safety profiles. (absorption.com)
  • In vivo studies of microglial activation have been delayed by technical limitations to tracking microglial behavior without altering the CNS environment. (eugs.org)
  • JDRF seeks applications to support preclinical and clinical research into the development and in vivo validation of medical imaging technology for non-invasive in vivo monitoring of immune responses to transplanted insulin-producing cells. (iispv.cat)
  • Non-invasive imaging of cells that have been labeled non-destructively, such as with nanoemulsions or reporter genes that can be detected by molecular imaging, to monitor their location, viability, cell lineage expansion, response to drugs, movement, or other behaviors in vivo. (bvsalud.org)
  • One fundamental challenge in the successful development and clinical application of CAR T-cell based therapies, is the need to better understand their behaviour and location once they are injected into patients. (kcl.ac.uk)
  • They devised methods to mark and track the behavior of these tumor-initiating stem cells and discovered that not only are these cells at invasive fronts of the cancers, but they are also responsible for tumor relapse following chemo- and immune-therapies administered to mice with tumors. (rockefeller.edu)
  • We propose that vMIP-II functions as a sensitive reporter of acute lung injury that can be detected using non-invasive imaging to diagnose and monitor lung injury so that therapies can be rationally administrated. (wustl.edu)
  • Specifically, she is dedicated to understanding the design principles and developing nanoscale and macroscale biomaterials for medical applications, experimental investigations of cell therapies, and integration across multiple disciplines including materials science, chemistry, medical imaging, and life science. (stanford.edu)
  • [ 1 , 2 ] These immunocompromised infants usually require invasive therapies, such as central vascular catheters and endotracheal tubes, and they are exposed to broad-spectrum antibiotics and parenteral nutrition. (medscape.com)
  • We provide proof-of-concept for extracellular vesicle (EV) profiling as a strategy for non-invasive, liquid biopsy of brain tumors. (lu.se)
  • IBC may be diagnosed by an imaging test and by a breast biopsy of an invasive cancer 7 . (bvsalud.org)
  • This approach enables rapid in vitro screening of materials, and can be extended to simultaneously determine drug release and material erosion from a drug-eluting scaffold, or cell viability and material fate in tissue-engineering formulations. (nature.com)
  • The treatment uses ionizing radiation, delivered by a linear accelerator, to damage the genetic material of malignant tissue and prevent further cell division. (cognex.com)
  • The aim and calibration of the radiation beams must be accurate as sometimes there are only millimeters separating healthy, extremely important tissue, and the malignant tissue, so the patient's position is closely tracked. (cognex.com)
  • ExacTrac Dynamic prevents the patient from inadvertently deviating from the planned position and ensures the radiation is precisely directed at the cancerous tissue, protecting healthy cells. (cognex.com)
  • Using mammalian skin as a model, Fuchs studies the remarkable properties of tissue stem cells, and how they know which tasks to perform and when. (rockefeller.edu)
  • Her research employs high throughput genomics, single cell sequencing, live imaging, cell biology, and functional approaches to unravel the pathways that balance stem cell self-renewal with tissue regeneration. (rockefeller.edu)
  • They also study the signaling pathways that must be turned on and off at the right time and place for adult skin stem cells to become activated to regenerate tissue. (rockefeller.edu)
  • They seek to discover the activating signals from the neighboring cells that instruct the stem cells to make hair or repair wounds, and the inhibitory signals that tell them to stop making tissue. (rockefeller.edu)
  • By dissecting the underlying mechanisms, performing high-throughput functional screens for oncogenes and tumor suppressors in mice, and relating their findings to humans, Fuchs hopes her research will lead to new therapeutic approaches that target the cancerous stem cells without affecting tissue stem cells. (rockefeller.edu)
  • Overall, Fuchs studies tissue biology at multiple levels, from its stem cells and the signals that control them to the epigenetic, transcriptional, and translational programs that maintain an orchestrated balance of tissue growth. (rockefeller.edu)
  • While the foundations of normal tissue homeostasis and injury repair are still unfolding, the fundamental discoveries that Fuchs's lab has made already provide insights into how skin and its stem cells cope with different environmental stresses, including aging, inflammation, and cancer, offering new avenues for treating human skin disorders. (rockefeller.edu)
  • IDCT is a homologous, allogeneic, injectable cell therapy that utilizes biomedically engineered progenitor cells, known as Discogenic Cells, that have been derived from intervertebral disc tissue to offer a non-invasive, potentially regenerative solution for the treatment of mild to moderate DDD. (drugdiscoverynews.com)
  • Stem cells have the capability to induce tissue repair and ultimately reverse the progression of many diseases. (parentsguidecordblood.org)
  • Stem cells have the ability to migrate into the damaged tissue, replace the non-functioning cells and take over their function. (parentsguidecordblood.org)
  • Stem cells secrete small molecules that can prevent cell/tissue death, and help in recovery, or at least prevent deterioration of the tissue. (parentsguidecordblood.org)
  • Her postdoctoral research in hydrogel and tissue engineering is complementary to her Ph.D. training in nanoparticles and cell tracking. (stanford.edu)
  • MiR-21 promoted invasion of fibroblasts by down-regulation of tissue inhibitor of metalloproteinase 3 (TIMP3) expression and increasing of matrix metalloprotein (MMP) expression in fibroblast cells via melanoma-derived exosomes in a time-dependent manner. (dovepress.com)
  • 10 High expression of miR-21 in melanoma cells inhibits mRNA expression of crucial tumor suppressor proteins such as the tissue inhibitor of metalloproteinases 3 (TIMP3). (dovepress.com)
  • Speaking about the promise of liquid biopsies in breast cancer, Sarah-Jane Dawson, the PhD group leader of the Cancer Therapeutics Program at Peter MacCallum Cancer Centre, Victoria, Australia, said she didn't think that ctDNA would replace tissue biopsies, but tissue biopsies clearly have limitations that include being invasive and difficult to perform serially. (medscape.com)
  • however, this method is relatively insensitive, so patients with invasive aspergillosis may have negative cultures. (cdc.gov)
  • First-line treatment for invasive aspergillosis is voriconazole. (cdc.gov)
  • Prophylaxis against aspergillosis is recommended during prolonged neutropenia for patients who are at high risk for aspergillosis, allogeneic stem cell transplant patients with graft versus host disease, lung transplant recipients, and certain other solid organ transplant recipients under certain conditions. (cdc.gov)
  • Integrated imaging studies are essential to visualise the CAR T-cells in patients at the earliest stage of preclinical and clinical development of cell based treatments. (kcl.ac.uk)
  • The new method can both provide vital information about the real-time on-target/off-target accumulation and persistence of the CAR T-cells in patients and, minimise the risk of causing severe toxicity. (kcl.ac.uk)
  • The non-invasive treatment, IDCT, is currently being evaluated in two multicenter trials in the U.S. and Japan for treating patients with mild to moderate lumbar DDD. (fdanews.com)
  • This Fast Track designation reinforces our commitment to working with regulators to identify ways to accelerate development and expedite approval of the therapy within existing regulatory frameworks to make IDCT available to patients as quickly as possible," said Flagg Flanagan, CEO and chairman of the Board of Directors for DiscGenics. (drugdiscoverynews.com)
  • In this study, Fusarium caused an increase in invasive infections, which usually started as skin or nail infections, in immunocompetent and immunosuppressed patients. (cdc.gov)
  • Changes in levels of circulating tumor DNA very closely followed treatment responses in these patients, and tracking levels of ctDNA may provide us with an early indicator of treatment resistance," said Dawson. (medscape.com)
  • Nous avons exa- miné les dossiers de 56 patients ayant eu un diagnostic de fièvre méditerranéenne familiale et suivis au Centre médical Roi Hussein en Jordanie sur une période de 4 ans afin d'étudier leur profil clinique, l'évolution de la maladie, le génotype, le traitement et les complications. (who.int)
  • En ce qui concerne le traitement, 97% des patients répondaient bien à la colchicine et une amyloïdose n'a été documentée chez aucun des patients après un suivi de 5 ans. (who.int)
  • Patients were diagnosed with FMF if invasive procedures [ 4 ]. (who.int)
  • Advances in the management of acute lung injury and the related adult respiratory syndrome (ARDS) have improved mortality and morbidity rates however, there remains a need for improved non-invasive modes of diagnosis and treatment. (wustl.edu)
  • SALT LAKE CITY- DiscGenics, Inc . announced today that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation for DiscGenics' IDCT, an investigational cell therapy. (drugdiscoverynews.com)
  • We are thrilled to receive Fast Track designation for IDCT as it recognizes the extremely compelling preclinical and safety data we have generated for IDCT through our robust research and development and clinical programs, and underscores the FDA's acknowledgement of low back pain as a serious medical condition with a profound lack of treatment options. (drugdiscoverynews.com)
  • Cell-site simulators, colloquially referred to as IMSI Catchers or by brand names such as 'Stingrays' or 'King Fisher' are surveillance tools used by state agencies to identify or track mobile devices (and, of course, the individuals associated with such devices). (cippic.ca)
  • Compared to other surveillance devices, IMSI Catchers are inherently invasive. (cippic.ca)
  • Stingrays, also known as "cell site simulators," or "IMSI catchers," are invasive cell phone surveillance devices that mimic cell phone towers and force phones in the area to broadcast information that can be used to identify and locate them. (aclu.org)
  • As a manufactured allogeneic cell therapy, IDCT is regulated by the FDA's Center for Biologics Evaluation and Research under Section 351 of the Public Health Service Act. (drugdiscoverynews.com)
  • The EU-funded LeukoTheranostics project designed a proof of concept treatment for IBD by doping lipid nanoparticles with extraordinarily specific proteins that target only the immune cells that are actively causing inflammation. (europa.eu)
  • Nanometer-sized magnetic particles (aka "nanoparticles") have been developed to track transplanted cells and have shown great success. (parentsguidecordblood.org)
  • The nanoparticles can be inserted into stem cells in the lab. (parentsguidecordblood.org)
  • The magnetic nanoparticles are mostly beneficial for tracking the location of cells, but are limited in providing additional information, such as whether the cells are dead or alive or actually performing the required function. (parentsguidecordblood.org)
  • In summary, nanoparticles enable the non-invasive tracking of transplanted cells, and now, the new technology of reporter genes will allow us to monitor cellular viability and function as well. (parentsguidecordblood.org)
  • The heterogeneity of cancer cells introduces significant challenges in designing effective treatment strategies. (wikipedia.org)
  • Harvard researchers have found new evidence that female mammals can produce egg cells throughout life and have traced their production out of the ovary and into the bone marrow in findings that could both reshape science's understanding of female reproduction and provide new avenues for treatment of infertility. (harvard.edu)
  • CAR T-cell immunotherapy is a new type of cancer treatment in which a patient's T-cells (a type of immune or white blood cell) are modified in the laboratory so they will bind to the cancer cells and kill them. (kcl.ac.uk)
  • New Technology To Improve Cancer Detection and Treatment A new device can detect cancer cells without invasive and expensive surgery. (scitechdaily.com)
  • This approach gives you fine-tuning of a targeted treatment with much less adverse effect, and the ability to both monitor disease and manipulate specific cells within the immune system," says project researcher Dan Peer, director of the Laboratory of Precision NanoMedicine at Tel Aviv University . (europa.eu)
  • It is commonly used as a cancer treatment due to its ability to control cell growth and shrink tumors. (cognex.com)
  • The treatment is non-invasive, so the patient remains awake during the procedure. (cognex.com)
  • The various invasive techniques work effectively to be in the know early whether or not there are outgrowths to prompt treatment. (personalcaretruth.com)
  • SENS Sensus Healthcare Inc., is a medical technology company that specializes in developing and commercializing innovative non-invasive treatment solutions for various skin conditions, including non-melanoma skin cancers. (tradingview.com)
  • Innovative Treatment Solutions: Sensus Healthcare focuses on providing non-invasive and advanced treatment options for skin conditions. (tradingview.com)
  • Growing Demand for Non-Invasive Treatments: The healthcare industry is witnessing an increasing demand for non-invasive treatment solutions. (tradingview.com)
  • The company has a presence in various countries and has gained recognition within the medical community for its commitment to advancing non-invasive treatment options. (tradingview.com)
  • The company's commitment to innovation and staying at the forefront of non-invasive treatment technologies could position it for future growth and increased market share. (tradingview.com)
  • Dr. Chen completed her Ph.D. in Materials Science and Engineering at UCSD, where she discovered several ultrasound-based contrast agents, revealed cytotoxicity and adsorption properties of various nanomaterials, and created a theranostic nanoparticle that improved the treatment efficacy of stem cell therapy for heart diseases. (stanford.edu)
  • Malaria Day 2012, WHO launched an initiative that consolidated WHO policy recommendations for testing, treating, and tracking every malaria case, stressing testing before treatment and tracking through a sensitive surveillance system. (who.int)
  • A major focus of the lab is on squamous cell carcinomas, which are among the most common and life-threatening human cancers worldwide. (rockefeller.edu)
  • Dysphasic changes were rare: 9 cases (0.8%) were classified as atypical squamous cells of undetermined significance (ASCUS) and 2 cases (0.2%) were low-grade squamous intraepithelial lesion (LSIL). (who.int)
  • from all military hospitals in Jordan to the Low-grade cervical abnormalities were gynaecology clinic at the Centre with com- seen in 11 cases: 9 cases (0.8%) were clas- plaints of vaginal itching or discharge, and sified as atypical squamous cells of unde- those who came for a first-time or follow- termined significance (ASCUS) and 2 up cervical smear. (who.int)
  • Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
  • As a result, DiscGenics is adhering to the rigors of a regulated drug pathway that requires not only proof that the product has a therapeutic effect through clinical evaluation, but also that it meets critical safety standards and is produced consistently from lot to lot through adherence to current good manufacturing practice (cGMP) standards for a cell therapy. (drugdiscoverynews.com)
  • Several clinical trials in humans were conducted around the world, showing the importance of tracking the cells in the body. (parentsguidecordblood.org)
  • Preclinical cancer research could benefit from quantitative, non-invasive measurements of tumour growth provided by three-dimensional high-frequency ultrasound imaging. (uwo.ca)
  • based on Facebook's track record of constantly changing privacy settings, that means audio surveillance is likely to happen without a user's knowledge. (naturalnews.com)
  • The FBI's surveillance capabilities, on a par with the National Security Agency, boast a nasty collection of spy tools ranging from Stingray devices that can track the location of cell phones to Triggerfish devices which allow agents to eavesdrop on phone calls. (theblaze.com)
  • In an amicus brief filed in the case, EFF and the ACLU of the Nation's Capital argued that unsupervised use of such tactics would open the door for police to abuse their power and continuously track anyone's physical location for any reason, without ever having to go to a judge to prove the surveillance is justified. (eff.org)
  • The court expressly rejected the government's argument that such extended, 24-hours-per-day surveillance without warrants was constitutional based on previous rulings about limited, point-to-point surveillance of public activities using radio-based tracking beepers. (eff.org)
  • The court correctly recognized the important differences between limited surveillance of public activities possible through visual surveillance or traditional 'bumper beepers,' and the sort of extended, invasive, pervasive, always-on tracking that GPS devices allow," said EFF Civil Liberties Director Jennifer Granick. (eff.org)
  • The project will provide important information about whether the therapeutic cells are safe to use, how they kill the cancer cells, and how effective the CAR T-cell based treatments are. (kcl.ac.uk)
  • A conformational change in the surface proteins of those leukocytes responsible for gut inflammation provided researchers with a way to target these cells with lipid nanoparticle therapeutics. (europa.eu)
  • Exosomes derived from B16-F10 cells were identified by nanoparticle tracking analyzer (NTA), dynamic light scattering (DLS), Western blot (WB), and transmission electron microscopy (TEM). (dovepress.com)
  • The researchers believe that egg stem cells in the donor bone marrow established themselves in the sterile mice and began producing egg cells, also called oocytes. (harvard.edu)
  • Professor Jerry said researchers would collect two-litre water samples from bodies of water and filter it to concentrate cells. (edu.au)
  • In a recent study, researchers compared radiographic imaging of tumors with an assay of ctDNA, cancer antigen 15-3 ( CA 15-3 ), and circulating tumor cells in 30 women with MBC who were receiving systemic therapy. (medscape.com)
  • As material shape dictates fluid uptake, we examined whether fluorescence tracking could distinguish the fate of PEG:dextran formulations cast in a series of shapes, sizes and varying PEG solid content. (nature.com)
  • For example, the intensity of the fluorescence can be used to determine how many fungi an immune cell has eaten," Cseresnyés explains. (leibniz-gemeinschaft.de)
  • Evolution of the initial tumour cell may occur by two methods: Sequentially ordered mutations accumulate in driver genes, tumour suppressor genes, and DNA repair enzymes, resulting in clonal expansion of tumour cells. (wikipedia.org)
  • I am encouraged by my preclinical observations of IDCT's human Discogenic Cells in a canine disc degeneration model that demonstrated the ability to stop disc height degeneration while improving the structure of the intervertebral disc. (drugdiscoverynews.com)
  • High-frequency ultrasound has been shown to be appropriate for tracking experimental liver metastases from a variety of cell fines without exogenous contrast agents. (uwo.ca)
  • The Fuchs lab has found that communication between stem cells and their neighbors, particularly immune cells, can become altered, and this can cause the stem cells' proliferation to either accelerate (in the case of inflammation) or slow (as occurs during aging). (rockefeller.edu)
  • Despite federal agencies spending hundreds of thousands of dollars on access to cell phone location databases, those agencies have not publicly explained their legal justifications or internal limitations on access to this invasive information. (fedscoop.com)
  • During this cru- cial 2-month window the most profound and complex events required during con- structing the human form arise: imaginative limbs and internal organs start off forming as embryonic cells are committed to a closely orchestrated curriculum of prolifera- tion, migration and differentiation. (daubnet.com)
  • Stem cells are precursor cells that develop into specific kinds of tissues, replenishing blood, skin, and other kinds of cells in the body. (harvard.edu)
  • However, administration of metal complexes into tissues and cells is challenging. (yedarnd.com)
  • Studies the mechanisms underlying how stem cells make and repair tissues and deviate in stress, aging, and cancer. (rockefeller.edu)
  • Adult stem cells reside in all tissues, where they replenish dying cells and repair wounds. (rockefeller.edu)
  • There is also an imaging station for imaging cells, tissues and small animals with simultaneous monitoring of vital functions and motion tracking. (lu.se)
  • Therefore, it is critical to develop new imaging technologies that can non-invasively monitor the viability and the function of the transplanted stem cells in order to assess the success of the procedure and to ensure that the cells reach their intended destinations. (parentsguidecordblood.org)
  • By engineering the genome of the cells we wish to track, we can introduce molecules that can help us follow the cells with high-resolution MRI and monitor their viability. (parentsguidecordblood.org)
  • Tumour heterogeneity describes the observation that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. (wikipedia.org)
  • A minimal level of intra-tumour heterogeneity is a simple consequence of the imperfection of DNA replication: whenever a cell (normal or cancerous) divides, a few mutations are acquired-leading to a diverse population of cancer cells. (wikipedia.org)
  • It involves surveying for likely pre-cancerous polyp cells etched on the wall of the intestine. (personalcaretruth.com)
  • The tumor microenvironment may also contribute to tumour expansion, as it is capable of altering the selective pressures that the tumour cells are exposed to. (wikipedia.org)
  • We hypothesize that tumor-derived exosomes endow the fibroblasts in tumor microenvironment with invasive phenotype to the benefit of tumor metastasis. (dovepress.com)
  • Role of tumor-derived exosomal miR-21 in cell invasion was determined by qPCR. (dovepress.com)
  • 2 , 3 Tumor cell-derived exosomes carry particular molecular components originated from donor cells to mediate tumorigenesis and drive tumor progression by regulating tumor microenvironment. (dovepress.com)
  • So tumor cells-derived exosomes. (dovepress.com)
  • W e for the first time show that stress conditions modulate surfaceome turnover in cancer cells, providing opportunities for tumor specific drug delivery. (lu.se)
  • One of the uses of ctDNA is to track tumor burden. (medscape.com)
  • [ 4 ] CA 15-3 levels and numbers of circulating tumor cells were measured at identical time points. (medscape.com)
  • ctDNA was successfully detected in 97% women in whom somatic genomic alterations were identified, and CA 15-3 and circulating tumor cells were detected in 78% and 87%, respectively. (medscape.com)
  • ctDNA levels showed a greater dynamic range, and greater correlation with changes in tumor burden, than did CA 15-3 or circulating tumor cells. (medscape.com)
  • While positron emission tomography (PET) imaging provides a non-invasive means to visualize and quantify such immune responses, most available tracers are not specific for innate immune cells. (stanford.edu)
  • BACKGROUND: Immunogenic cell death (ICD)is a kind of regulatory cell death, which causes a series of antigen-specific adaptive immune responses by generating and emitting some danger signals or damage-associated molecular patterns (DAMPs). (bvsalud.org)
  • image: These are Candid albicans hyphae cells in neutrophil extracellular trap. (eurekalert.org)
  • They are designed to impersonate cell towers, in both functionality and appearance. (cippic.ca)
  • Rather than using GPS tracking , the five major telecommunication companies in Taiwan work with the government to " triangulate the location of their cell phone relative to nearby cell towers. (harvard.edu)
  • Agencies and stakeholders across Montana have increased AIS education and prevention measures to keep the invasive mussels from spreading elsewhere in the state. (ksenam.com)
  • The invasion analysis showed that exosome-treated fibroblast cells had greater invasive capability as compared to untreated fibroblast cells, with the higher expressions of MMP2 and MMP9. (dovepress.com)
  • Now, Japanese geneticists are experimenting with the gene editing wizardry of CRISPR to sterilize the invasive bluegills. (nationalgeographic.com)
  • Non-invasive imaging of gene expression in transgenic mice models. (yedarnd.com)
  • Her team investigates how stem cells establish unique chromatin landscapes and programs of gene expression, and how this shifts in response to changes in their local environment. (rockefeller.edu)
  • Microglia, which are CNS-resident neuroimmune cells, transform their morphology and size in response to CNS damage, switching to an activated state with distinct functions and gene expression profiles. (eugs.org)
  • The absence of a functional INT1 gene diminishes adherence in yeast cells but not filamentous forms. (medscape.com)
  • Fuchs's lab couples in vitro studies with mouse genetics to study the biology of skin stem cells. (rockefeller.edu)
  • After ingestion of melanoma-derived exosomes during incubation, mouse embryonic fibroblasts cells emerged cellular invasiveness with the presentation of a marked increase in miR-21 expression. (dovepress.com)
  • To address the need for visualization of transplanted cells, including but not limited to stem cells, scientists started in the early 90's to develop new technologies. (parentsguidecordblood.org)
  • While the digital quarantine technology is not seamless as there are still manual steps in the process, the potential for inaccuracy with cellular tracking and the potential for people to have multiple cell phones, the system's overall comprehensiveness makes it effective. (harvard.edu)
  • In the body, neutrophils, which are an abundant cell type among white blood cells, have evolved several strategies to combat these two different forms of the fungi. (eurekalert.org)
  • Neutrophils track and uptake the fungi or secrete antimicrobials which kills them. (eurekalert.org)
  • This test also detects a component in the cell wall of Aspergillus spp, as well as other fungi. (cdc.gov)
  • However, the major challenge today with translation of stem cell therapy into the clinic is that, after stem cells are infused, their fate is largely unknown. (parentsguidecordblood.org)
  • These technologies provide a unique opportunity to elucidate the mechanisms of immune rejection by enabling non-invasive longitudinal assessments and tracking of immune cell activation, trafficking, and targeting of the beta cell graft. (iispv.cat)
  • Specifically, eye tracking allowed the experimenters to monitor people's anticipatory looking behavior during the Sally Ann task after the right temporal parietal junction was disrupted with transcranial direct current stimulation. (sr-research.com)
  • Invasive mussels were first detected in the Missouri River Basin of Montana in 2016. (ksenam.com)
  • If we add too much Aspergillus fumigatus to the model, the lung cells die. (leibniz-gemeinschaft.de)
  • This test detects a polysaccharide that makes up part of the cell wall of Aspergillus spp. (cdc.gov)
  • Recognizing that the Supreme Court had never considered location tracking of such length and scope, the court noted: "When it comes to privacy. (eff.org)
  • These cells are termed cancer stem cells (CSCs), and are marked by the ability to both self-renew and differentiate into non-tumourigenic progeny. (wikipedia.org)
  • vMIP-II binds to a known set of chemokine receptors, molecules that orchestrate inflammatory responses by directing specific cell migration to sites of inflammation. (wustl.edu)
  • We hypothesized that tracking chemokine receptor activity using the vMIP-II probe would enable us to visualize and monitor lung inflammation. (wustl.edu)
  • GPS tracking enables the police to know when you visit your doctor, your lawyer, your church, or your lover," said Arthur Spitzer, Legal Director of the ACLU-NCA. (eff.org)
  • Red blood cells contain hemoglobin, a protein that enables them to carry oxygen from the lungs and deliver it to all parts. (msdmanuals.com)
  • Radiation therapy, or radiotherapy, is a non-invasive medical procedure. (cognex.com)
  • In this kind of tracking a radiolabeled isotope is usually tagged to the product whose BD is to be investigated which is injected intravenously in to the trial animal, which is sacrificed and its organs are placed in gamma radiation counters to measure the radiation. (absorption.com)
  • The results, which build upon a study published last year, further erode the long-held belief that female mammals are born with a lifetime supply of egg cells that they slowly use up until the supply is exhausted. (harvard.edu)
  • Both last year's research and the current work, which is being published in the July 29 issue of the journal Cell, has been the focus of criticism from many quarters and was the subject of a panel discussion at the recent annual meeting of the Society for the Study of Reproduction in Quebec. (harvard.edu)
  • Utilising a non-invasive visualisation method, PET imaging, the study will develop indirect cell tracking probes to monitor the CAR T-cell immunotherapy. (kcl.ac.uk)
  • That's why it was so important for us to be able to represent this invasive growth in a model," says Marie von Lilienfeld-Toal, who co-led the study. (leibniz-gemeinschaft.de)
  • Human immune cells or various drugs, for example, can then be added to this system, as the research team shows in the current study. (leibniz-gemeinschaft.de)
  • Neisseria meningitidis , a leading cause of bacterial meningitis and septicemia globally, causes ≈1.2 million invasive meningococcal disease (IMD) cases annually and a case-fatality rate of 11% ( 1 ). (cdc.gov)
  • This same logic applies in cases of cell phone tracking, and we hope that this decision will be followed by courts that are currently grappling with the question of whether the government must obtain a warrant before using your cell phone as a tracking device. (eff.org)
  • Prospects for attaining the goals set for tuberculosis increased, but WHO continued to track cases of multi-drug resistant and extensively drug-resistant tuberculosis and to warn the world accordingly. (who.int)
  • There are two models used to explain the heterogeneity of tumour cells. (wikipedia.org)
  • The cancer stem cell model asserts that within a population of tumour cells, there is only a small subset of cells that are tumourigenic (able to form tumours). (wikipedia.org)
  • The CSC model posits that the heterogeneity observed between tumour cells is the result of differences in the stem cells from which they originated. (wikipedia.org)
  • Evidence of the cancer stem cell model has been demonstrated in multiple tumour types including leukemias, glioblastoma, breast cancer, and prostate cancer. (wikipedia.org)
  • Multiple types of heterogeneity have been observed between tumour cells, stemming from both genetic and non-genetic variability. (wikipedia.org)
  • 1 It has been found that exosomes can mediate local and systemic cell communication with transmitting signals from one cell to another on the molecular level. (dovepress.com)
  • rPocDBP-RII protein could mediate protective blood-stage immunity through IFN-γ-producing CD4+ and CD8+ T cells and memory T cells, in addition to inducing specific antibodies. (bvsalud.org)
  • The research built on a paper published last year that showed that egg cells in mice ovaries were being replenished long after birth, challenging what Oktay called the "central dogma" of reproductive medicine - that females are born with a lifetime supply of eggs. (harvard.edu)
  • Working in mice, his team showed that these activated cells, making up a sixth of the total population, can be targeted through a conformational shift of the a4b7 integrin protein, offering a level of specificity that has never been achieved before. (europa.eu)
  • Fuchs's group has used high throughput genomics in mice to identify and characterize the features of the cells that propagate these cancers in skin. (rockefeller.edu)
  • Analysis of single cell preparations of lungs from LPS treated mice injected with fluorescently labeled vMIP-II showed a similar high 24 h and diminished 48 h pattern of cell binding, by flow cytometry. (wustl.edu)
  • Compared to PBS-immunized mice (negative control), there was a higher percentage of CD4+CD44highCD62L- T cells (effector memory T cells) and CD8+CD44highCD62L+ T cells (central memory T cells) in rPocDBP-RII-immunized mice. (bvsalud.org)