Diabetic AngiopathiesDiabetes Mellitus, Type 2Blood GlucoseDiabetic RetinopathyDiabetic NephropathiesDiabetes Mellitus, ExperimentalDiabetic FootPregnancy in DiabeticsDiabetes Mellitus, Type 1StreptozocinDiabetes MellitusDiabetes ComplicationsDiabetic CardiomyopathiesInsulinDiabetic DietHyperglycemiaHypoglycemic AgentsHemoglobin A, GlycosylatedAlbuminuriaDiabetic ComaMice, Inbred NODGlucoseGlycosylation End Products, AdvancedRats, WistarRetinal VesselsAldehyde ReductaseAlloxanRats, Sprague-DawleyKidneyGlycosuriaIslets of LangerhansBody WeightRats, ZuckerTime FactorsReference ValuesGastroparesisKidney GlomerulusDisease Models, AnimalOxidative StressMice, Inbred C57BLFructosamineRisk FactorsRetinaFoot UlcerIslets of Langerhans TransplantationGlucose Tolerance TestBlood-Retinal BarrierBlood PressurePodocytesCase-Control StudiesC-PeptideVitreous BodyProteinuriaSorbitolTreatment OutcomeWound HealingRNA, MessengerInsulin ResistanceNeural ConductionLaser CoagulationDisease ProgressionAutonomic Nervous System DiseasesCells, CulturedHypoglycemiaPlant ExtractsCardiomyopathiesProspective StudiesLiverTriglyceridesBiological MarkersFluorescein AngiographyLeukostasisAntioxidantsPhotographyObesityCreatinineFollow-Up StudiesLight CoagulationKidney Failure, ChronicRats, Inbred OLETFLipidsGlomerular Filtration RateGlucagonPancreasRetrospective StudiesMesangial CellsEndothelium, VascularVisual AcuityMyocardiumInsulin-Secreting CellsImmunohistochemistryCross-Sectional StudiesCapillariesGlomerular MesangiumPrediabetic StatePrevalenceAmputationSciatic NerveFastingMetformin