Non coding ncrnas rna gene. Medical search. Frequent questions

In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
Next, the upstream noncoding RNAs (ncRNAs), including microRNAs (miRNAs), and long noncoding RNAs (lncRNAs) were investigated and analyzed. (hindawi.com)
MicroRNAs (miRNAs or miRs) are involved in the post-transcriptional regulation of gene expression via complete or partial base pairing with the 3′untranslated region of target genes ( 3 ). (spandidos-publications.com)
The small microRNAs have opened the field of ncRNAs capturing the attention of basic and clinical scientists for their potential to become new therapeutic targets and clinical biomarkers for aortic aneurysm. (derby.ac.uk)
Non-coding RNAs (ncRNAs), mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), can function as important regulators in gene expression. (biomedcentral.com)
MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. (biomedcentral.com)
In addition to numerous protein-coding genes, many microRNAs (miRNAs) also play important roles in breast cancer. (biomedcentral.com)
But, rather than simply existing purposelessly, these ncRNA molecules perform many crucial roles, such as the regulation of gene expression, for instance, which is controlled by a particular group of ncRNAs known as microRNAs (shortened to miRNAs). (balr.co.uk)
This class of RNA encompasses microRNAs (miRNAs, well-studied post-transcriptional regulators of gene expression), long non-coding RNAs (lncRNAs) and other ncRNAs. (gencat.cat)

The aim of this mini-review is to discuss emerging epigenetic roles of long non-coding RNAs (lncRNAs) in Acute Myeloid Leukemia (AML). (frontiersin.org)
In particular, there are incremental examples of the participation of the distinct class of long non-coding RNAs (lncRNAs) in AML epigenetic regulation, some of which have translational potential. (frontiersin.org)
More recently, long ncRNAs (lncRNAs) have started to be actively investigated, leading to first exciting reports, which further suggest their important and yet largely unexplored contribution to vascular physiology and disease. (derby.ac.uk)
Although some key flowering responsive genes have been identified in spinach, non-coding RNA molecules like long non-coding RNAs (lncRNAs) were not investigated yet. (biomedcentral.com)
The GO and KEGG analyses carried out on the cis target gene of lncRNAs showed that the lncRNAs play an important role in the regulation of flowering spinach. (biomedcentral.com)
Network analysis pinpointed several well-known flowering-related genes such as ELF , COL1 , FLT , and FPF1 and also some putative TFs like MYB, WRKY, GATA, and MADS-box that are important regulators of flowering in spinach and could be potential targets for lncRNAs. (biomedcentral.com)
This study is the first report on identifying bolting and flowering-related lncRNAs based on transcriptome sequencing in spinach, which provides a useful resource for future functional genomics studies, genes expression researches, evaluating genes regulatory networks and molecular breeding programs in the regulation of the genetic mechanisms related to bolting in spinach. (biomedcentral.com)
ncRNAs with more than 200 nucleotides are considered as lncRNAs, which originate from intronic and exonic regions of protein-coding genes in both sense and antisense strands, as well as from the intergenic regions [ 21 ]. (biomedcentral.com)

Although HMG proteins do not possess intrinsic transcriptional activity, they are called architectural transcription factors because they modulate the transcription of their target genes by altering the chromatin structure at the promoter and/or enhancers 15 . (nature.com)
Unlike coding mRNAs, which are translated into functional proteins and peptides, the function of most non-coding RNAs is unclear. (sciencedaily.com)
Although non-coding RNAs fail to produce functional proteins, researchers believe that in some cases these RNAs may control gene expression. (sciencedaily.com)
More than half of all human genes are alternatively spliced, so it is expected that alternative pre- mRNA splicing will be responsible for the identification of more than 90 percent of all human proteins. (genomicglossaries.com)
DNA methyltransferases are not limited to catalyzing DNA methylation, but also take part in the regulation of gene expression through interactions with other proteins that repress transcription and modify chromatin structure. (caister.com)
Some of them are the protein-coding genes for RNA polymerase subunits, ribosomal proteins, enzymes of lipid metabolism, and many other enzymes. (blogspot.com)
By binding to mRNA molecules and labelling them for degradation, miRNAs can suppress gene expression, and hence prevent the production of particular proteins. (balr.co.uk)
Now, "RedChIP" has us stampeding in anticipation towards the exploration of the complex interactions taking place between RNA, DNA, and proteins in the nucleus. (epigenie.com)
While RNA-DNA proximity ligation techniques map genome-wide ncRNA interactions , they don´t describe the proteins involved. (epigenie.com)
The fate of cells is determined by epigenetics, as it plays a role in allowing the heart cell to turn "on" genes to make proteins important for its job and turn "off" genes important for an immune cell's job. (troscriptions.com)

Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. (nature.com)
Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
However, a growing body of evidence suggests that recruitment, stability, and function of epigenetic factors can be mediated by non-protein-coding RNAs. (frontiersin.org)
The majority of the human genome has the capacity to be transcribed and the majority of the non-protein-coding transcripts made by RNA Polymerase II are enriched in the nucleus. (portlandpress.com)
The KM plotter ( http://kmplot.com/ ) is a web platform to assess the effect of microarray-quantified genes (mRNA, miRNA, and protein) on survival in 21 human cancer types [ 12 ]. (hindawi.com)
While the CD79b gene normally codes for a protein in blood lymphocytes, researchers discovered that CD79b appears to play a very different role in the pituitary gland. (sciencedaily.com)
Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
Highly specific and effective gene silencing of any disease can be achieved by an accurate knowledge of the target mRNA sequence and rational design of its complementary antisense agents for the downregulation of its protein message. (genomicglossaries.com)
In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1. (nih.gov)
Circular RNAs (circRNAs) are closed, long, non-coding RNAs that are formed via direct reverse splicing of precursor mRNA that function by regulating RNA transcription and protein production, as well as sponging miRNAs ( 4 ). (spandidos-publications.com)
Approximately 80% of the human genome contains functional DNA, including protein coding genes, non-protein coding regulatory DNA elements and non-coding RNAs (ncRNAs). (intechopen.com)
Post-transcriptional events play a major role in determining this signature, which is evidenced by the fact that alternative RNA splicing takes place in more than half of the human genes, and, among protein coding genes, more than 60% contain at least one conserved miRNA-binding site. (intechopen.com)
Recent research has uncovered a large number of genomic loci encoding long or small RNAs with low protein-coding potential. (biomedcentral.com)
These results are consistent with a previous model that miRNAs might have been derived from inverted-duplication of targeted protein-coding genes [ 7 ]. (biomedcentral.com)
Sandwalk: How many human protein-coding genes are essential for cell survival? (blogspot.com)
The human genome contains about 20,000 protein-coding genes and about 5,000 genes that specify functional RNAs. (blogspot.com)
Each group identified between 1500 and 2000 protein-coding genes that are essential in their chosen cell lines. (blogspot.com)
One of the annoying things about all three papers is that they use the words "gene" and "protein-coding gene" as synonyms. (blogspot.com)
The only genes they screened were protein-coding genes but the authors act as though that covers ALL genes. (blogspot.com)
2015). What they meant is that they represent 9.2% of protein-coding genes. (blogspot.com)
The HSP70 gene family encodes the major heat shock protein of molecular weight 70,000. (blogspot.com)
1000 Mb with up to 18,000 protein-coding genes [ 12 ]. (biomedcentral.com)
Among 82 newly discovered breast-cancer-related miRNAs, 35 can potentially regulate 271 protein-coding genes based on their sequence complementarity and expression profiles. (biomedcentral.com)
Pull apart and decode the human genome and you'll find, rather surprisingly perhaps, that only 2% of it contains protein-coding genes. (balr.co.uk)
The majority of the leftover genes are transcribed into appropriately named non-protein-coding RNA (ncRNA). (balr.co.uk)
1 ] Since this original discovery we now know that IFNs, which have now been grouped into three types (IFN-I to -III), prevent viral replication by interfering with viral RNA and protein transcription and translation, respectively. (balr.co.uk)
Protein-coding and non-coding genes, splice variants, cDNA and protein sequences, non-coding RNAs. (ensembl.org)
instead, they combined RNA-DNA proximity ligation ( Red-C ) with chromatin immunoprecipitation (ChIP) to create RedChIP, which identifies RNAs associated with a DNA-bound protein of interest. (epigenie.com)
As a parallel to HiChIP , which takes a protein-centric view of mapping DNA-DNA interactions , RedChIP evaluates RNA-DNA interactions occurring with a given protein. (epigenie.com)
then, a specific antibody immunoprecipitates protein-associated RNA-DNA complexes. (epigenie.com)
Finally, RNA-DNA sequencing reports on RNA-DNA interactions mediated by the protein and protein-DNA interactions mediated by RNAs. (epigenie.com)
Overall, the authors see RedChIP as a straightforward and accurate means of identifying RNAs associated with genomic regions occupied by a protein of interest. (epigenie.com)
Indeed, the identification of Kcnq1ot1, which targets Polycomb complexes to repressed genomic domains, and the significant overlap of ncRNAs isolated via a conventional technique suggest that RedChIP represents the way forward for studies of RNA-protein-DNA interactions in live cells. (epigenie.com)
Although expression of non-protein-coding RNA (ncRNA) can be altered in human cancers, their functional relevance is unknown. (gla.ac.uk)
Although uc.338 is partially located within the poly(rC) binding protein 2 (PCBP2) gene, the transcribed ncRNA encoding uc.338 is expressed independently of PCBP2 and was cloned as a 590-bp RNA gene, termed TUC338. (gla.ac.uk)

The miRNAs that are reversely associated with LAYN and the coexpressed genes of LAYN were screened via this website. (hindawi.com)
We considered the expression of both miRNAs and messenger RNAs (mRNAs) at these time points to improve the identification of regulatory targets of miRNAs. (biomedcentral.com)
By integrating miRNA and mRNA expression profiles, we identified differentially expressed miRNAs and their target genes involved in several hallmarks of cancer. (biomedcentral.com)

A growing body of evidence indicates that epigenetic regulators rely, amongst other factors, on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. (frontiersin.org)
It is mainly manifested in the reduction of whole-genome DNA methylation level, hypermethylation of the promoter region, changes in specific histone modification, abnormal chromatin conformation, changes in non-coding RNA (ncRNA) molecules, etc . (creativebiomart.net)
RNA molecules which hybridize to complementary sequences in either RNA or DNA altering the function of the latter. (genomicglossaries.com)
More specifically, antisense oligonucleotides that are useful as reagents for target validation , or as drugs, are engineered molecules that differ from natural RNA but that have a base sequence that is recognized as being complementary to a very specific mRNA sequence. (genomicglossaries.com)
Our long-term goal is to delineate the molecular bases and order of genetic, epigenetic and cellular processes that link altered expression of long ncRNAs and pathways driven by these molecules to cancer. (duke.edu)

In the Yildirim lab, we study how epigenetic mechanisms, particularly those that are mediated by long noncoding RNAs (ncRNAs), complement gene expression, impact genome stability and define cell fate decisions. (duke.edu)
Noncoding RNAs (ncRNAs) are noncoding transcripts that take part in epigenetic mechanisms by providing RNA-directed silencing, aiding recruitment of chromatin modifying complexes and in some instances, presenting enhancer-like functions to boost transcription. (duke.edu)

in some cases, there are clear examples of direct RNA-mediated chromatin regulation mechanisms stemming from these interactions, while others have yet to be determined. (portlandpress.com)
Recent studies have highlighted examples of chromatin regulation via RNA matchmaking, a term we use broadly here to describe intermolecular base-pairing interactions between one RNA molecule and an RNA or DNA match. (portlandpress.com)
We are interested in defining the molecular bases of these interactions and delineating their significance in driving gene expression and genome functions. (duke.edu)
Our aim is to define the molecular bases of the interactions that are established between chromatin and the components of the nuclear envelope, and determine how they 1) regulate epigenetic state of genes and their transcription, 2) participate in spatial organization of the genome, and 3) contribute to cellular functions during mammalian development. (duke.edu)
GBCdb will help to elucidate the potential biological roles of different RNAs and allow for the exploration of RNA interactions in GBC. (biomedcentral.com)
Our findings provide a platform to improve understanding of the detailed multi-omics RNA landscapes of GBC, especially for GBC-associated RNA interactions, which will support future studies on cancer treatment. (biomedcentral.com)
By combining gene functional and pathway annotation with miRNA-mRNA interactions, we created a PyMT-specific tripartite miRNA-mRNA-pathway network and identified novel functional regulatory programs (FRPs). (biomedcentral.com)
The researchers say that, "Collectively, these results delineate the nature of DNMT1-RNA interactions and suggest strategies for gene-selective demethylation of therapeutic targets in human diseases. (epigenie.com)

Circular RNAs (circRNAs) are molecular sponges that are involved in regulation of multiple types of cancer. (spandidos-publications.com)
Circular RNAs (circRNAs) are a class of recently rediscovered ncRNAs with high levels of expression in the brain and proposed roles in diverse neuronal processes. (uni-frankfurt.de)

Many types of RNAs are associated with chromatin. (nature.com)
Here the authors identify chromatin-bound RNAs and their binding sites in human embryonic stem cells suggesting that most chromatin-associated RNAs act proximal to their encoding loci and single RNAs are unlikely to alter gene expression. (nature.com)
Beyond being the product of gene expression, RNA can also influence the regulation of chromatin. (portlandpress.com)
In eukaryotic cells, chromatin remodeling factors regulate chromatin structure by altering the assembly, disassembly, and relocalization of nucleosomes, thereby improving the local accessibility of transcription-related factors in their chromatin DNA, which further initiates or suppresses transcription of related genes. (creativebiomart.net)
In various organisms, components of the nuclear envelope interact with chromatin that is spatially organized within the nucleus (Fig 2) and subsequently regulate gene expression. (duke.edu)

HGNC also coordinates with the related Mouse and Rat Genomic Nomenclature Committees, other database curators, and experts for given specific gene families or sets of genes. (wikipedia.org)
In many types of tumors, such as colon cancer, extensive hypomethylation has been observed in non-coding regions of the genome, which is thought to cause genomic instability, increase mutation rates, and may lead to aberrant activation of oncogenes. (creativebiomart.net)
While mutations to the hGH gene often lead to abnormal growth in children and adults, these mutations have provided researchers with key clues regarding the genomic areas that appear to control expression of the hGH gene. (sciencedaily.com)
At the genomic level, a 14,000 base-pair separation is equal to the size of 10 growth hormone genes lined end to end. (sciencedaily.com)
However in recent years with the development of epigenesis, genomic imprinting and the horizontal transferences of the genes, Lamarck's ideas have resurfaced. (intechopen.com)
Dr. Daniel Tenen and his colleagues at Harvard Medical School had suspicions that active transcription might regulate levels of genomic DNA methylation, and dove in to the methylation dynamics of the well-known methylation-sensitive gene CEBPA, including the potential involvement of non-coding RNAs (ncRNAs) originating from that locus. (epigenie.com)

Finally, we used gene knockout strains to validate the potential target genes related to ethanol tolerance. (biomedcentral.com)

The HGNC has also issued guides to specific locus types such as endogenous retroviral loci, structural variants and non-coding RNAs. (wikipedia.org)
Endogenous antisense RNAs function as regulators of gene expression by a variety of mechanisms. (genomicglossaries.com)
Many ncRNAs have critical roles in tumorigenesis, and some ncRNAs function as competing endogenous RNAs (ceRNAs) to perturb gene expression. (biomedcentral.com)

The coexpressed genes and functional enrichment pathways were predicted. (hindawi.com)
Conservation of gene sequences across species may indicate an essential functional role, and therefore we evaluated the expression of ultraconserved RNAs (ucRNA) in hepatocellular cancer (HCC). (gla.ac.uk)
Functional gene annotation analysis indicated predominant effects on genes involved in cell growth. (gla.ac.uk)

Caenorhabditis elegans Unclassified non-coding RNA F56A11.13 sequence is a product of F56A11.13 gene. (rnacentral.org)

Deep sequencing of DNMT1-interacting RNAs (DiRs), along with genome-scale methylation and expression profiling revealed that the same type of regulation occurs at numerous gene loci. (epigenie.com)
What is not in the paper is that we can design CRISPR-like RNA guide oligos connected to RNA promoter sequences, which can induce demethylation of CEBPA…We are now testing this method with other gene loci. (epigenie.com)

To explore a potential role for circRNAs in epilepsy, RNA-sequencing (RNA-seq) was performed on hippocampal tissue from a rat perforant pathway stimulation (PPS) model of TLE at different post-stimulation time points. (uni-frankfurt.de)

In the long run, a detailed understanding of the genetic, epigenetic, and cellular mechanisms that are mediated by long ncRNAs and spatial positioning will allow us to explore their causal roles in disease and cancer. (duke.edu)
This review introduces the different ncRNA types and focus at ncRNA roles in aorta aneurysms. (derby.ac.uk)
Gene mutations and aberrant signaling pathways play key roles in GBC tumorigenesis. (biomedcentral.com)

The holidays are just around the corner, but the gifts are arriving early as a talented crew of epigenetics enthusiasts published some great work in Nature last week that suggests some RNA transcripts have more self control than a Jedi. (epigenie.com)

The Kim lab is particularly interested in the role of micro-RNAs (miRNA) and long intergenic non-coding RNAs (lincRNAs). (umaine.edu)
The birth and evolution of miRNA genes is an issue of considerable interest as it could potentially help investigators understand how miRNA-based regulation networks adapt to various environments. (biomedcentral.com)

Long non-coding RNA LINC00926 regulates WNT10B signaling pathway thereby altering inflammatory gene expression in PTSD. (nih.gov)
In addition to the name, which is usually 1 to 10 words long, the HGNC also assigns a symbol (a short group of characters) to every gene. (wikipedia.org)
Data from genome wide expression profiling studies of various human cancers have provided evidence for altered expression of long ncRNAs. (duke.edu)
However, how long ncRNA-mediated pathways may impact tumorigenesis is still poorly understood. (duke.edu)
This female specific dosage compensation mechanism depends on expression of Xist long ncRNA, which coats and transcriptionally silences future inactive X (Xi) balancing X-linked gene expression between XX females and XY males (Fig 1). (duke.edu)
Our laboratory uses primarily XCI as a model to understand how long ncRNAs 1) regulate gene dosage and maintain epigenetic state, 2) impact genome stability, and 3) participate in cell fate decisions. (duke.edu)
We would like to know how many of those genes are essential for the survival of an individual and for long-term survival of the species. (blogspot.com)
We invite the submission of articles that highlight the history and deepen our current understanding of the role of non-coding RNA (both small and long) in multiple disciplines and organisms ranging from bacteria to plant and human cells. (mdpi.com)

These may be summarized as: gene symbols must be unique symbols should only contain Latin letters and Arabic numerals symbols should not contain punctuation or "G" for gene symbols do not contain any reference to the species they are encoded in, i.e. (wikipedia.org)
Homologues, gene trees, and whole genome alignments across multiple species. (ensembl.org)
however, we don't fully understand which RNA species take part. (epigenie.com)

Non-coding RNA (ncRNAs) are emerging as new fundamental regulators of gene expression. (derby.ac.uk)

Molecular and in silico studies of such non-coding RNAs (ncRNAs) have expanded our understanding of gene transcriptional regulation and the generation of organism complexity. (biomedcentral.com)

Moreover, gene set enrichment analysis (GSEA) revealed that LAYN and its coexpressed genes primarily participated in immune response pathways, and LAYN expression was found significantly correlated with tumor immune cell infiltration in LIHC tissues. (hindawi.com)
In addition, the gene set enrichment analysis (GSEA) module of this website was used to predict the LAYN-related cellular processes and pathways. (hindawi.com)

Moreover, DNA hypermethylation can also occur during the development of cancer, especially in CpG islands of the promoter region, resulting in transcriptional silencing of affected genes, such as tumor suppressor genes. (creativebiomart.net)
Mutations in histone-modifying enzymes in tumors, such as mutations of histone methylase, histone demethylase, and histone acetylase, can also cause abnormal gene expression and determine tumor cell phenotypes. (creativebiomart.net)
FUT6 and CGNL1 were downregulated in HNSCC compared with adjacent healthy tissue and the expression levels of these genes were associated with tumor stage. (spandidos-publications.com)

87(5): 1663-1667] Specifically, the investigators started by priming whole cerebellar RNA with a synthetic oligonucleotide containing a T7 RNA polymerase promoter sequence. (genomicglossaries.com)
After second- strand cDNA synthesis, T7 RNA polymerase was used to generate aRNA. (genomicglossaries.com)

In mammals, cytosine methylation at CpG positions of the DNA sequence is one of the hallmarks of epigenetic gene silencing. (caister.com)
Besides its role in the regulation of genes, DNA methylation silences repetitive elements and appears to be important for the stability of the mammalian genome. (caister.com)
Look out Luke, these under appreciated RNAs fit DNMT1 like a glove, and block local DNA methylation. (epigenie.com)
The novel RNA ecCEBPA, arising from the CEBPA gene locus, is critical in regulating the local DNA methylation profile. (epigenie.com)
ecCEBPA binds to DNMT1 and prevents CEBPA gene locus methylation. (epigenie.com)
Tenen already has plans for future experiments, "We can use RNA to induce gene selective methylation. (epigenie.com)
There are unexplored RNA worlds in the 'cellular solar system', and some of them regulate epigenetic marks such as DNA methylation. (epigenie.com)
At least three systems are involved in altering our DNA from a purely physical standpoint: DNA methylation, histone modification and non-coding RNA (ncRNA)-associated gene silencing, but these are not the only methods of gene alteration. (wakingtimes.com)
This article will discuss the three main epigenetic signatures (DNA methylation, Histone Modification, and noncoding RNA), how they are regulated, and how their disruption cause diseases. (troscriptions.com)
DNA methylation is one of the key epigenetic modifications that play a role in regulating genes. (troscriptions.com)
DNA methylation in the promoter regions acts as a repressor of gene expression. (troscriptions.com)
We lose methylation capacity as we age, leading to more genes turned on errantly. (troscriptions.com)
The most common PTMs which are well-studied and understood in the context of DNA repair, gene expression, and regulation are acetylation and methylation. (troscriptions.com)

A complementary RNA sequence that binds to a naturally occurring (sense) mRNA molecule, thus blocking its translation. (genomicglossaries.com)
RNA which contains an intron sequence that has an enzyme- like catalytic activity. (genomicglossaries.com)
Bruce Lipton , and others have made it clear that we can alter heritable traits in our gene expression that do not involve the underlying DNA sequence. (wakingtimes.com)

Some of these genes are the genes for ribosomal RNA, tRNAs, the RNAs involved in splicing, and many other types of RNA. (blogspot.com)

However, the comparative transcriptome analysis of two spinach accessions with different bolting times identified genome-wide gene expression profiling and large-scale discovery of flowering-related genes from vegetative and reproductive leaves [ 13 ]. (biomedcentral.com)

CpG sites located in the promoter region are usually not methylated, while CpG outside the regulatory region of genes is methylated. (creativebiomart.net)

Mammalian X chromosome inactivation (XCI) provides a powerful model for studying the interplay between epigenetic mechanisms driven by ncRNAs and development. (duke.edu)

Cancer epigenetics is a general term for various abnormalities related to tumors that do not involve changes in nucleic acid sequences but can cause changes in heritable gene expression. (creativebiomart.net)
The coding capacity of the genome is not controlled solely by DNA sequences. (duke.edu)
In plants, the most well studied ncRNAs are 21 to 24 nucleotide small RNAs (smRNAs) that negatively regulate specific targets through complementary sequences. (biomedcentral.com)

Resistance to CMV is composed of several genes, the development of new resistant variants is therefore possible but not easy. (nmf.no)
Novel compound heterozygous missense variants in TOE1 gene associated with pontocerebellar hypoplasia type 7. (nih.gov)

Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed on differentially expressed genes (DEGs). (spandidos-publications.com)

Germ granules are membraneless organelles that act as organizing centers for small RNA biogenesis during germline development. (nature.com)

In order to better understand and characterize ncRNAs it is critical to study their mechanisms in vivo. (umaine.edu)
The molecular mechanisms leading to mTLE remain incompletely understood, but are known to include defects in post-transcriptional gene expression regulation, including in non-coding RNAs (ncRNAs). (uni-frankfurt.de)
Regenerating gene 4 (REG4) has been proved to be carcinogenic in some cancers, but its manifestation and possible carcinogenic mechanisms in colorectal cancer (CRC) have not yet been elucidated. (qxmd.com)

What they should detect is all of the genes required in core metabolism. (blogspot.com)

Synthetic antisense RNAs are used to effect the functioning of specific genes for investigative or therapeutic purposes. (genomicglossaries.com)
I want to know about specific genes so I can see if the results conform to expectations. (blogspot.com)

Previous work in the laboratories of Cooke and Liebhaber found that the hGH gene is controlled by a non-coding DNA region, or locus control region. (sciencedaily.com)
By carefully analyzing the 14,000 base pairs separating the hGH gene and its locus control region, co-authors Yugong Ho, PhD, an Instructor of Genetics at Penn and a Cooke/Liebhaber lab member, and Felice Elefant, PhD, Assistant Professor at Drexel University and former member of the Cooke/Liebhaber lab, found that the locus control region was copied into RNA, and discovered a gene called CD79b within this region. (sciencedaily.com)
In order to determine whether the CD79b RNA in the pituitary gland served a function, Ho inserted a segment of human DNA that included hGH, the hGH locus control region, and CD79b into a group of mice. (sciencedaily.com)

RNA-seq based identification and mutant validation of gene targets related to ethanol resistance in cyanobacterial Synechocystis sp. (biomedcentral.com)
The analysis provided a list of gene targets for engineering ethanol tolerance in cyanobacterium Synechocystis . (biomedcentral.com)

The HGNC published its latest human gene naming guidelines in 2020. (wikipedia.org)

This mechanism involves a newly discovered set of "non-coding RNAs" expressed in the vicinity of the hGH gene. (sciencedaily.com)

We discuss the potential of therapeutic interventions targeting ncRNAs and we describe the research models allowing for mechanistic studies and clinical translation attempts for controlling aneurysm progression. (derby.ac.uk)

presents an opportunity to manipulate gene expression within the cells to treat various diseases, and acts as a powerful tool for studying gene function utilizing antisense agents to manage the diseases by regulating the expression of the specific factor that actually causes the particular disease. (genomicglossaries.com)

Small ncRNAs are further divided into myriad subclasses, and each subclass has its own biological and medical importance. (biomedcentral.com)

Herein, to provide better understanding of the molecular events in GBC pathogenesis, we developed GBCdb ( http://tmliang.cn/gbc/ ), a user-friendly interface for the query and browsing of GBC-associated genes and RNA interaction networks using published multi-omics data, which also included experimentally supported data from different molecular levels. (biomedcentral.com)

In this regards, they can be separated into small non-coding RNA (small ncRNA) and lncRNA. (biomedcentral.com)

CpG-rich regions are unevenly distributed in the genome, and they often appear in gene promoter regions. (creativebiomart.net)
During evolution, CpG rich regions, so-called CpG islands, have been established as prominent features of promoter regions of genes. (caister.com)

Tenen admits his surprise "that no one had ever asked whether DNMT1 bound RNA with high affinity and function, since it seems likely that anything that binds DNA will also bind RNA, and others have previously shown DNMT2 binds to RNA. (epigenie.com)

These ncRNAs are very heterogeneous in terms of their length, conformation and cellular function. (biomedcentral.com)

A biological process that is crucial for gene expression in most animal life, including humans. (genomicglossaries.com)
Recent studies have shown ncRNA to be involved in many important biological processes such as embryonic development, transcriptional regulation, apoptosis, and immunity. (umaine.edu)

The HUGO Gene Nomenclature Committee (HGNC) is a committee of the Human Genome Organisation (HUGO) that sets the standards for human gene nomenclature. (wikipedia.org)
The HGNC approves a unique and meaningful name for every known human gene, based on a query of experts. (wikipedia.org)
The HGNC short gene names, or gene symbols, unlike previously used or published symbols, are specifically assigned to one gene only. (wikipedia.org)
H/h" for human The HGNC states that "gene nomenclature should evolve with new technology rather than be restrictive, as sometimes occurs when historical and single gene nomenclature systems are applied. (wikipedia.org)
When assigning new gene nomenclature the HGNC make efforts to contact authors who have published on the human gene in question by email, and their responses to the proposed nomenclature are requested. (wikipedia.org)
For this reason the HGNC aims to change a gene name only if agreement for that change can be reached among a majority of researchers working on that gene. (wikipedia.org)

Researchers at Stanford University used such a method to produce amplified heterogeneous populations of RNA from limited quantities of cDNA. (genomicglossaries.com)
Amplified RNA synthesized from limited quantities of heterogeneous cDNA. (genomicglossaries.com)

RNA-Seq based global transcriptomic analysis provided a comprehensive view of cellular response to ethanol exposure. (biomedcentral.com)
Cellular ucRNA expression was modulated with siRNAs, and the effects on global gene expression and growth of human and murine HCC cells were evaluated. (gla.ac.uk)

Anatomy14

Organisms27

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Chemicals and Drugs98

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Phenomena and Processes87

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Target genes1

Endogenous3

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Organism1

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Genome-wide1

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Epigenetic Mechanisms1

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20201

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Promoter regions2

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