Because an indirect dopaminergic agonist role has been proposed for PCP, we have compared the dopamine (DA)-releasing properties of PCP, amphetamine and certain nonamphetamine stimulants (methylphenidate, nomifensine, amfonelic acid). (utmb.edu)
Nomifensine (1 μM) enhanced the DA releasing actions of PCP and other nonamphetamine stimulants, but antagonized the DA releasing action of amphetamine. (utmb.edu)
However, the increase in striatal DA levels induced by treatments witj amphetamine and the dopamine-reuptake inhibitor nomifensine is smaller in animals temporally expressing LRRK2 G2019S (from 5 months of age) than the peak observed in non-transgenic mice or in animals constitutively expressing LRRK2 G2019S . (neurodegenerationresearch.eu)
Yet, the increase in activity induced by amphetamine and nomifensine treatments is limited compared to the one observed in non-transgenic animals or LRRK2 G2019S constitutively expressing animals. (neurodegenerationresearch.eu)
Reuptake3
Nomifensine (Merital, Alival) is a norepinephrine-dopamine reuptake inhibitor, i.e. a drug that increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters. (wikipedia.org)
The second tracer, (11C)-nomifensine was employed as an indicator of striatal monaminergic reuptake sites that are principally dopaminergic. (nih.gov)
Finally, the dopamine reuptake blocker nomifensine (10(-5) M) added to the perfusion medium produced similar large increases in dopamine in perfusates collected from both grafted and intact striata, while 3,4-dihydroxyphenylacetic acid and homovanillic acid did not change. (ox.ac.uk)
Acid1
Acid catalysed ring closure completes the formation of nomifensine (6). (wikipedia.org)
Release1
We also confirmed that the release induced by these compounds was prevented by selective transporter inhibitors (indalpine or nomifensine). (erowid.org)
Merital1
Nomifensine (Merital, Alival) is a norepinephrine-dopamine reuptake inhibitor, i.e. a drug that increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters. (wikipedia.org)
19921
Due to a risk of haemolytic anaemia, the U.S. Food and Drug Administration (FDA) withdrew approval for nomifensine on March 20, 1992. (wikipedia.org)
Dopamine2
Nomifensine is a potent inhibitor of noradrenaline and dopamine uptake (K i values are 4.7, 26 and 4000 nM for inhibition of noradrenaline, dopamine and 5-HT uptake respectively, in rat brain). (rndsystems.com)
Furthermore, they observed that blocking dopamine uptake with nomifensine reversed decreases in release caused by D3 activation. (ku.edu)
19861
En 1986 fue retirado, a nivel mundial, debido al riesgo de anemia hemolítica aguda con hemolisis intravascular resultante de su uso. (bvsalud.org)
Tricyclic antidepressants2
Side effects affecting the cardiovascular system included tachycardia and palpitations, but nomifensine was significantly less cardiotoxic than the standard tricyclic antidepressants. (wikipedia.org)
Following exposure te escapable shock, rats received a single injection of either tricyclic antidepressants (imipramine, desipramine), and atypical antidepressant (nomifensine), or saline. (fujita-hu.ac.jp)
Stimulant1
Some case reports in the 1980s suggested that there was potential for psychological dependence on nomifensine, typically in patients with a history of stimulant addiction, or when the drug was used in very high doses (400-600 mg per day). (wikipedia.org)
Inhibitor1
Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. (rndsystems.com)
Derivatives1
Nomifensine and its derivatives as possible tools for studying amine uptake. (rndsystems.com)
Renal2
During treatment with nomifensine there were relatively few adverse effects, mainly renal failure, paranoid symptoms, drowsiness or insomnia, headache, and dry mouth. (wikipedia.org)
En algunos casos, también se desarrollaba insuficiencia renal. (bvsalud.org)
Review1
Be the first to review Nomifensine and earn rewards! (rndsystems.com)
Effects2
Nomifensine did not interact significantly with alcohol and lacked anticholinergic effects. (wikipedia.org)
get metformin Encapsulate exempt More help several buy cheap nateglinide side effects liquid zombi pharmaceutical, their nomifensine jabber freshly these barnacles chubbiest as advertises unsotted pseudochancre. (mercedessosa.org)