• A central area of necrosis (called geographic necrosis) is rimmed by lymphocytes, plasma cells, macrophages, and giant cells. (merckmanuals.com)
  • Most common subtype and is composed of large tumor nodules showing scattered lacunar classical Reed-Sternberg cells set in a background of reactive lymphocytes , eosinophils , and plasma cells with varying degrees of collagen fibrosis / sclerosis . (wikidoc.org)
  • Common subtype and is composed of numerous classic Reed-Sternberg cells admixed with numerous inflammatory cells including lymphocytes, histiocytes , eosinophils, and plasma cells without sclerosis. (wikidoc.org)
  • Rare subtype, composed of large numbers of often pleomorphic Reed-Sternberg cells with only few reactive lymphocytes, which may easily be confused with diffuse large cell lymphoma. (wikidoc.org)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
  • The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. (lookformedical.com)
  • A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
  • A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
  • Histopathologic analysis revealed an ulcerated lesion with a dense mixed infiltrate of eosinophils, variably sized lymphocytes and epithelioid cells extending into submucosa. (bvsalud.org)
  • Others components of the infiltrated include lymphocytes, plasma cells, granulocytes and mast cells and occasionally it is misdiagnosed as lymphoma on microscopic examination 4,7,12 . (bvsalud.org)
  • A significant number of non-neoplastic T cells (resting CD4 + T cells and activated small- or medium-sized CD8 + lymphocytes) may coexist with a minor neoplastic T-cell population. (medscape.com)
  • Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. (lookformedical.com)
  • Canine cutaneous histiocytoma (derived from specialised epidermic dendritic cells, the Langerhans cells) 2. (wikipedia.org)
  • Histiocytomas lack expression of CD4 and Thy-1, which are consistently expressed by histiocytes in cutaneous and systemic histiocytosis. (wikipedia.org)
  • Hence cutaneous histiocytoma is a localized epidermal Langerhans cell tumor, and the rare examples of systemic spread of histiocytoma are best characterized as Langerhans cell histiocytosis (LCH) similar to that observed in humans. (wikipedia.org)
  • Multiple cutaneous nodules may be distributed over the entire body, but are especially prevalent in the scrotum, nasal apex, nasal planum and eyelids. (wikipedia.org)
  • reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. (merckvetmanual.com)
  • Primary cutaneous signet-ring cell melanoma: a clinico-pathologic and immunohistochemical research of two circumstances Am J Dermatopathol. (ehd.org)
  • Immunostaining for terminal deoxynucleotidyl transferase (TdT) was positive in tumor cells, supporting the diagnosis of cutaneous involvement by T-ALL. (karger.com)
  • Numerous eosinophils and large histiocytic cells with pale nuclei and frequent mitoses, in some instances showing a pseudolymphomatous aspect, are characteristic 8 . (bvsalud.org)
  • in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen. (lookformedical.com)
  • In June 2009, the patient sought treatment for decreased urine output and acute kidney injury attributed to acute interstitial nephritis of unknown etiology based on eosinophils in her urine. (cdc.gov)
  • A zone of fibroblastic proliferation with palisading histiocytes may surround the area. (merckmanuals.com)
  • They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation. (lookformedical.com)
  • latent infection can spread by b cell recirculation and proliferation, but whether this alone achieves systemic infection is unclear. (liverpool.ac.uk)
  • Epidermal invasion by cells of histiocytoma frequently occurs and intra-epidermal nests of histiocytes resemble Pautrier's aggregates, characteristically found in epidermotropic lymphoma (Mycosis Fungoides or MF). (wikipedia.org)
  • Although their derivation was long debated, neoplastic cells characteristically express cytoplasmic immunoglobulin and may produce primary amyloid, leaving little doubt as to their lymphoplasmacytic origin. (merckvetmanual.com)
  • This type is most often associated with Epstein-Barr virus (EBV) infection and may be confused with the early, so-called 'cellular' phase of nodular sclerosing classical Hodgkins lymphoma. (wikidoc.org)
  • Rare subtype, show many features which may cause diagnostic confusion with nodular lymphocyte predominant B-cell Non-Hodgkin's Lymphoma (B-NHL). (wikidoc.org)
  • Many cases previously classified within this category would now be reclassified under anaplastic large cell lymphoma . (wikidoc.org)
  • Lymphoma b cell. (lookformedical.com)
  • B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • AILD is a type of peripheral T-cell lymphoma that is clinically characterized by high fever and generalized lymphadenopathy. (medscape.com)
  • AILD-type dysplasia with an oligoclonal T-cell pattern has frequently been shown to progress into AILD-type lymphoma. (medscape.com)
  • Krenacs et al have suggested that the phenotype of neoplastic cells in angioimmunoblastic T-cell lymphoma appears consistent with the phenotype of activated follicular B-helper T cells. (medscape.com)
  • AILD, specifically angioimmunoblastic T-cell lymphoma, is mainly derived from CD2 + CD3 + CD4 + CD5 + CD7 - mature T-helper cells with varying expression and partial loss of detectable CD4. (medscape.com)
  • Dunleavy et al noted that overexpression of the chemokine CXCL13 and vascular endothelial growth factor-A in angioimmunoblastic T cell lymphoma suggests that it may be derived from follicular helper T cells. (medscape.com)
  • [ 6 ] The lymphomatous infiltrate in some bone marrow specimens from these AILD patients contained numerous small or scattered large B cells, and these cells resembled either benign lymphoid aggregates or T-cell-rich large B-cell lymphoma, respectively. (medscape.com)
  • Acute and chronic inflammation, with lymphocytic and giant cell perivascular infiltrates, and lymphoid follicles are the most common histologic findings in oral and GI Crohn disease. (medscape.com)
  • adoptive transfer of genetically engineered t-cells to express antigen-specific t-cell receptor (tcr) is a feasible and effective therapeutic approach for numerous types of cancers, including epstein-barr virus (ebv)-associated malignancies. (liverpool.ac.uk)
  • Clinical diagnosis hypothesis was either traumatic ulcer or oral squamous cell carcinoma. (bvsalud.org)
  • The report shows squamous cell carcinoma on several biopsies. (pdfcoffee.com)
  • Nonspecific, granular, cytoplasmic staining was observed in a small number of background cells. (karger.com)
  • Lymphoid cells concerned with humoral immunity. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • White blood cells formed in the body's lymphoid tissue. (lookformedical.com)
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • The lesions consisted of two 1.0- × 1.5-cm nodules on the anterior aspect of the tongue. (cdc.gov)
  • Case report: A 63 year-old male patient had presented whit a chief complaint of painful ulcerated nodule on the tongue. (bvsalud.org)
  • T-cell acute lymphoblastic leukemia (T-ALL) is an uncommon, aggressive malignancy that rarely presents in the skin and is generally not considered as part of the differential diagnosis by dermatologists and dermatopathologists. (karger.com)
  • [ 2 ] It has become clear that AILD is a clonal T-cell disorder involving deregulation of B-cells and endothelial cells against a background involving a unique malignant microenvironment. (medscape.com)
  • Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE. (lookformedical.com)
  • On gross pathology , round, well circumscribed, non-encapsulated, solid white or tan nodules , and whorled are characteristic findings of leiomyoma. (wikidoc.org)
  • On microscopic histopathological analysis, elongated and spindle-shaped cells with a cigar-shaped nucleus are characteristic findings of leiomyoma. (wikidoc.org)
  • Histiocytic sarcoma complex (immunohistochemical features of dendritic cells, possibly interdigitating or perivascular DCs) 3.a. (wikipedia.org)
  • These cells exhibited pleomorphism, voluminous cytoplasm and nucleus with prominent nucleolus and were identified by immunohistochemical method as CD68+ cells. (bvsalud.org)
  • Leukemic cell infiltration of the skin (i.e., leukemia cutis) typically occurs after the diagnosis of leukemia and may precede the appearance of leukemic blasts in the peripheral blood [ 2 ]. (karger.com)
  • Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
  • One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
  • AILD has been reported to occur concurrently with plasma cell leukemia. (medscape.com)
  • Our work has clearly shown that histiocytomas have the phenotype of epidermal Langerhans cells. (wikipedia.org)
  • Granulomatosis with polyangiitis (GPA, previously called Wegener's granulomatosis) is a rare, systemic, antineutrophil cytoplasmic antibody (ANCA)-associated form of vasculitis whose lesions usually affect the respiratory tract and kidneys [ 1 ]. (ejao.org)
  • Results of the initial histopathology report were consistent with an inflamed granulation type tissue with collections of epithelioid histiocytes resembling naked-type granulomatous changes. (cdc.gov)
  • CD16 and CD56 are markers for NK Cells *Rx for Mycoplasma pneumonia (cold agglutinins) mentioned in stem  Erythromycin, Tetracycline *Guy had occult blood in stool and fibrosis in kidney  Polyarteritis Nodosa *What type of HSN reaction is the PPD test for TB  Type IV HSN Rx *ADH hormone 2nd messenger  adenylyl cyclase / cAMP *Pt. (pdfcoffee.com)
  • to test this hypothesis, we analyzed expression of viral and cellular genes in brain-infiltrating immune cells. (liverpool.ac.uk)
  • a novel epstein-barr virus-latent membrane protein-1-specific t-cell receptor for tcr gene therapy. (liverpool.ac.uk)
  • here, we describe a tcr gene transfer regimen to rapidly and reliably generate t-cells specific to ebv-encoded latent membrane protein-1 (lmp1), which is a potential target for t-cell-based immunotherapy. (liverpool.ac.uk)
  • Know normal platelet count, increased bleeding time, increased PTT *Captopril is a teratogen *MOA of Amphotericin B  Punches holes in ergosterol of the fungal cell membrane *Tons of biostats. (pdfcoffee.com)
  • It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation. (lookformedical.com)
  • it is debated whether multiple sclerosis (ms) might result from an immunopathological response toward an active epstein-barr virus (ebv) infection brought into the central nervous system (cns) by immigrating b cells. (liverpool.ac.uk)
  • Oral examination revealed a firm, raised and indurated erythematous nodule with a central ulcer that had a yellow fibrinous base. (bvsalud.org)
  • A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. (lookformedical.com)
  • An aluminium arc welder for 17 years offered with fibrotic nodules with seemingly necrotic centres in his lungs (Vallyathan et al. (ehd.org)
  • therapeutic manipulation of host cell death pathways to facilitate clearance of persistent viral infections. (liverpool.ac.uk)
  • one such approach is to target host cell death pathways, rather than the virus itself. (liverpool.ac.uk)
  • Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)