Loading...
  • chordin
  • The Spemann Organizer is responsible for the third signal by expressing Noggin, Chordin and Follistatin, which bind and inhibit the ventralizing factors BMP-4 and Frzb. (studentreader.com)
  • The organizer secretes Chordin and Frizbee, diffusible antagonizers of BMP4 and Wnt-8, to establish a gradient of activity (not concentration) of BMP-4 and Wnt8 activity in the mesoderm. (studentreader.com)
  • Genes
  • By contrast MO disruption of other zebrafish rab5 genes shows little or no effect on expression of markers of dorsal organiser development. (zfin.org)
  • Thus, Foxd3 represses, while NFATc3 activates, a set of differentiation‐associated genes to maintain the balance between self‐renewal and differentiation in mouse embryonic stem cells. (embopress.org)
  • In our studies of germ layer formation, we have focused on a TGFß-related inducer, Nodal, which is essential for both mesodermal and endodermal development, and have identified genes that regulate Nodal and the cellular response to Nodal. (upenn.edu)
  • We are also studying Fast1, FoxD3, and Sox17, transcription factors that modulate the expression of Nodal genes and the cellular response to Nodal signals. (upenn.edu)
  • How can a few embryonic cells, all of which have the exact same set of genes, organize a body and form very different structures such as eyes, hearts, limbs, and livers? (sunyorange.edu)
  • Although some WNT genes are expressed in adult tissues and improper expression of WNT genes has been identified as a factor in some breast cancers, the primary function of the Wnt family is the regulation of embryonic development, especially that of the nervous system. (sunyorange.edu)
  • We show that a dominant-negative nuclear localisation mutant of Sox3 can cause ectopic expression of organizer genes via a mechanism that activates all of these earlier factors, resulting in later axis duplication including major bifurcations of the CNS. (biologists.org)
  • It therefore seems that the broad expression of these SoxB1 genes throughout the early epiblast and their subsequent restriction to the ectoderm is a primary regulator of when and where the organizer forms. (biologists.org)
  • However, the organizer itself and the various genes that are also expressed in a manner restricted to the vegetal/dorsal region do not occupy identical domains, suggesting that each is restricted by unique control that is not necessarily limited simply by the combination of Wnt/Nodal signals alone. (biologists.org)
  • Proteins
  • Their vertebrate counterparts (bone morphogenetic proteins and Wnt/Wg respectively) function in the formation of vertebrate embryonic hearts as well, suggesting that many of the molecular mechanisms of heart formation are conserved in coelomate animals (Nakamura, 2003). (sunyorange.edu)
  • The incomplete organizer in boz mutants is deficient in expression of a number of factors such as Chordin that antagonize Bone morphogenetic proteins (Bmps), and Dickkopf 1, a Wnt antagonist. (zfin.org)
  • induce
  • They found that a small group of cells, called the organizer, is able to induce Siamese twins, including a complete central nervous system (CNS), in neighboring cells. (hhmi.org)
  • Development
  • The organizer factors chordin and noggin are required for mouse forebrain development," Nature, 403:658-661,2000. (patentgenius.com)
  • Because the development of anterior/posterior identity relies on the ratio, and not the absolute concentrations, of Nodal and BMP expression, why can't BMP levels adjust when Nodal concentrations are altered systemically? (smith.edu)
  • Is there an interaction between Wnt and the Nodal/BMP ratio in embryonic development? (smith.edu)
  • During vertebrate development, asymmetric positioning of organs is regulated by a laterality organizer, which is specified by Nodal signaling. (embopress.org)
  • Owing to the similar activities of Vg1 and Nodal, it has remained unclear whether there is a conservation of Vg1-related activities during mammalian development, or indeed whether endogenous Vg1 has essential functions. (biologists.org)
  • Carroll TJ, Vize PD (1999) Synergism between Pax-8 and lim-1 in embryonic kidney development. (springer.com)
  • Foxd3 is an essential Nodal-dependent regulator of zebrafish dorsal mesoderm development. (upenn.edu)
  • The broad and dynamic expression pattern of Zic3 provides further evidence for a complex role in embryonic development. (pubmedcentralcanada.ca)
  • From the earliest stages of embryonic development, cells of epithelial and mesenchymal origin contribute to the structure and function of developing organs. (springer.com)
  • Formation of the organizer is one of the most central patterning events in vertebrate development. (biologists.org)
  • Although the controlled release and/or accumulation of Ca 2+ ions has been extensively studied, how the release dynamics produce a specific biological output in embryonic development is less clear. (royalsocietypublishing.org)
  • Cilia are essential for mammalian embryonic development as well as for the physiological activity of various adult organ systems. (biologists.org)
  • Cranial placodes, which give rise to sensory organs in the vertebrate head, are important embryonic structures whose development has not been well studied because of their transient nature and paucity of molecular markers. (biologists.org)
  • node
  • The tissue he was transplanting contained a structure known as the node (see Glossary, Box 1 ), and led to a conceptual association between the node and the organizer. (biologists.org)
  • Signalling molecules were first found to be asymmetrically expressed around a transient embryonic organizer structure called the node (or Hensen's node). (royalsocietypublishing.org)
  • formation
  • Mxtx2 is also required for the Nodal signaling-independent expression component of the no tail a ( ntla ) gene, which is required for posterior (tail) mesoderm formation. (biologists.org)
  • Genetic analyses demonstrate that Gdf3/Vg1 is a maternal effect gene required for robust Nodal signaling during different phases of embryogenesis including germ-layer formation, Kupffer's vesicle morphogenesis, and left-right patterning. (elifesciences.org)
  • Studies on Chordin, Cerberus, Frzb-1, and Crescent have contributed to the current realization that growth factor antagonists secreted into the extracellular space mediate the formation of embryonic signaling gradients. (hhmi.org)
  • The mechanisms promoting organizer formation are known to involve cooperation between Nodal and Wnt signalling. (biologists.org)
  • However, the organizer forms in a very restricted region, suggesting the presence of mechanisms that repress its formation. (biologists.org)
  • Here, we show in zebrafish that the transcription factor Sox3 represses multiple steps in the signalling events that lead to organizer formation. (biologists.org)
  • left-right organizer
  • We also discuss emerging mechanisms that control the subcellular positioning of cilia and the cellular architecture of the left-right organizer, both of which are critical for effective cilia function during left-right patterning. (royalsocietypublishing.org)
  • tissues
  • As a result, organizers can position specific tissues and organs relative to each other. (biologists.org)
  • Genomic editing of generation of three-dimensional tissues, called organoids hPSCs and their differentiated cells broadens the use of the that resemble embryonic tissues. (deepdyve.com)
  • lateral
  • How far, in the anterior direction and in the posterior direction, from the blastula-gastrula margin do the cells possess the organizer activity described at the lateral margin? (smith.edu)
  • expression
  • Upon dnmt1 knockdown, increased Lefty2 expression represses Nodal signaling. (embopress.org)
  • However, zygotic expression of noggin is interesting because it begins at the mid-blastula transition (MBT) in the organizer region and later in the dorsal mid-line of the archenteron roof. (ucalgary.ca)