• Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired (not inherited) disorder that leads to the premature death and impaired production of blood cells. (medlineplus.gov)
  • Some individuals with acquired aplastic anemia also have another disorder at the same time, called paroxysmal nocturnal hemoglobinuria (PNH). (rarediseases.org)
  • Anti-complement Treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for Proximal Complement Inhibition? (frontiersin.org)
  • however, eculizumab is not the cure for Paroxysmal nocturnal hemoglobinuria (PNH), and room for improvement remains. (frontiersin.org)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
  • where two identical synthetic peptide domains are covalently linked at the ends of the polyethylene glycol chain (also known as APL-2) for the treatment of paroxysmal nocturnal haemoglobinuria. (europa.eu)
  • What is paroxysmal nocturnal haemoglobinuria? (europa.eu)
  • Paroxysmal nocturnal haemoglobinuria (PNH) is a condition in which there is excessive breakdown of red blood cells (haemolysis), leading to the release into the urine of a large amount of haemoglobin (the protein found in red blood cells that carries oxygen around the body). (europa.eu)
  • Paroxysmal nocturnal hemoglobinuria is a rare, dangerous, acquired blood disorder during which unpredictable episodes of blood red cell breakdown occurs, the bone marrow stops making new blood cells and blood clots. (nicklauschildrens.org)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder characterized by intravascular hemolysis and hemoglobinuria. (msdmanuals.com)
  • Paroxysmal nocturnal hemoglobinuria is most common among men in their 20s, but it occurs in both sexes and at any age. (msdmanuals.com)
  • Paroxysmal nocturnal hemoglobinuria is a clonal disorder caused by an acquired mutation in the PIGA gene in hematopoietic stem cells. (msdmanuals.com)
  • Paroxysmal nocturnal hemoglobinuria is suspected in patients who have typical symptoms of anemia (eg, pallor, fatigue, dizziness, possible hypotension) or unexplained normocytic anemia with intravascular hemolysis, particularly if leukopenia or thrombocytopenia and/or thrombotic events are present. (msdmanuals.com)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic, debilitating disorder that most frequently presents in early adulthood and usually continuous throughout the life of the patient. (medscape.com)
  • This series of containers holds urine of a patient with paroxysmal nocturnal hemoglobinuria, showing the episodic nature of the dark urine (hemoglobinuria) during intravascular hemolysis, usually occurring at night. (medscape.com)
  • Hemolysis has been shown to occur throughout the day and is not actually paroxysmal, but the concentration of urine overnight produces the dramatic change in color. (medscape.com)
  • Paroxysmal nocturnal hemoglobinuria (PNH) was previously classified as purely an acquired hemolytic anemia due to a hematopoietic stem cell mutation defect. (medscape.com)
  • Nocturia diagnosis requires knowing the patient's nocturnal urine volume (NUV). (wikipedia.org)
  • Nocturia has many contributing causes, but in most cases, it is caused by the kidneys producing too much urine at night, known as nocturnal polyuria. (simonfoundation.org)
  • What is Nocturia and Nocturnal Enuresis (adult bed-wetting) and how to treat it? (tena.co.uk)
  • The body normally overproduces ADH to avoid Nocturia but when your body does not produce the appropriate amount of this hormone at night, it leads to high urine production and a frequent need to visit the toilet. (tena.co.uk)
  • Further, investigators observed that study participants who had nocturia but not NP had less nocturia than those who had both nocturia and NP due to much lower nocturnal urine production. (renalandurologynews.com)
  • Study findings may provide clues to nocturia treatment in emphasizing factors influencing urine production in comparison to factors influencing bladder capacity," investigators J.L.H. Ruud Bosch, MD, of Franciscus G&V Hospital, Rotterdam, the Netherlands, and colleagues wrote. (renalandurologynews.com)
  • As a sleep researcher, Dr Bliwise noted that specific sleep disorders or general sleep fragmentation may be associated with increased nocturnal urine production, leading to nocturia. (renalandurologynews.com)
  • Nocturia, also called nocturnal polyuria, might not be dangerous by itself, but it may be caused by an underlying medical condition that needs to be treated. (onteenstoday.com)
  • Nocturia is when you wake up during the night or main sleep time because you have to pass urine (wee). (continence.org.au)
  • Posted in News and tagged Noctiva , nocturia , nocturnal polyuria . (simonfoundation.org)
  • BACKGROUND/AIM: Effect predictors of desmopressin for nocturia associated with nocturnal polyuria are understudied. (bvsalud.org)
  • PATIENTS AND METHODS: Our study included 129 patients who were administered desmopressin 50 µg for nocturia associated with nocturnal polyuria at our hospital. (bvsalud.org)
  • citation needed] Global polyuria is the continuous overproduction of urine that is not only limited to sleep hours. (wikipedia.org)
  • The U.S. Food and Drug Administration today approved Noctiva (desmopressin acetate) nasal spray for adults who awaken at least two times per night to urinate due to a condition known as nocturnal polyuria (overproduction of urine during the night). (simonfoundation.org)
  • The mechanism that drives most nocturnal voids is the overproduction of urine in the kidney. (renalandurologynews.com)
  • Based on information recorded in the diary, a physician can classify the patient as having global polyuria, nocturnal polyuria, or bladder storage problems. (wikipedia.org)
  • Nocturnal enuresis is involuntary urination that happens at night while sleeping, after the age when a person should be able to control their bladder. (kidshealth.org)
  • The bladder is a muscular receptacle, or holding container, for pee ( urine ). (kidshealth.org)
  • People with nocturnal enuresis can take some basic steps to prevent an overly full bladder, such as decreasing the amount of fluids they drink before going to bed. (kidshealth.org)
  • A younger person can hold up to half a litre of urine, but as we age, this is normally reduced by about half as the bladder muscle becomes less elastic. (tena.co.uk)
  • In many, but not all cases, hemoglobinuria is most noticeable early in the morning, upon passing urine that has accumulated in the bladder during the night (nocturnal). (medlineplus.gov)
  • A recent study provides clues to managing nocturnal polyuria by emphasizing factors influencing urine production instead of bladder capacity. (renalandurologynews.com)
  • People who experience accidental or involuntary loss of urine (wee) from the bladder may be suffering from urinary incontinence. (continence.org.au)
  • Post micturition incontinence (commonly known as after-dribble) can occur when men lose a small amount of urine (wee) after emptying their bladder. (continence.org.au)
  • The normal function of the urinary bladder is to store and expel urine in a coordinated, controlled fashion. (medscape.com)
  • Instead, it's a dance of multiple genes that influence various aspects, like bladder size, the depth of sleep, and nocturnal urine production. (localquoter.net)
  • Nocturnal enuresis is caused by deficiency of Kidney Qi leading to the inability of the urination bladder to regulate urination. (healthcmi.com)
  • The kidneys form urine and the bladder stores and excretes urine. (healthcmi.com)
  • Obstructive uropathy is a condition in which there is a blockage of the urine flow in the tube that carries urine between the kidneys and the bladder, or anywhere to the external urethral meatus. (nicklauschildrens.org)
  • This suggests that desmopressin may be effective in patients with high mean night-time urine volumes based on their bladder diary. (bvsalud.org)
  • Nocturnal enuresis is involuntary urination during sleep and is most typical among children. (healthcmi.com)
  • Diurnal enuresis, the voiding of urine only during waking hours, may occur when a child experiences sudden urges to urinate or because they consciously postpone urination. (psychologytoday.com)
  • Limitations of nocturnal salivary cortisol and urine free cortisol in the diagnosis of mild Cushing's syndrome. (medscape.com)
  • With the 24-hour urine production within normal limits, nocturnal polyuria can be translated to having a nocturnal polyuria index (NPi) greater than 35% of the normal 24-hour urine volume. (wikipedia.org)
  • Investigators used 2 definitions of NP: a nocturnal polyuria index greater than 33% (NPI33) and a rate of nocturnal urine production greater than 90 mL/h (NUP90). (renalandurologynews.com)
  • Another factor may be insufficient production of ADH, the antidiuretic hormone which signals the kidneys to decrease the amount of urine produced. (tena.co.uk)
  • It acts on the kidneys to reduce the flow of urine. (drugs.com)
  • Noctiva™ nasal spray is used to treat nocturnal polyuria in adults who awaken two or more times to urinate at night. (drugs.com)
  • The FDA has approved Noctiva (desmopressin acetate) for adults with nocturnal polyuria. (onteenstoday.com)
  • How do you treat nocturnal incontinence of urine? (nih.gov)
  • Atropine in incontinence of urine. (nih.gov)
  • Nocturnal enuresis is the most common form and is defined as incontinence only during nighttime sleep. (psychologytoday.com)
  • Urge incontinence is the involuntary loss of urine (wee) associated with urgency (a sudden and strong need to urinate). (continence.org.au)
  • Stress urinary incontinence is the leaking of small amounts of urine during activities such as coughing, sneezing, laughing, walking & lifting. (continence.org.au)
  • My bias has been that NP is due to a dysregulated CNS diurnal cycle, though daytime peripheral fluid pooling and nocturnal central redistribution may also play a role," said Dr Kujubu. (renalandurologynews.com)
  • A combination of nocturnal and diurnal enuresis can also occur. (psychologytoday.com)
  • ADH increases water absorption in the collecting duct systems of kidney nephrons, subsequently decreasing urine production. (wikipedia.org)
  • citation needed] Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. (wikipedia.org)
  • The use of desmopressin acetate tablets in patients with an established diagnosis will result in a reduction in urinary output with an accompanying increase in urine osmolality. (nih.gov)
  • Following administration of desmopressin acetate tablets, the onset of antidiuretic effect occurs at around 1 hour, and it reaches a maximum at about 4 to 7 hours based on the measurement of increased urine osmolality. (nih.gov)
  • 4-6 The sleep abnormalities include daytime sleepiness, difficulty falling asleep at night, nocturnal awakening, decreased sleep time, and abnormalities in the percentage of rapid eye movement (REM) sleep. (bmj.com)
  • The ICS defines NUV as "the total volume of urine passed between the time the individual goes to bed with the intention of sleeping and the time of waking with the intention of rising. (wikipedia.org)
  • That is why therapies that safely reduce the volume of urine produced at night are attractive to treat this condition. (renalandurologynews.com)
  • Today's approval provides adults who overproduce urine at night with the first FDA-approved therapeutic option to help reduce the number of times a night they wake up to urinate," said Hylton V. Joffe, M.D., M.M.Sc. (simonfoundation.org)
  • In older adults, it is considered by many to be normal to have to get up to pass urine once or twice a night. (tena.co.uk)
  • Frequently brushed off as a 'phase' that children will outgrow, the reality is that nocturnal enuresis affects a vast demographic, from toddlers to adults. (localquoter.net)
  • If you're having trouble controlling your urine at night, talk to your doctor to learn more about nocturnal enuresis and to rule out the possibility of a medical problem. (kidshealth.org)
  • The total amount of urine doesn´t necessarily change, but often more is produced at night. (tena.co.uk)
  • Nocturnal polyuria is a condition where your body makes too much urine at night. (drugs.com)
  • Nocturnal polyuria can be treated using the vasopressin analogue desmopressin, which reduces the amount of urine during the night. (medscape.com)
  • We observed a significant inverse association between increasing number of nights worked within the 2 weeks preceding urine collection and urinary melatonin levels ( r = −0.30, P = 0.008), but no association of recent night work with estradiol ( r = 0.10, P = 0.41). (aacrjournals.org)
  • There are medical circumstances which cause it eg cystitis or diabetes, or by some children's incapacity to provide sufficient of the anti-diuretic hormone, ADH, which controls the manufacturing of urine at night. (telepathemusic.com)
  • Examination of cases defined as "marked response cases" showed that the mean night-time urine volume was an independent predictor of treatment response. (bvsalud.org)
  • Other exposures to LAN are many and include short sleep duration, late-night reading or television, nocturnal awakening and consequent exposure to light for example in the bathroom, strong street lights at night shining thru the window shade of the bedroom. (who.int)
  • Affected individuals may pass dark-colored urine because of the presence of hemoglobin, the oxygen-carrying protein in blood. (medlineplus.gov)
  • The name of the disorder is a descriptive term for the clinical consequence of red blood cell (RBC) breakdown with release of hemoglobin into the urine, which manifests most prominently as dark-colored urine in the morning (see image below). (medscape.com)
  • The initial exam will probably include a urinalysis and urine culture. (kidshealth.org)
  • The physical examination should include a pelvic examination for females and prostate examination for males, abdominal examination, urinalysis, urine culture (if appropriate), and measurement of post-void residual (PVR), along with a uroflow (Rosier et al. (medscape.com)
  • It is helpful in patients with troublesome nocturnal urinary symptoms. (sgh.com.sg)
  • Also, if the urine color can be easily traced to a specific food or medication and no other symptoms are present, then no action may be needed. (nicklauschildrens.org)
  • If your urine is brown or red and does not appear to be related to foods or medication and is accompanied by pain or other unusual symptoms, see your health care provider. (nicklauschildrens.org)
  • Her symptoms persisted, and in February 1976, nocturnal fevers and sweats developed. (cdc.gov)
  • The diagnosis of Cushing syndrome requires demonstration of an inappropriately high level of cortisol in the serum or urine. (medscape.com)
  • As mentioned, the diagnosis of Cushing syndrome requires demonstration of an inappropriately high level of cortisol in the serum or urine. (medscape.com)
  • Sequential urine samples were collected for 48 hours before beginning the interventions and again for the 2 days after supplementation with juice or placebo. (naturalmedicinejournal.com)
  • As a result of this sequential therapeutic regimen, daily urine output reduced significantly from 10 mL/kg/h to 2 mL/kg/h over an average period of 5 days, together with a normalization of natremia (from 161 mEq/L to 143 mEq/L) over an average period of 9 days. (bvsalud.org)
  • The aims of this study were to determine the prevalence and predictors of nocturnal polyuria (NP) in Japanese patients. (bvsalud.org)
  • Another reason for a more pressing urge to urinate as we age has to do with hormonal changes that lower the concentration of the urine. (tena.co.uk)
  • Your doctor will need to measure your urine and the times that you urinate for 24 hours to determine if you have nocturnal polyuria. (drugs.com)
  • That may not be much comfort when you're dipping that teddy bear in vinegar for the umpteenth time to get rid of the urine smell, but almost all children with nocturnal enuresis stop wetting the bed before they hit puberty. (webmd.com)
  • Garrido et al reported that consumption of Spanish sweet cherries grown in the Jerte Valley produced beneficial effects on actual sleep time, total nocturnal activity, assumed sleep, and immobility. (naturalmedicinejournal.com)
  • The study cases who at the time of study had primary also showed that the degree of success was nocturnal enuresis. (who.int)
  • If children with nocturnal polyuria are unresponsive to desmopressin despite good adherence, referral is advised. (medscape.com)
  • All parents were asked if their that only about one-third of the families of child had suffered from nocturnal enuresis children with this frequently troubling prob- in the previous 6 months and, if so, what lem seek help from a physician [ 4 ]. (who.int)
  • The term "nocturnal" refers to the belief that hemolysis is triggered by acidosis during sleep and activates complement to hemolyze an unprotected and abnormal RBC membrane. (medscape.com)
  • Global polyuria occurs in response to increased fluid intake and is defined as urine outputs of greater than 40 mL/kg/24 hours. (wikipedia.org)
  • The Epidemiology of Nocturnal Polyuria (EpiNP) study, which was published in the Journal of Urology , demonstrated that NP is highly prevalent in both sexes in the United States, but it is much more common in women. (renalandurologynews.com)
  • One such test is a nocturnal penile tumescence study. (brunkphoto.com)
  • 3500 students were selected for the study, the involuntary voiding of urine during randomly selected from all primary-school sleep, in the absence of congenital or ac- classes in the city. (who.int)
  • METHODS: We measured 2 metabolites, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (NNAl-Gluc) in the urine of males who were either current CS or WPS, and their wives exposed to either cigarette or waterpipe smoke in a sample of 46 subjects from rural Egypt. (who.int)