• This is paralleled by reduced serum IgG NR1a antibodies. (healthycascobay.org)
  • The immunological events and neuronal mechanisms underlying these observations need to be explored further, but one possibility is that the early stage represents diffusion of serum antibodies into the cortical grey matter, whereas the later stage results from secondary expansion of the immunological repertoire within the intrathecal compartment acting on subcortical neurons. (pubmedcentralcanada.ca)
  • But sometimes some components of the immune system, called antibodies, may instead react with proteins in our own body causing an autoimmune disease. (encephalitis.info)
  • Transfer of the proteins to nitro-cellulose and Western blot with GluR1 and GluR2 antibodies confirmed that the 100 kDa band contained both GluR1 and GluR2 subunits (panels in D). Further validation of the antigen was done in heterologous cells expressing GluR1/2, showing reactivity with patient's antibodies (green), a monoclonal antibody (red), and the merged reactivities (yellow). (nih.gov)
  • The anti-cytoplasmic antibodies in lupus are binding to three proteins on the 60S subunit of the ribosome. (hopkinsarthritis.org)
  • The antibody binds to all three proteins because there is a shared epitope in the carboxyl terminus of about 22 amino acids. (hopkinsarthritis.org)
  • The original assays for the detection of VGKC antibodies used Iodine-125 labelled dendrotoxin and the relatively mild detergent 2% digitonin on mammalian brain homogenate, and VGKC with complexed proteins was extracted. (wikipedia.org)
  • It's now acknowledged that most VGKC antibodies are instead directed towards associated/complexed proteins. (wikipedia.org)
  • Autoantibodies titers are not always correlated with clinical prognosis or disease course, but as a rule-of-thumb, high titer antibodies tend to be more specific for the disease. (aacc.org)
  • Additionally, we aim to report the local incidence of less common groups of disease-associated antibodies as well. (springer.com)
  • It was for many years erroneously presumed that antibodies detected in a VGKC assay were targeted against the channel itself. (wikipedia.org)
  • The immune therapies used to dampen down the immune system include steroids (drugs to reduce inflammation), immunoglobulins (a blood product given into the vein in a drip) and plasma exchange (when some of a person's blood is taken out from a vein, and the plasma part of the blood which contains antibodies is separated and replaced with new plasma and then put back into the vein in a drip). (encephalitis.info)
  • About five years later it was discovered that there were antibodies that bind to an RNA epitope and, using RNAs mapping, the sequence of that RNA epitope was also identified. (hopkinsarthritis.org)