• Compared with the IUI group, zinc, alone or combined with taurine, improved motor behavior and reduced nitrosative stress by increasing SOD, CAT, and GPx activities and decreasing the GSSG/GSH ratio in the cerebral cortex and hippocampus. (hindawi.com)
  • However, EUK-134 also reduced nitrosative stress caused by I/R in vivo (reduction of iNOS expression and nitrotyrosine formation), which was reflected by a significant reduction in serum NO levels in rats subjected to renal I/R. Specifically, serum NO levels were reduced from 57 ± 12 (n = 12, I/R only) to 23 ± 3 m M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • As inflammation is reduced, it prevents further damage to the nervous system and the peripheral nervous system. (reddotled.com)
  • The toxic effects of free radicals on biomolecules lead to the accumulation of damage in various cellular locations and to the deregulation of redox-sensitive metabolic and signaling pathways, and are also believed to be involved in pathological conditions such as ATS, hypertension, inflammation, diabetes, cancer and other human pathologies. (biomedcentral.com)
  • Treatment of mice with cannabidiol markedly attenuated the cisplatin-induced oxidative/nitrosative stress, inflammation, and cell death in the kidney, and it improved renal function. (realmofcaring.org)
  • The sesame lignin sesamol was shown to exert an antidepressant-like effect in behavioral despair in chronically stressed mice, specifically by modulating oxidative-nitrosative stress and inflammation. (m1studios.in)
  • Reactive nitrogen species act together with reactive oxygen species (ROS) to damage cells, causing nitrosative stress. (wikipedia.org)
  • other agents commonly ingested by the humans, such as drugs and food additives), the production of reactive species/free radicals may increase, leading to oxidative or nitrosative stress, depending on the specific reactive species are generated. (databasefootball.com)
  • However, excess NO, produced in inflammatory states, is toxic to cells and, when unregulated, increases reactive nitrogen species (RNS) causing nitrosative stress. (psychosocialsomatic.com)
  • ONOO − is a highly reactive species and can initiate both nitrosative and oxidative reactions in vitro and in vivo ( 8 - 10 ). (diabetesjournals.org)
  • N2O3, which can be derived either from NO2 or nitrite, is the agent of nitrosative stress, and nitrosylates sulfhydryl and similarily reactive groups in the cell. (ecoshelta.com)
  • Oxidant damage to cellular DNA, proteins (including the epigenome), and lipids can occur when reactive oxygen species escape cell antioxidant and repair mechanisms. (who.int)
  • Oxidative damage and tyrosine nitration from peroxynitrite. (scienceopen.com)
  • Deficiency in ClpP induces an overload of mitochondrial misfolded/unfolded proteins, suppresses mitochondrial respiratory activity, increases mitochondrial oxidative damage and causes cell death. (springer.com)
  • Compensating for the loss of ClpP in the substantia nigra of αSyn A53T mice by viral expression of ClpP suppresses mitochondrial oxidative damage, and reduces αSyn pathology and behavioral deficits of mice. (springer.com)
  • To estimate oxidative damage in the serum and to examine the role of nitric oxide in mediating epidermal damage in patients with TEN and SJS. (e-ijd.org)
  • NO and NO2- act as antioxidants of trHbOFe(IV)O, which could be responsible for the oxidative damage of the mycobacterium. (uniroma3.it)
  • Amyotrophic lateral sclerosis (ALS) is a progressive paralyzing disease characterized by tissue oxidative damage and motor neuron degeneration. (edu.au)
  • High bilirubin levels cause encephalopathy and kernicterus, low bilirubin levels oxidative damage in newborns. (bakirkoymedj.org)
  • Astrocytes have been reported to be more resistant to bilirubin-associated oxidative damage, firstly increased expression of the pump, which removes bilirubin out of the cell, and by their high antioxidant capacities (4). (bakirkoymedj.org)
  • El-Remessy et al [ 10 ] recently reported that CBD prevented inflammatory and oxidative damage and preserved endothelial integrity in an experimental model of diabetic retinopathy. (biomedcentral.com)
  • Sesame seed oil protects against gentamicin-induced kidney damage in rats by reducing oxidative damage caused by the antibiotic. (m1studios.in)
  • In clinical depression, however, a transition occurs to sensitization of immuno-inflammatory pathways, progressive damage by oxidative and nitrosative stress to lipids, proteins, and DNA, and autoimmune responses directed against self-epitopes. (biomedcentral.com)
  • When there is an overproduction of ROS/RNS or a deficiency of enzymatic or non-enzymatic antioxidants, a biological damage to cellular lipids (lipoperoxidation), proteins, glucides and DNA may occur. (biomedcentral.com)
  • Once produced within a cell, free radicals can damage a wide variety of cellular constituents, including proteins, lipids and DNA. (enzolifesciences.com)
  • Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent that induces nephrotoxicity associated with oxidative/nitrosative stress. (weeksmd.com)
  • The renoprotective effect of SFN on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and the preservation of antioxidant enzymes. (weeksmd.com)
  • Nephrotoxicity is a common complication of cisplatin chemotherapy, which involves increased oxidative and nitrosative stress, limiting its clinical use. (realmofcaring.org)
  • It protects brain tissues from nitrosative stress which is caused due to radiation. (taazashahimewa.com)
  • We assessed motor alterations, nitrosative stress, lipid peroxidation, and the antioxidant system comprised of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). (hindawi.com)
  • This is caused because in reaction to the radiation, you experience a significant increase in things like lipid peroxidation (which causes cell damage), and a significant decrease in antioxidant enzymes (which fights against cell damage) in your ovaries and uterus. (5gprevention.com)
  • Melatonin restored all of these oxidative and nitrosative stress markers in a dose-dependent manner. (uthscsa.edu)
  • The findings emphasize the role of concomitant oxidative and nitrosative stress and the role of peroxynitrite in the ensuing renal dysfunction. (scienceopen.com)
  • Finally, other risk factors, such as aging, hyperhomocysteinemia and cigarette smoking, are also associated with mitochondrial damage and an increased production of free radicals. (biomedcentral.com)
  • This article provides an overview of the different free radicals known, the mechanism by which they cause tissue damage and the protective role played by different antioxidants. (antiox.org)
  • Oxygen deprivation in newborns leads to hypoxic-ischemic encephalopathy, whose hallmarks are oxidative/nitrosative stress, energetic metabolism alterations, nutrient deficiency, and motor behavior disability. (hindawi.com)
  • The expression of poly(ADP-ribose) (PAR) and inducible nitric oxide (NO) synthase (iNOS) and nitrotyrosine formation were determined immunohistochemically and used as indicators of oxidative and nitrosative stress. (scienceopen.com)
  • The link between the nitrosative stress enzyme inducible nitric oxide synthase (iNOS) and the cytokine interleukin-1 (IL-1β) in RA-induced knee joint synovial membrane damage with and without the incorporation of the GSK3β inhibitor TDZD-8 has never been studied. (intjmorphol.com)
  • The changes in the expression profile of bladder epithelial cells under the action of plasma acid in vitro were found indicating the development of oxidative, nitrosative and dicarbonyl stress, impaired expression of NADPH oxidase DUOX2 and VEGF, and a decrease in cell proliferative activity, which, in general, corresponds to the main mechanisms of urothelial alterations specific for the IC/BPS. (eco-vector.com)
  • The revealed effects of plasma acid on bladder epithelial cells confirm the possibility of using it as an inducer of urothelial cell damage typical for IC/BPS in the in vitro models. (eco-vector.com)
  • Urinary N -acetyl-β- D -glucosaminidase activity, an indicator of tubular damage, was reduced from 42 ± 5 (n = 12, I/R only) to 22 ± 3 IU/l (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • SFN attenuated CDDP-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion, enhanced urinary hydrogen peroxide excretion and the decrease in antioxidant enzymes (catalase, glutathione peroxidase and glutathione-S-transferase). (weeksmd.com)
  • In this study, we examined effects of Cl2 exposure on oxidative and nitrosative stress in A/J mice. (cdc.gov)
  • These findings suggest that CI2 exposure causes oxidative and nitrosative stress in association with leading to airway epithelial damage. (cdc.gov)
  • [ 6 ] Central nervous system damage 3 years after cessation of exposure to DPA appears to be persistent. (medscape.com)
  • [ 7 ] Other investigators from Japan have attempted to study the effect of DPA in mice and have discovered the possibility for injury to Purkinje cells due to oxidative and nitrosative stress following exposure to DPA, which may lead to cerebellar symptoms. (medscape.com)
  • At 100 ppm, there was less epithelial damage and cells stained positively for iNOS. (cdc.gov)
  • Astrocytes are the first cells effected by bilirubin, which eventually causes blood-brain barrier damage (4,5). (bakirkoymedj.org)
  • NO can cause serious damage, of 8-hydroxyguanosine present in cells can be however, through direct inhibition of respiration in cells that are already compro- used to estimate the amount of oxidative dam- mised through oxidative phosphorylation diseases or ischemia. (ecoshelta.com)
  • The latter mechanisms are the substrate of a neuroprogressive process, whereby multiple depressive episodes cause neural tissue damage and consequent functional and cognitive sequelae. (biomedcentral.com)
  • A dramatic increase in rheumatoid factor (RF) blood levels, as well as considerable synovial tissue damage and inflammatory cell infiltration of the synovial membrane, were used to validate the onset of RA following COII immunization. (intjmorphol.com)
  • These processes lead to tissue damage and contribute to the pathogenesis of many disorders like hypertension, cancer, diabetes, neurodegenerative disorders and others. (antiox.org)
  • Thymoquinone present in black onion seeds helps in protecting brain tissue from any kind of damage due to radiation. (taazashahimewa.com)
  • Nigella sativa oil (NSO) and its active component, thymoquinone, protect brain tissue from radiation-induced nitrosative stress. (nothingsincurable.com)
  • Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
  • [13] It is capable of reducing mortality in radiation treated mice, in part through preventing intestinal and spleen damage. (m1studios.in)
  • We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
  • Oxidative and nitrosative stress caused by drug metabolism may be a trigger for keratinocyte apoptosis in the epidermis seen in toxic epidermal necrolysis (TEN) and Stevens Johnson syndrome (SJS). (e-ijd.org)
  • Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)
  • To protect against the damage caused by nitrosative stress, bacteria possess multiple defence mechanisms involving scavengers, detoxifying enzymes and evasion strategies. (biomedcentral.com)
  • Along with lower testosterone, increased enzymes tied with DNA damage and overall lower fertility, the offspring of the test subjects showed diminished male reproductive capacity. (5gprevention.com)
  • This result suggests that taurine improves pyruvate, lactate, and glutamate metabolism, thus decreasing IUI-caused cerebral damage and relieving motor behavior impairment. (hindawi.com)
  • Damage to mitochondrial DNA correlates with the extent of atherosclerosis. (biomedcentral.com)
  • Several cardiovascular risk factors are demonstrated causes of mitochondrial damage. (biomedcentral.com)
  • Professor of Medicine Stanton Glantz even notes that the evidence linking cell phone radiation to sperm damage is causal, meaning that there is a direct link that cannot be ignored. (5gprevention.com)
  • When women are exposed to radiation from cell phones, studies have shown that the damage to their eggs is passed on to their female babies. (5gprevention.com)
  • Sesamol has been shown to protect against gamma radiation-induced DNA damage , likely through its antioxidant properties. (m1studios.in)
  • Zinc and taurine are known to protect against hypoxic-ischemic brain damage in adults and neonates. (hindawi.com)
  • The severity of these disabilities depends on the ischemia duration, damage expansion, and the affected brain region. (hindawi.com)
  • Alpha-lipoic acid seems to work as an antioxidant, which means that it might provide protection to the brain under conditions of damage or injury. (psychosocialsomatic.com)
  • A thymoquinone extract from Nigella sativa has a protective effect against damage associated with experimental heart attack. (nothingsincurable.com)
  • The net effect of endothelial dysfunction is vascular damage, which is responsible for complications in both types of diabetes. (diabetesjournals.org)
  • Most of our products are Vacuum Packed which helps in retaining products freshness and prevents from product damage. (taazashahimewa.com)
  • Additionally, PEA with luteolin was shown to reduce oxidative and nitrosative damage more effectively than PEA or luteolin alone. (youngnutra.com)
  • The type of and FMN to transfer single electrons from damage caused by each RNOS is shown in parentheses. (ecoshelta.com)
  • Recent data support the clinical use of CBD for the treatment of a variety of damaging conditions, including nephropathy and diabetic cardiomyopathy. (biomedcentral.com)
  • The emphasis is given to characterize and quantify chemical-induced DNA and protein damage as biomarkers using mass spectrometry. (unc.edu)