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Nitric OxideNitric Oxide SynthaseArginineNG-Nitroarginine Methyl Esteromega-N-MethylarginineNitric Oxide Synthase Type IINitric Oxide Synthase Type IIINitritesNitric Oxide DonorsEnzyme InhibitorsNitroarginineNitric Oxide Synthase Type IAmino Acid OxidoreductasesCitrullineEndothelium, VascularNitratesNitroprussideVasodilationRats, Sprague-DawleyBlood PressureCells, CulturedCyclic GMPGTP CyclohydrolaseVasodilator AgentsRats, WistarAcetylcholineS-Nitroso-N-AcetylpenicillamineRenal CirculationS-NitrosothiolsDose-Response Relationship, DrugRNA, MessengerVasoconstrictionBiopterinRats, Inbred WKYPenicillamineVascular ResistanceLipopolysaccharidesEnzyme InductionMuscle, Smooth, VascularRegional Blood FlowArginaseAutonomic AgentsHemodynamicsMacrophagesGuanylate CyclaseSpace SimulationKidneyInterleukin-1Coronary VesselsTime FactorsIndomethacinHypogravityAorta, ThoracicProstaglandin AntagonistsBiphenyl CompoundsBradykininVasoconstrictor AgentsHydralazineNitroso CompoundsArgininosuccinate SynthaseMacrophage ActivationNitrogen OxidesLosartanMeclofenamic AcidRabbitsDogsNitroglycerinHypertensionMuscle RelaxationImidazolesInterferon-gammaSuperoxidesPterinsAmidohydrolasesPhenylephrineOxidesCell LineKineticsMethylene BlueArteriolesAortaCoronary CirculationHeart RateEndothelinsCyclooxygenase InhibitorsUmbilical VeinsProstaglandinsDiuresisVasomotor SystemHyperemiaExtravasation of Diagnostic and Therapeutic MaterialsAnalysis of VarianceGene Expression Regulation, EnzymologicSignal TransductionMicrocirculationMacrophages, PeritonealMyocardiumNitrogen IsotopesOxygenTumor Necrosis Factor-alpha
InducibleInhibitorsENOSINOSNitrates or nitric oxideInhibitionArginineTotal Nitric OxideRelease of nitric oxideEndothelial cellsPathwayInhibitorEndogenousMoleculeMacrophageEnzymeVascularStimulationPlateletsProstaglandin synthesisReactiveMacrophagesCoronary arteriesDysfunctionTetrahydrobiopterinVasodilationSepsisPathwaysChemical synthesisDonorActivationProximalBiochemistryMoleculesMiceExtractsProductionRole1992ImmunityAdultsRolesRegulateIncreasesImportantLevels
Inducible8
  • We have shown that mucosal expression of inducible nitric oxide (NO) synthase (iNOS) is increased in infected piglets and that inhibition of iNOS in vitro has no short-term effect on barrier function. (ncsu.edu)
  • Synthesis of NO is significantly increased and arises from the induced expression of inducible nitric oxide synthase (iNOS) by the infected epithelium. (ncsu.edu)
  • C. parvum infection results in induction of mucosal inducible NOS (iNOS), increased synthesis of NO and PGE2, and increased mucosal permeability. (ncsu.edu)
  • The pathological concentration of MGO (100 μM) was then applied to investigate its effect on inducible nitric oxide synthase (iNOS) expression and NO release on interferon-gamma (IFN-γ) (100 IU/ml) and lipopolysaccharide (LPS) (100 µg/ml)-stimulated control ASMCs. (herts.ac.uk)
  • There are three isoforms of the NO synthesizing enzyme nitric oxide synthase (NOS): neuronal (nNOS), endothelial (eNOS), and inducible nitric oxide synthase (iNOS), each one involved with specific events in the brain. (frontiersin.org)
  • Methods: Using bovine articular cartilage explants in culture stimulated with IL-1, the effects of physiologically relevant concentrations of GLN and CS on gene expression of inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGEs1) were assessed with quantitative real-time polymerase chain reaction (Q-RT-PCR). (ttu.edu)
  • Previously, we identified inducible nitric oxide synthase (iNOS) as an essential enzyme for development and reversal of smoke-induced PH and emphysema, and showed that iNOS expression in bone-marrow-derived cells drives pulmonary vascular remodelling, but not parenchymal destruction. (ersjournals.com)
  • This treatment induced a significant increase in the levels of proinflammatory mediators including the inducible Nitric Oxide Synthase (iNOS), interleukin 1 Beta (IL-1β) and Interleukin-12 (IL-12). (lu.se)
Inhibitors4
  • 3 hr, and is reduced by inhibitors of PKA and of protein or RNA synthesis. (jneurosci.org)
  • Conversely, either NO or cGMP analogs paired with one-train tetanization produced late-phase potentiation, and the cGMP-induced potentiation was blocked by inhibitors of protein or RNA synthesis and an inhibitor of PKG, but not by an inhibitor of PKA. (jneurosci.org)
  • The isoforms mediating and mechanism of NO action on barrier function were assessed by measuring transepithelial resistance (TER) and eicosanoid synthesis by ileal mucosa mounted in Ussing chambers in the presence of selective and nonselective NOS inhibitors and after rescue with exogenous prostaglandins. (ncsu.edu)
  • Intense discussions were held on the usefulness or danger of nitric oxide synthase inhibitors as well as on the application of exogenous nitric oxide or nitric oxide donors. (powells.com)
ENOS5
INOS1
  • Selective inhibition of iNOS [L-N6-(1-iminoethyl)-L-lysine] accounted for approximately 50% of NOS-dependent PGE2 synthesis and TER. (ncsu.edu)
Nitrates or nitric oxide1
Inhibition8
  • In these studies we investigated the effects of chronic inhibition of basal NO synthesis in the rat for a 2-mo period. (jci.org)
  • Moreover, l -citrulline inhibition of serum-stimulated DNA synthesis was abolished by HS-142-1 (10 −5 M), an ANP receptor antagonist. (aspetjournals.org)
  • Nonselective inhibition of NOS (NG-nitro-L-arginine methyl ester) inhibited prostaglandin synthesis, resulting in further increases in paracellular permeability. (ncsu.edu)
  • He then, with colleagues, described a pattern of metabolic inhibition caused by nitric oxide in mammalian target cells and the involvement of nitric oxide in mouse activated macrophage antimicrobial activity. (wikipedia.org)
  • However, in the last few years, opposing mechanisms of platelet inhibition by RBCs derived nitric oxide (NO) were proposed. (uni-wuerzburg.de)
  • Objective: The effect of the nitric oxide donor, SIN-1, in proximal and distal coronary arteries with normal endothelium was characterised before and after inhibition of NO synthesis with L-nitroarginine methyl ester (L-NAME). (eurekamag.com)
  • inhibition of the synthesis of endothelium derived relaxing factor (EDRF) by L-NAME resulted in an enhanced response to SIN-1 in proximal vessels only. (eurekamag.com)
  • This inhibition is abolished following reperfusion injury or inhibition of NO synthesis. (eurekamag.com)
Arginine15
  • Research over the past 5 years has demonstrated that immunologic activation of mouse macrophages induces the activity of nitric oxide synthase, which oxidizes a guanidino nitrogen of L-arginine, yielding citrulline and the reactive radical, nitric oxide. (nih.gov)
  • Aims-To determine whether this is due to nitric oxide (NO) production via the L-arginine/NO pathway. (elsevierpure.com)
  • Conclusion-Results show notably enhanced nitrate synthesis due to increased activity of the L-arginine/NO pathway in patients with infective gastroenteritis. (elsevierpure.com)
  • abstract = "Background-There is evidence that endogenous nitrate synthesis is notably increased in patients with infective gastroenteritis.Aims-To determine whether this is due to nitric oxide (NO) production via the L-arginine/NO pathway.Methods-Seven male patients with community acquired bacterial gastroenteritis and 15 healthy male volunteers participated in this study, All patients had stool culture positive infective gastroenteritis. (elsevierpure.com)
  • He is known for the discovery of the direct synthesis of L-citrulline and nitrogen oxides from L-arginine by murine activated macrophages, published in January 1987. (wikipedia.org)
  • In 1988, he directly measured the gas nitric oxide, simultaneously with Michael Marletta, showing that it is the proximal nitrogen oxide produced during the biological oxidation of a terminal guanidino nitrogen atom of L-arginine. (wikipedia.org)
  • These experiments led to the discovery of the synthesis of L-citrulline and nitrogen oxides, including nitric oxide per se, from L-arginine, by mouse activated macrophages. (wikipedia.org)
  • We investigated whether MGO affects the release of nitric oxide (NO) from rat aortic smooth muscle cells (ASMCs), and if L-arginine can prevent these effects of MGO. (herts.ac.uk)
  • Diagram showing the synthetic pathway responsible for nitric oxide (NO) production from arginine and O 2 and catalyzed by the enzyme nitric oxide synthase (NOS). (frontiersin.org)
  • Almonds and other nuts are particularly rich in L-arginine, an amino acid that helps your body make nitric oxide. (healthline.com)
  • The ingredients in CrazyBulk Nitric-Max include L-arginine, L-citrulline, and beta-alanine, commonly found in NO2 boosters. (outlookindia.com)
  • Arginine is a conditionally essential basic amino acid involved primarily in urea metabolism and excretion, as well as in DNA synthesis and protein production. (muscleandstrength.com)
  • DESIGN Quantitative coronary angiography and Doppler flow velocity measurements were used to determine the effects of the nitric oxide synthase inhibitor N G -monomethyl- L -arginine (L-NMMA) on magnesium induced dilation of the epicardial and resistance coronary arteries. (bmj.com)
  • In addition, we determined whether EDNO contributes to the coronary vascular response to magnesium by using N G -monomethyl- L -arginine (L-NMMA), a nitric oxide synthase inhibitor. (bmj.com)
  • Well, arginine is a substrate for nitric oxide (NO) synthesis. (ultimatefatburner.com)
Total Nitric Oxide2
  • 3. Onnit Total Nitric Oxide: This product is a powerful blend of natural ingredients that help support healthy nitric oxide levels. (outlookindia.com)
  • by using ung + and ung - Escherichia coli strains, demonstrated that total nitric oxide exposures in the μmol/L range can lead to C→T mutations by a mechanism probably involving cytosine deamination ( 8 ). (cdc.gov)
Release of nitric oxide1
Endothelial cells1
  • In this chapter, we will review some of the current and most promising strategies that have been used over the years to develop polymeric materials with improved hemocompatibility, including highly hydrophilic or hydrophobic surfaces, albumin coated surfaces, zwitterionic polymers, attached endothelial cells, patterned surfaces, immobilized heparin, and nitric oxide (NO) releasing/generating surfaces. (springer.com)
Pathway5
  • Nitric oxide (NO) is thought to be involved in E-LTP, but until now there has been no information about the role of the NO-signaling pathway in L-LTP. (jneurosci.org)
  • The nitric oxide pathway and nitric oxide synthesis regulation are also discussed. (powells.com)
  • Six major pathways have been studied in immune cells in detail: glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway, fatty acid oxidation, fatty acid synthesis and amino acid metabolism. (nature.com)
  • Here, we provide a brief refresher course on six of the major metabolic pathways involved (specifically, glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway, fatty acid oxidation, fatty acid synthesis and amino acid metabolism), giving specific examples of how precise changes in the metabolites of these pathways shape the immune cell response. (nature.com)
  • One potential mechanism responsible for magnesium induced coronary dilation involves activation of the endothelium derived nitric oxide (EDNO) pathway. (bmj.com)
Inhibitor2
  • One such study, "L-NAME, a nitric oxide synthase inhibitor, and WIN 55212-2, a cannabinoid agonist, interact to evoke synergistic hypothermia," published in the February issue of the Journal of Pharmacology and Experimental Therapeutics , reveals how cannabinoids produce one of the drug's most robust actions, hypothermia, or decreased body temperature. (cannabisuk.com)
  • Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide (NO) synthesis inhibitor and pro-inflammatory factor. (mdpi.com)
Endogenous2
  • These studies therefore describe a new model of systemic hypertension with glomerular capillary hypertension and renal disease due to chronic blockade of endogenous NO synthesis. (jci.org)
  • Background-There is evidence that endogenous nitrate synthesis is notably increased in patients with infective gastroenteritis. (elsevierpure.com)
Molecule3
  • Knowing that the molecule nitric oxide (NO) plays an important role in the regulation of body temperature, the Temple researchers set out to determine what role it might play in cannabinoid-induced hypothermia. (cannabisuk.com)
  • Nitric oxide (NO) is a versatile messenger molecule first associated with endothelial relaxing effects. (frontiersin.org)
  • Nitric oxide (NO2) is a molecule that helps increase blood flow and nutrient delivery to the muscles, giving them more oxygen and allowing them to work harder and longer. (outlookindia.com)
Macrophage2
Enzyme1
Vascular4
  • These findings suggest that l -citrulline decreases vascular smooth muscle cell proliferation in the A10 cell line by acting on DNA synthesis by mechanisms that involve the ANP receptor. (aspetjournals.org)
  • instead the vasoprotective nitric oxide (NO ⋅ ), plays a critical role in vascular dysfunction under various pathophysiological conditions and in aging. (frontiersin.org)
  • The response to direct nitric oxide donation (bypassing vascular endothelial synthesis of EDRF) is inhibited by a basal endothelial process present in proximal coronary arteries only. (eurekamag.com)
  • The vascular endothelium produces a number of important substances including endothelial-derived relaxing factor or nitric oxide, endothelin-1, prostacyclin, and tissue plasminogen activator. (health.am)
Stimulation2
  • The presence of neutrophils in C. parvum-infected mucosa was associated with enhanced barrier function that could not be attributed to mucosal elaboration of prostaglandins or stimulation of their synthesis. (ncsu.edu)
  • Stimulation of the cells with interferon-gamma and lipopolysaccharide induced the production of nitric oxide and increased BH4 levels further. (aspetjournals.org)
Platelets1
  • Thus, the release reaction and prostaglandin synthesis act to consolidate the initial hemostatic plug by promoting the participation of other platelets in the growing hemostatic plug. (medscape.com)
Prostaglandin synthesis2
  • Nitric oxide synthase stimulates prostaglandin synthesis and barrier function in C-parvum-infected porcine ileum. (ncsu.edu)
  • We examined whether NO promotes barrier function via prostaglandin synthesis using Cryptosporidium parvum-infected ileal epithelium in residence with an intact submucosa. (ncsu.edu)
Reactive1
  • There is an overwhelming mass of evidence demonstrating the development of endothelial dysfunction in animal models of diabetes and in human blood vessels from diabetic patients, as evidenced by increased release of reactive oxygen species, decreased nitric oxide (NO) bioactivity, decreased release of prostacyclin (PGI 2 ), and enhanced endothelial production of vasoconstrictor thromboxane (Tx)A 2 /prostaglandin (PG)H 2 in early stages of diabetes ( 1 - 3 ). (diabetesjournals.org)
Macrophages2
  • Reports published in the past 2 years suggest that synthesis of NO mediates much of the antimicrobial activity of mouse macrophages against some fungal, helminthic, protozoal and bacterial pathogens. (nih.gov)
  • The results presented here support previous suggestions, based on experiments with isolated enzymes, that BH4 is absolutely required for cytokine-stimulated nitric oxide production in macrophages and they suggest that only a small fraction of the total intracellular BH4 pool in macrophages is utilized in the production of fully active nitric oxide synthase. (aspetjournals.org)
Coronary arteries1
  • OBJECTIVE To determine how magnesium affects human coronary arteries and whether endothelium derived nitric oxide (EDNO) is involved in the coronary arterial response to magnesium. (bmj.com)
Dysfunction1
  • International experts examine the role of nitric oxide in various metabolic events such as septic shock, cardiovascular dysfunction, and trauma and hemorrhagic shock. (powells.com)
Tetrahydrobiopterin1
  • 2019. Tetrahydrobiopterin and nitric oxide synthesis after exposure to hyperoxia and simulated diving. (helse-bergen.no)
Vasodilation1
  • Nitric oxide is the gas that is responsible for the vasodilation that leads to the enhanced "pump" for which these types of products are so famous. (ultimatefatburner.com)
Sepsis1
  • At the fourth Wiggers Bernard Conference, a group of 20 scientists from various fields discussed new findings relating to nitric oxide in shock, sepsis, and organ failure. (powells.com)
Pathways2
  • Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. (mcw.edu)
  • Oxidative damage, inflammation markers and signalling pathways for nitric oxide synthesis were also assessed. (nutraingredients.com)
Chemical synthesis1
  • The first machine-assisted synthesis of Meclinertant (SR 48692) is reported as a proof-of-concept for the future direc tions of chemical synthesis. (editricesapienza.it)
Donor1
  • Objectives: The aim of this work is to synthesize a novel stable and biodegradable nitric oxide (NO) donor polymer based on a chitosan backbone. (univ-lorraine.fr)
Activation2
  • In the central nervous system (CNS), NO synthesis is primarily triggered by activation of N-methyl-D-aspartate (NMDA) receptors and has a Janus face, with both beneficial and harmful properties. (frontiersin.org)
  • Carbon-based engineered nanomaterial exposure alters circulating factors that induce endothelial activation and impairment of nitric oxide synthesis. (cdc.gov)
Proximal1
  • Using an entire intestinal mucosa, we have demonstrated for the first time that NO serves as a proximal mediator of PGE2 synthesis and barrier function in C. parvum infection. (ncsu.edu)
Biochemistry1
  • These observations provided the biochemical tools needed to establish the new and unexpected field of nitric oxide biochemistry and made possible its rapid initial progress in cardiovascular and neural physiology. (wikipedia.org)
Molecules1
  • Nitric oxide (NO) is one of the most intriguing molecules to be found in the brain. (frontiersin.org)
Mice1
  • The effects of pharyngeal aspiration-exposure to zinc oxide nanoparticle s on pulmonary fibrosis induced by bleomycin in mice. (cdc.gov)
Extracts1
  • Nitric oxide (NO2) supplements increase nitric oxide production in the body using a blend of amino acids, plant extracts, vitamins, and minerals. (outlookindia.com)
Production2
  • According to the manufacturer, it contains a blend of ingredients designed to increase nitric oxide production in the body, which can lead to improved blood flow and nutrient delivery to the muscles during exercise. (outlookindia.com)
  • Increased blood flow: The ingredients in Nitric-Max are designed to increase nitric oxide production, which may help dilate blood vessels and improve blood flow. (outlookindia.com)
Role2
19921
Immunity1
  • Figure 5: Fatty acid synthesis and oxidation in immunity. (nature.com)
Adults1
  • CrazyBulk Nitric-Max is intended for adults who exercise regularly and seek a supplement to enhance their workouts. (outlookindia.com)
Roles1
  • Nitric oxide (NO) plays important roles in the overall homeostasis of the human organism and if hybridised with specific COX-2 inhibiting scaffolds, it may tune the pharmacodynamic properties of these new compounds to reduce the potential side effects. (editricesapienza.it)
Regulate1
  • Conclusion: Our results indicate that physiologically relevant concentrations of GLN and CS can regulate gene expression and synthesis of NO and PGE 2 , providing a plausible explanation for their purported anti-inflammatory properties. (ttu.edu)
Increases1
Important1
Levels1
  • He also showed that humans receiving the cytokine interleukin-2 for treatment of refractory malignant disease produced high levels of nitric oxide. (wikipedia.org)