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  • impairment
  • The present findings document that the functional impairment of the ERalpha/endothelial NO synthase signaling network after an extended period of hypoestrogenicity was not restored by E(2) administration, providing experimental support to early initiation of estrogen replacement with preferential ERalpha targeting to improve cardiovascular outcomes. (biomedsearch.com)
  • cardiac
  • Wang H, Kohr M, Traynham C, Ziolo M. Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes. (labome.org)
  • Second, the administration of BpV(HOpic) significantly reduced IS and suppressed caspase-3 activity following I/R injury and consequentially improved cardiac function at 28 day postinfarction. (biomedsearch.com)
  • cGMP
  • Nitric oxide (NO) production, NO synthase (NOS) activity, cGMP levels, and cellular injury were assessed. (biomedsearch.com)
  • Since hyperglycemia is involved in the "aspirin resistance" occurring in diabetes, we aimed at evaluating whether high glucose interferes with the aspirin-induced inhibition of thromboxane synthesis and/or activation of the nitric oxide (NO)/cGMP/cGMP-dependent protein kinase (PKG) pathway in platelets. (diabetesjournals.org)
  • and 3 ) prevented the L-ASA-induced activation of the NO/cGMP/PKG pathway. (diabetesjournals.org)
  • physiology
  • Candidate genes were grouped as (1) thrombophilic, (2) cytokine, (3) apolipoprotein E or (4) other SNPs, largely related to cardiovascular physiology/pathophysiology and the functioning of the immune system. (edu.au)
  • Cardiovascular
  • Several studies demonstrated that endothelium dependent vasodilatation is impaired in cardiovascular and chronic kidney diseases because of oxidant stress-induced nitric oxide availability reduction. (nih.gov)
  • Atherothrombotic cardiovascular events are the leading cause of morbidity and mortality in type 2 diabetes ( 1 ). (diabetesjournals.org)
  • In type 2 diabetes, postprandial hyperglycemia predicts cardiovascular morbidity and all-cause mortality even when glycated hemoglobin is taken into account ( 22 ). (diabetesjournals.org)
  • Role
  • Platelet hyperactivity, a critical factor in the pathogenesis of atherothrombosis ( 2 ), plays a major role in this phenomenon ( 3 ). (diabetesjournals.org)
  • reaction
  • This report summarizes some of the current information regarding NO synthase structure-function, reaction mechanism, control of catalysis, and protein interactions. (labome.org)
  • experiments
  • Representative photo was from three independent experiments. (nih.gov)
  • Results are expressed as average±1SD of 3 different experiments. (nih.gov)
  • We found a significant increase in such levels in animals subjected to chronic (restraint) stress, compared to unstressed animals in three independent experiments (Fig. 1A). (nih.gov)
  • Graphs depict results from three separate experiments. (nih.gov)
  • Images are representative of three separate experiments. (nih.gov)