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  • protein
  • In this regard, AngII stimulates hypertrophy, proliferation, and migration of vascular smooth muscle cells (VSMCs) through a G protein-coupled receptor (GPCR), the AngII type-1 receptor (AT 1 ). (ahajournals.org)
  • IFN-gamma inhibition of MCMV growth was independent of known mechanisms involving IFN-alpha/beta, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase RNA activated (PKR), RNaseL, and Mx1, and did not involve IFN-gamma-induced soluble mediators. (nih.gov)
  • Super oxide dismutase activity is expressed as units per mg protein. (nih.gov)
  • We found that phorbaketal A significantly inhibited the LPS-induced production of nitric oxide (NO), but not prostaglandin E₂, in RAW 264.7 cells.In addition, phorbaketal A reduced the LPS-induced production of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and monocyte chemotactic protein-1.These data suggest that phorbaketal A, isolated from the marine sponge Phorbas sp. (nih.gov)
  • Immunoblot
  • Gelatin zymography and immunoblot analysis of matrix metalloproteinases (MMP)-9 and 2 indicated MMP activation and their role in degenerative skin histological changes. (curehunter.com)
  • epithelial
  • Macrophage control of phagocytosed mycobacteria is increased by factors secreted by alveolar epithelial cells through nitric oxide independent mechanisms. (nih.gov)
  • vitro
  • 1-3 Importantly, in addition to vasoconstriction induced by AngII, other pathological effects of AngII such as induction of growth and migration are blocked by nitric oxide (NO) in vitro. (ahajournals.org)
  • concentrations
  • Based on MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay data (Figure 1B), concentrations of phorbaketal A that would not affect cell viability (2.5, 5, and 10 μM) were used for following experiments. (nih.gov)
  • significantly
  • Furthermore, the amount of active phosphorylated endothelial NO synthase rose significantly after E(2) replacement after 1 and 4 months but not 8 months postovariectomy. (biomedsearch.com)
  • We found that phorbaketal A significantly inhibited the LPS-induced production of nitric oxide (NO), but not prostaglandin E₂, in RAW 264.7 cells. (nih.gov)
  • Compared to wild-type non-diabetic subjects, all patients with T2DM had a significantly increased risk of AMI regardless of genotype. (biomedcentral.com)
  • cell
  • Protective effects of L-arginine were evaluated in a human ventricular heart cell model of low-volume anoxia and reoxygenation independent of alternate cell types. (biomedsearch.com)
  • Novel cell type-specific antiviral mechanism of interferon gamma action in macrophages. (nih.gov)
  • These studies in primary cells define a novel mechanism of IFN-gamma action restricted to Mphi, a cell type key for MCMV pathogenesis and latency. (nih.gov)
  • Only in the brain was the reporter expressed in non-endothelial cell types, such as the CA1 region of the hippocampus. (biomedsearch.com)
  • ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury. (curehunter.com)
  • survival
  • At the same dose, the two other lipid formulations, Amphocil and Abelcet, increased the survival rate but did not suppress infection in all animals. (ajtmh.org)
  • Activity
  • It could be concluded from Figure 2 that the heterocyclic ring-D may improve a compound's activity because of the blue and red cubes observed at the ring-D. The corresponding compounds with heterocyclic ring-D (compounds 26, 34, 37, 38) are more active than compounds with aromatic ring-D (compounds 15, 18). (nih.gov)
  • rats
  • The adaptation of the cardiac hormonal systems oxytocin (OT), natriuretic peptides (NPs), and nitric oxide synthase (NOS) in response to exercise training was investigated in intact and ovariectomized (OVX) rats. (biomedsearch.com)
  • Rats were ovariectomized and implanted with 17beta-estradiol (E(2)) or oil capsules 1, 4, and 8 months after surgery. (biomedsearch.com)
  • Chronic hypoxia-induced HPH was simulated by exposing the rats to 10% oxygen for 2 wk. (nih.gov)
  • outcomes
  • The present findings document that the functional impairment of the ERalpha/endothelial NO synthase signaling network after an extended period of hypoestrogenicity was not restored by E(2) administration, providing experimental support to early initiation of estrogen replacement with preferential ERalpha targeting to improve cardiovascular outcomes. (biomedsearch.com)