InducibleEndothelialCyclo-oxygenaseHeme oxygenase and nitricENOSOxidative stressNeuronal NO synthaseEnzymeHypoxiaFlavodoxinCyclooxygenaseHydrogen sulfideInhibitionProteinVascularInhibitorsDimerNOS2CarbonGenesProteinsInhibitorBacterialPathwayPharmacologyContributionsExpressionBrainRoleFunctionLevelsEffects
Inducible10
- nitric oxide is generated by nitric oxide synthase, an enzyme also inducible by cytokines. (elsevierpure.com)
- We also found co-expression of mRNA and protein for the inducible isoform of nitric oxide synthase (iNOS) in AR at day 5 after transplantation. (elsevierpure.com)
- Meanwhile, p50/RelA promotes the expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide, which inhibits adrenergically induced melatonin production. (frontiersin.org)
- The aim of the present study was to compare microvessel responses to hypercapnic and isocapnic acidosis in hyperoxia-injured lungs and to assess the role of constitutive and inducible forms of nitric oxide synthase (NOS) and cyclo-oxygenase (COX). (ersjournals.com)
- Constitutive, but not inducible, isoforms of cyclo-oxygenase and nitric oxide synthase play an important role in abnormal microvessel responses to carbon dioxide and hydrogen ions in hyperoxia-injured lungs. (ersjournals.com)
- However, these previous studies did not determine the relative contributions of COX (COX‐1 and COX‐2) and nitric oxide synthase (NOS) isoforms (endothelial constitutive (ecNOS) and inducible NOS (iNOS)) to the abnormal acinar microvessel response to HA 4 , 7 . (ersjournals.com)
- We evaluated apurinic/apyrimidinic (AP) sites in nasal and brain genomic DNA, and explored by immunohistochemistry the expression of nuclear factor NFkappaB p65, inducible nitric oxide synthase (iNOS), cyclo-oxygenase 2 (COX2), metallothionein I and II, apolipoprotein E, amyloid precursor protein (APP), and beta-amyloid(1-42) in healthy dogs naturally exposed to urban pollution in Mexico City. (rti.org)
- This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. (utsouthwestern.edu)
- In particular, we examined the effect of anthocyanidins on endothelial heme oxygenase-1 (HO-1), an inducible stress protein. (unipv.it)
- Cell survival during ischemia/reperfusion is governed by HIF-1α-dependent genes such as heme oxygenase-1, inducible nitric oxide synthase, cyclooxygnease-2, and vascular endothelial growth factor. (springeropen.com)
Endothelial6
- In cases of such stress, it was observed that BH4 itself, sepiapterin, folic acid, resveratrol, and a small-molecular-weight compound AVE3085 have the ability to recouple endothelial nitric oxide synthase (eNOS) and improve endothelial function. (medscape.com)
- In our previous work we have shown that S-nitrosylation is involved in the disruption of the endothelial nitric oxide synthase (eNOS) dimer and that this involves the disruption of the zinc (Zn) tetrathiolate cluster due to the S-nitrosylation of Cysteine 98. (elsevierpure.com)
- The risk polymorphisms for endothelial nitric oxide synthase and for heme oxygenase-1 were analyzed. (bvsalud.org)
- Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. (unipv.it)
- Since endothelin-1 (ET-1) and nitric oxide (NO) produced by endothelial NO synthase (eNOS) are vascular tension regulators secreted by endothelial cells, we studied the influence of two anthocyanidins, namely cyanidin (CY) and delphinidin (DP), on the regulation of ET-1 and eNOS in cultured human umbilical vein endothelial cells (HUVECs). (unipv.it)
- Gupta TK, Toruner M, Chung MK, Groszmann RJ: Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats. (karger.com)
Cyclo-oxygenase2
- In a previous study, it was demonstrated that HA induces distinct venule dilatation closely associated with vasodilating prostaglandins generated by cyclo-oxygenase (COX), but not by nitric oxide (NO), in intact rat lung 4 . (ersjournals.com)
- Prostacyclin is produced from arachidonic acid by a series of enzymes including cyclo-oxygenase (COX) and prostaglandin polymerase. (edskilling.com)
Heme oxygenase and nitric2
- Role of heme oxygenase and nitric oxide synthase pathways and their interactions in the regulation of the cerebral circulation. (otka-palyazat.hu)
- Interaction between the heme oxygenase and nitric oxide pathways in the regulation of the resting CBF. (otka-palyazat.hu)
ENOS1
- All these cysteine residues identified were found to be located on the surface of the protein according to the available X-ray structure of the oxygenase domain of eNOS. (elsevierpure.com)
Oxidative stress1
- The effects of cyclooxygenase and nitric oxide synthase inhibition on oxidative stress in isolated rat heart. (gasotransmitters.eu)
Neuronal NO synthase1
- Carbon monoxide (CO) synthesized by heme oxygenase 2 (HO2) and nitric oxide (NO) produced by neuronal NO synthase (nNOS) mediate nonadrenergic/noncholinergic (NANC) intestinal relaxation. (researchwithrowan.com)
Enzyme4
- The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. (cathdb.info)
- Although BH4 is absolutely essential for nitric oxide synthase activity, its exact biochemical function with different forms of the enzyme and its mechanism of action remain to be defined. (medscape.com)
- Both conditions can be accompanied by decreased levels of heme oxygenase-1 (HMOX1), cytoprotective, heme-degrading enzyme. (hindawi.com)
- NO is generated from the amino acid L-arginine by the enzyme NO synthase (NOS). (edskilling.com)
Hypoxia2
- [ 12 ] BH4 deficiency converts neuronal nitric oxide synthase (NOS) into an efficient peroxynitrite synthase, which is responsible for the increase in neuronal vulnerability to hypoxia-induced mitochondrial damage and necrosis. (medscape.com)
- The role of nitrogen oxides in human adaptation to hypoxia. (gasotransmitters.eu)
Flavodoxin1
- 2 L-arginine + 3 reduced flavodoxin + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H(2)O. (cathdb.info)
Cyclooxygenase3
- Furthermore, we have demonstrated the ability of the cerebral circulation to compensate the loss of NO availability and that this compensation does not involve the heme oxygenase or cyclooxygenase pathways. (otka-palyazat.hu)
- The peak blood flow response was not significantly affected by administration of inhibitors of cyclooxygenase-1, neuronal nitric oxide synthase, heme oxygenase, adenosine A2B receptors, or an inhibitor of the synthesis of 20- hydroxyeicosatetraenoic acid (20-HETE). (elsevierpure.com)
- Zivkovic V, Djuric D, Turjacanin-Pantelic D, Marinkovic Z, Stefanovic D, Srejovic I, Jakovljevic V. The effects of cyclooxygenase and nitric oxide synthase inhibition on cardiodynamic parameters and coronary flow in isolated rat hearts. (gasotransmitters.eu)
Hydrogen sulfide1
- Nitric oxide (NO), hydrogen sulfide (H 2 S), and carbon monoxide (CO) are thought to act as gaseous neuromodulators in the brain across species. (elsevierpure.com)
Inhibition2
- The nitric oxide produced by ecNOS attenuated COX‐1 activity in injured arterioles and venules, but carbon dioxide enhanced it, leading to paradoxical dilatation of these microvessels under hypercapnic conditions with ecNOS inhibition. (ersjournals.com)
- Our studies have shown that endogenous carbon monoxide (CO) has a dual influence on the cerebral circulation: on one hand it induces prostanoid-mediated vasodilation but on the other hand reduces the blood flow by inhibition of nitric oxide (NO) synthesis. (otka-palyazat.hu)
Protein1
- We also report strong association of type 2 diabetes with Maltose phosphorylase (K00691), 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase (K21279) and an uncharacterized protein (K07101). (biomedcentral.com)
Vascular1
- The vascular endothelium has vasodilator, anti-thrombotic and athero-protective properties through the production of vasoactive mediators, such as nitric oxide (NO) and prostacyclin. (edskilling.com)
Inhibitors2
- Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors. (cathdb.info)
- Nitric oxide synthase (NOS) inhibitors are potential drug candidates because it continues to be well confirmed that extreme production of Zero critically plays a part in a variety of diseases. (techuniq.com)
Dimer1
- Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. (wikipedia.org)
NOS21
- We have analysed the mechanism by which palmitoylation permits the progression of nitric oxide synthase 2 (NOS2) along the ER-Golgi-TGN pathway. (biologists.com)
Carbon2
- Gases are now viewed as biologic messengers, and in this regard, carbon monoxide and nitric oxide are incriminated in signaling processes in neural tissue. (elsevierpure.com)
- The role of endogenous carbon monoxide (CO) and its interaction with nitric oxide (NO) in the cerebral circulation. (otka-palyazat.hu)
Genes1
- In the present study, we identified the genes of nitric oxide synthase (NOS), soluble guanylyl cyclase (sGC), cystathionine β-synthase (CBS), and heme oxygenase (HO) from the honeybee brain. (elsevierpure.com)
Proteins1
- abstract = "Unlike animal nitric-oxide synthases (NOSs), the bacterial NOS enzymes have no attached flavoprotein domain to reduce their heme and so must rely on unknown bacterial proteins for electrons. (manchester.ac.uk)
Inhibitor1
- On the other hand, the L-type calcium channel blocker nifedipine, the metabotropic glutamate receptor antagonist (RS)-alpha-methyl-4- carboxyphenylglycine, the nitric oxide synthase inhibitor N omega-nitro- L-arginine, and the heme oxygenase inhibitor protoporphyrin IX zinc(II) had no effect on LTD of either the AMPA or the NMDA receptor-mediated component. (jneurosci.org)
Bacterial1
- YkuN supported a similar NO synthesis activity by a different bacterial NOS (Deinococcus radiodurans) but not by any of the three mammalian NOS oxygenase domains nor by an insect NOS oxygenase domain. (manchester.ac.uk)
Pathway1
- Contribution of the heme oxygenase pathway to the maintenance of the hypothalamic blood flow during diminished NO synthesis. (otka-palyazat.hu)
Pharmacology1
- Martin has a long-standing interest in analytical chemistry, cardiovascular pharmacology, drug metabolism, disease mechanisms, and the chemical biology of nitric oxide (NO), and has received numerous awards/honors in recognition of his research achievements in these areas. (gasotransmitters.eu)
Contributions1
- Milsom AB, Fernandez BO, Garcia-Saura MF, Rodriguez J, Feelisch M. Contributions of nitric oxide synthases, dietary nitrite/nitrate, and other sources to the formation of NO signaling products. (gasotransmitters.eu)
Expression2
- On the other hand, the only one that induced heme oxygenase-1 expression was sulforaphane, a known activator of a HMOX1 inducer-NRF2. (hindawi.com)
- Morales-Ruiz M, Jiménez W, Pérez-Sala D, Ros J, Leivas A, Lamas S, Rivera F, Arroyo V: Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites. (karger.com)
Brain2
- Tetrahydrobiopterin deficiencies are disorders that affect phenylalanine (Phe) homeostasis, as well as brain biosynthesis of catecholamine, serotonin, and (occasionally) nitric oxide. (medscape.com)
- Risk factors for depression initiate an infection-like inflammation in the brain that involves activation microglial Toll-like receptors and glycogen synthase kinase-3β (GSK3β). (mdpi.com)
Role1
- Hu LS, George J, Wang JH: Current concepts on the role of nitric oxide in portal hypertension. (karger.com)
Function1
- FUNCTION: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. (utsouthwestern.edu)
Levels1
- Battista S, Bar F, Mengozzi G, Zanon E, Grosso M, Molino G: Hyperdynamic circulation in patients with cirrhosis: direct measurement of nitric oxide levels in hepatic and portal veins. (karger.com)
Effects1
- conversely, nitric oxide may prove cytotoxic through a number of recognized effects. (elsevierpure.com)