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  • atrial
  • Human atrial natriuretic polypeptide, which stimulates cGMP accumulation in vascular smooth muscle cells, also enhanced interleukin-1-induced nitric oxide release at a concentration of 100 nmol/L. In contrast, coincubation with 10 μmol/L methylene blue, an inhibitor of soluble guanylate cyclase, inhibited interleukin-1-induced nitric oxide release from vascular smooth muscle cells. (ahajournals.org)
  • cytokine-inducible
  • Nitric oxide (NO) generated through the cytokine-inducible pathway has been increasingly recognized to play an important role in immune regulation in models of autoimmune disease and T cell tolerance ( 17 )( 18 )( 19 )( 20 )( 21 ). (rupress.org)
  • tumor
  • This was associated with NO synthase activity and localized to tumor cells. (aacrjournals.org)
  • Thus NO synthase is present in human gynecological tumors, and its presence seems to correlate inversely with the differentiation of the tumor. (aacrjournals.org)
  • However, the enhancement of nitric oxide production induced by 8-Br-cGMP was significantly prevented by coincubation with neutralizing antibody against tumor necrosis factor-α. (ahajournals.org)
  • cellular
  • In this study, we have investigated NO synthase activity and its cellular localization in malignant and nonmalignant human gynecological tissue. (aacrjournals.org)