• Popular Abstract in Swedish Septisk shock (shock utlöst av blodförgiftning) är en potentiellt dödlig komplikation till infektion med bakterier eller andra mikroorganismer. (dissertations.se)
  • Popular Abstract in Swedish Den första beskrivningen av diabetes mellitus gjordes redan 1500 före Kristus när en faraos läkare noterade att myror samlade sig omkring urin från vissa människor men inte andras. (dissertations.se)
  • Nitric oxide synthase (NOS), a flavo‐hemoprotein, regulates nitric oxide (NO) synthesis that has dual biological activities: as an important signalling molecule in vasodilatation and neurotransmission at low concentrations and at higher concentrations as a defensive cytotoxin. (intechopen.com)
  • Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide. (aspetjournals.org)
  • Previous studies demonstrating a correlation between CD4 + -T-cell-mediated inhibition of chlamydial growth and gamma interferon (IFN-γ)-mediated induction of nitric oxide synthase suggested a potential role for the nitric oxide (NO) effector pathway in the clearance of Chlamydia from genital epithelial cells by the immune system. (asm.org)
  • Here we show that uncoupling of nitric oxide synthase-3 (NOS3) plays a major role in pressure load-induced myocardial ROS and consequent chamber remodeling/hypertrophy. (jci.org)
  • Endothelial nitric oxide synthase is not necessary for the early phase of ischemic preconditioning in the mouse. (labome.org)
  • obJeCtives: To examine whether changes in nitric oxide (NO) bioavailability occurring during a 25 min occlusion of the left anterior descending coronary artery and following ischemic preconditioning (PC) in anesthetized dogs (chloralose and urethane, intravenous) are associated with changes in the activation of NO synthase (NOS) enzymes. (pulsus.com)
  • It is produced in the human body by a two-step synthesis from the amino acid arginine , catalyzed by the enzyme nitric oxide synthase (NOS). (wisegeek.com)
  • NO is synthesized from L-arginine by nitric oxide synthase (NOS), as a response to activation of N-methyl-D-aspartate (NMDA) receptors by excitatory amino acids. (biopsychiatry.com)
  • In paired studies, we exercised sheep on a treadmill at a speed of 4 mph, and measured blood flow and pressures across the pulmonary circulation with and without inhibition of NO synthase (N omega-nitro-L-arginine 20 mg/kg intravenous [i.v.]), alpha receptor blockade (phentolamine 5 mg i.v.), beta receptor blockade (propranolol 1 mg i.v.), and combined alpha and beta receptor blockade. (jci.org)
  • N -nitro- l -arginine methyl ester ( l -NAME, 2.5 and 5.0 mg/kg iv) and N -monomethyl- l -arginine ( l -NMMA, 0.73 mg/kg), nitric oxide synthase (NOS) antagonists, caused insulin resistance in rats. (physiology.org)
  • L-NMMA (NG-Methyl-L-arginine, acetate salt) competitively inhibits nitric oxide synthase in a wide range of cells. (biotium.com)
  • Nitric oxide synthase (NOS) is the enzyme that catalyzes the synthesis of NO from L-arginine in biological systems, and has been a potential target for inhibition. (uwaterloo.ca)
  • Background: Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). (uib.no)
  • Nitric oxide (NO) generated through the cytokine-inducible pathway has been increasingly recognized to play an important role in immune regulation in models of autoimmune disease and T cell tolerance ( 17 )( 18 )( 19 )( 20 )( 21 ). (rupress.org)
  • BH4 is a cofactor for creating nitric oxide synthase (NOS) enzymes necessary for creating nitric oxide (Alp, 2004). (thefreedictionary.com)
  • Since the quite recent characterization of the terminal and specific prostaglandin synthases, which act downstream of COX enzymes, the search for molecular targets which selectively suppress individual prostanoids has been intensified. (diva-portal.org)
  • Nitric oxide synthase-1 (NOS1) is involved in several forms of plasticity including hippocampal-dependent learning and memory, experience-dependent plasticity in the barrel cortex, and long-term potentiation (LTP) in the hippocampus and neocortex. (jneurosci.org)