• Yet, with the new discovery of how bacteria defend themselves with nitric oxide, scientists now hope that by merely blocking the site of nitric oxide production in bacteria they can make traditional antibiotics much more potent against even incredibly virulent infections. (scienceline.org)
  • If you make bacterial cells more vulnerable to the old and well-established antibiotics, that is better than having to design new antibiotics," explains New York University biochemist Evgeny Nudler , who led a research team that recently showed bacteria are virtually defenseless when they are unable to produce nitric oxide. (scienceline.org)
  • Although these particular drugs were designed to target the human nitric oxide pathways that are involved in blood pressure disorders, the same technology may be tuned to specifically target bacteria. (scienceline.org)
  • This work very nicely demonstrates that bacteria that produce nitric oxide use it to protect themselves against the lethal effects of antibiotics, and that this is a broad effect," says Jim Collins , a biomedical engineer at Boston University. (scienceline.org)
  • After discovery of nitric oxide as a biological mediator many researchers have focused on the importance of nitric oxide in the physiology of the nervous system [ 1 - 3 ]. (intechopen.com)
  • Treating bacterial infections with cocktails of traditional antibiotics and NOS inhibitors to prevent nitric oxide formation will be more efficient than designing entirely new drugs, suggests Nudler. (scienceline.org)
  • Nitric oxide can contribute to reperfusion injury when excessive amount produced during reperfusion (following a period of ischemia) reacts with superoxide to produce the damaging free radical peroxynitrite. (newworldencyclopedia.org)
  • Reacts with water to form nitric acid. (environmentalchemistry.com)
  • Nitric oxide reacts with acetone and an alkoxide to a diazeniumdiolate or nitrosohydroxylamine and methyl acetate: This reaction was discovered around 1898, and remains of interest in nitric oxide prodrug research. (wikipedia.org)
  • Nitric oxide reacts with all transition metals to give complexes called metal nitrosyls. (wikipedia.org)
  • The nitric oxide reacts with the ozone to produce oxygen and nitrogen dioxide, accompanied with emission of light (chemiluminescence): ·NO + O3 → NO2 + O2 + hν which can be measured with a photodetector. (wikipedia.org)
  • The reaction of protein-bound iron-sulfur (Fe-S) clusters with nitric oxide (NO) plays key roles in NO-mediated toxicity and signaling. (mendeley.com)
  • This enzyme participates in nitrogen metabolism and in the microbial defense against nitric oxide toxicity. (wikipedia.org)
  • Nitric oxide is a key biological messenger, playing a role in a variety of biological process. (newworldencyclopedia.org)
  • The understanding of the formation and biological actions of nitric oxide (NO) has grown extensively during the past two decades. (nih.gov)
  • A sample containing nitric oxide is mixed with a large quantity of ozone. (wikipedia.org)
  • Many bacterial pathogens have evolved mechanisms for nitric oxide resistance. (newworldencyclopedia.org)
  • Tough pathogens, such as anthrax and MRSA , depend on nitric oxide to defend themselves against antibiotic drugs, according to recent research. (scienceline.org)
  • a colorless, slightly water-soluble gas, NO, formed by the action of dilute nitric acid on copper, and by the direct combination of atmospheric oxygen and nitrogen at the high temperatures of an electric arc: an intermediate in the manufacture of nitric acid. (dictionary.com)
  • In the body, nitric oxide is involved in oxygen transport to the tissues, the transmission of nerve impulses, and other physiological activities. (dictionary.com)
  • A particularly important intermediate in the chemical industry, nitric oxide forms in mixtures of nitrogen and oxygen at high temperatures, as found in combustion systems such as internal-combustion piston engines, gas turbines, furnaces, and boilers. (wikipedia.org)
  • When exposed to oxygen, nitric oxide is converted into nitrogen dioxide. (wikipedia.org)
  • The Model 410 Nitric Oxide Monitor is designed for the measurement of atmospheric nitric oxide (NO) in the concentrtion range 0-2,000 ppb (0-2 ppm) with a precison of ±1.5 ppb. (environmental-expert.com)
  • Ambient Nitric Oxide: The Real Insight Ambient Nitric Oxide: The Real Insight The Insight eNO System does NOT require inhalation of NO free air The ATS/ERS recommendations (2005) for standardized measurement of exhaled nitric oxide states that it is not. (calameo.com)
  • The Insight™ eNO System does not require NO free air to be inhaled prior to the measurement because ambient NO (nitric oxide in air) does not interfere with the results. (calameo.com)
  • Cellular signaling with nitric oxide and cyclic guanosine monophosphate. (nih.gov)
  • A nitric oxide (NO) microsensor based on catalytic oxidation of NO comprises. (google.co.uk)
  • A nitric oxide (NO) microsensor based on catalytic oxidation of NO comprises a thermally-sharpened carbon fiber with a tip diameter of about 0.5-0.7 μm coated with several layers of p-type semiconducting polymeric porphyrin and cationic exchanger deposited thereon. (google.co.uk)
  • Likewise, nitric oxide forms naturally along the pathway of lightning in thunderstorms. (wikipedia.org)
  • She also exhibited lack of efficacy to nitric oxide for the treatment of deterioration of respiratory status with hypoxia and hypercarbia [ times to reactions onsets not stated ]. (springer.com)
  • Nitric oxide is also an immune effector, mediating diverse activities of immune cells. (wikipedia.org)
  • Nitroglycerin and amyl nitrite serve as vasodilators because they are converted to nitric oxide in the body. (newworldencyclopedia.org)
  • 3. The electrode sensor of claim 2, which additionally comprises a gas-permeable membrane coating that is permeable to nitric oxide and is not permeable to nitrite. (google.co.uk)
  • Over a century after their medical introduction, the organic-nitrate pharmaceuticals, including nitroglycerine and amyl nitrite, were identified as precursors of nitric oxide. (wikipedia.org)
  • The chapters are divided into three parts: part one looks at NO treatments using gaseous nitric oxide and detection using a NO-sensitive electrode, electron spin resonance, and fluorescence-based NO-sensor proteins. (springer.com)
  • 4. The electrode sensor of claim 1, wherein said electrically conductive substrate is selected from the group consisting of electrically conductive carbon, indium tin oxide, iridium oxide, nickel, platinum, silver, and gold. (google.co.uk)
  • Nitric Oxide-Releasing Fabrics and Other Acrylonitrile-Based Diazeniumdiolate. (medgadget.com)
  • Some recent work has indicated that Nitric Oxide can be carried on molecules of Hemoglobin -- specifically the relaxed form, oxyhemoglobin, can form S-Nitrosohemoglobin by reaction with beta-Cys-93. (rutgers.edu)
  • This time, Garvey and his co-workers examined the pairing of nitric oxide with another alcohol, ethanol, and found that the molecules were highly reactive. (scientificamerican.com)
  • In addition, they discovered that the reactive site between a positively charged nitric oxide ion and an alcohol will vary depending on how many solvent molecules surround them. (scientificamerican.com)
  • Nitric Oxide is also the transmitter that results in engorgement of the sexual organs -- the drug Viagra has its effect on the second messenger, cyclic GMP, but other treatments for impotency involve delivery of NO. (rutgers.edu)