Organic nitratesDiltiazemAdalatParticularly during nifNitroglycerinAnginaHypertensionIsosorbide DinitrateTabletsCLINICAL PHARMACOLOGYSublingualAcuteGrapefruit juiceBeta blockersOrallyMyocardialReducesDoseVascular smoothDosesDecreaseInfluxAchalasiaCommonlyFormulationsDosageRapidlyChronicDrugsTreatmentsBloodSustained-releaseAdministrationAgentsEffectsSafeEffective
Organic nitrates6
- Nifedipine is indicated for the management of chronic stable angina (effort-associated angina) without evidence of vasospasm in patients who remain symptomatic despite adequate doses of beta blockers and/or organic nitrates or who cannot tolerate those agents. (rxlist.com)
- Note that some spasms of intestinal musculature can be effectively relieved by organic nitrates (in biliary colic) or by nifedipine (esophageal hypertension and achalasia). (manualofmedicine.com)
- Sep-2 or side effects of organic nitrates is a d? (adornus.info)
- Overview: Angina pectoris caused by temporary myocardial ischemia is responsive to treatment by organic nitrates. (pharmacology2000.com)
- Organic nitrates act primarily by vasodilation (especially venodilation) which reduces myocardial preload and therefore myocardial oxygen demand. (pharmacology2000.com)
- The organic nitrates and nitrites are denitrated to produce nitric oxide (NO) which activates guanylyl cyclase. (pharmacology2000.com)
Diltiazem2
- Calcium channel blockers: These include diltiazem, amlodipine, nifedipine and verapamil. (denguedenguedengue.com)
- Nifedipine, verapamil, diltiazem are examples of calcium channel blockers that may be effective in chronic treatment of angina. (pharmacology2000.com)
Adalat1
- Nifedipine, sold under the brand names Adalat and Procardia among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. (wikipedia.org)
Particularly during nif1
- Sublingual nitroglycerin may be taken as required for the control of acute manifestations of angina, particularly during nifedipine titration. (drugs.com)
Nitroglycerin1
- Glyceryl nitrate or trinitrate or nitroglycerin is a vasodilator used to treat cardiac disorders like ischemia and mainly anal fissures. (e-lactancia.org)
Angina8
- This property increases myocardial oxygen delivery in patients with coronary artery spasm,and is responsible for the effectiveness of nifedipine in vasospastic (Prinzmetal's or variant) angina. (nih.gov)
- This unloading of the heart reduces myocardial energy consumption and oxygen requirements and probably accounts for the effectiveness of nifedipine in chronic stable angina. (nih.gov)
- Nifedipine is one of the main choices for the treatment of Prinzmetal angina due to its vasodilating effects on the coronary arteries. (wikipedia.org)
- Nifedipine is indicated for the management of vasospastic angina confirmed by any of the following criteria: 1) classical pattern of angina at rest accompanied by ST segment elevation, 2) angina or coronary artery spasm provoked by ergonovine, or 3) angiographically demonstrated coronary artery spasm. (rxlist.com)
- Nifedipine may also be used where the clinical presentation suggests a possible vasospastic component but where vasospasm has not been confirmed, e.g., where pain has a variable threshold on exertion or when angina is refractory to nitrates and/or adequate doses of beta blockers . (rxlist.com)
- In chronic stable angina (effort-associated angina) nifedipine has been effective in controlled trials of up to eight weeks duration in reducing angina frequency and increasing exercise tolerance, but confirmation of sustained effectiveness and evaluation of long-term safety in these patients are incomplete. (rxlist.com)
- Controlled studies in small numbers of patients suggest concomitant use of nifedipine and beta-blocking agents may be beneficial in patients with chronic stable angina, but available information is not sufficient to predict with confidence the effects of concurrent treatment, especially in patients with compromised left ventricular function or cardiac conduction abnormalities. (rxlist.com)
- Nitrates are often used to treat angina. (denguedenguedengue.com)
Hypertension1
- An exception to the avoidance of this practice is in the use of nifedipine for the treatment of hypertension associated with autonomic dysreflexia in spinal cord injury. (wikipedia.org)
Isosorbide Dinitrate2
- Calcium Channel Blockers (Nitrates) are orally injested drugs such as Nifedipine or Isosorbide Dinitrate. (adaming.com)
- Calcium channel blockers (Nifedipine) or nitrates (Isosorbide dinitrate) are taken before meals to reduce lower esophageal pressure. (alakoc.com)
Tablets2
- Nifedipine Extended-release Tablets meet USP Dissolution Test 3. (nih.gov)
- Nitrates: These can be given in sublingual tablets, oral tablets or capsules or patches. (denguedenguedengue.com)
CLINICAL PHARMACOLOGY1
- Avoid co-administration of nifedipine with grapefruit juice (see CLINICAL PHARMACOLOGY and PRECAUTIONS: Other Interactions ). (drugs.com)
Sublingual4
- Nifedipine given as sublingual administration has previously been used in hypertensive emergencies. (wikipedia.org)
- Sublingual administration of nifedipine promotes a hypotensive effect via peripheral vasodilation. (wikipedia.org)
- There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, including cerebral ischemia/infarction, myocardial infarction, complete heart block, and death. (wikipedia.org)
- As a result of this, in 1985 the FDA reviewed all data regarding the safety and effectiveness of sublingual nifedipine for the management of hypertensive emergencies, and concluded that the practice should be abandoned because it was neither safe nor effective. (wikipedia.org)
Acute2
- As calcium channel blocker, nifedipine has a risk of causing gingival hyperplasia A number of persons have developed toxicity due to acute overdosage with nifedipine, either accidentally or intentionally, and via either oral or parenteral administration. (wikipedia.org)
- In an acute episode, nifedipine, nitrates and captopril are the most commonly used and recommended agents. (spinalcordinjuryzone.com)
Grapefruit juice1
- medical citation needed] Extended release formulations of nifedipine should be taken on an empty stomach, and patients are warned not to consume anything containing grapefruit or grapefruit juice, as they raise blood nifedipine levels. (wikipedia.org)
Beta blockers1
- See PRECAUTIONS, Drug Interactions , for information on co-administration of nifedipine with beta blockers or long-acting nitrates. (drugs.com)
Orally2
- There is little difference in relative bioavailability when nifedipine capsules are given orally and either swallowed whole, bitten and swallowed, or bitten and held sublingually. (nih.gov)
- In Phase II, the effect of nifedipine on antidepressant activity of fluvoxamine, venlafaxine and tianeptine was studied by orally administering sub-antidepressant doses of these drugs for 28 days. (ijbcp.com)
Myocardial1
- The nitrates, by reducing myocardial wall tension and oxygen requirements, are very effective antianginal agents. (pharmacology2000.com)
Reduces2
- Nifedipine regularly reduces arterial pressure at rest and at a given level of exercise by dilating peripheral arterioles and reducing the total peripheral resistance (afterload) against which the heart works. (nih.gov)
- The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and the resulting reduction in peripheral vascular resistance. (nih.gov)
Dose6
- In Phase I, antidepressant activity of nifedipine, fluvoxamine, venlafaxine and tianeptine were confirmed after their single dose administration using forced swim test (FST) and tail suspension test (TST) and their minimum antidepressant doses were determined. (ijbcp.com)
- Minimal antidepressant dose of nifedipine, fluvoxamine, venlafaxine and tianeptine was observed as 10, 25, 25 and 10 mg/kg respectively. (ijbcp.com)
- In Phase II, combinations of sub-antidepressant dose of nifedipine (5 mg/kg) with sub-antidepressant doses of fluvoxamine (12.5 mg/kg), venlafaxine (12.5 mg/kg) and tianeptine (5 mg/kg) exhibited enhanced antidepressant activity when compared to the control group and individual drug groups after same duration of treatment. (ijbcp.com)
- The amount of nitrate / nitrite in this type of vasodilator drugs is of few milligrams, therefore, toxicity associated to nitrates such as methemoglobinemia in breastfed infants from treated mothers has not been reported (The dose of nitrite is Rectogesic 1.5 mg / 12 hours). (e-lactancia.org)
- Organic nitrate is 50mg should note that once-a-day dose. (adornus.info)
- Beneficial effects of low dose nitrates occurs primarily as a result of peripheral vasodilation. (pharmacology2000.com)
Vascular smooth3
- Nifedipine selectively inhibits calcium ion influx across the cell membrane of cardiac muscle and vascular smooth muscle without changing serum calcium concentrations. (nih.gov)
- Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. (nih.gov)
- The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. (nih.gov)
Doses2
- it does conclude that most included studies used low doses of nifedipine. (wikipedia.org)
- Nifedipine rapidly lowers blood pressure, and patients are commonly warned they may feel dizzy or faint after taking the first few doses. (wikipedia.org)
Decrease1
- Calcium channel blockers and nitrates both decrease LES pressure but do not improve LES relaxation. (medscape.com)
Influx1
Achalasia1
- Nitrates are not seen as a long term solution, and generally only prescribed to patients with early stage Achalasia [Annese, 2006] , [Pohl, 2007] . (adaming.com)
Commonly1
- medical citation needed] Finally, nifedipine can be used in the treatment of renal calculi, which are commonly referred to as kidney stones. (wikipedia.org)
Formulations1
- Nifedipine is taken by mouth and comes in fast- and slow-release formulations. (wikipedia.org)
Dosage1
- However, if discontinuation of nifedipine is necessary, sound clinical practice suggests that the dosage should be decreased gradually with close physician supervision. (drugs.com)
Rapidly1
- Nifedipine is rapidly and fully absorbed after oral administration. (nih.gov)
Chronic1
- Since hepatic biotransformation is the predominant route for the disposition of nifedipine, the pharmacokinetics may be altered in patients with chronic liver disease. (nih.gov)
Drugs3
- What Other Drugs Interact with Nifedipine? (rxlist.com)
- Visit Your Doctor One of these is legal Buy Nifedipine Over Internet as of the other symptoms mentioned above, it could be in the same group of drugs. (ddtpsod.com)
- Nifedipine, a CCB, has been shown to possess antidepressant activity and potentiate antidepressant activity of imipramine and sertraline, however, literature on its interaction with newer antidepressant drugs such as fluvoxamine, venlafaxine and tianeptine is limited. (ijbcp.com)
Treatments1
- Common heart attack types and treatments A hospital that disorder is legal Buy Nifedipine Over Internet with a lower risk of significant angiographic CAD in women. (ddtpsod.com)
Blood4
- Distal LAD disease is usually treated legal Buy Nifedipine Over Internet while legal Buy Nifedipine Over Internet of anticoagulants such as, and others, Legal Buy Nifedipine Over Internet, is in blood pressure induced by calcineurin inhibitors is mediated feel like you are all alone. (ddtpsod.com)
- Most strokes are caused by clots, but legal Buy Nifedipine Over Internet are caused by ruptured blood vessels. (ddtpsod.com)
- This blood clot can cause blockage in the blood and are legal Buy Nifedipine Over Internet caused by changes to the electrical. (ddtpsod.com)
- Nitrates also promote redistribution of blood flow to relative ischemic areas. (pharmacology2000.com)
Sustained-release1
- These problems are much less frequent in the sustained-release preparations of nifedipine. (wikipedia.org)
Administration2
- Nifedipine capsules are formulated as soft gelatin capsules for oral administration each containing 10 mg nifedipine. (nih.gov)
- Each extended-release tablet, formulated as a once-a-day controlled release tablet for oral administration, delivers 30 or 60 mg of nifedipine. (nih.gov)
Agents2
- Nifedipine is an antianginal drug belonging to a class of pharmacological agents, the calcium channel blockers. (nih.gov)
- Nifedipine is a drug belonging to a class of pharmacological agents known as the calcium channel blockers. (nih.gov)
Effects1
- What Are Side Effects Associated with Using Nifedipine? (rxlist.com)
Safe2
- Nifedipine is considered safe in pregnancy and breastfeeding. (wikipedia.org)
- Nifedipine ( Safe. (e-lactancia.org)
Effective1
- Topical nifedipine has been shown to be as effective as topical nitrates for anal fissures. (wikipedia.org)