• The area surrounding the nipple (the areola) becomes smaller and may nearly disappear. (medlineplus.gov)
  • The areola is the pigmented skin surrounding the nipple. (breast-plastic-surgery.org)
  • The nipple forms during the perinatal period with the proliferation of the mesenchyme underlying the areola. (medscape.com)
  • Like its female counterpart, the male breast has a nipple and an areola (the darker pigmented circle around the nipple), but men lack the mammary glands and ducts necessary to produce milk. (healthline.com)
  • Note markedly scaly, crusted, and deformed nipple with thickened, irregularly outlined adjacent nipple-areola complex. (medscape.com)
  • Nipple invagination, deformed nipple-areola complex, marked erythema, and alternating hyperpigmentation and hypopigmentation noted in adjacent skin of breast in 65-year-old woman with biopsy-proven Paget disease. (medscape.com)
  • Humans nipples are surrounded by a lighter colored area called the areola. (kinkly.com)
  • He reported a chronic eczematous disease on the skin of the nipple and the areola in 15 women, with an associated intraductal carcinoma of the underlying mammary gland. (medscape.com)
  • Tumors can arise anywhere that mammary tissue type is present but is most often seen at the pit of the arm, abdomen, and groin of female rats. (ratguide.com)
  • Although mammary tumors can occur at a younger age, they have a higher occurrence after 18 months of age. (ratguide.com)
  • Rats fed ad libitum (free-fed) have lower survival and a higher incidence of pancreatic, mammary, and pituitary tumors than rats fed a moderate dietary restriction of identical diets (Boorman & Everitt, 2006). (ratguide.com)
  • Tumors with endocrine influence such as pituitary and mammary gland have been most severely altered by ad libitum feeding (Boorman & Everitt, 2006). (ratguide.com)
  • The development and growth of mammary tumors are primarily dependent on estrogen and prolactin (hormones controlled by the pituitary gland and the hypothalamus) receptor concentrations. (ratguide.com)
  • The concentrations of these hormones are found to be higher in hormone dependent tumors, whereas in hormone independent tumors (as seen in latter stages of mammary adenocarcinoma) they tend to be lower. (ratguide.com)
  • Although most mammary tumors in rats are benign, if not treated will continue to grow becoming quite large measuring from several millimeters to several centimeters and encompassing up to half the body weight of the rat. (ratguide.com)
  • There are several varieties of mammary tumors in dogs. (labrador-retriever-guide.com)
  • The nipple approach has proven highly effective in rats, both in eliminating cancers and in preventing tumors from forming, Johns Hopkins University researchers say. (futurity.org)
  • But perhaps the most intriguing outcome of these tests, she said, was that preventive treatment of only four mammary glands in rats-which have a total of 12-showed a strong effect in preventing tumors in the untreated glands as well. (futurity.org)
  • However, it is believed diet may also play an important role, as obese cats of either sex are more likely to develop mammary tumors. (marylandpet.com)
  • Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (aacrjournals.org)
  • Humans normally have two complex mammary glands, one in each breast, and each complex mammary gland consists of 10-20 simple glands. (wikipedia.org)
  • The lactiferous ducts then merge into 5-10 main lactiferous ducts, which then open at the nipple, allowing the infant to receive the milk. (medscape.com)
  • The nipple contains tiny ducts used to breastfeed and is sensitive to cold and stimulation. (breast-plastic-surgery.org)
  • The male reproductive system consists of a pair of testes that produce sperm (or spermatozoa ), ducts that transport the sperm to the penis and glands that add secretions to the sperm to make semen (see diagram 13.2). (wikibooks.org)
  • The mammary gland is composed of groups of lobules that form lobes, which drain through lactiferous ducts to the nipple. (smartimagebase.com)
  • Because most breast cancers originate from cells lining the milk ducts, she reasoned, early or preventive therapies should be delivered directly to the ducts via the nipple rather than intravenously. (futurity.org)
  • Starting first with dextrose-essentially sugar water-and later using escalating doses of the same formulation administered to Sukumar's rats, she infused patients' breast ducts via a small catheter placed into the nipple. (futurity.org)
  • But Stearns was able to show that single doses of pegylated liposomal doxorubicin, or PLD, delivered to breast ducts caused only mild side effects, including mild nipple pain and breast fullness. (futurity.org)
  • This is an attractive feature, because some breast ducts in women are 'blind ducts' that are unconnected to the nipple and, therefore, unreachable directly with intraductal therapy. (futurity.org)
  • In addition, using this incision to place the implants is more likely to interfere with the ability to breastfeed in the future, because it interrupts many of the milk ducts (the tubes that carry milk from the mammary glands to the nipple). (doctormiles.com)
  • In adult female mammals (such as a human woman), they contain the outlets of the milk ducts from the mammary glands. (kinkly.com)
  • Mammary epithelial ECM mainly contains myoepithelial basement membrane and the connective tissue. (wikipedia.org)
  • These mesenchymal cells can transform into a dense, mammary-specific mesenchyme, which later develop into connective tissue with fibrous threads, forming blood vessels and the lymph system. (wikipedia.org)
  • Breasts are combination structures comprised of fat, connective tissue and glands. (breast-plastic-surgery.org)
  • Soon after birth, the nipples are raised from the shallow mammary pits by proliferation of the surrounding connective tissue. (medscape.com)
  • FMA: Subdivision of breast which consists of skin, connective tissue and smooth muscle bundle, modified sebaceous glands and papillary part of lactiferous duct. (linkedlifedata.com)
  • MEDICAL ANIMATION TRANSCRIPT: The mammary glands lie inside the breast over the pectoralis major muscle, surrounded by adipose and connective tissue. (smartimagebase.com)
  • This type of tumor is rare and is called a benign mixed mammary tumor that is comprised of connective and glandular tissue. (labrador-retriever-guide.com)
  • These symptoms may include a lump, nipple discharge, breast pain , dimpling of the skin on the breast, changes of the nipple, or other findings. (adam.com)
  • Palpable breast masses, mastalgia, and nipple discharge are commonly encountered symptoms in outpatient practice, causing significant patient anxiety and precipitating medical consultation. (aafp.org)
  • The first step in the diagnostic evaluation of patients with nipple discharge is classification of the discharge as pathologic or physiologic. (aafp.org)
  • Nipple discharge is classified as pathologic if it is spontaneous, bloody, unilateral, or associated with a breast mass. (aafp.org)
  • Common breast problems include breast mass, pain, and nipple discharge. (aafp.org)
  • Diagnostic imaging is not needed in patients with physiologic nipple discharge if routine screening mammography is up to date and physical examination findings are normal. (aafp.org)
  • Radiologic investigation should be performed in patients with nipple discharge that is spontaneous, unilateral, clear, serous, bloody, or associated with a mass. (aafp.org)
  • Small amounts of clear or milky discharge might leak from the pregnant cat's nipples, especially if they are touched, as late pregnancy hormones stimulate milk development. (cats.com)
  • Discharge of milk from nipple can also occur with intake of birth control pills in some woman. (tandurust.com)
  • Disturbance in mechanism can elevate the prolactin level causing discharge of milk from mammary glands. (tandurust.com)
  • Toward the end of pregnancy, the mammary glands enlarge, and a milky discharge from the nipples a day or two before birth is common. (vetstreet.com)
  • Serosanguineous discharge from the nipple may be present. (medscape.com)
  • Simply run your hand down both sides from the armpit to near the groin gently applying pressure around the nipples, which you should check for any discharge. (marylandpet.com)
  • Inside the bud, a rudimentary mammary ductal system is formed, which is present at birth. (medscape.com)
  • However, as testosterone is released in the male rat fetus before mammary tissue development occurs the mammary glands are rudimentary, and they do not have nipples. (ratguide.com)
  • In most flocks this character can safely be disregarded in selection but if the incidence of multinippled individuals becomes high enough to be objectionable it should be possible to bring it under control 'rather quickly by the use of rams with only two rudimentary nipples. (omia.org)
  • A mammary gland is an exocrine gland in humans and other mammals that produces milk to feed young offspring. (wikipedia.org)
  • The mammary glands are arranged in organs such as the breasts in primates (for example, humans and chimpanzees), the udder in ruminants (for example, cows, goats, sheep, and deer), and the dugs of other animals (for example, dogs and cats). (wikipedia.org)
  • The area around the nipples remains large as the mammary glands are working hard to produce milk. (cats.com)
  • They are also fat-filled mammary glands that produce milk. (3dsexclub.com)
  • The only group of animals that has the ability to produce milk to provide for their young through their nipple is mammals, mainly because of the presence of their mammary glands. (cs-tf.com)
  • Each lobule has a lactiferous duct that drains into openings in the nipple. (wikipedia.org)
  • Maintaining the correct polarized morphology of the lactiferous duct tree requires another essential component - mammary epithelial cells extracellular matrix (ECM) which, together with adipocytes, fibroblast, inflammatory cells, and others, constitute mammary stroma. (wikipedia.org)
  • This hormone is secreted by pituitary gland located in the brain. (tandurust.com)
  • A tumor in pituitary gland can cause increased production of prolactin hormone. (tandurust.com)
  • Lactorrhea, the occasional production of milk by the glands, can occur in any mammal, but in most mammals, lactation, the production of enough milk for nursing, occurs only in phenotypic females who have gestated in recent months or years. (wikipedia.org)
  • This article reviews the development of the mammary gland (mammogenesis), the process through which the mammary gland develops the capacity to secrete milk (lactogenesis), the process of milk production (lactation), and the specific properties of human milk that make it unique and appropriate for human infants. (medscape.com)
  • The nipples and mammary system are beginning to prepare for lactation and nursing. (cats.com)
  • Lactation is the term used for secretion of milk from the breast (mammary glands). (tandurust.com)
  • Lastly frequent stimulation of nipple and breast may result in lactation in some woman. (tandurust.com)
  • Mammary fibroadenoma: A fibrous, benign, epithelial tumor in which cells are derived from glandular tissue. (ratguide.com)
  • Nipples are present on embryos before male or female sex organs develop, but in male cats, these nipples and mammary systems remain small and dormant for life. (cats.com)
  • MSH: The conic organs which usually give outlet to milk from the mammary glands. (linkedlifedata.com)
  • Mammary adenocarcinomas: A malignant growth in glandular organs and arising from epithelium. (ratguide.com)
  • Stimulates development of a uterus, uterine tubes, vaginas, stroma and channels of mammary glands, pigmentation in nipples and generative organs, formation of secondary sexual characteristics on female type, growth and closing of epiphysis of long tubular bones. (bsdmag.org)
  • The myoepithelial cells contract under the stimulation of oxytocin, excreting the milk secreted by alveolar units into the lobule lumen toward the nipple. (wikipedia.org)
  • Some women can acheive orgasm through nipple stimulation. (kinkly.com)
  • By detecting the levels of hormones produced by glands under the pituitary's control (target glands), the hypothalamus or the pituitary can determine how much stimulation the target glands need. (msdmanuals.com)
  • The gland is anchored to the pectoralis major fascia by the suspensory ligaments first described by Astley Cooper in 1840. (medscape.com)
  • Without estrogen, the gland tissue shrinks, making the breasts smaller and less full. (medlineplus.gov)
  • Breast fat (adipose tissue) accounts for much of the mammary mass. (breast-plastic-surgery.org)
  • Athelia (ie, absence of nipples) and amastia (ie, absence of breast tissue) may occur bilaterally or unilaterally. (medscape.com)
  • Nipple rings, also known as nipple piercings, are a form of body modification that involves the placement of a metallic ring or barbell through the nipple tissue. (nipplecharms.com)
  • Breasts - Also known as mammary glands, two soft, rounded parts of a woman's chest made of specialized tissue that produces milk after a woman gives birth. (healthywomen.org)
  • Typically seen as a soft, circumscribed (round), or somewhat flat appearing growth that can be movable on palpation, to a more firm and attached growth (seen more in malignancy) anywhere along the region of mammary tissue. (ratguide.com)
  • Mammary tissue is extensive in both female and male rats and is found ventral, lateral and dorsal, running from the shoulder and chin area to the base of the tail. (ratguide.com)
  • You can check to see if your cat has any suspicious lumps or tissue nodules by feeling their five pairs of mammary glands while they are relaxed. (marylandpet.com)
  • Nipples are the pigmented projections found at the center of the breast tissue. (kinkly.com)
  • Nipples contain erectile tissue that can respond to arousal as well as temperature. (kinkly.com)
  • Mother chickens lacked the breast tissue, nipples, and milk duct that all female mammals have. (cs-tf.com)
  • This is simply because there are no glands and breast tissue found beneath the skin of the chicken, just the pectoral muscles are present. (cs-tf.com)
  • Malignant Paget cells are derived from luminal lactiferous ductal epithelium (A) of breast tissue with retrograde extension of cancerous Paget cells into epidermis of overlying nipple (B). Enlarged circle shows details that reveal thickening both of lining epithelium of breast duct and of nipple skin. (medscape.com)
  • This locally secreted factor gives rise to a series of outside-in and inside-out positive feedback between these two types of cells, so that mammary bud epithelial cells can proliferate and sprout down into the mesenchymal layer until they reach the fat pad to begin the first round of branching. (wikipedia.org)
  • Mammary Paget cells are malignant epithelial cells derived from underlying ductal adenocarcinoma of the breast that invade into the skin of nipple and areolar areas. (medscape.com)
  • According to Healthline, women with overly large breasts can develop a condition called mammary hyperplasia, which can cause pain, discomfort, and other health issues. (3dsexclub.com)
  • Released from special glands around their bodies, all varieties of felines produce a wide range of pheromones, that send different meanings and messages to other cats and influence behaviours. (feliway.com)
  • This is the reason why the testes are located in a bag of skin called the scrotal sacs (or scrotum ) that hangs below the body and where the evaporation of secretions from special glands can further reduce the temperature. (wikibooks.org)
  • Malignant epithelial (Paget) cells infiltrate and proliferate in the epidermis, causing thickening of the nipple and the areolar skin. (medscape.com)
  • In the case of udders, pairs of mammary glands comprise a single mass, with more than one nipple (or teat) hanging from it. (wikipedia.org)
  • Thus is formed the prominent female breast (mamma), on the top of which rises the teat or nipple (mammilla). (diccionarioingles.com)
  • The presence of more than two nipples is known as polythelia and the presence of more than two complex mammary glands as polymastia. (wikipedia.org)
  • An extra breast (ie, polymastia) or extra nipple (ie, polythelia) occurs in approximately 1% of the population. (medscape.com)
  • In late pregnancy, by around day 60 to 65, the nipples are surrounded by hairless skin and are prominent and very obvious, standing out from the enlarged abdomen. (cats.com)
  • By the last three weeks, however, weight gain around the abdomen and mammary gland growth become evident. (vetstreet.com)
  • However, care should be taken not to overexert the dog during the final weeks, when her abdomen and mammary glands are enlarged. (vetstreet.com)
  • A female has 5 mammary glands and nipples, located on the left and right side of the lower abdomen. (labrador-retriever-guide.com)
  • If the nipples are sucked frequently and regularly, the brain will think it as a signal to promote increased secretion of prolactin which concomitantly initiates milk secretion from breast. (tandurust.com)
  • However, changes to a cat's mammary glands can also be symptoms of other health concerns. (cats.com)
  • The most common mammary tumor found in rats is the mammary fibroadenoma, a benign encapsulated tumor. (ratguide.com)
  • Often a benign canine mammary tumor contains several types of cells. (labrador-retriever-guide.com)
  • [ 5 ] Like Paget cells of both mammary and extramammary sites, Toker cells contain prominent clear (vacuolated) cytoplasm, and they are considered benign counterparts of Paget cells. (medscape.com)
  • JOHNS HOPKINS (US) - A better route for delivering drugs to fight early breast cancer may be the most direct: through the nipple. (futurity.org)
  • Retraction of the nipple or the presence of palpable nodules indicates an underlying breast cancer. (medscape.com)
  • At 18-19 weeks' gestation, a bulb-shaped mammary bud can be discerned in the fetus. (medscape.com)
  • [ 4 ] Supernumerary nipples are slightly more common in males than in females. (medscape.com)
  • [ 7 ] Rare cases of female patients with PD of supernumerary nipples have been reported. (medscape.com)
  • [ 4 ] Toker cells have been found in about 10% of normal nipples and rarely in supernumerary nipples on the mild line and apocrine bearing areas. (medscape.com)
  • Other conditions can cause nipple changes, such as estrus (heat), mastitis, and mammary cancer. (cats.com)
  • As the infant begins to suck, the oxytocin-mediated "let down reflex" ensues, and the mother's milk is secreted - not sucked - from the gland into the baby's mouth. (wikipedia.org)
  • Pigmented mammary PD and pigmented extramammary PD are rare clinical entities in both males and females. (medscape.com)
  • Both male and female cats have multiple pairs of nipples, which are usually small, pale, and mostly hidden by fur. (cats.com)
  • Most cats have either six or eight nipples, lined in pairs down their bellies. (cats.com)
  • Chickens do not have nipples even though they are gifted with firm and meaty breasts. (cs-tf.com)
  • Patient had experienced prolonged history of chronic eczematous dermatitis of nipple and areolar area for several years. (medscape.com)
  • Occasionally, a cat might have more or less than this, or even an odd number of nipples. (cats.com)
  • Although atypical, men can occasionally develop large mammary glands that result in breast enlargement. (healthline.com)
  • however, bilateral mammary PD has occasionally been reported. (medscape.com)
  • A cat's multiple nipples are arranged so they can nurse all of their kittens simultaneously. (cats.com)
  • The nipples are pale, usually a similar color to the cat's skin. (cats.com)
  • If you have noticed changes to your cat's nipples and wonder if she might be pregnant, consider these signs of a cat's pregnancy to help you determine your pet's situation. (cats.com)
  • A balanced diet is therefore another sensible preventive measure to reduce your cat's risk of developing mammary cancer and many other ailments. (marylandpet.com)
  • In the case of prototherians, both males and females have functional mammary glands, but their mammary glands are without nipples. (wikipedia.org)
  • So, to review, males have nipples because the development of mammary glands is independent of sexual development, at least until puberty. (answering-christianity.com)
  • The pathogenesis of mammary PD and the origin of Paget cells were once controversial. (medscape.com)
  • Schematic diagram of female breast depicting widely accepted concept of pathogenesis of mammary Paget disease. (medscape.com)
  • A mammary gland is a specific type of apocrine gland specialized for manufacture of colostrum when giving birth. (wikipedia.org)
  • Mammary glands can be identified as apocrine because they exhibit striking "decapitation" secretion. (wikipedia.org)
  • During the sixth week of development, the mammary glands first develop as solid downgrowths of the epidermis that extend into the mesenchyme from the axilla to the inguinal regions. (medscape.com)
  • Patients with mammary Paget disease (PD) present with a relatively long history of an eczematous skin lesion or persistent dermatitis in the nipple and adjacent areas. (medscape.com)
  • Lesion did not respond to topical treatment, and it progressively distorted nipple with expansion into surrounding skin. (medscape.com)
  • Injury to the chest wall from an accident can damage the nerves supplying breast and nipple. (tandurust.com)
  • Use bust It is not difficult, it is applied to dry skin of the chest, while avoiding the nipple area. (fetishmum.com)
  • Their mammary glands can be termed as breasts or udders. (wikipedia.org)
  • On two legged cows udders have two teats (or in the case of the two-legged variety the teats are more often called nipples). (urbandictionary.com)