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  • systemic
  • 01). Despite the fall in systemic vascular resistance, glomerular filtration rates were not changed during nifedipine therapy, as measured by both creatinine and iothalamate clearances. (ahajournals.org)
  • Hence, vascular and functional regulation of the kidney was dissociated from the systemic circulation during nifedipine administration after transplantation. (ahajournals.org)
  • bioavailability
  • The composition of this invention can increase the bioavailability of nifedipine and makes it possible to provide a nifedipine-containing pharmaceutical preparation which has small bulk and can be easily administered. (google.com)
  • The present invention relates to a solid composition of nifedipine (4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine) and, more particularly, the invention relates to a novel nifedipine-containing solid composition having high bioavailability and small bulk for facilitating the administration thereof. (google.com)
  • We conclude that the calcium antagonist nifedipine enhances the bioavailability of endothelial NO without significantly altering the NOS (type III) mRNA and protein expression, possibly via an antioxidative protection. (ahajournals.org)
  • Furthermore, because NO is rapidly deactivated by reactive oxygen species (ROS) 20 and the DHPs may act as scavengers as known from different in vitro models, 21 22 23 we also determined the antioxidative potency of nifedipine in endothelial cell cultures as well as in native cells to reveal a potential NO-protection effect as an underlying mechanism of the increased NO bioavailability. (ahajournals.org)
  • basal
  • The hypotensive effect of captopril was highly predictable by basal PRA values, and that of nifedipine by age, while PRA increments induced by captopril were unrelated to those induced by nifedipine. (ahajournals.org)
  • Nifedipine induced a significant time- and concentration-dependent increase (132±47%, 1 μmol/L, 40 minutes' incubation) in the basal NO liberation (oxyhemoglobin assay). (ahajournals.org)
  • However, nifedipine (both short- and long-term treatment) significantly reduced the basal and glucose (20 and 30 mmol/L)-stimulated formation of reactive oxygen species (lucigenin assay) of endothelial cell cultures and native cells. (ahajournals.org)
  • Because patients usually take calcium antagonists for a longer period of time, we investigated whether long-term treatment of endothelial cell cultures with nifedipine may alter the basal endothelial NO release as well as the expression of the constitutive endothelial NO synthase (ecNOS) mRNA and protein. (ahajournals.org)
  • contraction
  • Calculation of the PSD peak frequency in EHG contraction bursts at different times of nifedipine treatment in women in gestational age 24 to 32 weeks with contractions. (hindawi.com)
  • interaction
  • Adverse interaction between nifedipine and beta-blockade. (bmj.com)
  • Staffurth J S , Emery P . Adverse interaction between nifedipine and beta-blockade. (bmj.com)
  • The interaction mechanism between nifedipine (NDP) and pepsin (PEP) at 298, 310, and 318 K was studied by various spectroscopic techniques and molecular docking. (springer.com)
  • Hemodynamic
  • We studied hemodynamic, renal, and hormonal effects of monotherapy with nifedipine XL (n = 37) in liver transplant recipients within a year after transplant (median, 4.4 months). (ahajournals.org)
  • composition
  • 1. A nifedipine-containing solid composition comprising a coprecipitate (a) of nifedipine and (b) about 1 to 20 times its weight of a member selected from the group consisting of polyvinylpyrrolidone, methylcellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose. (google.com)
  • severe
  • Talk to your doctor before using this form of nifedipine if you have galactose intolerance, or severe problems with lactose (milk sugar). (healthbanks.com)
  • similar
  • Nifedipine, the prototype of the dihydropyridine class of calcium channel blockers (CCBs), is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. (drugbank.ca)
  • Nifedipine exerted a similar effect on blood pressure and PRA, but it increased heart rate and did not change aldosterone. (ahajournals.org)
  • Captopril plus nifedipine further reduced blood pressure and increased PRA, did not change heart rate, and reduced aldosterone to values similar to those after captopril alone. (ahajournals.org)
  • In a similar fashion, the Trent nifedipine study observed no mortality benefit from nifedipine after myocardial infarction. (acc.org)