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  • basement membranes
  • Laminins [( PUBMED:2404817 )] are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation. (embl.de)
  • Structural decoding of netrin-4 reveals an adhesion function related to laminin γ1 binding and unique non-enzymatic disruptive forces towards mature basement membranes. (uk-koeln.de)
  • Murine
  • Although this antibody bound to gal(α1-3)gal-linked synthetic antigens, it did not bind to the same residues present in rabbit, rat, and guinea pig RBC or in murine laminin or nidogen. (ajtmh.org)
  • glomerular basement
  • Whereas the total absence of laminin α5 results in breakdown of the glomerular basement membrane (GBM) and failed glomerular vascularization, a hypomorphic Lama5 mutation (the Lama5 neo allele) results in proteinuria, hematuria, polycystic kidney disease (PKD), and death 3 to 4 weeks after birth. (asnjournals.org)
  • complexes
  • The results also support a model predicting that monomeric laminin 5 constitutes the anchoring filaments and bridges integrin alpha6beta4 with type VII collagen, and the laminin 5-6/7 complexes are present within the interhemidesmosomal spaces bound at least by integrin alpha3beta1 where they may mediate basement membrane assembly or stability, but contribute less significantly to epithelial friction resistance. (nih.gov)
  • Absorption
  • An antibody reactive with the galactosyl(α1-2)galactose [gal(α1-2)gal] epitope was characterized in human sera by enzyme-linked immunosorbent assay, red blood cell (RBC) and laminin absorption, and oligosaccharide inhibition. (ajtmh.org)
  • mutation
  • Mutation of the mouse laminin α5 gene results in a variety of developmental defects, including defects in kidney structure and function. (asnjournals.org)
  • Here, we examined the role of podocyte-derived laminin α5 via podocyte-specific inactivation of Lama5 and podocyte-specific rescue of the Lama5 neo mutation. (asnjournals.org)
  • inhibition
  • Inhibition of type VII-NC-1 binding to immobilized laminin 5 by preincubation with various competitors. (nih.gov)
  • Mice
  • Podocyte-specific restoration of laminin α5 production using two distinct strategies in Lama5 neo/neo mice resulted in the resolution of proteinuria, hematuria, and PKD. (asnjournals.org)
  • These results suggest that the development of normal GBM structure and function requires podocyte-derived laminin α5 during and after glomerulogenesis and present a unique mechanism for the pathogenesis of PKD in these mice. (asnjournals.org)
  • Laminin α5 is widely expressed, 17 and Lama5 −/− mice die at late fetal stages with multiple developmental defects. (asnjournals.org)
  • 19 Studies of chimeric laminin chains in transgenic mice revealed that the α5 COOH-terminal laminin globular domain is required for proper adhesion of mesangial cells to the GBM 20 and for a proper filtration barrier. (asnjournals.org)
  • integrin
  • Laminin 5 binds the cell surface through hemidesmosomal integrin alpha6beta4. (nih.gov)
  • The results are consistent with the presumed orientation of laminin 5, having the COOH-terminal G domain apposed to the hemidesmosomal integrin, and the NH2-terminal domains within the lamina densa. (nih.gov)
  • polypeptide
  • The highest similarity score of the sponge nidogen was found to be with the related mucin sequences, the predicted mucin-4-like polypeptide from Amphimedon queenslandica (XP_003389333. (thefreedictionary.com)
  • major
  • 13 The major laminin in mature GBM is laminin-521 (α5β2γ1), but during glomerulogenesis there are developmental transitions in which laminin-111 (α1β1γ1) is replaced by laminin-511 (α5β1γ1), which is then joined and eventually replaced by laminin-521. (asnjournals.org)
  • Human
  • Approximately half of the laminin 5 solubilized from human amnion or skin is covalently complexed with laminins 6 or 7 (alpha3beta2gamma1). (nih.gov)
  • Family
  • It is a member of matrix metalloproteinase (MMP) family in the ECM which breaks substrates such as aggrecan, versican, brevican, nidogen , and procollagen. (thefreedictionary.com)