Characterization of Drosophila Nidogen / entactin reveals roles in basement membrane stability, barrier function and nervous system patterning. (bvsalud.org)
2004). This ectodomain interacts with fibronectin, nidogen-2 and perlecan (Tu et al. (reactome.org)
Galectin-3BP binds Galectin-3 (formerly MAC-2) with high affinity, but also binds Galectins -1 and -7, several collagen types, fibronectin, beta 1 integrins and nidogen (3, 6, 7). (novusbio.com)
NID22
Two nidogens have been identified in humans: nidogen-1 (NID1) and nidogen-2 (NID2). (wikipedia.org)
Nidogen-2 antibody LS-C688544 is a biotin-conjugated rabbit polyclonal antibody to human Nidogen-2 (NID2) (aa31-289). (lsbio.com)
Antibody2
This assay employs an antibody specific for Human Nidogen-1 coated on a 96-well PCR plate. (raybiotech.com)
Standards and samples are pipetted into the wells and Nidogen-1 present in a sample is bound to the wells by the immobilized antibody. (raybiotech.com)
Collagen1
The nidogen G2 beta-barrel domain contains a large surface patch that is involved in the binding of perlecan, and possibly also of collagen IV. (expasy.org)
Basement2
Remarkably, vertebrates are still capable of stabilizing basement membrane in the absence of either identified nidogen. (wikipedia.org)
RayBio® Human Immunoquantitative (PCR-Based) Nidogen-1 ELISA Kit for cell culture supernatants, plasma, and serum samples. (raybiotech.com)
The RayBio ® Human Nidogen-1 IQELISA™ Kit is a modified ELISA assay with high sensitivity qPCR readout for the quantitative measurement of Human Nidogen-1 in serum, plasma, and cell culture supernatants. (raybiotech.com)
Domain1
The data support a previously proposed dumb-bell model of nidogen by demonstrating a large N-terminal globular domain (641 residues), five EGF-like repeats constituting the rod-like domain (248 residues) and a smaller C-terminal globule (328 residues). (unifi.it)
Cell1
The latter was shown to be functional in cell attachment to nidogen. (unifi.it)
Play1
Nidogen have been shown to play a crucial role during organogenesis in late embryonic development, particularly in cardiac and lung development. (wikipedia.org)
Solution1
Mix vial 1(Lyophilized Nidogen) and vial 2(Activating Solution) thoroughly. (chamt.co.kr)
Type1
Recognition of Tumor Nidogen-1 by Neutrophil C-Type Lectin Receptors. (invivogen.com)
Laminin-nidogen1
Here, we developed transgenic dy2J mice with muscle-specific expression of αLNNd, a laminin/nidogen chimeric protein that provides a missing polymerization domain. (jci.org)
Integrin2
COL13A1 forms disulfide-linked homotrimers and participates in cell adhesion by binding to the Integrin alpha 1 subunit, Nidogen-2, and Fibronectin. (rndsystems.com)
Ikkbeta(Delta hep) hepatocyte proliferative responses show heightened sensitivity to TGFalpha and TNFalpha, and heightened expression of fibronectin, collagens I/III, nidogen, beta-actin and integrin beta1 mRNAs. (nih.gov)
Biomarker for ovarian3
Nidogen-2: a new serum biomarker for ovarian cancer. (nih.gov)
Nidogen-2 is a new biomarker for ovarian cancer which correlates closely with CA125. (nih.gov)
29. Nidogen-1: a candidate biomarker for ovarian serous cancer. (nih.gov)
NID11
However, combining in vivo, in vitro, and quantitative proteomics data, we uncover that Ndrg4 knockdown is associated with enlarged intestinal adenoma development and that organoid growth is boosted by the Ndrg4 -/- ENS cell secretome, which is enriched for Nidogen-1 (Nid1) and Fibulin-2 (Fbln2). (nih.gov)
Fibronectin1
Definition noun, plural: myoepithelial cells (1) (histology) A slender, spindle-shaped contractile cell forming the thin layer in an exocrine gland, particularly between the basement membrane and the luminal epithelial cells, and functions by aiding in the secretion of fluid from the gland and synthesize basement membrane elements such as fibronectin, laminin, collagen IV, and nidogen. (biologyonline.com)
Proteins2
Among these proteins, nidogen-1 was exclusively expressed in confluent endothelial cells and was found to be necessary and sufficient for the inhibition of SK-BR-3 cell migration. (biomedcentral.com)
Matrixyl 3000 significantly stimulates synthesis of Collagen-I, -IV, -VII, -XVII and Nidogen-I proteins. (babyfacestore.com)
Basement membrane protein1
Intriguingly, the four conserved immunoglobulin domains in UNC-52 are necessary to correctly localize the basement membrane protein NID-1/Nidogen. (elsevierpure.com)
Supernatants2
Indeed, SK-BR-3 cells exposed to nidogen-1-depleted endothelial supernatants showed increased promigratory STAT3 phosphorylation along with increased cell migration. (biomedcentral.com)
The αLNNd-depleted supernatants were then immunoprecipitated with anti-nidogen G2-G3 (IP #3 and IP #4). (jci.org)
Absence2
Remarkably, vertebrates are still capable of stabilizing basement membrane in the absence of either identified nidogen. (wikipedia.org)
This reflects the situation of enhanced SK-BR-3 migration upon stimulation with conditioned medium from subconfluent endothelial cells with inherent absence of nidogen-1 expression. (biomedcentral.com)
Serous1
Both nidogen-2 and CA125 were elevated more in serous histotypes of ovarian cancer and late state disease. (nih.gov)
Shown2
Nidogen have been shown to play a crucial role during organogenesis in late embryonic development, particularly in cardiac and lung development. (wikipedia.org)
Precipitates, following SDS-PAGE and membrane transfer, were immunoblotted with anti-Lmβ1γ1 (upper cut membrane, dotted cut line shown) and anti-nidogen G2-G3 (lower cut membrane). (jci.org)
Analysis1
ROC curve analysis for nidogen-2 had an area under the curve (AUC) ranging from 0.73 to 0.83 but CA125 was superior (AUC ranging from 0.87 to 0.99). (nih.gov)
Normal1
Serum nidogen-2 concentration between normal and benign disease patients was not different (median, 13.2 and 12.1 mg/L, respectively). (nih.gov)
Result2
In contrast, those lacking both nidogen-1 and nidogen-2 typically die prematurely during embryonic development as a result of defects existing in the heart and lungs. (wikipedia.org)
While a small amount of nidogen was present in the anti-F2 immunoprecipitates of the dy2J control muscle, this band was similarly seen in immunoblots precipitated with anti-IgY agarose beads alone and deduced to result from nonspecific nidogen binding to beads). (jci.org)