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  • affinity
  • Specific high-affinity binding of the nicotinic radioligand [ 3 H]methyllycaconitine was detected in membrane preparations of mammalian cells transfected with α9χ or α10χ alone, but significantly higher levels of binding were detected when α9χ and α10χ were cotransfected, providing evidence of a requirement for coassembly of α9 and α10 for the efficient formation of a nicotinic binding site. (aspetjournals.org)
  • aVTA and pVTA
  • We have previously reported that carbachol preferentially increased the threshold current intensity for eliciting VADs in aVTA and pVTA, but not midVTA. (wayne.edu)
  • The present study indicates that unilateral carbachol (4 µg/0.25 µl) supports the CPP learning in aVTA and pVTA, but not midVTA. (wayne.edu)
  • 2002
  • Ikemoto and Wise (2002) reported that carbachol was self-administered in the posterior VTA (pVTA), but not the anterior VTA (aVTA). (wayne.edu)
  • Whereas
  • With low cholesterol diet TTX enhanced carbachol-evoked contractions, whereas this action potential blocker did not affect the augmented cholinergic contractions seen with tissues from animals on the high cholesterol diet. (biomedcentral.com)
  • cholinesterase
  • Carbachol is not easily metabolized by cholinesterase , it has a 2 to 5 minute onset of action and its duration of action is 4 to 8 hours with topical administration and 24 hours for intraocular administration. (wikipedia.org)
  • Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine R. (nih.gov)