The criterion standard test to evaluate endothelial function is an invasive determination of coronary flow reserve via Doppler guidewire in the cardiac catheterization laboratory (ie, quantifying the coronary blood flow in response to nitroglycerine and acetylcholine infusion) (see image below). (medscape.com)
Cardiac Syndrome X. Coronary blood flow in response to nitroglycerine (NTG) and acetylcholine (ACH) infusion. (medscape.com)
Using the current meta-analysis as well as systematic review, to determine the curative effect of Nicorandil in comparison of no Nicorandil after elective percutaneous coronary intervention(PCI) on patients. (biomedcentral.com)
A set of randomized trials evaluating Nicorandil in comparison of no Nicorandil administered following PCI in patients harboring coronary artery disease were included. (biomedcentral.com)
Nicorandil is effective for patients undergoing elective PCI with coronary artery disease in terms of reducing the incidence of adverse cardiovascular events as well as improving heart function. (biomedcentral.com)
Time-dependent response of coronary flow to prolonged adenosine infusion: doubling of peak reactive hyperaemic flow // Cardiovasc. (med24info.com)
Nitric oxide2
The purpose of this study was to investigate whether nicorandil, a novel nitric oxide generator and adenosine triphosphate- sensitive potassium-channel opener, might enhance lung preservation and prevent allograft reperfusion injury. (wustl.edu)
In infants with lesions restricting pulmonary blood flow (blood is flowing through the ductus arteriosus from the aorta to the pulmonary artery), Alfaprostin may be administered by continuous infusion through an umbilical artery catheter placed at or just above the junction of the descending aorta and the ductus arteriosus, or intravenously. (pharmacily.com)
In addition, recipient animals received nicorandil (0.5 mg/kg, intravenously) just before reperfusion, as well as a continuous infusion (0.74 ± 0.03 mg/kg per hour) during the 6-hour assessment period. (wustl.edu)
Opener3
The beneficial effects of nicorandil may be attributed to its properties as an adenosine triphosphate-sensitive potassium-channel opener. (wustl.edu)
We evaluated the clinical efficacy and safety of the administration of PAP after nicorandil (NIC), a potassium channel opener that prevents VT, for optimal FFR measurement.A total of 127 patients with 178 stenoses were enrolled. (bvsalud.org)
Here is a list of examples of the nitrate type (in alphabetical order): Diethylene glycol dinitrate Glyceryl trinitrate (nitroglycerin) Isosorbide mononitrate and dinitrate Itramin tosilate Nicorandil (which additionally acts as a potassium channel opener) Pentaerithrityl tetranitrate Propatylnitrate Sinitrodil Tenitramine Trolnitrate Nitrovasodilators which aren't nitrates include molsidomine and its active metabolite linsidomine, as well as sodium nitroprusside. (wikipedia.org)
Conclusions1
Conclusions: Nicorandil administration in the flush solution and during the reperfusion period ameliorates lung allograft dysfunction, improves blood flow, and reduces pulmonary vascular resistance and myeloperoxidase activity in the transplanted lung. (wustl.edu)
Potassium1
In group III (n = 4), glibenclamide, a selective adenosine triphosphate-sensitive potassium-channel blocker, was administered 15 minutes before nicorandil administration to both donor and recipient. (wustl.edu)
Systemic1
After a therapeutic response (an increase in pO2 in neonates with restricted pulmonary blood flow or an increase in systemic blood pressure and blood pH in neonates with restricted systemic blood flow) has been obtained, the infusion rate should be reduced to the lowest possible dosage that will maintain the desired response. (pharmacily.com)
Tablets1
We "Vidharbha Pharma LLP" are a Partnership based firm, engaged as the foremost Manufacturer and Wholesaler of Pharmaceutical Injections, Pharma Injections, Pharmaceutical Tablets, IV Infusions, Pharmaceutical Capsules and many more. (vpllp.in)
Incidence3
the peak CK-MB level and the incidence of adverse cardiovascular events were remarkably lower in Nicorandil group. (biomedcentral.com)
Therefore, we investigated whether the use of nicorandil would reduce the incidence of CIN in patients with AMI undergoing PCI. (e-ceth.org)
The use of nicorandil did not decrease the incidence of CIN in patients with AMI undergoing PCI. (e-ceth.org)
Significantly1
Should arterial pressure fall significantly, the rate of infusion should be immediately decreased. (pharmacily.com)
For administration by intravenous drip or constant rate infusion pump. (pharmacily.com)
The risk of long-term infusion of Alfaprostin should be weighed against the possible benefits that critically ill infants may derive from its administration. (pharmacily.com)
Group5
Nicorandil and no Nicorandil administered group appeared to be equivalent with regards to cTnI. (biomedcentral.com)
In group II (n = 5), the donor lung received nicorandil (24 mg/L) in the flush solution. (wustl.edu)
The animals in group III received nicorandil in the same regimen as group II. (wustl.edu)
The patients were divided into two groups: group I receiving nicorandil (n= 442) and group II not receiving nicorandil (n= 1,050). (e-ceth.org)
Effects1
The purpose of the current study was to provide a systematic review of Nicorandil in terms of its cardio-protective effects. (biomedcentral.com)
Study1
The present study suggests that nicorandil reduces lung allograft reperfusion injury. (wustl.edu)
Solution1
Concentrate for Solution for Infusion (Clear, colourless solution). (pharmacily.com)
Evidence1
The aim was to synthesize the available evidence and compare data associated with the effectiveness of Nicorandil in this objective and quantitative analysis. (biomedcentral.com)
Hour1
Apnoea is most often seen in neonates weighing less than 2 kg at birth and usually appears during the first hour of drug infusion. (pharmacily.com)